| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michaeline L Hebron, Monica Javidnia, Charbel E-H Mouss. Tau clearance improves astrocytic function and brain glutamate-glutamine cycle. Journal of the neurological sciences. vol 391. 2019-06-27. PMID:30103978. |
existing animal models of tauopathies express tau in neurons within the forebrain and do not often show tau accumulation in the brainstem and astrocytes. |
2019-06-27 |
2023-08-13 |
mouse |
| Francesca Vitale, Luca Giliberto, Santiago Ruiz, Kristen Steslow, Philippe Marambaud, Cristina d'Abram. Anti-tau conformational scFv MC1 antibody efficiently reduces pathological tau species in adult JNPL3 mice. Acta neuropathologica communications. vol 6. issue 1. 2019-06-05. PMID:30134961. |
passive immunization experiments using intra-peritoneal injections have previously shown that mc1 is effective at reducing tau pathology in the forebrain of tau transgenic jnpl3 mice. |
2019-06-05 |
2023-08-13 |
mouse |
| Xiaohai Wang, Karen Smith, Michelle Pearson, Anna Hughes, Mali L Cosden, Jacob Marcus, J Fred Hess, Mary J Savage, Thomas Rosahl, Sean M Smith, Joel B Schachter, Jason M Uslane. Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy. PloS one. vol 13. issue 4. 2018-07-25. PMID:29624602. |
here we found that rtg4510 mice, which overexpress human mutant tau in the forebrain, develop progressive age-dependent increases in locomotor activity (lma), which correlates with neurofibrillary tangle (nft) pathology, hyperphosphorylated tau levels, and brain atrophy. |
2018-07-25 |
2023-08-13 |
mouse |
| Noah R Johnson, Carlo Condello, Shenheng Guan, Abby Oehler, Julia Becker, Marta Gavidia, George A Carlson, Kurt Giles, Stanley B Prusine. Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 51. 2018-07-02. PMID:29203673. |
unexpectedly, tau mrna and protein levels did not differ between the forebrain and hindbrain, suggesting that other factors modulating the conversion of tau into a prion exist and are region specific. |
2018-07-02 |
2023-08-13 |
mouse |
| Noah R Johnson, Carlo Condello, Shenheng Guan, Abby Oehler, Julia Becker, Marta Gavidia, George A Carlson, Kurt Giles, Stanley B Prusine. Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 51. 2018-07-02. PMID:29203673. |
we also show that sortilin expression is higher in the forebrain than the hindbrain across the life span of the tg mice, suggesting that sortilin, at least in part, inhibits forebrain tau prion replication in vivo. |
2018-07-02 |
2023-08-13 |
mouse |
| David J Koss, Lianne Robinson, Benjamin D Drever, Kaja Plucińska, Sandra Stoppelkamp, Peter Veselcic, Gernot Riedel, Bettina Plat. Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology. Neurobiology of disease. vol 91. 2018-02-20. PMID:26949217. |
after confirmation of an additional htau species (~60kda) in forebrain samples, we identified age-dependent progressive tau phosphorylation which coincided with the emergence of ftd relevant behavioural traits. |
2018-02-20 |
2023-08-13 |
mouse |
| Hans Zempel, Frank J A Dennissen, Yatender Kumar, Julia Luedtke, Jacek Biernat, Eva-Maria Mandelkow, Eckhard Mandelko. Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture. The Journal of biological chemistry. vol 292. issue 29. 2017-08-08. PMID:28536263. |
here, we investigated the properties and distributions of human and rodent tau isoforms in primary forebrain rodent neurons. |
2017-08-08 |
2023-08-13 |
human |
| Sulana K Schroeder, Aurelie Joly-Amado, Marcia N Gordon, Dave Morga. Tau-Directed Immunotherapy: A Promising Strategy for Treating Alzheimer's Disease and Other Tauopathies. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 11. issue 1. 2016-11-09. PMID:26538351. |
we review initial studies on tau-directed immunotherapy, and present data from our laboratory testing antibodies using the rtg4510 mouse model, which deposits tau in forebrain neurons. |
2016-11-09 |
2023-08-13 |
mouse |
| Magdalena Gąssowska, Irena Baranowska-Bosiacka, Joanna Moczydłowska, Maciej Tarnowski, Anna Pilutin, Izabela Gutowska, Lidia Strużyńska, Dariusz Chlubek, Agata Adamczy. Perinatal exposure to lead (Pb) promotes Tau phosphorylation in the rat brain in a GSK-3β and CDK5 dependent manner: Relevance to neurological disorders. Toxicology. vol 347-349. 2016-08-18. PMID:27012722. |
28-day old pups were sacrificed and tau mrna and protein level as well as tau phosphorylation were analyzed in forebrain cortex (fc), cerebellum (c) and hippocampus (h). |
2016-08-18 |
2023-08-13 |
rat |
| Steven Moore, Lewis D B Evans, Therese Andersson, Erik Portelius, James Smith, Tatyana B Dias, Nathalie Saurat, Amelia McGlade, Peter Kirwan, Kaj Blennow, John Hardy, Henrik Zetterberg, Frederick J Livese. APP metabolism regulates tau proteostasis in human cerebral cortex neurons. Cell reports. vol 11. issue 5. 2016-02-05. PMID:25921538. |
to investigate the relationship between app metabolism and tau protein levels and phosphorylation, we studied human-stem-cell-derived forebrain neurons with genetic forms of ad, all of which increase the release of pathogenic aβ peptides. |
2016-02-05 |
2023-08-13 |
human |
| Tabassum Majid, Yousuf O Ali, Deepa V Venkitaramani, Ming-Kuei Jang, Hui-Chen Lu, Robia G Pautle. In vivo axonal transport deficits in a mouse model of fronto-temporal dementia. NeuroImage. Clinical. vol 4. 2015-10-30. PMID:24936422. |
this mouse model exhibits tau pathology, neurodegeneration in the forebrain, and associated behavioral deficits beginning at 4-5 months of age. |
2015-10-30 |
2023-08-13 |
mouse |
| Xiao Zhang, Ming Shi, Ruidong Ye, Wei Wang, Xuedong Liu, Guangyun Zhang, Junliang Han, Yunxia Zhang, Bing Wang, Jun Zhao, Juan Hui, Lize Xiong, Gang Zha. Ginsenoside Rd attenuates tau protein phosphorylation via the PI3K/AKT/GSK-3β pathway after transient forebrain ischemia. Neurochemical research. vol 39. issue 7. 2015-10-19. PMID:24792734. |
ginsenoside rd attenuates tau protein phosphorylation via the pi3k/akt/gsk-3β pathway after transient forebrain ischemia. |
2015-10-19 |
2023-08-13 |
rat |
| Boris Mravec, Katarina Lejavova, Veronika Cubinkov. Locus (coeruleus) minoris resistentiae in pathogenesis of Alzheimer's disease. Current Alzheimer research. vol 11. issue 10. 2015-08-03. PMID:25387337. |
moreover, the lc undergoes significant degeneration in the brains of ad patients and is considered a source of the prion-like spreading of tau pathology to forebrain structures innervated by the noradrenergic neurons of the lc. |
2015-08-03 |
2023-08-13 |
Not clear |
| Christian Hölsche. The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 1 Suppl. 2014-10-06. PMID:24529525. |
in an (18)fluorodeoxyglucoe positron emission tomographic/computed tomographic imaging study in plb1-triple mice, a mouse model that expresses human mutated app, ps1, and tau proteins, glucose metabolism was found to be normalized in forebrain areas after liraglutide treatment, demonstrating that neuronal metabolic activity was normalized. |
2014-10-06 |
2023-08-12 |
mouse |
| Virginie Stygelbout, Karelle Leroy, Valérie Pouillon, Kunie Ando, Eva D'Amico, Yonghui Jia, H Robert Luo, Charles Duyckaerts, Christophe Erneux, Stéphane Schurmans, Jean-Pierre Brio. Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology. Brain : a journal of neurology. vol 137. issue Pt 2. 2014-04-11. PMID:24401760. |
transgenic overexpression of itpkb in mouse forebrain neurons was not sufficient to induce amyloid plaque formation or tau hyperphosphorylation. |
2014-04-11 |
2023-08-12 |
mouse |
| Li Yan, Li Li, Wenfei Han, Boxi Pan, Xiaolin Xue, Bing Me. Age-related neuropsychiatric symptoms in presenilins conditional double knockout mice. Brain research bulletin. vol 97. 2014-03-18. PMID:23792007. |
conditional presenilin1 (ps1) and presenilin2 (ps2) double knockout (dko) mice have age-related forebrain atrophy, tau hyperphosphorylation, synaptic dysfunction, cognitive deficits and increased inflammatory responses in both the periphery and the brain. |
2014-03-18 |
2023-08-12 |
mouse |
| Sefika Ozcelik, Graham Fraser, Perrine Castets, Véronique Schaeffer, Zhiva Skachokova, Karin Breu, Florence Clavaguera, Michael Sinnreich, Ludwig Kappos, Michel Goedert, Markus Tolnay, David Theo Winkle. Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice. PloS one. vol 8. issue 5. 2013-12-09. PMID:23667480. |
rapamycin treatment resulted in a significant reduction in cortical tau tangles, less tau hyperphosphorylation, and lowered levels of insoluble tau in the forebrain. |
2013-12-09 |
2023-08-12 |
mouse |
| Pablo D Perez, Gabrielle Hall, Tetsuya Kimura, Yan Ren, Rachel M Bailey, Jada Lewis, Marcelo Febo, Naruhiko Sahar. In vivo functional brain mapping in a conditional mouse model of human tauopathy (tauP301L) reveals reduced neural activity in memory formation structures. Molecular neurodegeneration. vol 8. 2013-07-22. PMID:23379588. |
the rtg4510 mouse conditionally expresses mutant human tau protein in various forebrain areas under the tet-off expression system. |
2013-07-22 |
2023-08-12 |
mouse |
| Felix Hernandez, Jose J Lucas, Jesus Avil. GSK3 and tau: two convergence points in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 33 Suppl 1. 2013-06-06. PMID:22710914. |
thus, mice generated in our laboratory with conditional overexpression of gsk3 in forebrain neurons (tet/gsk3β mice) recapitulate aspects of ad neuropathology such as tau hyperphosphorylation, apoptotic neuronal death, and reactive astrocytosis, as well as spatial learning deficit. |
2013-06-06 |
2023-08-12 |
mouse |
| Yan Cai, Hai-Xia Zhu, Jian-Ming Li, Xue-Gang Luo, Peter R Patrylo, Gregory M Rose, Jackson Streeter, Ron Hayes, Kevin K W Wang, Xiao-Xin Yan, Andreas Jeromi. Age-related intraneuronal elevation of αII-spectrin breakdown product SBDP120 in rodent forebrain accelerates in 3×Tg-AD mice. PloS one. vol 7. issue 6. 2012-12-12. PMID:22723836. |
the intraneuronal sbdp120 occurrence was not spatiotemporally correlated with transgenic amyloid precursor protein (app) expression, β-amyloid plaque development, or phosphorylated tau expression over various forebrain regions or lamina. |
2012-12-12 |
2023-08-12 |
mouse |