| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah Buchholz, Michael Bell-Simons, Natja Haag, Hans Zempe. Tracking Tau in Neurons: How to Grow, Fix, and Stain Primary Neurons for the Investigation of Tau in All Developmental Stages. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512686. |
here, we describe (i) a relatively cheap and easy cell culture procedure for the cultivation of forebrain neurons from embryonic mice (e13.5) based on a commercially available neuronal supplement (ns21), (ii) a protocol for the cultivation of hippocampal and cortical neurons from postnatal (p0-p3) animals, and (iii) basic fixation and immunofluorescence techniques for the staining of neuronal markers and endogenous tau. |
2024-03-21 |
2024-03-24 |
mouse |
| Paromita Das-Earl, Derek A Schreihofer, Nathalie Sumien, Ann M Schreihofe. Temporal and region-specific tau hyperphosphorylation in the medulla and forebrain coincides with development of functional changes in male obese Zucker rats. Journal of neurophysiology. 2024-02-28. PMID:38416718. |
temporal and region-specific tau hyperphosphorylation in the medulla and forebrain coincides with development of functional changes in male obese zucker rats. |
2024-02-28 |
2024-03-02 |
rat |
| Shenee C Martin, Kathryn K Joyce, Kathryn M Harper, Viktoriya D Nikolova, Todd J Cohen, Sheryl S Moy, Graham H Dierin. Sleep disruption precedes forebrain synaptic Tau burden and contributes to cognitive decline in a sex-dependent manner in the P301S Tau transgenic mouse model. bioRxiv : the preprint server for biology. 2023-06-19. PMID:37333395. |
sleep disruption precedes forebrain synaptic tau burden and contributes to cognitive decline in a sex-dependent manner in the p301s tau transgenic mouse model. |
2023-06-19 |
2023-08-14 |
mouse |
| M Bell-Simons, S Buchholz, J Klimek, H Zempe. Laser-Induced Axotomy of Human iPSC-Derived and Murine Primary Neurons Decreases Somatic Tau and AT8 Tau Phosphorylation: A Single-Cell Approach to Study Effects of Acute Axonal Damage. Cellular and molecular neurobiology. 2023-05-12. PMID:37171549. |
we cultivated human ipsc-derived cortical neurons and mouse primary forebrain neurons in specialized chambers allowing reliable post-fixation identification and tau analysis. |
2023-05-12 |
2023-08-14 |
mouse |
| Michael A Kelberman, Jacki M Rorabaugh, Claire R Anderson, Alexia Marriott, Seth D DePuy, Kurt Rasmussen, Katharine E McCann, Jay M Weiss, David Weinshenke. Age-dependent dysregulation of locus coeruleus firing in a transgenic rat model of Alzheimer's disease. Neurobiology of aging. vol 125. 2023-03-08. PMID:36889122. |
we assessed single unit lc activity in anesthetized wild-type (wt) and tgf344-ad rats at 6 months, which represents a prodromal stage when lc neurons are the only cells containing hyperphosphorylated tau in tgf344-ad animals, and at 15 months when amyloid-β (aβ) and tau pathology are both abundant in the forebrain. |
2023-03-08 |
2023-08-14 |
rat |
| Jialu Tu, Haiyang Zhang, Ting Yang, Yun Liu, Solomon Kibreab, Yunpeng Zhang, Liangcai Gao, Robb E Moses, Bert W O'Malley, Jianru Xiao, Xiaotao L. Aging-associated REGγ proteasome decline predisposes to tauopathy. The Journal of biological chemistry. 2022-10-09. PMID:36209822. |
regγ-mediated proteasomal degradation of tau was validated in 3-12-month-old regγ knockout (ko) mice, regγ ko;ps19 mice, and ps19 mice with forebrain conditional neuron-specific overexpression of regγ (regγ oe) and behavioral abnormalities. |
2022-10-09 |
2023-08-14 |
mouse |
| Hiroko Shimada, Yuta Sato, Takashi Sasaki, Aki Shimozawa, Kent Imaizumi, Tomoko Shindo, Sachiyo Miyao, Kosuke Kiyama, Takahiro Kondo, Shinsuke Shibata, Seiji Ishii, Junro Kuromitsu, Hirofumi Aoyagi, Daisuke Ito, Hideyuki Okan. A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer. Cell reports methods. vol 2. issue 9. 2022-09-26. PMID:36160042. |
a next-generation ipsc-derived forebrain organoid model of tauopathy with tau fibrils by aav-mediated gene transfer. |
2022-09-26 |
2023-08-14 |
human |
| Moorthi Ponnusamy, Shuai Wang, Melike Yuksel, Mitchell T Hansen, Danielle M Blazier, Joseph D McMillan, Xiaolin Zhang, Eric B Dammer, Lisa Collier, Gopal Thinakara. Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model. Brain : a journal of neurology. 2022-09-04. PMID:36059072. |
we generated conditional knock-out mice with a selective loss of bin1 expression in the forebrain excitatory neurons and oligodendrocytes in p301s human tau transgenic background (line ps19). |
2022-09-04 |
2023-08-14 |
mouse |
| Moorthi Ponnusamy, Shuai Wang, Melike Yuksel, Mitchell T Hansen, Danielle M Blazier, Joseph D McMillan, Xiaolin Zhang, Eric B Dammer, Lisa Collier, Gopal Thinakara. Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model. Brain : a journal of neurology. 2022-09-04. PMID:36059072. |
the loss of forebrain bin1 expression in ps19 mice exacerbated tau pathology in the somatosensory cortex, thalamus, spinal cord, and sciatic nerve, accelerated disease progression, and caused early death. |
2022-09-04 |
2023-08-14 |
mouse |
| Moorthi Ponnusamy, Shuai Wang, Melike Yuksel, Mitchell T Hansen, Danielle M Blazier, Joseph D McMillan, Xiaolin Zhang, Eric B Dammer, Lisa Collier, Gopal Thinakara. Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model. Brain : a journal of neurology. 2022-09-04. PMID:36059072. |
we conclude that forebrain neuronal bin1 expression promotes hippocampal tau pathogenesis and neuroinflammation. |
2022-09-04 |
2023-08-14 |
mouse |
| Prita R Asih, Kristie Stefanoska, Emmanuel Prikas, Arne Ittne. High level forebrain expression of active tau kinase p38γ exacerbates cognitive dysfunction in aged APP-transgenic alzheimer's mice. Neuroscience. 2022-01-15. PMID:35031398. |
high level forebrain expression of active tau kinase p38γ exacerbates cognitive dysfunction in aged app-transgenic alzheimer's mice. |
2022-01-15 |
2023-08-13 |
mouse |
| Anthoni M Goodman, Bethany M Langner, Nateka Jackson, Capri Alex, Lori L McMaho. Heightened Hippocampal β-Adrenergic Receptor Function Drives Synaptic Potentiation and Supports Learning and Memory in the TgF344-AD Rat Model during Prodromal Alzheimer's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 26. 2021-11-22. PMID:33952633. |
in fact, the locus coeruleus (lc), the sole source of norepinephrine (ne) for >90% of the brain, is the first site of pathologic tau accumulation in human ad with axon loss throughout forebrain, including hippocampus. |
2021-11-22 |
2023-08-13 |
human |
| Naomi Kouri, Melissa E Murray, Joseph S Reddy, Daniel J Serie, Alexandra Soto-Beasley, Mariet Allen, Minerva M Carrasquillo, Xue Wang, Monica Casey Castanedes, Matthew C Baker, Rosa Rademakers, Ryan J Uitti, Neill R Graff-Radford, Zbigniew K Wszolek, Gerard D Schellenberg, Julia E Crook, Nilüfer Ertekin-Taner, Owen A Ross, Dennis W Dickso. Latent trait modeling of tau neuropathology in progressive supranuclear palsy. Acta neuropathologica. vol 141. issue 5. 2021-11-16. PMID:33635380. |
significant snp/lt associations were identified at rs242557 (mapt h1c sub-haplotype) with hindbrain cbs and rs1768208 (mobp) with forebrain tau threads. |
2021-11-16 |
2023-08-13 |
Not clear |
| Daijiro Yanagisawa, Hamizah Shahirah Hamezah, Aslina Pahrudin Arrozi, Ikuo Tooyam. Differential accumulation of tau pathology between reciprocal F1 hybrids of rTg4510 mice. Scientific reports. vol 11. issue 1. 2021-10-22. PMID:33953293. |
as compared with rtg4510_cxf mice, the rtg4510_fxc mice showed marked levels of tau pathology in the forebrain. |
2021-10-22 |
2023-08-13 |
mouse |
| Ting Cao, Xiaojuan Zhou, Xianjie Zheng, Yue Cui, Joe Z Tsien, Chunxia Li, Huimin Wan. Histone Deacetylase Inhibitor Alleviates the Neurodegenerative Phenotypes and Histone Dysregulation in Presenilins-Deficient Mice. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:29867447. |
the forebrain presenilin-1 and presenilin-2 conditional double knockout (cdko) mice showed memory impairment, forebrain degeneration, tau hyperphosphorylation and inflammation that closely mimics ad-like phenotypes. |
2020-10-01 |
2023-08-13 |
mouse |
| HoChung Jang, Jung Hwa Ryu, Kyung Min Shin, Na-Young Seo, Gyu Hyun Kim, Yang Hoon Huh, Ae Nim Pae, Kea Joo Le. Gait Ignition Failure in JNPL3 Human Tau-mutant Mice. Experimental neurobiology. vol 28. issue 3. 2020-10-01. PMID:31308799. |
considering the normal gait ignition in rtg4510 mice expressing the same mutant tau in the forebrain, gif in jnpl3 mice seems to arise from abnormal tau deposition in the hindbrain areas involved in locomotor initiation. |
2020-10-01 |
2023-08-13 |
mouse |
| Yi Sui, Yao Zhang, Chunyao Dong, Bing Xu, Xiaohong Su. The small molecular CCR3 antagonist YM344031 attenuates neurodegenerative pathologies and improves learning and memory performance in a mouse model of Alzheimer's disease. Brain research. vol 1719. 2020-09-25. PMID:31121157. |
for two months resulted in dramatic decreases in β-amyloid deposition, tau hyperphosphorylation and synaptic loss in the forebrain, significant attenuation of microgliosis and astrogliosis, and marked improvement of spatial learning and memory performance compared with the vehicle-treated mice. |
2020-09-25 |
2023-08-13 |
mouse |
| Seong Su Kang, Xia Liu, Eun Hee Ahn, Jie Xiang, Fredric P Manfredsson, Xifei Yang, Hongbo R Luo, L Cameron Liles, David Weinshenker, Keqiang Y. Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus. The Journal of clinical investigation. vol 130. issue 1. 2020-07-21. PMID:31793911. |
activation of asparagine endopeptidase-cleaved tau aggregation in vitro and in intact cells was triggered by 3,4-dihydroxyphenylglycolaldehyde, resulting in lc neurotoxicity and propagation of pathology to the forebrain. |
2020-07-21 |
2023-08-13 |
human |
| Yan Zhu, Guanxia Zhan, Polina Fenik, Madison Brandes, Patrick Bell, Noelle Francois, Katherine Shulman, Sigrid Vease. Chronic Sleep Disruption Advances the Temporal Progression of Tauopathy in P301S Mutant Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 48. 2019-10-10. PMID:30322903. |
over time tau pathology, including tangles, was evident in forebrain tau-vulnerable regions. |
2019-10-10 |
2023-08-13 |
mouse |
| Aurélien Lathuilière, Pamela Valdés, Stéphanie Papin, Matthias Cacquevel, Catherine Maclachlan, Graham W Knott, Andreas Muhs, Paolo Paganetti, Bernard L Schneide. Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects. Scientific reports. vol 7. issue 1. 2019-07-02. PMID:29051562. |
human tau was overexpressed in the adult mouse forebrain to compare variants carrying residues that modulate tau propensity to acquire a β-sheet conformation. |
2019-07-02 |
2023-08-13 |
mouse |