| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christina D Orrú, Bradley R Groveman, Andrew G Hughson, Tomás Barrio, Kachi Isiofia, Brent Race, Natalia C Ferreira, Pierluigi Gambetti, David A Schneider, Kentaro Masujin, Kohtaro Miyazawa, Bernardino Ghetti, Gianluigi Zanusso, Byron Caughe. Sensitive detection of pathological seeds of α-synuclein, tau and prion protein on solid surfaces. PLoS pathogens. vol 20. issue 4. 2024-04-19. PMID:38640117. |
prions or prion-like aggregates such as those composed of prp, α-synuclein, and tau are key features of proteinopathies such as prion, parkinson's and alzheimer's diseases, respectively. |
2024-04-19 |
2024-04-22 |
mouse |
| Christina D Orrú, Bradley R Groveman, Andrew G Hughson, Tomás Barrio, Kachi Isiofia, Brent Race, Natalia C Ferreira, Pierluigi Gambetti, David A Schneider, Kentaro Masujin, Kohtaro Miyazawa, Bernardino Ghetti, Gianluigi Zanusso, Byron Caughe. Sensitive detection of pathological seeds of α-synuclein, tau and prion protein on solid surfaces. PLoS pathogens. vol 20. issue 4. 2024-04-19. PMID:38640117. |
we also show that contamination of larger objects with pathological seeds of α-synuclein, tau, and prp can be detected by simply assaying a sampling medium that has been transiently applied to the surface. |
2024-04-19 |
2024-04-22 |
mouse |
| Christina D Orrú, Bradley R Groveman, Andrew G Hughson, Tomás Barrio, Kachi Isiofia, Brent Race, Natalia C Ferreira, Pierluigi Gambetti, David A Schneider, Kentaro Masujin, Kohtaro Miyazawa, Bernardino Ghetti, Gianluigi Zanusso, Byron Caughe. Sensitive detection of pathological seeds of α-synuclein, tau and prion protein on solid surfaces. PLoS pathogens. vol 20. issue 4. 2024-04-19. PMID:38640117. |
our findings demonstrate practical prototypic surface rt-quic protocols for the highly sensitive detection of pathologic seeds of α-synuclein, tau, and prp on solid objects. |
2024-04-19 |
2024-04-22 |
mouse |
| Koya Yakabi, Eloise Berson, Kathleen S Montine, Sean C Bendall, Michael J MacCoss, Kathleen L Poston, Thomas J Montin. Human cerebrospinal fluid single exosomes in Parkinson's and Alzheimer's diseases. bioRxiv : the preprint server for biology. 2024-01-08. PMID:38187636. |
single events were captured with mouse monoclonal antibodies to one of three different tetraspanins (cd9, cd63, or cd81) or with mouse (m) igg control, and then probed with fluorescently labeled antibodies to prion protein (prp) or cd47 to mark neuronal or presynaptic origin, as well as add- and pdd-related proteins: amyloid beta (aβ), tau, α-synuclein, and apolipoprotein (apo) e. data were collected only from captured events that were within the size range of 50 to 200 nm. |
2024-01-08 |
2024-01-10 |
mouse |
| Saira Jahangir, Manoj Allala, Armughan S Khan, Veronica E Muyolema Arce, Anandkumar Patel, Karsh Soni, Alireza Sharafsha. A Review of Biomarkers in Delirium Superimposed on Dementia (DSD) and Their Clinical Application to Personalized Treatment and Management. Cureus. vol 15. issue 5. 2023-05-09. PMID:37159618. |
we identify 17 genes commonly associated with both dementia and delirium including apolipoprotein e (apoe), brain-derived neurotrophic factor (bdnf), catechol-o-methyltransferase (comt), butyrylcholinesterase (bche), acetylcholinesterase (ache), dna methyltransferase 1 (dnmt1), prion protein (prp), tumor necrosis factor (tnf), serine palmitoyltransferase long chain base subunit 1 (sptlc1), microtubule-associated protein tau (mapt), alpha-synuclein (αs), superoxide dismutase 1 (sod1), amyloid beta precursor protein (app), neurofilament light (nfl), neurofilament heavy, 5-hydroxytryptamine receptor 2a (htr2a), and serpin family a member 3 (erap3). |
2023-05-09 |
2023-08-14 |
Not clear |
| Sandeep K Rai, Roopali Khanna, Anamika Avni, Samrat Mukhopadhya. Heterotypic electrostatic interactions control complex phase separation of tau and prion into multiphasic condensates and co-aggregates. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 2. 2023-01-03. PMID:36595668. |
the acidic n-terminal segment of tau interacts electrostatically with the polybasic n-terminal intrinsically disordered segment of the prion protein (prp). |
2023-01-03 |
2023-08-14 |
human |
| Sandeep K Rai, Roopali Khanna, Anamika Avni, Samrat Mukhopadhya. Heterotypic electrostatic interactions control complex phase separation of tau and prion into multiphasic condensates and co-aggregates. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 2. 2023-01-03. PMID:36595668. |
we also show that upon aging, tau:prp droplets gradually convert into solid-like co-assemblies by sequestration of persistent intermolecular interactions. |
2023-01-03 |
2023-08-14 |
human |
| Sandeep K Rai, Roopali Khanna, Anamika Avni, Samrat Mukhopadhya. Heterotypic electrostatic interactions control complex phase separation of tau and prion into multiphasic condensates and co-aggregates. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 2. 2023-01-03. PMID:36595668. |
our findings provide mechanistic underpinnings of overlapping neuropathology involving tau and prp and highlight a broader biological role of complex phase transitions in physiology and disease. |
2023-01-03 |
2023-08-14 |
human |
| Heidi G Standke, Allison Krau. Seed amplification and RT-QuIC assays to investigate protein seed structures and strains. Cell and tissue research. 2022-03-08. PMID:35258712. |
first shown for prp prions and prion diseases, it is now recognized that self-propagating misfolded proteins occur broadly in neurodegenerative diseases and include amyloid-β (aβ) and tau in alzheimer's disease (ad), tau in chronic traumatic encephalopathy (cte), pick's disease (pid), corticobasal degeneration (cbd), and progressive supranuclear palsy (psp), and α-synuclein (α-syn) in parkinson's disease (pd) and lewy body dementias (lbd). |
2022-03-08 |
2023-08-13 |
Not clear |
| Nikol Jankovska, Radoslav Matej, Tomas Oleja. Extracellular Prion Protein Aggregates in Nine Gerstmann-Sträussler-Scheinker Syndrome Subjects with Mutation P102L: A Micromorphological Study and Comparison with Literature Data. International journal of molecular sciences. vol 22. issue 24. 2021-12-24. PMID:34948096. |
co-expression with hyperphosphorylated protein tau protein or amyloid beta-peptide (aβ) in gss prp plaques is generally a rare observation, even in cases with comorbid neuropathology. |
2021-12-24 |
2023-08-13 |
human |
| Nikol Jankovska, Radoslav Matej, Tomas Oleja. Extracellular Prion Protein Aggregates in Nine Gerstmann-Sträussler-Scheinker Syndrome Subjects with Mutation P102L: A Micromorphological Study and Comparison with Literature Data. International journal of molecular sciences. vol 22. issue 24. 2021-12-24. PMID:34948096. |
the dominant picture of the gss brain is small, condensed plaques, often multicentric, while presence of dystrophic neuritic changes accumulating hyperphosphorylated protein tau or aβ in the prp plaques are rare and, thus, their presence probably constitutes a trivial observation without any relationship to gss development and progression. |
2021-12-24 |
2023-08-13 |
human |
| Ivan Martinez-Valbuena, Rafael Valenti-Azcarate, Irene Amat-Villegas, Irene Marcilla, Gloria Marti-Andres, Maria-Cristina Caballero, Mario Riverol, María-Teresa Tuñon, Paul E Fraser, María-Rosario Luqui. Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta neuropathologica communications. vol 9. issue 1. 2021-11-10. PMID:33832546. |
furthermore, we also assessed the pancreatic expression of prion protein (prp) in these subjects and its interaction, both in the pancreas and brain, with α-synuclein, tau, aβ and amylin. |
2021-11-10 |
2023-08-13 |
human |
| Ivan Martinez-Valbuena, Rafael Valenti-Azcarate, Irene Amat-Villegas, Irene Marcilla, Gloria Marti-Andres, Maria-Cristina Caballero, Mario Riverol, María-Teresa Tuñon, Paul E Fraser, María-Rosario Luqui. Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta neuropathologica communications. vol 9. issue 1. 2021-11-10. PMID:33832546. |
our study shows, for the first time, that along with amylin, pancreatic α-synuclein, aβ, prp and tau may contribute together to the complex pathophysiology of type two diabetes and in the appearance of insulin resistance in alzheimer's and parkinson's disease. |
2021-11-10 |
2023-08-13 |
human |
| Ivan Martinez-Valbuena, Rafael Valenti-Azcarate, Irene Amat-Villegas, Irene Marcilla, Gloria Marti-Andres, Maria-Cristina Caballero, Mario Riverol, María-Teresa Tuñon, Paul E Fraser, María-Rosario Luqui. Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta neuropathologica communications. vol 9. issue 1. 2021-11-10. PMID:33832546. |
finally, we provide the first histological evidence of an interaction between prp and aβ, α-synuclein, amylin or tau in the pancreas and locus coeruleus. |
2021-11-10 |
2023-08-13 |
human |
| Ryuichi Koizumi, Naohisa Ueda, Atsushi Mugita, Katsuo Kimura, Hitaru Kishida, Fumiaki Tanak. Case Report: Extremely Early Detection of Preclinical Magnetic Resonance Imaging Abnormality in Creutzfeldt-Jakob Disease With the V180I Mutation. Frontiers in neurology. vol 12. 2021-10-26. PMID:34690919. |
the levels of total tau protein, 14-3-3 protein, and protease-resistant isoform of prion protein (prp |
2021-10-26 |
2023-08-13 |
Not clear |
| Alan David Snow, Joel A Cummings, Thomas Lak. The Unifying Hypothesis of Alzheimer's Disease: Heparan Sulfate Proteoglycans/Glycosaminoglycans Are Key as First Hypothesized Over 30 Years Ago. Frontiers in aging neuroscience. vol 13. 2021-10-22. PMID:34671250. |
neurons full of hs demonstrate marked accumulation and fibrillization of aβ, tau, α-synuclein, and prion protein (prp) in mucopolysaccharidosis animal models demonstrating that hs gag accumulation is a precursor to aβ accumulation in neurons. |
2021-10-22 |
2023-08-13 |
Not clear |
| Brent Race, Katie Williams, James F Striebel, Bruce Chesebr. Prion-associated cerebral amyloid angiopathy is not exacerbated by human phosphorylated tau aggregates in scrapie-infected mice expressing anchorless prion protein. Neurobiology of disease. vol 144. 2021-09-24. PMID:32829029. |
in human genetic prion diseases, tau aggregates are detected in association with amyloid plaques consisting of prion protein (prp). |
2021-09-24 |
2023-08-13 |
mouse |
| Brent Race, Katie Williams, James F Striebel, Bruce Chesebr. Prion-associated cerebral amyloid angiopathy is not exacerbated by human phosphorylated tau aggregates in scrapie-infected mice expressing anchorless prion protein. Neurobiology of disease. vol 144. 2021-09-24. PMID:32829029. |
however, the role of abnormal tau aggregates in prp amyloid disease remains unclear. |
2021-09-24 |
2023-08-13 |
mouse |
| Brent Race, Katie Williams, James F Striebel, Bruce Chesebr. Prion-associated cerebral amyloid angiopathy is not exacerbated by human phosphorylated tau aggregates in scrapie-infected mice expressing anchorless prion protein. Neurobiology of disease. vol 144. 2021-09-24. PMID:32829029. |
previously we inoculated scrapie prions into transgenic mice expressing human tau, mouse tau, glycophosphatidylinositol (gpi) anchored prp, and anchorless prp. |
2021-09-24 |
2023-08-13 |
mouse |
| Brent Race, Katie Williams, James F Striebel, Bruce Chesebr. Prion-associated cerebral amyloid angiopathy is not exacerbated by human phosphorylated tau aggregates in scrapie-infected mice expressing anchorless prion protein. Neurobiology of disease. vol 144. 2021-09-24. PMID:32829029. |
these mice developed both spongiform vacuolar pathology and prp amyloid pathology, and human tau was detected near prp amyloid plaques. |
2021-09-24 |
2023-08-13 |
mouse |