| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Priyanshy Sharma, V Sri Swetha Victoria, P Praneeth Kumar, Sarbani Karmakar, Mudduluru Swetha, Amala Redd. Cross-talk between insulin resistance and nitrogen species in hypoxia leads to deterioration of tissue and homeostasis. International immunopharmacology. vol 122. 2023-07-01. PMID:37392570. |
hypoxia has been linked with insulin resistance as it produces changes in the metabolism of the cell; in which the adipocytes impede the insulin receptor tyrosine, phosphorylation, directing at decreased levels of transport of glucose. |
2023-07-01 |
2023-08-14 |
Not clear |
| Saori Kakehi, Yoshifumi Tamura, Shin-Ichi Ikeda, Naoko Kaga, Hikari Taka, Yuya Nishida, Ryuzo Kawamori, Hirotaka Watad. Physical inactivity induces insulin resistance in plantaris muscle through protein tyrosine phosphatase 1B activation in mice. Frontiers in physiology. vol 14. 2023-06-30. PMID:37389126. |
insulin-stimulated phosphorylation levels of insulin receptor (ir), ir substrate-1, and akt were reduced in parallel with the decrease in insulin sensitivity. |
2023-06-30 |
2023-08-14 |
mouse |
| Ranran Sun, Liwei Jiang, Wenlong Chen, Yuanhao Xu, Xin Yi, Guohua Zhon. Azadirachtin exposure inhibit ovary development of Spodoptera litura (Lepidoptera: Noctuidae) by altering lipids metabolism event and inhibiting insulin signaling pathways. Ecotoxicology and environmental safety. vol 262. 2023-06-25. PMID:37356396. |
besides, following the abnormal lipids metabolism, western blot analysis suggested that aza induce insulin resistance-like phenotypes by inhibiting insulin receptor substrates (irs) /pi3k/akt pathway, which might be responsible for the ovary abnormalities of s. litura. |
2023-06-25 |
2023-08-14 |
Not clear |
| Shin-Ichi Kuno, Ikuo Yasumas. Does phosphatidylinositol 3-kinase play a role in insulin-induced outgrowth of pseudopodial cables in cultured cells derived from micromeres of sea urchin embryos? Development, growth & differentiation. vol 38. issue 3. 2023-06-07. PMID:37281666. |
cultured cells derived from micromeres isolated from sea urchin embryos at the 16-cell stage, which have insulin receptors, undergo pseudopodial cable growth and spicule rod formation in culture with horse serum and only cable growth in culture with insulin. |
2023-06-07 |
2023-08-14 |
Not clear |
| Shin-Ichi Kuno, Keiko Mitsunaga-Nakatsubo, Takanori Nagura, Ikuo Yasumas. Changes in Insulin-Binding Capacity of the Plasma Membrane Fraction during Culture in vitro of Cells Derived from Micromeres of 16-Cell-Stage Sea Urchin Embryos: (sea urchin/development/micromere/insulin/insulin receptor). Development, growth & differentiation. vol 36. issue 3. 2023-06-07. PMID:37281772. |
in cultured cells derived from isolated micromeres of 16-cell stage sea urchin embryos, which undergo insulin-induced pseudopodial cable growth, specific and reversible insulin binding by a 52-kda protein, probably an insulin receptor in the plasma membrane, is augmented during 5 h of culture without any change in the dissociation constant (kuno et al : 1994). |
2023-06-07 |
2023-08-14 |
Not clear |
| Lingling E, Rongjian Lu, Ying Zheng, Li Zhang, Xiaocao Ma, Yan Lv, Mingzhu Gao, Shaoli Zhang, Limei Wang, Hongchen Liu, Rong Zhan. Effect of insulin on bone formation ability of rat alveolar bone marrow mesenchymal stem cells. Stem cells and development. 2023-06-07. PMID:37282516. |
acute insulin stimulation significantly promoted insulin receptor (ir) phosphorylation, insulin receptor substrate-1 (irs-1) protein expression and mammalian target of rapamycin (mtor) phosphorylation, but chronic insulin stimulation decreased these values, while inhibitor nt219 could attenuate these responses. |
2023-06-07 |
2023-08-14 |
mouse |
| Kirti Baraskar, Pratibha Thakur, Renu Shrivastava, Vinoy Kumar Shrivastav. Ameliorative effects of gallic acid on GLUT-4 expression and insulin resistance in high fat diet-induced obesity animal model mice, Journal of diabetes and metabolic disorders. vol 22. issue 1. 2023-05-31. PMID:37255787. |
the present study aimed to investigate the effects of the antidote gallic acid (ga) on expression-related changes in glut-4 and insulin receptor substrate-1 (irs-1) in the visceral adipose tissue and on the subsequent development of insulin resistance in a high-fat diet (hfd)-induced obesity animal model. |
2023-05-31 |
2023-08-14 |
mouse |
| Ashraf N Abdalla, Asaad Khalid, Alanood S Algarni, Bao Le Van, Gokhan Zengin, Muhammad Zakariyyah Aumeeruddy, Mohamad Fawzi Mahomoodall. Zingiber Pfficinale Roscoe (Ginger) and its Bioactive Compounds in Diabetes: A Systematic Review of Clinical Studies and Insight of Mechanism of Action. Current medicinal chemistry. 2023-05-25. PMID:37226794. |
overall, these mechanisms were by increasing glucose-stimulated insulin secretion, sensitising insulin receptors and raising glucose uptake, translocation of glut4, inhibition of advanced glycation end product-induced increase of reactive oxygen species, regulation of hepatic gene expression of enzymes associated with glucose metabolism, regulation of the level of pro-inflammatory cytokines, amelioration of the pathological injuries of kidneys, protective effect on the morphology of β-cells as well as its antioxidant mechanisms, among others. |
2023-05-25 |
2023-08-14 |
human |
| Claire Park, Yanxian Zhang, Jae Un Jung, Line Due Buron, Nai-Pin Lin, Thomas Hoeg-Jensen, Danny Hung-Chieh Cho. Antagonistic Insulin Derivative Suppresses Insulin-Induced Hypoglycemia. Journal of medicinal chemistry. 2023-05-25. PMID:37227951. |
we investigated insulin modifications on the c-terminal a chain with insulin receptor (ir) peptide binders and presented a full and potent ir antagonist. |
2023-05-25 |
2023-08-14 |
human |
| Adrien J R Molinas, Lucie D Desmoulins, Roslyn K Davis, Hong Gao, Ryousuke Satou, Andrei V Derbenev, Andrea Zsombo. High-Fat Diet Modulates the Excitability of Neurons within the Brain-Liver Pathway. Cells. vol 12. issue 8. 2023-05-16. PMID:37190103. |
insulin receptor expression was detected in a population of liver-related neurons, and insulin suppressed the firing activity of liver-related pvn and pre-sympathetic vlm/vmm neurons in hfd mice; however, it did not affect vlm-projecting liver-related pvn neurons. |
2023-05-16 |
2023-08-14 |
mouse |
| Zahid Khan, Syed Aun Muhammad, Jonard Carpio, Yousif Yousif, Amresh Gul, Sahar Hamid, Animesh Gupt. The Effect of Vitamin D Supplementation on Incidence of Type 2 Diabetes: A Systematic Review. Cureus. vol 15. issue 3. 2023-05-01. PMID:37123701. |
one such intervention is vitamin d supplementation, as it affects insulin secretion from the pancreas and insulin receptors in the cells of the body. |
2023-05-01 |
2023-08-14 |
Not clear |
| Sayantani Pramanik Palit, Roma Patel, Nishant Parmar, Nirali Rathwa, Nilay Dalvi, A V Ramachandran, Rasheedunnisa Begu. Repurposing Pitavastatin and L-Glutamine: Replenishing β-Cells in Hyperlipidemic Type 2 Diabetes Mouse Model. Life (Basel, Switzerland). vol 13. issue 4. 2023-04-28. PMID:37109458. |
significant amelioration was observed in the combination therapy as compared to monotherapies in respect of (i) insulin resistance, glucose intolerance, lipid profile, adiponectin levels, and mitochondrial complexes i, ii, and iii activities, (ii) reduced phosphoenolpyruvate carboxykinase, glucose 6-phophatase, glycogen phosphorylase, and glut2 transcript levels with increased glycogen content in the liver, (iii) restoration of insulin receptor 1β, pakt/akt, and adipor1 protein levels in skeletal muscle, and (iv) significant increase in islet number due to β-cell regeneration and reduced β-cell death. |
2023-04-28 |
2023-08-14 |
mouse |
| Yuying Zhang, Miaomiao Lan, Chang Liu, Tongtong Wang, Chuncheng Liu, Sen Wu, Qingyong Men. Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice. The international journal of biochemistry & cell biology. 2023-04-28. PMID:37116777. |
islr regulates insulin sensitivity by interacting with psma4 to control insulin receptor alpha levels in obese mice. |
2023-04-28 |
2023-08-14 |
mouse |
| Yuying Zhang, Miaomiao Lan, Chang Liu, Tongtong Wang, Chuncheng Liu, Sen Wu, Qingyong Men. Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice. The international journal of biochemistry & cell biology. 2023-04-28. PMID:37116777. |
insulin resistance is the leading cause of type 2 diabetes (t2d), and dysfunctional insulin receptor signaling is a major manifestation of this insulin resistance. |
2023-04-28 |
2023-08-14 |
mouse |
| Yuying Zhang, Miaomiao Lan, Chang Liu, Tongtong Wang, Chuncheng Liu, Sen Wu, Qingyong Men. Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice. The international journal of biochemistry & cell biology. 2023-04-28. PMID:37116777. |
in t2d, the corresponding insulin receptor levels are aberrantly down-regulated, which is one of the major factors underlying obesity-induced insulin resistance in adipose tissue. |
2023-04-28 |
2023-08-14 |
mouse |
| Jie Chen, Lingmin Hu, Yingchun Ling, Yuhua Xu, Xiao Yu, Luping Ma, Mengna Sho. Risk Correlation Analysis between Polycystic Ovary Syndrome (PCOS) and Serum Visfatin Levels in Middle-Aged Women: Systematic Review and Meta-Analysis. Discovery medicine. vol 35. issue 175. 2023-04-27. PMID:37105926. |
serum visfatin can affect insulin resistance by binding to insulin receptors and further affect the occurrence and development of pcos. |
2023-04-27 |
2023-08-14 |
Not clear |
| Matthäus Metz, James O'Hare, Bob Cheng, Michelle Puchowicz, Christoph Buettner, Thomas Schere. Brain insulin signaling suppresses lipolysis in the absence of peripheral insulin receptors and requires the MAPK pathway. Molecular metabolism. 2023-04-26. PMID:37100238. |
brain insulin signaling suppresses lipolysis in the absence of peripheral insulin receptors and requires the mapk pathway. |
2023-04-26 |
2023-08-14 |
Not clear |
| Mengjuan Wei, Tianyu Zhang, Hao Ouyang, Zhenlin Huang, Bin Lu, Jian Li, Hong Xu, Zhengtao Wang, Lili J. Erianin alleviated liver steatosis by enhancing Nrf2-mediated VE-cadherin expression in vascular endothelium. European journal of pharmacology. 2023-04-24. PMID:37094711. |
insulin reduced nrf2 activation by decreasing sequestosome-1 (p62/sqstm1) expression downstream of insulin receptor. |
2023-04-24 |
2023-08-14 |
mouse |
| Nazia Siddiqui, Javed Ali, Suhel Parvez, Abul Kalam Najmi, Mohd Akhta. Neuroprotective Role of DPP-4 Inhibitor Linagliptin Against Neurodegeneration, Neuronal Insulin Resistance and Neuroinflammation Induced by Intracerebroventricular Streptozotocin in Rat Model of Alzheimer's Disease. Neurochemical research. 2023-04-20. PMID:37079222. |
type 2 diabetes mellitus and neuronal insulin resistance due to serine phosphorylation of insulin receptor substrate-1 at 307 exhibits correlation with ad. |
2023-04-20 |
2023-08-14 |
rat |
| Sarah Wing-Yiu Poon, Brian Hon-Yin Chung, Mabel Siu-Chun Wong, Anita Man-Ching Tsan. Diazoxide-unresponsive Hyperinsulinemic Hypoglycaemia in a Preterm Infant with Heterozygous Insulin Receptor Gene Mutation. Journal of clinical research in pediatric endocrinology. 2023-04-19. PMID:37074094. |
homozygous or compound heterozygous mutations in insulin receptor gene (insr) lead to marked insulin resistance and hyperglycaemia in donohue syndrome and rabson-mendenhall syndrome, conditions which are associated with significant morbidity early in life. |
2023-04-19 |
2023-08-14 |
Not clear |