| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hakyun Ryu, Minseok Kim, Hoyong Park, Han Kyoung Choi, ChiHye Chun. Stress-induced translation of KCNB1 contributes to the enhanced synaptic transmission of the lateral habenula. Frontiers in cellular neuroscience. vol 17. 2024-01-09. PMID:38193032. |
the lateral habenula (lhb) is a well-established brain region involved in depressive disorders. |
2024-01-09 |
2024-01-10 |
Not clear |
| Ethan S Bromberg-Martin, Yang-Yang Feng, Takaya Ogasawara, J Kael White, Kaining Zhang, Ilya E Monoso. A neural mechanism for conserved value computations integrating information and rewards. Nature neuroscience. 2024-01-04. PMID:38177339. |
we then identify a neural substrate in a highly conserved ancient structure, the lateral habenula (lhb). |
2024-01-04 |
2024-01-07 |
human |
| S C Simmons, W J Flerlage, L D Langlois, R D Shepard, C Bouslog, E H Thomas, K M Gouty, J L Sanderson, S Gouty, B M Cox, M L Dell'Acqua, F S Nugen. AKAP150-anchored PKA regulation of synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the lateral habenula. bioRxiv : the preprint server for biology. 2023-12-18. PMID:38106086. |
here we focused on an unexplored role of akap150 in the lateral habenula (lhb), a diencephalic brain region that integrates and relays negative reward signals from forebrain striatal and limbic structures to midbrain monoaminergic centers. |
2023-12-18 |
2023-12-21 |
mouse |
| Rui Liu, Huan Xiang, Chunyang Liu, Qiuyi Jiang, Yanchao Liang, Guangzheng Wang, Lu Wang, Yi Sun, Guang Yan. Lateral Habenula Neurons Signal Cold Aversion and Participate in Cold Aversion. Neurochemical research. 2023-12-15. PMID:38102342. |
however, the involvement of the lateral habenula (lhb) as a regulatory hub for negative emotions in this physiological process remains uninvestigated. |
2023-12-15 |
2023-12-18 |
mouse |
| Abudula Aji, Chen Zhang, Wenbo Liu, Teng Chen, Zhechen Liu, Jiaxin Zuo, Haojun Li, Wenli Mi, Qi-Liang Mao-Ying, Yanqing Wang, Qing Zhao, Yu-Xia Ch. Foxg1 Modulation of the Prkcd Gene in the Lateral Habenula Mediates Trigeminal Neuralgia-Associated Anxiety-Like Behaviors in Mice. Molecular neurobiology. 2023-12-12. PMID:38085455. |
targeted knockdown of foxg1, achieved through bilateral microinjection of adeno-associated virus harboring foxg1-specific shrna into the lateral habenula (lhb), resulted in a significant attenuation of both orofacial pain and anxiety-like behaviors. |
2023-12-12 |
2023-12-17 |
mouse |
| Ekaterina Martianova, Renata Sadretdinova, Alicia Pageau, Nikola Pausic, Tommy Doucet Gentiletti, Danahé Leblanc, Arturo Marroquin Rivera, Benoît Labonté, Christophe D Proul. Hypothalamic neuronal outputs transmit sensorimotor signals at the onset of locomotor initiation. iScience. vol 26. issue 11. 2023-12-01. PMID:38026162. |
here, using multi-fiber photometry, we show that three major lh neuronal outputs projecting to the dorsal raphe nucleus (drn), ventral tegmental area (vta), and lateral habenula (lhb) exhibit significant coherent activity in mice engaging sensory-evoked or self-initiated motor responses. |
2023-12-01 |
2023-12-10 |
mouse |
| Dan Bi Ahn, Han Byeol Jang, Yeonhee Ryu, Hyung Kyu Kim, Xiaowei Guan, Yu Fan, Bae Hwan Lee, Hee Young Ki. A hypothalamus-habenula circuit regulates psychomotor responses induced by cocaine. Addiction biology. vol 28. issue 12. 2023-11-29. PMID:38017642. |
it has been suggested that the lateral hypothalamus (lh) or lateral habenula (lhb) is involved in drug-seeking behaviours. |
2023-11-30 |
2023-12-07 |
Not clear |
| Dan Bi Ahn, Han Byeol Jang, Yeonhee Ryu, Hyung Kyu Kim, Xiaowei Guan, Yu Fan, Bae Hwan Lee, Hee Young Ki. A hypothalamus-habenula circuit regulates psychomotor responses induced by cocaine. Addiction biology. vol 28. issue 12. 2023-11-29. PMID:38017642. |
it has been suggested that the lateral hypothalamus (lh) or lateral habenula (lhb) is involved in drug-seeking behaviours. |
2023-11-29 |
2023-12-07 |
Not clear |
| Ana Raquel Pereira, Mobina Alemi, Mariana Cerqueira-Nunes, Clara Monteiro, Vasco Galhardo, Helder Cardoso-Cru. Dynamics of Lateral Habenula-Ventral Tegmental Area Microcircuit on Pain-Related Cognitive Dysfunctions. Neurology international. vol 15. issue 4. 2023-11-24. PMID:37987455. |
increasing evidence from preclinical and clinical studies suggests that aberrant activity of the lateral habenula (lhb) is associated with depressive symptoms characterized by excessive negative focus, leading to high-level cognitive dysfunctions. |
2023-11-24 |
2023-11-28 |
Not clear |
| Matthew V Green, David A Gallegos, Jane-Valeriane Boua, Luke C Bartelt, Arthy Narayanan, Anne E Wes. Single-Nucleus Transcriptional Profiling of GAD2-Positive Neurons From Mouse Lateral Habenula Reveals Distinct Expression of Neurotransmission- and Depression-Related Genes. Biological psychiatry global open science. vol 3. issue 4. 2023-10-26. PMID:37881543. |
glutamatergic projection neurons of the lateral habenula (lhb) drive behavioral state modulation by regulating the activity of midbrain monoaminergic neurons. |
2023-10-26 |
2023-11-08 |
mouse |
| Jamie C Moffa, India N Bland, Jessica R Tooley, Vani Kalyanaraman, Monique Heitmeier, Meaghan C Creed, Bryan A Copit. Cell specific single viral vector CRISPR/Cas9 editing and genetically encoded tool delivery in the central and peripheral nervous systems. bioRxiv : the preprint server for biology. 2023-10-24. PMID:37873336. |
we tested these tools in multiple brain regions and cell types, including gabaergic neurons in the nucleus accumbens (nac), glutamatergic neurons projecting from the ventral pallidum (vp) to the lateral habenula (lhb), dopaminergic neurons in the ventral tegmental area (vta), and parvalbumin (pv)-positive proprioceptive neurons in the periphery. |
2023-10-24 |
2023-11-08 |
mouse |
| Younsoo Byun, Jihyun No. Social play exclusion model in adolescent rats: Monitoring locomotor and emotional behavior associated with social play and examining c-Fos expression in the brain. Physiology & behavior. 2023-10-20. PMID:37858915. |
we found that c-fos expression in the dentate gyrus (dg) of the exclusion group was lower than that in the non-exclusion group, whereas c-fos expression in the lateral habenula (lhb) of the exclusion group was higher than that in the non-exclusion group. |
2023-10-20 |
2023-11-08 |
human |
| Chun-Kui Zhang, Pan Wang, Yuan-Yuan Ji, Jian-Shuai Zhao, Jun-Xiang Gu, Xian-Xia Yan, Hong-Wei Fan, Ming-Ming Zhang, Yu Qiao, Xiao-Die Liu, Bao-Juan Li, Ming-Hui Wang, Hai-Long Dong, Hao-Hong Li, Peng-Cheng Huang, Yun-Qing Li, Wu-Gang Hou, Jin-Lian Li, Tao Che. Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain. Science China. Life sciences. 2023-10-20. PMID:37864083. |
we determined that the spike discharges of the ventral tegmental area (vta)-projecting lateral habenula (lhb) glutamatergic (glu) neurons were sequentially increased in sham, resilient and susceptible mice, which consequently inhibited vta dopaminergic (da) neurons through a lhb |
2023-10-20 |
2023-11-08 |
mouse |
| Miseon Kang, Jun-Mo Chung, Jihyun Noh, Jeongyeon Ki. The mineralocorticoid receptor and extra-synaptic NMDA receptor in the lateral habenula involve in the vulnerability to early life stress in the maternal separation model. Neurobiology of stress. vol 27. 2023-09-29. PMID:37771409. |
the lateral habenula (lhb) plays a pivotal role in regulating emotional responses during stress reactions, and its hyperactivity has been associated with depression. |
2023-09-29 |
2023-10-07 |
Not clear |
| Suchan Chang, Hyung Kyu Kim, Yeonhee Ryu, Han Byeol Jang, DanBi Ahn, Bong Hyo Lee, Dong-Ho Youn, Bae Hwan Lee, Hee Young Ki. Mediation of mPFC-LHb pathway in acupuncture inhibition of cocaine psychomotor activity. Addiction biology. vol 28. issue 10. 2023-09-27. PMID:37753567. |
the medial prefrontal cortex (mpfc) and the lateral habenula (lhb) play roles in drug addiction and cognitive functions. |
2023-09-27 |
2023-10-07 |
rat |
| Xin-Yue Wang, Xiang Xu, Rui Chen, Wen-Bin Jia, Peng-Fei Xu, Xiao-Qing Liu, Ying Zhang, Xin-Feng Liu, Yan Zhan. The thalamic reticular nucleus-lateral habenula circuit regulates depressive-like behaviors in chronic stress and chronic pain. Cell reports. vol 42. issue 10. 2023-09-22. PMID:37738124. |
enhanced excitatory input to the lateral habenula (lhb) has been implicated in the pathophysiology of depression. |
2023-09-22 |
2023-10-07 |
mouse |
| Na Su, Pingping Cai, Zhiqiang Dou, Xiaoxue Yin, Hongmin Xu, Jing He, Zhaofeng Li, Changzhong L. Brain nuclei and neural circuits in neuropathic pain and brain modulation mechanisms of acupuncture: a review on animal-based experimental research. Frontiers in neuroscience. vol 17. 2023-09-15. PMID:37712096. |
with the help of various animal models of np, a literature search on np brain regions and circuits revealed that the related brain nuclei included the periaqueductal gray (pag), lateral habenula (lhb), medial prefrontal cortex (mpfc), and anterior cingulate cortex (acc); the related brain circuits included the pag-lhb and mpfc-acc. |
2023-09-15 |
2023-10-07 |
Not clear |
| Lu Huang, Xi Chen, Qian Tao, Xiaoli Wang, Xiaodan Huang, Yunwei Fu, Yan Yang, Shijie Deng, Song Lin, Kwok-Fai So, Xingrong Song, Chaoran Re. Bright light treatment counteracts stress-induced sleep alterations in mice, via a visual circuit related to the rostromedial tegmental nucleus. PLoS biology. vol 21. issue 9. 2023-09-07. PMID:37676855. |
here, we show that bright light treatment reduces the increase in nonrapid eye movement (nrem) sleep induced by chronic stress through a di-synaptic visual circuit consisting of the thalamic ventral lateral geniculate nucleus and intergeniculate leaflet (vlgn/igl), lateral habenula (lhb), and rostromedial tegmental nucleus (rmtg). |
2023-09-07 |
2023-10-07 |
mouse |
| Wenjie Chen, Yiping Chen, Muhammad Shahzad Aslam, Junliang Shen, Tao Tong, Simin Yan, Wenjing Cheng, Zichun Huang, Jiawei Li, Siyu Liu, Jianguo Li, Xianjun Men. Acupuncture mitigates chronic unpredictable mild stress-induced depression-like behaviours via Lateral Habenula and Gut-Liver-Brain Axis. Behavioural brain research. 2023-08-24. PMID:37619770. |
methods the study involved chronic unpredictable mild stress (cums) depression model mice to administer acupuncture as a preventative measure to investigate the mechanism of acupuncture's antidepressant and observe the effect of acupuncture on impact via the lateral habenula (lhb) and gut-liver-brain axis. |
2023-08-24 |
2023-09-07 |
mouse |
| Mohammad Akhoondian, Samira Rashtiani, Behrooz Khakpour Taleghani, Mohammad Rostampour, Adele Jafari, Kambiz Rohampou. Lateral habenula deep brain stimulation alleviates depression-like behaviors and reverses the oscillatory pattern in the nucleus accumbens in an animal model of depression. Brain research bulletin. 2023-08-20. PMID:37598800. |
after surgery and electrode placement in the lateral habenula (lhb), nucleus accumbens (nac), and prelimbic cortex (prl), the cms protocol was applied for 3 weeks to create depression-like models. |
2023-08-20 |
2023-09-07 |
rat |