| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Han, Jin Zhang, Hailan Yao, Xiaofan Wang, Feng Li, Lan Chen, Chen Gao, Jianmei Gao, Kai Nie, Wei Zhou, Xiaoping Don. Study on interaction between microtubule associated protein tau and prion protein. Science in China. Series C, Life sciences. vol 49. issue 5. 2007-02-06. PMID:17172055. |
to address the possible molecular linkage of prion protein (prp) and tau, a gst-fusion segment of human tau covering the three-repeat region and various prp segments was used in the tests of gst pull-down and immunoprecipitation. |
2007-02-06 |
2023-08-12 |
human |
| Jun Han, Jin Zhang, Hailan Yao, Xiaofan Wang, Feng Li, Lan Chen, Chen Gao, Jianmei Gao, Kai Nie, Wei Zhou, Xiaoping Don. Study on interaction between microtubule associated protein tau and prion protein. Science in China. Series C, Life sciences. vol 49. issue 5. 2007-02-06. PMID:17172055. |
co-localization signals of tau and prp were found in the cho cell tranfected with both prp and tau gene. |
2007-02-06 |
2023-08-12 |
human |
| Jun Han, Jin Zhang, Hailan Yao, Xiaofan Wang, Feng Li, Lan Chen, Chen Gao, Jianmei Gao, Kai Nie, Wei Zhou, Xiaoping Don. Study on interaction between microtubule associated protein tau and prion protein. Science in China. Series C, Life sciences. vol 49. issue 5. 2007-02-06. PMID:17172055. |
the domain of interaction with tau was located at n-terminal of prp (residues 23 to 91). |
2007-02-06 |
2023-08-12 |
human |
| Jun Han, Jin Zhang, Hailan Yao, Xiaofan Wang, Feng Li, Lan Chen, Chen Gao, Jianmei Gao, Kai Nie, Wei Zhou, Xiaoping Don. Study on interaction between microtubule associated protein tau and prion protein. Science in China. Series C, Life sciences. vol 49. issue 5. 2007-02-06. PMID:17172055. |
the evidence of molecular interactions between prp and tau protein highlights a potential role of tau in the biological function of prp and the pathogenesis of tses. |
2007-02-06 |
2023-08-12 |
human |
| Silke Vogelgesang, Markus Glatzel, Lary C Walker, Heyo K Kroemer, Adriano Aguzzi, Rolf W Warzo. Cerebrovascular P-glycoprotein expression is decreased in Creutzfeldt-Jakob disease. Acta neuropathologica. vol 111. issue 5. 2007-01-09. PMID:16523342. |
cjd is marked primarily by the buildup of misfolded prion protein (prp(sc)) in brain, whereas the accrual of beta-amyloid protein (abeta) and tau protein are characteristic for ad. |
2007-01-09 |
2023-08-12 |
Not clear |
| I Ferre. Differential expression of phosphorylated translation initiation factor 2 alpha in Alzheimer's disease and Creutzfeldt-Jakob's disease. Neuropathology and applied neurobiology. vol 28. issue 6. 2003-01-23. PMID:12445160. |
single and double-labelling immunohistochemistry to phosphorylated tif 2 alpha, phosphorylated sapk/jnk, phosphorylated p38, tau, cu/zn superoxide dismutase 1 (sod 1) and cleaved caspase-3 (17 kda), and in situ end-labelling of nuclear dna fragmentation, was carried out in postmortem samples of 10 patients with ad (stages iii and vi of braak and braak), seven patients with cjd (five cases with methionine/methionine and two cases with methionine/valine at the codon 129 of the prp gene) and eight age-matched controls. |
2003-01-23 |
2023-08-12 |
human |
| Keisuke Ishizawa, Takashi Komori, Tomokazu Shimazu, Toshimasa Yamamoto, Tetsuyuki Kitamoto, Kunio Shimazu, Takanori Hiros. Hyperphosphorylated tau deposition parallels prion protein burden in a case of Gerstmann-Sträussler-Scheinker syndrome P102L mutation complicated with dementia. Acta neuropathologica. vol 104. issue 4. 2002-12-27. PMID:12200619. |
hyperphosphorylated tau (p-tau) deposition has been documented in a limited population of patients with gerstmann-sträussler-scheinker syndrome (gss) with particular point mutations of the prion protein (prp) gene. |
2002-12-27 |
2023-08-12 |
Not clear |
| Gabor G Kovacs, Pietro Zerbi, Till Voigtländer, Michaela Strohschneider, Gianriccardo Trabattoni, Johannes A Hainfellner, Herbert Budk. The prion protein in human neurodegenerative disorders. Neuroscience letters. vol 329. issue 3. 2002-10-28. PMID:12183028. |
we use immunohistochemistry for prp, including five monoclonal antibodies against different epitopes and three different pretreatments, alpha-synuclein, phosphorylated tau, beta-amyloid, and ubiquitin. |
2002-10-28 |
2023-08-12 |
human |
| Gabor G Kovacs, Pietro Zerbi, Till Voigtländer, Michaela Strohschneider, Gianriccardo Trabattoni, Johannes A Hainfellner, Herbert Budk. The prion protein in human neurodegenerative disorders. Neuroscience letters. vol 329. issue 3. 2002-10-28. PMID:12183028. |
using double immunofluorescence and confocal laser microscopy we observe focal overlapping of prp(c) with tau and with alpha-synuclein in early, but not in fully developed inclusions. |
2002-10-28 |
2023-08-12 |
human |
| Gabor G Kovacs, Pietro Zerbi, Till Voigtländer, Michaela Strohschneider, Gianriccardo Trabattoni, Johannes A Hainfellner, Herbert Budk. The prion protein in human neurodegenerative disorders. Neuroscience letters. vol 329. issue 3. 2002-10-28. PMID:12183028. |
however, prp(c) ir neurons may contain abnormal tau or alpha-synuclein aggregates. |
2002-10-28 |
2023-08-12 |
human |
| Yves Christe. [Proteins and mutations: a new vision (molecular) of neurodegenerative diseases]. Journal de la Societe de biologie. vol 196. issue 1. 2002-08-23. PMID:12134639. |
it now appears that numerous neurodegenerative diseases of the central nervous system correspond to the aggregation of specific proteins: beta-amyloid in alzheimer disease, tau protein in alzheimer disease, fronto-temporal dementia, progressive supranuclear palsy and corticobasal degeneration, alpha-synuclein in parkinson disease and lewy body dementia, prp protein in prion diseases, sod in amyotrophic lateral sclerosis, polyglutamine expansions in huntington's disease and other diseases, etc. |
2002-08-23 |
2023-08-12 |
mouse |
| U Finckh, T Müller-Thomsen, U Mann, C Eggers, J Marksteiner, W Meins, G Binetti, A Alberici, P Sonderegger, C Hock, R M Nitsch, A Ga. High frequency of mutations in four different disease genes in early-onset dementia. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193137. |
heterozygous mutations in the genes for amyloid precursor protein (app), the presenilins (ps1, ps2), prion protein (prp), neuroserpin, and tau are associated with early-onset dementia (eod) with or without neurological signs in the early disease stage. |
2001-02-08 |
2023-08-12 |
Not clear |
| M I Herz, J S Lamberti, J Mintz, R Scott, S P O'Dell, L McCartan, G Ni. A program for relapse prevention in schizophrenia: a controlled study. Archives of general psychiatry. vol 57. issue 3. 2000-03-21. PMID:10711914. |
this study examined whether a program for relapse prevention (prp) is more effective than treatment as usual (tau) in reducing relapse and rehospitalization rates among outpatients with schizophrenia. |
2000-03-21 |
2023-08-12 |
Not clear |
| J J Hauw, D Seilhean, M A Colle, J Hogenhuys, C Duyckaert. [Neuropathologic markers in degenerative dementias]. Revue neurologique. vol 154 Suppl 2. 1999-01-12. PMID:9834544. |
this review summarizes the main criteria for identification, and the presumed meaning of the chief markers indicating the presence of abnormally phosphorylated tau proteins, a beta peptides, and prp proteins. |
1999-01-12 |
2023-08-12 |
Not clear |
| L W Duchen, M Poulter, A E Hardin. Dementia associated with a 216 base pair insertion in the prion protein gene. Clinical and neuropathological features. Brain : a journal of neurology. vol 116 ( Pt 3). 1993-07-21. PMID:8513392. |
in some places plaques bore a resemblance to senile neuritic plaques and in the hippocampus there were abundant typical neuritic plaques giving positive staining reactions for beta-amyloid protein and tau protein, but not prp. |
1993-07-21 |
2023-08-12 |
Not clear |
| M Frojmovic, T Wong, T van de Ve. Dynamic measurements of the platelet membrane glycoprotein IIb-IIIa receptor for fibrinogen by flow cytometry. I. Methodology, theory and results for two distinct activators. Biophysical journal. vol 59. issue 4. 1991-08-14. PMID:1905966. |
human citrated platelet-rich plasma (prp; diluted 1:10) was incubated with adenosine diphosphate (adp) or phorbol myristate acetate (pma) for varying times (tau = 0-10 s, out to 60 min), followed by incubation with fluorescein isothiocyanate (fitc)-pac1 antibody at saturating concentrations. |
1991-08-14 |
2023-08-11 |
human |