| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Donghong Su, Wenlong Li, Xiaojun She, Xuewei Chen, Qingfeng Zhai, Bo Cui, Rui Wan. Chronic noise exposure exacerbates AD-like neuropathology in SAMP8 mice in relation to Wnt signaling in the PFC and hippocampus. Scientific reports. vol 8. issue 1. 2019-10-31. PMID:30279527. |
chronic noise exposure led to progressive overproduction of aβ and increased the hyperphosphorylation of tau at ser396, thr205, and thr231 sites in the hippocampus and the prefrontal cortex (pfc) in young samp8 mice, similar to that observed in aging samp8 mice. |
2019-10-31 |
2023-08-13 |
mouse |
| Donghong Su, Wenlong Li, Xiaojun She, Xuewei Chen, Qingfeng Zhai, Bo Cui, Rui Wan. Chronic noise exposure exacerbates AD-like neuropathology in SAMP8 mice in relation to Wnt signaling in the PFC and hippocampus. Scientific reports. vol 8. issue 1. 2019-10-31. PMID:30279527. |
these findings demonstrate that chronic noise stress exacerbated ad-like neuropathology, possibly by disrupting wnt signaling and triggering aberrant tau hyperphosphorylation and aβ in the pfc and hippocampus. |
2019-10-31 |
2023-08-13 |
mouse |
| Sonia Lorena Espíndola, Ana Damianich, Rodrigo Javier Alvarez, Manuela Sartor, Juan Emilio Belforte, Juan Esteban Ferrario, Jean-Marc Gallo, María Elena Aval. Modulation of Tau Isoforms Imbalance Precludes Tau Pathology and Cognitive Decline in a Mouse Model of Tauopathy. Cell reports. vol 23. issue 3. 2019-09-17. PMID:29669277. |
modulating the 3r/4r ratio in the prefrontal cortex led to a significant reduction of pathological tau accumulation concomitant with improvement of neuronal firing and reduction of cognitive impairments. |
2019-09-17 |
2023-08-13 |
mouse |
| Belinda M Brown, Stephanie R Rainey-Smith, Vincent Dore, Jeremiah J Peiffer, Samantha C Burnham, Simon M Laws, Kevin Taddei, David Ames, Colin L Masters, Christopher C Rowe, Ralph N Martins, Victor L Villemagn. Self-Reported Physical Activity is Associated with Tau Burden Measured by Positron Emission Tomography. Journal of Alzheimer's disease : JAD. vol 63. issue 4. 2019-06-10. PMID:29758940. |
the difference between the lmpa and hpa groups was also evident when examining regional tau burden in the temporoparietal cortex and the prefrontal cortex. |
2019-06-10 |
2023-08-13 |
human |
| Isabel Barón-Mendoza, Octavio García, Erika Calvo-Ochoa, Jorge Omar Rebollar-García, Daniel Garzón-Cortés, Reyes Haro, Aliesha González-Arena. Alterations in neuronal cytoskeletal and astrocytic proteins content in the brain of the autistic-like mouse strain C58/J. Neuroscience letters. vol 682. 2019-03-11. PMID:29885454. |
our results show that autistic-like mice present: 1) region-dependent altered expression and phosphorylation patterns of tau isoforms, associated with anomalous microtubule depolymerization; 2) reduced map2 a content in prefrontal cortex; 3) region-dependent changes in cofilin expression and phosphorylation, associated with abnormal actin filament depolymerizing dynamics; 4) diminished synaptopodin levels in the hippocampus; and 5) reduced content of the astrocyte-secreted protein tsp-1 in the prefrontal cortex and hippocampus. |
2019-03-11 |
2023-08-13 |
mouse |
| Edna Maria Camelo Chaves, Jose Eduardo Ribeiro Honório-Júnior, Caren Nádia Soares Sousa, Valdécio Silveira Monteiro, Dayanne Terra Tenório Nonato, Leonardo Pimentel Dantas, Ana Silvia Suassuna Carneiro Lúcio, José Maria Barbosa-Filho, Manoel Cláudio Azevedo Patrocínio, Glauce Socorro Barros Viana, Silvânia Maria Mendes Vasconcelo. The anxiolytic-like effect of 6-styryl-2-pyrone in mice involves GABAergic mechanism of action. Metabolic brain disease. vol 33. issue 1. 2019-01-31. PMID:29086102. |
after behavioral tests, these animals were sacrificed and had their prefrontal cortex (pfc), hippocampus (hc) and striatum (st) dissected for assaying amino acids (aspartate- asp, glutamate- glu, glycine- gly, taurine- tau and gamma-aminobutyric acid- gaba). |
2019-01-31 |
2023-08-13 |
mouse |
| Edna Maria Camelo Chaves, Jose Eduardo Ribeiro Honório-Júnior, Caren Nádia Soares Sousa, Valdécio Silveira Monteiro, Dayanne Terra Tenório Nonato, Leonardo Pimentel Dantas, Ana Silvia Suassuna Carneiro Lúcio, José Maria Barbosa-Filho, Manoel Cláudio Azevedo Patrocínio, Glauce Socorro Barros Viana, Silvânia Maria Mendes Vasconcelo. The anxiolytic-like effect of 6-styryl-2-pyrone in mice involves GABAergic mechanism of action. Metabolic brain disease. vol 33. issue 1. 2019-01-31. PMID:29086102. |
the effects of the sty on amino acid concentration in pfc showed increased glu, gaba and tau concentrations. |
2019-01-31 |
2023-08-13 |
mouse |
| Stergios Tsartsalis, Aikaterini Xekardaki, Patrick R Hof, Enikö Kövari, Constantin Boura. Early Alzheimer-type lesions in cognitively normal subjects. Neurobiology of aging. vol 62. 2018-09-26. PMID:29107845. |
to define whether amyloid β protein deposits or tau protein lesions appear first during normal brain aging, we performed an immunohistological study on serial sections from 105 autopsy brains (age range: 40-104 years) from patients free of clinical signs of cognitive decline, using anti-tau (at8) and anti-amyloid (4g8) antibodies in the hippocampus, entorhinal cortex, inferior temporal cortex (brodmann area 20), prefrontal cortex (brodmann area 9), occipital cortex (brodmann areas 17 and 18), and in the brainstem. |
2018-09-26 |
2023-08-13 |
human |
| Sabrina Salberg, Glenn Yamakawa, Jennaya Christensen, Bryan Kolb, Richelle Mychasiu. Assessment of a nutritional supplement containing resveratrol, prebiotic fiber, and omega-3 fatty acids for the prevention and treatment of mild traumatic brain injury in rats. Neuroscience. vol 365. 2018-06-22. PMID:28988852. |
following the test battery, tissue was collected from the prefrontal cortex (pfc) and primary auditory cortex for golgi-cox analysis of spine density, and for changes in expression of 6 genes (aqp4, gfap, igf1, nfl, sirt1, and tau). |
2018-06-22 |
2023-08-13 |
rat |
| Dongsheng Zhou, Huaxia Liu, Chenli Li, Fangyan Wang, Yaosheng Shi, Lingjiang Liu, Xin Zhao, Aiming Liu, Junfang Zhang, Chuang Wang, Zhongming Che. Atorvastatin ameliorates cognitive impairment, Aβ1-42 production and Tau hyperphosphorylation in APP/PS1 transgenic mice. Metabolic brain disease. vol 31. issue 3. 2018-01-12. PMID:26883430. |
moreover, atorvastatin significantly attenuated aβ1-42 accumulation and phosphorylation of tau (ser396) in the hippocampus and prefrontal cortex of tg app/ps1 mice. |
2018-01-12 |
2023-08-13 |
mouse |
| Zi-Ai Zhao, Ya-Lei Ning, Ping Li, Nan Yang, Yan Peng, Ren-Ping Xiong, Yan Zhao, Dong Liu, Xu-Jia Zeng, Jiang-Fan Chen, Yuan-Guo Zho. Widespread hyperphosphorylated tau in the working memory circuit early after cortical impact injury of brain (Original study). Behavioural brain research. vol 323. 2017-12-13. PMID:28163095. |
given that tau hyperphosphorylation is an important cause of cognitive impairment in patients of alzheimer's disease, our present study detected the presence of hyperphosphorylated tau (p-tau), mainly at ser404, in multiple brain regions, including the ipsilateral parietal cortex, contralateral hippocampus and prefrontal cortex, immediately after the injury in a mouse tbi model; these changes lasted for at least 4w. |
2017-12-13 |
2023-08-13 |
mouse |
| Glenn R Yamakawa, Connor Lengkeek, Sabrina Salberg, Simon C Spanswick, Richelle Mychasiu. Behavioral and pathophysiological outcomes associated with caffeine consumption and repetitive mild traumatic brain injury (RmTBI) in adolescent rats. PloS one. vol 12. issue 11. 2017-11-28. PMID:29108016. |
finally, modifications to expression of 12 genes (adora2a, app, aqp4, bdnf, bmal1, clock, cry, gfap, orx1, orx2, per, tau), in the prefrontal cortex, hippocampus, and/or the hypothalamus were assessed. |
2017-11-28 |
2023-08-13 |
rat |
| Rosaliana Libro, Placido Bramanti, Emanuela Mazzo. Endogenous glucocorticoids: role in the etiopathogenesis of Alzheimer's disease. Neuro endocrinology letters. vol 38. issue 1. 2017-08-29. PMID:28456142. |
ad is the most common form of dementia, characterized by the pathological accumulation of two proteins: the amyloid beta (aβ) and the microtubule-associated protein tau in the neurons of the hippocampus and prefrontal cortex. |
2017-08-29 |
2023-08-13 |
Not clear |
| Helen Ling, Gabor G Kovacs, Jean Paul G Vonsattel, Karen Davey, Kin Y Mok, John Hardy, Huw R Morris, Thomas T Warner, Janice L Holton, Tamas Reves. Astrogliopathy predominates the earliest stage of corticobasal degeneration pathology. Brain : a journal of neurology. vol 139. issue Pt 12. 2017-05-10. PMID:27797812. |
relatively greater tau burden in the anterior frontal cortex, striatum and subthalamic nucleus suggests the striatal afferent connection to the dorsolateral prefrontal cortex and basal ganglia circuitry are the earliest neural network connections affected by corticobasal degeneration-related tau pathology. |
2017-05-10 |
2023-08-13 |
Not clear |
| Sofia Lopes, Larysa Teplytska, Joao Vaz-Silva, Chrysoula Dioli, Rita Trindade, Monica Morais, Christian Webhofer, Giuseppina Maccarrone, Osborne F X Almeida, Christoph W Turck, Nuno Sousa, Ioannis Sotiropoulos, Michaela D Filio. Tau Deletion Prevents Stress-Induced Dendritic Atrophy in Prefrontal Cortex: Role of Synaptic Mitochondria. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 4. 2017-04-27. PMID:27073221. |
tau deletion prevents stress-induced dendritic atrophy in prefrontal cortex: role of synaptic mitochondria. |
2017-04-27 |
2023-08-13 |
mouse |
| Sofia Lopes, Larysa Teplytska, Joao Vaz-Silva, Chrysoula Dioli, Rita Trindade, Monica Morais, Christian Webhofer, Giuseppina Maccarrone, Osborne F X Almeida, Christoph W Turck, Nuno Sousa, Ioannis Sotiropoulos, Michaela D Filio. Tau Deletion Prevents Stress-Induced Dendritic Atrophy in Prefrontal Cortex: Role of Synaptic Mitochondria. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 4. 2017-04-27. PMID:27073221. |
to test the involvement of tau in stress-induced impairments of cognition, we investigated the impact of stress on cognitive behavior, neuronal structure, and the synaptic proteome in the prefrontal cortex (pfc) of tau knock-out (tau-ko) and wild-type (wt) mice. |
2017-04-27 |
2023-08-13 |
mouse |
| Zhihui Gai, Kang Li, Huanrui Sun, Xiaojun She, Bo Cui, Rui Wan. Effects of chronic noise on mRNA and protein expression of CRF family molecules and its relationship with p-tau in the rat prefrontal cortex. Journal of the neurological sciences. vol 368. 2017-04-21. PMID:27538655. |
chronic noise exposure has been associated with alzheimer's disease (ad)-like pathological changes, such as tau hyperphosphorylation and β-amyloid peptide accumulation in the prefrontal cortex (pfc). |
2017-04-21 |
2023-08-13 |
rat |
| Zhihui Gai, Kang Li, Huanrui Sun, Xiaojun She, Bo Cui, Rui Wan. Effects of chronic noise on mRNA and protein expression of CRF family molecules and its relationship with p-tau in the rat prefrontal cortex. Journal of the neurological sciences. vol 368. 2017-04-21. PMID:27538655. |
the aim of this study was to explore the effects of chronic noise exposure on the crf system in the pfc of rats and its relationship to tau phosphorylation. |
2017-04-21 |
2023-08-13 |
rat |
| Trine Schütt, Lone Helboe, Lars Østergaard Pedersen, Gunhild Waldemar, Mette Berendt, Jan Torleif Pederse. Dogs with Cognitive Dysfunction as a Spontaneous Model for Early Alzheimer's Disease: A Translational Study of Neuropathological and Inflammatory Markers. Journal of Alzheimer's disease : JAD. vol 52. issue 2. 2017-01-27. PMID:27003213. |
the neuropathological investigations included evaluation of amyloid-β (aβ) plaque deposition (n-terminally truncated and pyroglutamyl-modified aβ included), tau pathology, and inflammatory markers in prefrontal cortex. |
2017-01-27 |
2023-08-13 |
human |
| Josiane Budni, Robson Pacheco, Sabrina da Silva, Michelle Lima Garcez, Francielle Mina, Tatiani Bellettini-Santos, Jesiel de Medeiros, Bruna Constantino Voss, Amanda Valnier Steckert, Samira da Silva Valvassori, João Queved. Oral administration of d-galactose induces cognitive impairments and oxidative damage in rats. Behavioural brain research. vol 302. 2016-12-13. PMID:26748256. |
in the 8th week of d-gal administration, we also observed reductions in synaptophysin and tau protein levels in the prefrontal cortex. |
2016-12-13 |
2023-08-13 |
rat |