| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marinna C Okawa, Rebecca M Tuska, Marissa Lightbourne, Brent S Abel, Mary Walter, Yuhai Dai, Elaine Cochran, Rebecca J Brow. Insulin signaling through the insulin receptor increases linear growth through effects on bone and the GH-IGF-1 axis. The Journal of clinical endocrinology and metabolism. 2023-08-18. PMID:37595266. |
insulin signaling through the insulin receptor increases linear growth through effects on bone and the gh-igf-1 axis. |
2023-08-18 |
2023-10-07 |
Not clear |
| Yoo Kim, Junsik M Lee, Youngah Han, Rongya Tao, Morris F White, Renyan Liu, Sang Won Par. BRD7 improves glucose homeostasis independent of IRS proteins. The Journal of endocrinology. vol 258. issue 3. 2023-08-14. PMID:37578842. |
of note, the upregulation of hepatic brd7 levels activates the akt cascade in response to insulin without enhancing the sensitivity of the insulin receptor (insr)-insulin receptor substrate (irs) axis. |
2023-08-14 |
2023-09-07 |
mouse |
| Juan A Estrada, Norio Hotta, Han-Kyul Kim, Rie Ishizawa, Ayumi Fukazawa, Gary A Iwamoto, Scott A Smith, Wanpen Vongpatanasin, Masaki Mizun. Blockade of endogenous insulin receptor signaling in the nucleus tractus solitarius potentiates exercise pressor reflex function in healthy male rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 9. 2023-08-11. PMID:37566482. |
evidence suggests that insulin signaling decreases neuronal excitability in the brain, thus antagonizing insulin receptors (irs) may increase neuronal excitability. |
2023-08-11 |
2023-08-16 |
rat |
| Chandra I Mohani, Achmad Rudijanto, Aulanni'am Aulanni'am, Setyawati Soehart. DLBS3233 enhances nephrin and podocin expression also reduces oxidative stress marker and insulin receptor serine diabetic rats' podocytes. Annals of medicine and surgery (2012). vol 85. issue 8. 2023-08-09. PMID:37554909. |
renal podocytes insensitive to insulin lead to decreased nephrin and podocin and increased insulin receptor serine. |
2023-08-09 |
2023-08-16 |
rat |
| Natasha Brown, Marianne S Elsto. Systematic Review - Type B insulin Resistance with Isolated Hypoglycemia and Supressed Insulin. The Journal of clinical endocrinology and metabolism. 2023-08-08. PMID:37552775. |
type b insulin resistance syndrome is a rare autoimmune disorder affecting glucose homeostasis, characterised by serum autoantibodies to the insulin receptor (airab). |
2023-08-08 |
2023-08-16 |
Not clear |
| Deepa Mathew, Julia Barillas-Cerritos, Ana Nedeljkovic-Kurepa, Mabel Abraham, Matthew D Taylor, Clifford S Deutschma. Phosphorylation of insulin receptor substrates (IRS-1 and IRS-2) is attenuated following cecal ligation and puncture in mice. Molecular medicine (Cambridge, Mass.). vol 29. issue 1. 2023-08-07. PMID:37550630. |
the molecular activity driving insulin signaling is controlled by tyrosine phosphorylation of the insulin receptor β-subunit (irβ) and of insulin receptor substrate molecules (irs) -1 and irs-2. |
2023-08-07 |
2023-08-14 |
mouse |
| Saverio Cint. Obese Adipocytes Have Altered Redox Homeostasis with Metabolic Consequences. Antioxidants (Basel, Switzerland). vol 12. issue 7. 2023-07-29. PMID:37507987. |
during their chronic scavenging activity, macrophages produce several secretory products that have collateral consequences, including interference with insulin receptor activity, causing insulin resistance. |
2023-07-29 |
2023-08-14 |
mouse |
| Junaid Iqbal, Hong-Li Jiang, Hui-Xuan Wu, Long Li, Ying-Hui Zhou, Nan Hu, Fen Xiao, Ting Wang, Shi-Na Xu, Hou-De Zho. Hereditary severe insulin resistance syndrome: Pathogenesis, pathophysiology, and clinical management. Genes & diseases. vol 10. issue 5. 2023-07-26. PMID:37492723. |
hereditary severe insulin resistance syndrome (h-sirs) is a rare disorder classified into four principal categories: primary insulin receptor defects, lipodystrophies, complex syndromes, and obesity-related h-sirs. |
2023-07-26 |
2023-08-14 |
Not clear |
| Xiaolong Yuan, Na Chen, Yance Feng, Nian Li, Xiangchun Pan, Yuhan Tian, Junwen Wang, Yao Jiang, Dou He, Jiaqi Li, Fei Ga. Single-cell multi-omics profiling reveals key regulatory mechanisms that poise germinal vesicle oocytes for maturation in pigs. Cellular and molecular life sciences : CMLS. vol 80. issue 8. 2023-07-22. PMID:37480402. |
we further confirmed insulin receptor substrate-1 in insulin signaling pathway is a key regulator on maturation by in vitro maturation experiments. |
2023-07-22 |
2023-08-14 |
Not clear |
| Bryan A Martinez, Matthew S Gil. The C. elegans truncated insulin receptor DAF-2B regulates survival of L1 arrested larvae. PloS one. vol 18. issue 7. 2023-07-21. PMID:37471418. |
using a novel splicing reporter system, we observe an increase in the ratio of truncated to full length insulin receptor splicing capacity in starved l1 larvae compared with fed, that may indicate a decrease in whole body insulin responsiveness. |
2023-07-21 |
2023-08-14 |
caenorhabditis_elegans |
| Suélen Santos Alves, Gabriel Servilha-Menezes, Leticia Rossi, Rui Milton Patrício da Silva Junior, Norberto Garcia-Cairasc. Evidence of Disturbed Insulin Signaling in Animal Models of Alzheimer's Disease. Neuroscience and biobehavioral reviews. 2023-07-21. PMID:37479008. |
consequently, the identification of insulin receptors in the central nervous system has fueled investigations of insulin functions in the brain. |
2023-07-21 |
2023-08-14 |
Not clear |
| Suélen Santos Alves, Gabriel Servilha-Menezes, Leticia Rossi, Rui Milton Patrício da Silva Junior, Norberto Garcia-Cairasc. Evidence of Disturbed Insulin Signaling in Animal Models of Alzheimer's Disease. Neuroscience and biobehavioral reviews. 2023-07-21. PMID:37479008. |
the identification of high density of insulin receptors in the hippocampus also suggests that insulin may present important roles related to memory. |
2023-07-21 |
2023-08-14 |
Not clear |
| Víctor Navalón-Monllor, Laura Soriano-Romaní, Mariana Silva, María-Carmen López de Las Hazas, Natalia Hernando-Quintana, Teodoro Suárez Diéguez, Pere Morell Esteve, Juan Antonio Niet. Microbiota dysbiosis caused by dietetic patterns as a promoter of Alzheimer's disease through metabolic syndrome mechanisms. Food & function. 2023-07-20. PMID:37470232. |
in this context, higher glucose levels, together with higher free fatty acids in the bloodstream, promote glycolipotoxicity, provoking a reduction in insulin released, insulin receptor resistance, advanced glycation products (ages) and type 2 diabetes. |
2023-07-20 |
2023-08-14 |
Not clear |
| A Leung, P Rangaman. Computational modeling of AMPK and mTOR crosstalk in glutamatergic synapse calcium signaling. NPJ systems biology and applications. vol 9. issue 1. 2023-07-17. PMID:37460570. |
further, we also investigate the crosstalk between insulin receptor and calcium signaling on ampk and mtor activation and predict that the pathways demonstrate multistability dependent on strength of insulin signaling and metabolic consumption rate. |
2023-07-17 |
2023-08-14 |
human |
| Stanley T Lewis, Frank Greenway, Tori R Tucker, Michael Alexander, Levonika K Jackson, Scott A Hepford, Brian Loveridge, Jonathan R T Lake. A Receptor Story: Insulin Resistance Pathophysiology and Physiologic Insulin Resensitization's Role as a Treatment Modality. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446104. |
when ligand/receptors are constantly exposed to insulin, a negative feedback loop down regulates insulin receptor availability to insulin, creating a relative hyperinsulinemia. |
2023-07-14 |
2023-08-14 |
Not clear |
| Vanessa Rück, Narendra K Mishra, Kasper K Sørensen, Mikkel B Liisberg, Ane B Sloth, Cecilia Cerretani, Christian B Mollerup, Andreas Kjaer, Chenguang Lou, Knud J Jensen, Tom Vosc. Bioconjugation of a Near-Infrared DNA-Stabilized Silver Nanocluster to Peptides and Human Insulin by Copper-Free Click Chemistry. Journal of the American Chemical Society. 2023-07-13. PMID:37441791. |
for dna-agnc-conjugated human insulin, fluorescence imaging studies were performed on chinese hamster ovary (cho) cells overexpressing human insulin receptor b (hir-b). |
2023-07-13 |
2023-08-14 |
human |
| Anmol Mohan, Ramsha Haider, Hajar Fakhor, Fnu Hina, Vikash Kumar, Aleeza Jawed, Koushik Majumder, Aliza Ayaz, Priyanka Mohan Lal, Usha Tejwaney, Nanik Ram, Saka Kazee. Vitamin D and polycystic ovary syndrome (PCOS): a review. Annals of medicine and surgery (2012). vol 85. issue 7. 2023-07-10. PMID:37427232. |
vitamin d dramatically improves glucose metabolism by increasing insulin production, insulin receptor expression and reducing pro-inflammatory cytokines. |
2023-07-10 |
2023-08-14 |
Not clear |
| Adriana C Norris, Eugenia M Yazlovitskaya, Lin Zhu, Bailey S Rose, Alex Mansueto, Katherine N Gibson-Corley, Jody C May, John A McLean, John M Stafford, Todd R Graha. ATP10A promotes endothelial cell insulin sensitivity and protects against diet-induced dyslipidemia in female mice. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398141. |
this unique form of insulin resistance suggests that atp10a promotes insulin receptor desensitization to maintain endothelial cell insulin sensitivity. |
2023-07-03 |
2023-08-14 |
mouse |
| Joanne M Gladding, Nura W Lingawi, Beatrice K Leung, Michael D Kendig, Billy C Chieng, Vincent Lauren. High fat diet allows food-predictive stimuli to energize action performance in the absence of hunger, without distorting insulin signaling on accumbal cholinergic interneurons. Appetite. 2023-07-03. PMID:37399905. |
to interfere with insulin signaling we used a high-fat diet (hfd) or genetic excision of insulin receptor (insr) from cholinergic cells. |
2023-07-03 |
2023-08-14 |
mouse |
| Yuka Nakaya, Satoshi Kosukegawa, Satomi Kobayashi, Kensuke Hirose, Kouhei Kitano, Kotoe Mayahara, Hiroki Takei, Mitsuru Motoyoshi, Masayuki Kobayash. Insulin potentiates inhibitory synaptic currents between fast-spiking and pyramidal neurons in the rat insular cortex. Neuropharmacology. 2023-07-02. PMID:37393988. |
insulin had little effect on uipscs under the coapplication of s961, an insulin receptor antagonist, or lavendustin a, an inhibitor of tyrosine kinase. |
2023-07-02 |
2023-08-14 |
rat |