| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tobias Engel, Félix Hernández, Jesús Avila, José J Luca. Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 19. 2006-05-31. PMID:16687499. |
in good agreement, mice with conditional overexpression of gsk-3 in forebrain neurons (tet/gsk-3beta mice) recapitulate aspects of ad neuropathology such as tau hyperphosphorylation, apoptotic neuronal death, and reactive astrocytosis as well as spatial learning deficit. |
2006-05-31 |
2023-08-12 |
mouse |
| C Hawkes, J H Jhamandas, S Ka. Selective loss of basal forebrain cholinergic neurons by 192 IgG-saporin is associated with decreased phosphorylation of Ser glycogen synthase kinase-3beta. Journal of neurochemistry. vol 95. issue 1. 2005-11-08. PMID:16181430. |
these results provide the first evidence that increased gsk-3beta activity, via decreased ser9 phosphorylation, can mediate, at least in part, 192-igg saporin-induced in vivo degeneration of forebrain cholinergic neurons by enhancing tau phosphorylation. |
2005-11-08 |
2023-08-12 |
rat |
| Gary W Arendash, Jada Lewis, Ralph E Leighty, Eileen McGowan, Jennifer R Cracchiolo, Mike Hutton, Marcos F Garci. Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain. Brain research. vol 1012. issue 1-2. 2004-08-17. PMID:15158158. |
multi-metric behavioral comparison of appsw and p301l models for alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain. |
2004-08-17 |
2023-08-12 |
mouse |
| Robert Siman, Tracy K McIntosh, Kristie M Soltesz, Zhaoming Chen, Robert W Neumar, Victoria L Robert. Proteins released from degenerating neurons are surrogate markers for acute brain damage. Neurobiology of disease. vol 16. issue 2. 2004-08-13. PMID:15193288. |
the value of this approach was established by immunodetection of the released proteins 14-3-3 zeta and 14-3-3 beta, as well as calpain and caspase derivatives of tau and alpha-spectrin in cerebrospinal fluid (csf) following traumatic brain injury (tbi) or transient forebrain ischemia in the rat. |
2004-08-13 |
2023-08-12 |
rat |
| Yoshitaka Tatebayashi, Tomohiro Miyasaka, De-Hua Chui, Takumi Akagi, Ken-ichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara, Kentaro Tanemura, Miyuki Murayama, Koichi Ishiguro, Emmanuel Planel, Shinji Sato, Tsutomu Hashikawa, Akihiko Takashim. Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 21. 2002-12-04. PMID:12368474. |
expression of modest levels of the longest human tau isoform with this mutation under the control of the alpha-calcium-calmodulin-dependent kinase-ii promoter in transgenic (tg) mice resulted in the development of congophilic hyperphosphorylated tau inclusions in forebrain neurons. |
2002-12-04 |
2023-08-12 |
mouse |
| R Sinigaglia-Coimbra, E A Cavalheiro, C G Coimbr. Postischemic hyperthermia induces Alzheimer-like pathology in the rat brain. Acta neuropathologica. vol 103. issue 5. 2002-06-21. PMID:11935259. |
associated immunohistochemical findings after 2 or 6 months of recovery included: (1) complement activation (membrane attack complex formation); (2) generalized overexpression of ubiquitin in surviving forebrain neurons; (3) persistent activation of macrophages; (4) presence of gemistocytic astrocytes in the hippocampus; (5) maturation of amyloid plaques (identified by immunohistochemistry using anti-human beta-a4 primary antibody) in cerebral cortex; and (6) intracellular deposits identified by anti-human hyperphosphorylated tau protein antibodies. |
2002-06-21 |
2023-08-12 |
human |
| Sozos Ch Papasozomenos, Alikunju Shanava. Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3 beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau: implications for Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 3. 2002-03-07. PMID:11805297. |
in kinase assays of forebrain homogenates, overactivation of gsk-3 beta at 0-6 h after heat shock toward human recombinant tau, bovine tau, and phosphoglycogen synthase peptide 2 was prevented in ovx + tp and ovx + (eb + tp) but not in sham-ovx + so, ovx + so, and ovx + eb. |
2002-03-07 |
2023-08-12 |
human |
| F Lim, F Hernández, J J Lucas, P Gómez-Ramos, M A Morán, J Avil. FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain. Molecular and cellular neurosciences. vol 18. issue 6. 2002-02-21. PMID:11749044. |
ftdp-17 mutations in tau transgenic mice provoke lysosomal abnormalities and tau filaments in forebrain. |
2002-02-21 |
2023-08-12 |
mouse |
| M L Schmidt, R Garruto, J Chen, V M Lee, J Q Trojanowsk. Tau epitopes in spinal cord neurofibrillary lesions in Chamorros of Guam. Neuroreport. vol 11. issue 16. 2001-05-31. PMID:11095492. |
most (16/20) spinal cords, including some from chamorros without documented clinical disease, contained tangles with a tau epitope profile similar to the tangles found in the forebrain and brain stem of these patients. |
2001-05-31 |
2023-08-12 |
Not clear |
| M Bennecib, C X Gong, I Grundke-Iqbal, K Iqba. Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356. FEBS letters. vol 490. issue 1-2. 2001-03-29. PMID:11172803. |
the regulation of the activity of camkii by pp-1 and pp-2a, as well as the role of this protein kinase in the phosphorylation of tau protein in forebrain were investigated. |
2001-03-29 |
2023-08-12 |
rat |
| M Bennecib, C X Gong, I Grundke-Iqbal, K Iqba. Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356. FEBS letters. vol 490. issue 1-2. 2001-03-29. PMID:11172803. |
these studies suggest (i) that in mammalian forebrain the cytosolic camkii activity is regulated mainly by pp-2a, (ii) that camkii is the major tau ser 262/356 kinase in brain, and (iii) that a decrease in pp-2a/pp-1 activities in the brain leads to hyperphosphorylation of tau not only by inhibition of its dephosphorylation but also by promoting the camkii activity. |
2001-03-29 |
2023-08-12 |
rat |
| M Bennecib, C X Gong, I Grundke-Iqbal, K Iqba. Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356. FEBS letters. vol 490. issue 1-2. 2001-03-29. PMID:11172803. |
inhibition of pp-2a upregulates camkii in rat forebrain and induces hyperphosphorylation of tau at ser 262/356. |
2001-03-29 |
2023-08-12 |
rat |
| T Pratt, T Vitalis, N Warren, J M Edgar, J O Mason, D J Pric. A role for Pax6 in the normal development of dorsal thalamus and its cortical connections. Development (Cambridge, England). vol 127. issue 23. 2001-01-25. PMID:11060242. |
we exploited a new transgenic mouse ubiquitously expressing green fluorescent protein tagged with tau, in which axonal tracts are clearly visible, and co-cultured dorsal thalamic explants from pax6(+/+ )or pax6(sey/sey )embryos carrying the transgene with wild-type tissues from other regions of the forebrain. |
2001-01-25 |
2023-08-12 |
mouse |
| M Bennecib, C X Gong, I Grundke-Iqbal, K Iqba. Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain. FEBS letters. vol 485. issue 1. 2000-12-28. PMID:11086171. |
employing rat forebrain slices kept metabolically active in oxygenated artificial csf as a model system, we investigated the role of pp-2a/pp-1 in the regulation of some of the major abnormally hyperphosphorylated sites of tau and the protein kinases involved. |
2000-12-28 |
2023-08-12 |
rat |
| M Bennecib, C X Gong, I Grundke-Iqbal, K Iqba. Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain. FEBS letters. vol 485. issue 1. 2000-12-28. PMID:11086171. |
role of protein phosphatase-2a and -1 in the regulation of gsk-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain. |
2000-12-28 |
2023-08-12 |
rat |
| D A Shackelford, R Y Ye. Dephosphorylation of tau during transient forebrain ischemia in the rat. Molecular and chemical neuropathology. vol 34. issue 2-3. 1999-06-21. PMID:10327411. |
dephosphorylation of tau during transient forebrain ischemia in the rat. |
1999-06-21 |
2023-08-12 |
rat |
| M A Burack, S Halpai. Site-specific regulation of Alzheimer-like tau phosphorylation in living neurons. Neuroscience. vol 72. issue 1. 1996-10-24. PMID:8730715. |
in neonatal forebrain slices, tau became rapidly dephosphorylated at the at8 and tau1 sites during incubation at 34 degrees c, but was incompletely dephosphorylated at the phf1 site. |
1996-10-24 |
2023-08-12 |
rat |
| K M Cullen, G M Hallida. Mechanisms of cell death in cholinergic basal forebrain neurons in chronic alcoholics. Metabolic brain disease. vol 10. issue 1. 1995-07-31. PMID:7596331. |
tau immunoreactivity was not however observed in cortical, brainstem, diencephalic or non-cholinergic forebrain structures. |
1995-07-31 |
2023-08-12 |
Not clear |
| C Mavilia, D Couchie, J Nune. Diversity of high-molecular-weight tau proteins in different regions of the nervous system. Journal of neurochemistry. vol 63. issue 6. 1994-12-23. PMID:7964751. |
we show in this work that high-molecular-weight (hmw) tau transcripts are present in all the regions of the cns and pns studied, i.e., the dorsal root ganglia (drg), spinal cord, cerebellum, and forebrain. |
1994-12-23 |
2023-08-12 |
human |
| C Mavilia, D Couchie, J Nune. Diversity of high-molecular-weight tau proteins in different regions of the nervous system. Journal of neurochemistry. vol 63. issue 6. 1994-12-23. PMID:7964751. |
rat forebrain, rat cerebellum, and human forebrain express much lower levels of hmw tau transcripts compared with the spinal cord and the drg. |
1994-12-23 |
2023-08-12 |
human |