| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexis Fenyi, Audrey Coens, Tracy Bellande, Ronald Melki, Luc Bousse. Assessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils from laboratory material and surfaces. Scientific reports. vol 8. issue 1. 2019-11-20. PMID:30018327. |
we show that commercial detergents and sds are way more suited to detach α-synuclein fibrillar polymorphs, tau and aß 1-42 fibrillar assemblies from contaminated surfaces and disassemble the fibrils than methods designed to decrease prp prion infectivity. |
2019-11-20 |
2023-08-13 |
Not clear |
| Keisuke Ishizawa, Takashi Mitsufuji, Kei Shioda, Atsushi Kobayashi, Takashi Komori, Yoshihiko Nakazato, Tetsuyuki Kitamoto, Nobuo Araki, Toshimasa Yamamoto, Atsushi Sasak. An autopsy report of three kindred in a Gerstmann-Sträussler-Scheinker disease P105L family with a special reference to prion protein, tau, and beta-amyloid. Brain and behavior. vol 8. issue 10. 2019-07-22. PMID:30240140. |
this report describes a clinicopathological analysis of three autopsied kindred from a japanese gss105 family, plus a topological analysis of prp, hyperphosphorylated tau (p-tau), and beta-amyloid (aβ). |
2019-07-22 |
2023-08-13 |
Not clear |
| Anne H S Martinelli, Fernanda C Lopes, Elisa B O John, Célia R Carlini, Rodrigo Ligabue-Brau. Modulation of Disordered Proteins with a Focus on Neurodegenerative Diseases and Other Pathologies. International journal of molecular sciences. vol 20. issue 6. 2019-07-03. PMID:30875980. |
in this review, we discuss some idps that are involved in neurodegenerative diseases (such as beta amyloid, alpha synuclein, tau, and the "idp-like" prp), cancer (p53, c-myc), and diabetes (amylin), focusing on the structural changes of these idps that are linked to such pathologies. |
2019-07-03 |
2023-08-13 |
Not clear |
| Franc Llorens, Tomás Barrio, Ângela Correia, Anna Villar-Piqué, Katrin Thüne, Peter Lange, Juan José Badiola, Matthias Schmitz, Ingolf Lachmann, Rosa Bolea, Inga Zer. Cerebrospinal Fluid Prion Disease Biomarkers in Pre-clinical and Clinical Naturally Occurring Scrapie. Molecular neurobiology. vol 55. issue 11. 2018-12-17. PMID:29572672. |
while decreased total prion protein (prp) levels and positive prp seeding activity were already detectable at pre-symptomatic stages, the surrogate markers of neuronal damage total tau (tau) and 14-3-3 proteins were exclusively increased at clinical stages. |
2018-12-17 |
2023-08-13 |
human |
| Isidro Ferre. Diversity of astroglial responses across human neurodegenerative disorders and brain aging. Brain pathology (Zurich, Switzerland). vol 27. issue 5. 2018-08-20. PMID:28804999. |
in addition to the well-known increase in glial fibrillary acidic protein and other proteins in reactive astrocytes, astrocytopathy is evidenced by deposition of abnormal proteins such as β-amyloid, hyper-phosphorylated tau, abnormal α-synuclein, mutated huntingtin, phosphorylated tdp-43 and mutated sod1, and prp |
2018-08-20 |
2023-08-13 |
human |
| Gabor G Kovacs, Jasmin Rahimi, Thomas Ströbel, Mirjam I Lutz, Günther Regelsberger, Nathalie Streichenberger, Armand Perret-Liaudet, Romana Höftberger, Pawel P Liberski, Herbert Budka, Beata Sikorsk. Tau pathology in Creutzfeldt-Jakob disease revisited. Brain pathology (Zurich, Switzerland). vol 27. issue 3. 2017-04-24. PMID:27377321. |
the frequency of tau pathologies is not unusually high in sporadic cjd and does not precisely relate to prp deposition. |
2017-04-24 |
2023-08-13 |
human |
| Ariel A Valiente-Gabioud, Marco C Miotto, María E Chesta, Verónica Lombardo, Andres Binolfi, Claudio O Fernánde. Phthalocyanines as Molecular Scaffolds to Block Disease-Associated Protein Aggregation. Accounts of chemical research. vol 49. issue 5. 2017-03-10. PMID:27136297. |
these tetrapyrrolic compounds modulate the amyloid assembly of αs, tau, aβ, and the prp in vitro, and protect cells from the toxic effects of amyloid aggregates. |
2017-03-10 |
2023-08-13 |
mouse |
| Takashi Miyamoto, Daniel Kim, Joseph A Knox, Erik Johnson, Lennart Muck. Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity. The Journal of biological chemistry. vol 291. issue 4. 2016-08-22. PMID:26589795. |
in addition, we show that the aβ-induced depletion of surface nmdars does not depend on several factors that have been implicated in the pathogenesis of aβ-induced neuronal dysfunction, including aberrant neuronal activity, tau, prion protein (prp(c)), and ephb2 itself. |
2016-08-22 |
2023-08-13 |
Not clear |
| Lary C Walker, Mathias Jucke. The Malignant Protein Puzzle. Cerebrum : the Dana forum on brain science. vol 2016. 2016-07-13. PMID:27408676. |
studying how proteins such as prp, amyloid beta, tau, and others aggregate and spread, and kill brain cells, represents a crucial new frontier in neuroscience. |
2016-07-13 |
2023-08-13 |
Not clear |
| C Vergara, L Ordóñez-Gutiérrez, F Wandosell, I Ferrer, J A del Río, R Gaví. Role of PrP(C) Expression in Tau Protein Levels and Phosphorylation in Alzheimer's Disease Evolution. Molecular neurobiology. vol 51. issue 3. 2016-03-10. PMID:24965601. |
role of prp(c) expression in tau protein levels and phosphorylation in alzheimer's disease evolution. |
2016-03-10 |
2023-08-13 |
mouse |
| C Vergara, L Ordóñez-Gutiérrez, F Wandosell, I Ferrer, J A del Río, R Gaví. Role of PrP(C) Expression in Tau Protein Levels and Phosphorylation in Alzheimer's Disease Evolution. Molecular neurobiology. vol 51. issue 3. 2016-03-10. PMID:24965601. |
reported data suggest a regulatory tendency of prp(c) expression in the development of ad, and a putative relationship between prp(c) and tau processing is emerging. |
2016-03-10 |
2023-08-13 |
mouse |
| C Vergara, L Ordóñez-Gutiérrez, F Wandosell, I Ferrer, J A del Río, R Gaví. Role of PrP(C) Expression in Tau Protein Levels and Phosphorylation in Alzheimer's Disease Evolution. Molecular neurobiology. vol 51. issue 3. 2016-03-10. PMID:24965601. |
in this study, we show increased susceptibility to aβ-derived diffusible ligands (addls) in neuronal primary cultures from prp(c) knockout mice, compared to wild-type, which correlates with increased tau expression. |
2016-03-10 |
2023-08-13 |
mouse |
| C Vergara, L Ordóñez-Gutiérrez, F Wandosell, I Ferrer, J A del Río, R Gaví. Role of PrP(C) Expression in Tau Protein Levels and Phosphorylation in Alzheimer's Disease Evolution. Molecular neurobiology. vol 51. issue 3. 2016-03-10. PMID:24965601. |
moreover, we found increased prp(c) expression that paralleled with tau at early ages in an ad murine model and in early braak stages of ad in affected individuals. |
2016-03-10 |
2023-08-13 |
mouse |
| C Vergara, L Ordóñez-Gutiérrez, F Wandosell, I Ferrer, J A del Río, R Gaví. Role of PrP(C) Expression in Tau Protein Levels and Phosphorylation in Alzheimer's Disease Evolution. Molecular neurobiology. vol 51. issue 3. 2016-03-10. PMID:24965601. |
taken together, these results suggest a protective role for prp(c) in ad by downregulating tau expression, and they point to this protein as being crucial in the molecular events that lead to neurodegeneration in ad. |
2016-03-10 |
2023-08-13 |
mouse |
| Thomas Tousseyn, Krystyna Bajsarowicz, Henry Sánchez, Ania Gheyara, Abby Oehler, Michael Geschwind, Bernadette DeArmond, Stephen J DeArmon. Prion Disease Induces Alzheimer Disease-Like Neuropathologic Changes. Journal of neuropathology and experimental neurology. vol 74. issue 9. 2015-11-16. PMID:26226132. |
we conclude that priond may trigger biochemical changes similar to those triggered by ad and suggest that priond is a disease involving prp, aβ42, apoe-4, and abnormal tau. |
2015-11-16 |
2023-08-13 |
human |
| Kathrin Andrich, Jan Bieschk. The Effect of (-)-Epigallo-catechin-(3)-gallate on Amyloidogenic Proteins Suggests a Common Mechanism. Advances in experimental medicine and biology. vol 863. 2015-10-02. PMID:26092630. |
studies on the interaction of the green tea polyphenol (-)-epigallocatechin-3-gallate (egcg) with fourteen disease-related amyloid polypeptides and prions huntingtin, amyloid-beta, alpha-synuclein, islet amyloid polypeptide (iapp), sup35, nm25 and nm4, tau, msp2, semen-derived enhancer of virus infection (sevi), immunoglobulin light chains, beta-microglobulin, prion protein (prp) and insulin, have yielded a variety of experimental observations. |
2015-10-02 |
2023-08-13 |
Not clear |
| Pedro Piccardo, Juraj Cervenak, Ming Bu, Lindsay Miller, David M Ashe. Complex proteinopathy with accumulations of prion protein, hyperphosphorylated tau, α-synuclein and ubiquitin in experimental bovine spongiform encephalopathy of monkeys. The Journal of general virology. vol 95. issue Pt 7. 2014-08-22. PMID:24769839. |
squirrel monkeys infected with the classical bovine spongiform encephalopathy agent developed an encephalopathy resembling variant creutzfeldt-jakob disease with accumulations not only of abnormal prion protein (prp(tse)), but also three other proteins: hyperphosphorylated tau (p-tau), α-synuclein and ubiquitin; β-amyloid protein (aβ) did not accumulate. |
2014-08-22 |
2023-08-13 |
mouse |
| Monique Antoinette David, Daryl Rhys Jones, Mourad Tayeb. Potential candidate camelid antibodies for the treatment of protein-misfolding diseases. Journal of neuroimmunology. vol 272. issue 1-2. 2014-07-31. PMID:24864011. |
these antibodies could prove to be a valuable tool for the neutralization/clearance of prp(sc), aβ and tau proteins in cellular compartments of affected neurons and could potentially have wider applicability for the treatment of pmds. |
2014-07-31 |
2023-08-13 |
Not clear |
| Matthias Schmitz, Katharina Wulf, Sandra C Signore, Walter J Schulz-Schaeffer, Pawel Kermer, Mathias Bähr, Fred S Wouters, Saima Zafar, Inga Zer. Impact of the cellular prion protein on amyloid-β and 3PO-tau processing. Journal of Alzheimer's disease : JAD. vol 38. issue 3. 2014-07-17. PMID:24028865. |
in the present study, we analyzed the involvement of prp(c) in different pathological mechanisms underlying ad: the processing of the amyloid-β protein precursor (aβpp) and its interaction with aβpp, tau, and different phosphorylated forms of the tau protein (p-tau). |
2014-07-17 |
2023-08-12 |
mouse |
| Matthias Schmitz, Katharina Wulf, Sandra C Signore, Walter J Schulz-Schaeffer, Pawel Kermer, Mathias Bähr, Fred S Wouters, Saima Zafar, Inga Zer. Impact of the cellular prion protein on amyloid-β and 3PO-tau processing. Journal of Alzheimer's disease : JAD. vol 38. issue 3. 2014-07-17. PMID:24028865. |
the effect of prp(c) on tau expression was investigated in various cellular compartments using a hek293 cell model expressing a tau mutant (3po-tau) or wild type (wt)-tau. |
2014-07-17 |
2023-08-12 |
mouse |