| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ann Van der Jeugd, Katja Hochgräfe, Tariq Ahmed, Jochen M Decker, Astrid Sydow, Anne Hofmann, Dan Wu, Lars Messing, Detlef Balschun, Rudi D'Hooge, Eva-Maria Mandelko. Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau. Acta neuropathologica. vol 123. issue 6. 2012-09-24. PMID:22532069. |
our regulatable (tet-off) mouse models of tauopathy express variants of human full-length tau in the forebrain (camkiiα promoter) either with mutation Δk280 (pro-aggregant) or Δk280/i277p/i308p (anti-aggregant). |
2012-09-24 |
2023-08-12 |
mouse |
| Sébastien S Hébert, Nicolas Sergeant, Luc Bué. MicroRNAs and the Regulation of Tau Metabolism. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22720189. |
recently, we showed that mice lacking dicer in the forebrain displayed progressive neurodegeneration accompanied by disease-like changes in tau phosphorylation and splicing. |
2012-08-23 |
2023-08-12 |
mouse |
| Bin Zhang, Jenna Carroll, John Q Trojanowski, Yuemang Yao, Michiyo Iba, Justin S Potuzak, Anne-Marie L Hogan, Sharon X Xie, Carlo Ballatore, Amos B Smith, Virginia M-Y Lee, Kurt R Brunde. The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 11. 2012-05-01. PMID:22423084. |
moreover, the epod-treated ps19 mice had less forebrain tau pathology and increased hippocampal neuronal integrity, with no dose-limiting side effects. |
2012-05-01 |
2023-08-12 |
mouse |
| Yan Jiang, Anouch Matevossian, Yin Guo, Schahram Akbaria. Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice. Neuropharmacology. vol 60. issue 7-8. 2012-01-18. PMID:20869373. |
a myc-tagged setdb1 cdna was expressed through the tau locus for ubiquitous expression in cns neurons, or under control of the calcium/calmodulin-dependent protein kinase ii (ck) promoter to selectively target postmitotic neurons in forebrain. |
2012-01-18 |
2023-08-12 |
mouse |
| John Koren, Umesh K Jinwal, Zachary Davey, Janine Kiray, Karthik Arulselvam, Chad A Dicke. Bending tau into shape: the emerging role of peptidyl-prolyl isomerases in tauopathies. Molecular neurobiology. vol 44. issue 1. 2011-11-04. PMID:21523562. |
fkbp51 was also found to increase in forebrain neurons with age, further supporting a novel role for fkbp51 in tau processing. |
2011-11-04 |
2023-08-12 |
Not clear |
| M Hundelt, T Fath, K Selle, K Oesterwind, J Jordan, C Schultz, J Götz, J von Engelhardt, H Monyer, L Lewejohann, N Sachser, L Bakota, R Brand. Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation. Neurobiology of aging. vol 32. issue 6. 2011-09-13. PMID:19660835. |
here we describe a novel transgenic mouse model, expressing a pseudohyperphosphorylated (php) variant of the longest human cns tau isoform in forebrain neurons. |
2011-09-13 |
2023-08-12 |
mouse |
| Sébastien S Hébert, Aikaterini S Papadopoulou, Pascal Smith, Marie-Christine Galas, Emmanuel Planel, Asli N Silahtaroglu, Nicolas Sergeant, Luc Buée, Bart De Stroope. Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration. Human molecular genetics. vol 19. issue 20. 2011-03-01. PMID:20660113. |
genetic ablation of dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration. |
2011-03-01 |
2023-08-12 |
mouse |
| Brian R Hoover, Miranda N Reed, Jianjun Su, Rachel D Penrod, Linda A Kotilinek, Marianne K Grant, Rose Pitstick, George A Carlson, Lorene M Lanier, Li-Lian Yuan, Karen H Ashe, Dezhi Lia. Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron. vol 68. issue 6. 2011-01-19. PMID:21172610. |
the microtubule-associated protein tau accumulates in alzheimer's and other fatal dementias, which manifest when forebrain neurons die. |
2011-01-19 |
2023-08-12 |
Not clear |
| Kurt R Brunden, Bin Zhang, Jenna Carroll, Yuemang Yao, Justin S Potuzak, Anne-Marie L Hogan, Michiyo Iba, Michael J James, Sharon X Xie, Carlo Ballatore, Amos B Smith, Virginia M-Y Lee, John Q Trojanowsk. Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 41. 2010-11-04. PMID:20943926. |
we demonstrate here that the mt-stabilizing agent, epothilone d (epod), is brain-penetrant and we subsequently evaluated whether epod can compensate for tau loss-of-function in ps19 tau transgenic mice that develop forebrain tau inclusions, axonal degeneration and mt deficits. |
2010-11-04 |
2023-08-12 |
mouse |
| Gregory A Elder, Miguel A Gama Sosa, Rita De Gasperi, Dara L Dickstein, Patrick R Ho. Presenilin transgenic mice as models of Alzheimer's disease. Brain structure & function. vol 214. issue 2-3. 2010-06-15. PMID:19921519. |
mice in which ps1 has been conditionally knocked out in adult forebrain on a ps2 null background (ps1/2 cdko) develop a striking neurodegeneration that mimics ad neuropathology in being associated with neuronal and synaptic loss, astrogliosis and hyperphosphorylation of tau, although it is not accompanied by plaque deposits. |
2010-06-15 |
2023-08-12 |
mouse |
| R T Robertson, J Baratta, J Yu, F M LaFerl. Amyloid-beta expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum. Neuroscience. vol 164. issue 3. 2010-02-08. PMID:19772895. |
triple transgenic (3xtg-ad) mice harboring the presenilin 1, amyloid precursor protein, and tau transgenes (oddo et al., 2003b) display prominent levels of amyloid-beta (abeta) immunoreactivity in forebrain regions. |
2010-02-08 |
2023-08-12 |
mouse |
| Cassia R Overk, Christy M Kelley, Elliott J Mufso. Brainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease. Neurobiology of disease. vol 35. issue 3. 2009-12-03. PMID:19524671. |
the triple transgenic mouse (3xtgad), harboring human app(swe), ps1(m146v) and tau(p301l) genes, develops age-dependent forebrain intraneuronal abeta and tau as well as extraneuronal plaques. |
2009-12-03 |
2023-08-12 |
mouse |
| Manuela Polydoro, Christopher M Acker, Karen Duff, Pablo E Castillo, Peter Davie. Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 34. 2009-09-10. PMID:19710325. |
the presence of nfts in the forebrain is associated with impairments of cognitive function, supporting a central role for tau in dementia. |
2009-09-10 |
2023-08-12 |
mouse |
| Chad Dickey, Clara Kraft, Umesh Jinwal, John Koren, Amelia Johnson, Laura Anderson, Lori Lebson, Daniel Lee, Dennis Dickson, Rohan de Silva, Lester I Binder, David Morgan, Jada Lewi. Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy. The American journal of pathology. vol 174. issue 1. 2009-02-03. PMID:19074615. |
we have extensively analyzed the biochemical and histochemical profiles of the tau protein from the rtg4510 transgenic mouse model in which the animals uniquely develop forebrain tau pathologies similar to those found in human tauopathies. |
2009-02-03 |
2023-08-12 |
mouse |
| Pu Wu, Qian Shen, Suzhen Dong, Zhiliang Xu, Joe Z Tsien, Yinghe H. Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice. Neurobiology of aging. vol 29. issue 10. 2008-11-17. PMID:17499883. |
conditional double knockout of presenilin-1 and presenilin-2 (cdko) in forebrain of mice led to brain atrophy, tau hyperphosphorylation, synaptic dysfunction and cognitive deficit. |
2008-11-17 |
2023-08-12 |
mouse |
| Qian Chen, Akira Nakajima, Se Hoon Choi, Xiaoli Xiong, Ya-Ping Tan. Loss of presenilin function causes Alzheimer's disease-like neurodegeneration in the mouse. Journal of neuroscience research. vol 86. issue 7. 2008-07-08. PMID:18189321. |
in the present article, we show that conditional knockout of ps1 from the adult stage in the forebrain of mice with the ps2 null mutation triggers robust ad-like neurodegeneration including brain shrinkage, cortical and hippocampal atrophy,ventricular enlargement, severe neuronal loss, gliosis, tau hyperphosphorylation, neurofillament tangle-like structures, and intracellular filaments. |
2008-07-08 |
2023-08-12 |
mouse |
| Karelle Leroy, Alexis Bretteville, Katharina Schindowski, Emmanuel Gilissen, Michèle Authelet, Robert De Decker, Zehra Yilmaz, Luc Buée, Jean-Pierre Brio. Early axonopathy preceding neurofibrillary tangles in mutant tau transgenic mice. The American journal of pathology. vol 171. issue 3. 2007-12-06. PMID:17690183. |
we have generated a transgenic mouse line (tg30tau) expressing in the forebrain and the spinal cord a human tau protein bearing two pathogenic mutations (p301s and g272v). |
2007-12-06 |
2023-08-12 |
mouse |
| D Muyllaert, D Terwel, P Borghgraef, H Devijver, I Dewachter, F Van Leuve. Transgenic mouse models for Alzheimer's disease: the role of GSK-3B in combined amyloid and tau-pathology. Revue neurologique. vol 162. issue 10. 2006-11-14. PMID:17028556. |
at the same time, tau-p301lxgsk-3b mice have dramatic forebrain tauopathy, with "tangles in almost all neurons", although without hyper-phosphorylation of tau. |
2006-11-14 |
2023-08-12 |
mouse |
| Motohiro Morioka, Takayuki Kawano, Shigetoshi Yano, Yutaka Kai, Hiromasa Tsuiki, Yutaka Yoshinaga, Jun Matsumoto, Tatsumi Maeda, Jun-Ichiro Hamada, Hideyuki Yamamoto, Kohji Fukunaga, Jun-Ichi Kurats. Hyperphosphorylation at serine 199/202 of tau factor in the gerbil hippocampus after transient forebrain ischemia. Biochemical and biophysical research communications. vol 347. issue 1. 2006-09-13. PMID:16815303. |
we examined the phosphorylation state of tau factor in hippocampal delayed neuronal death (dnd) after transient forebrain ischemia. |
2006-09-13 |
2023-08-12 |
human |
| Motohiro Morioka, Takayuki Kawano, Shigetoshi Yano, Yutaka Kai, Hiromasa Tsuiki, Yutaka Yoshinaga, Jun Matsumoto, Tatsumi Maeda, Jun-Ichiro Hamada, Hideyuki Yamamoto, Kohji Fukunaga, Jun-Ichi Kurats. Hyperphosphorylation at serine 199/202 of tau factor in the gerbil hippocampus after transient forebrain ischemia. Biochemical and biophysical research communications. vol 347. issue 1. 2006-09-13. PMID:16815303. |
hyperphosphorylation at serine 199/202 of tau factor in the gerbil hippocampus after transient forebrain ischemia. |
2006-09-13 |
2023-08-12 |
human |