| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenichi Okazaki, Yong-Juan Fu, Yasushi Nishihira, Minoru Endo, Takao Fukushima, Takeshi Ikeuchi, Kouichirou Okamoto, Osamu Onodera, Masatoyo Nishizawa, Hitoshi Takahash. Alzheimer's disease: report of two autopsy cases with a clinical diagnosis of corticobasal degeneration. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 30. issue 2. 2010-08-13. PMID:19780981. |
these findings further strengthen the idea that in ad, neurodegeneration with tau and abeta deposits may begin in the fronto-parietal neocortical areas, which are often preferentially affected in cbd, earlier than, or as early as the medial temporal lobe, and that extrapyramidal signs, such as rigidity and tremor, can occur in the absence of neuronal loss in the basal ganglia and substantia nigra. |
2010-08-13 |
2023-08-12 |
Not clear |
| Lascelles E Lyn-Cook, Margot Lawton, Ming Tong, Elizabeth Silbermann, Lisa Longato, Ping Jiao, Princess Mark, Jack R Wands, Haiyan Xu, Suzanne M de la Mont. Hepatic ceramide may mediate brain insulin resistance and neurodegeneration in type 2 diabetes and non-alcoholic steatohepatitis. Journal of Alzheimer's disease : JAD. vol 16. issue 4. 2009-07-07. PMID:19387108. |
in hfd fed mice, temporal lobe levels of ubiquitin (p<0.001) and 4-hydroxynonenal (p<0.05 or p<0.01) increased, and tau, beta-actin, and choline acetyltransferase levels decreased (p<0.05-p<0.001) with development of nash. |
2009-07-07 |
2023-08-12 |
mouse |
| b' Sanna-Kaisa Herukka, Corina Pennanen, Hilkka Soininen, Tuula Pirttil\\xc3\\xa. CSF Abeta42, tau and phosphorylated tau correlate with medial temporal lobe atrophy. Journal of Alzheimer\'s disease : JAD. vol 14. issue 1. 2008-08-18. PMID:18525127.' |
csf abeta42, tau and phosphorylated tau correlate with medial temporal lobe atrophy. |
2008-08-18 |
2023-08-12 |
human |
| David G Munoz, John Woulfe, Andrew Kertes. Argyrophilic thorny astrocyte clusters in association with Alzheimer's disease pathology in possible primary progressive aphasia. Acta neuropathologica. vol 114. issue 4. 2007-12-26. PMID:17637999. |
the intensely tau immunoreactive astrocytes in atac were morphologically similar to the perivascular, subpial, and subependymal astrocytes in elderly brains, but atac differ from the latter by the cortical and subcortical location, widespread distribution outside the medial temporal lobe, and intense argyrophilia. |
2007-12-26 |
2023-08-12 |
Not clear |
| Jeffrey L Cummings, Rachelle Doody, Christopher Clar. Disease-modifying therapies for Alzheimer disease: challenges to early intervention. Neurology. vol 69. issue 16. 2007-11-08. PMID:17938373. |
enrichment strategies for clinical trials with mci include use of biomarkers such as amyloid imaging, mri with demonstration of medial temporal lobe atrophy, bilateral parietal hypometabolism on pet, and reduced amyloid beta peptide and increased tau protein in csf. |
2007-11-08 |
2023-08-12 |
Not clear |
| F H Bouwman, S N M Schoonenboom, W M van der Flier, E J van Elk, A Kok, F Barkhof, M A Blankenstein, Ph Schelten. CSF biomarkers and medial temporal lobe atrophy predict dementia in mild cognitive impairment. Neurobiology of aging. vol 28. issue 7. 2007-05-24. PMID:16782233. |
to study csf biomarkers, beta-amyloid(1-42) (abeta(1-42)) and tau, and medial temporal lobe atrophy (mta) on mri in their ability to predict dementia in patients with mild cognitive impairment (mci). |
2007-05-24 |
2023-08-12 |
Not clear |
| John F Crary, Charles Y Shao, Suzanne S Mirra, A Ivan Hernandez, Todd C Sackto. Atypical protein kinase C in neurodegenerative disease I: PKMzeta aggregates with limbic neurofibrillary tangles and AMPA receptors in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 65. issue 4. 2006-06-09. PMID:16691113. |
unlike tau, which is present in all nfts regardless of location, pkmzeta was found in a subset of nfts restricted to limbic or medial temporal lobe structures (i.e. |
2006-06-09 |
2023-08-12 |
drosophila_melanogaster |
| Kenichi Oshima, Kuniaki Tsuchiya, Shuji Iritani, Hideki Ueno, Kazuhiro Niizato, Ryosuke Nakamura, Tetsuaki Arai, Haruhiko Akiyama, Kenji Iked. [An autopsy case of argyrophilic grain dementia with abundant neurofibrillary tangles]. No to shinkei = Brain and nerve. vol 55. issue 2. 2003-06-06. PMID:12684993. |
sarkosyl-insoluble tau extracted from the temporal lobe consisted predominantly of four-repeat tau isoforms. |
2003-06-06 |
2023-08-12 |
Not clear |
| Gaël Chetelat, Jean-Claude Baro. Early diagnosis of Alzheimer's disease: contribution of structural neuroimaging. NeuroImage. vol 18. issue 2. 2003-04-11. PMID:12595205. |
these data, although still preliminary, are consistent with postmortem studies describing the hierarchical progression of tau lesions in normal aging and early stages of ad, such that damage to the medial temporal lobe and association cortex would account for the memory and nonmemory cognitive impairments, respectively, the combination of which is required to operationally define probable ad. |
2003-04-11 |
2023-08-12 |
human |
| Takashi Togo, Naruhiko Sahara, Shu-Hui Yen, Natalie Cookson, Takashi Ishizawa, Mike Hutton, Rohan de Silva, Andrew Lees, Dennis W Dickso. Argyrophilic grain disease is a sporadic 4-repeat tauopathy. Journal of neuropathology and experimental neurology. vol 61. issue 6. 2002-07-08. PMID:12071638. |
the tau isoform composition of agd was confirmed with densitometric analysis of western blots of sarkosyl-insoluble tau from the medial temporal lobe of agd brains with a range of concurrent neurofibrillary pathology and compared with alzheimer controls. |
2002-07-08 |
2023-08-12 |
Not clear |
| Jean C Augustinack, Judith L Sanders, Li-Huei Tsai, Bradley T Hyma. Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles. Journal of neuropathology and experimental neurology. vol 61. issue 6. 2002-07-08. PMID:12071639. |
adjacent temporal lobe sections were double immunostained with a polyclonal anti-cdk5 and monoclonal at8 (which recognizes phosphorylated serine 199, serine 202, and threonine 205 in tau) antibodies. |
2002-07-08 |
2023-08-12 |
Not clear |
| Thomas W Mitchell, Elliott J Mufson, Julie A Schneider, Elizabeth J Cochran, Jonathan Nissanov, Li-Ying Han, Julia L Bienias, Virginia M -Y Lee, John Q Trojanowski, David A Bennett, Steven E Arnol. Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease. Annals of neurology. vol 51. issue 2. 2002-03-01. PMID:11835374. |
these data indicate that phosphorylated tau pathology in the ventromedial temporal lobe develop prior to the onset of clinical dementia and their presence is associated with cognitive impairment, particularly impairment of episodic memory. |
2002-03-01 |
2023-08-12 |
human |
| E B Mukaetova-Ladinska, J Hurt, R Jakes, J Xuereb, W G Honer, C M Wischi. Alpha-synuclein inclusions in Alzheimer and Lewy body diseases. Journal of neuropathology and experimental neurology. vol 59. issue 5. 2000-07-19. PMID:10888371. |
the novel alpha-synuclein inclusion body identified in pyramidal cells of the medial temporal lobe in particular was found in ad and in the lewy body variant of ad, and was associated neither with ubiquitin nor tau protein. |
2000-07-19 |
2023-08-12 |
Not clear |
| L Chen, L Baum, H K Ng, L Y Chan, C P Pan. Apolipoprotein E genotype and its pathological correlation in Chinese Alzheimer's disease with late onset. Human pathology. vol 30. issue 10. 1999-11-02. PMID:10534164. |
hippocampus (including entorhinal cortex), amygdala, superior temporal lobe, middle frontal gyrus, and inferior parietal lobule of the brains of ad and poss were examined with beta amyloid (a beta) immunostaining, and the same regions plus medial occipital lobe were examined with tau immunostaining. |
1999-11-02 |
2023-08-12 |
human |
| P Vermersch, J P David, B Frigard, C Fallet-Bianco, A Wattez, H Petit, A Delacourt. Cortical mapping of Alzheimer pathology in brains of aged non-demented subjects. Progress in neuro-psychopharmacology & biological psychiatry. vol 19. issue 6. 1996-03-19. PMID:8584681. |
some cases and especially those with tau pathology in the temporal lobe contained numerous senile plaques (sp) in the neocortex. |
1996-03-19 |
2023-08-12 |
human |
| P Vermersch, J P David, B Frigard, C Fallet-Bianco, A Wattez, H Petit, A Delacourt. Cortical mapping of Alzheimer pathology in brains of aged non-demented subjects. Progress in neuro-psychopharmacology & biological psychiatry. vol 19. issue 6. 1996-03-19. PMID:8584681. |
the authors conclude that control cases with tau pathology in the temporal lobe and numerous sp in the neocortex were likely to be subclinical stages of ad whereas others with tau pathology exclusively detected in the ec and hippocampus and without or few sp in the neocortex were related to normal aging. |
1996-03-19 |
2023-08-12 |
human |
| J G Sheng, R E Mrak, W S Griffi. Microglial interleukin-1 alpha expression in brain regions in Alzheimer's disease: correlation with neuritic plaque distribution. Neuropathology and applied neurobiology. vol 21. issue 4. 1996-01-11. PMID:7494597. |
in alzheimer's disease, tau 2+ neuritic plaques occurred with increasing frequency in grey matter of frontal and occipital lobes, temporal lobe, and hippocampus. |
1996-01-11 |
2023-08-12 |
Not clear |
| K Oyanagi, F Ikut. [The aging of central nervous system in methylmercury intoxication in Niigata, Japan--quantitative investigation of neurofibrillary tangles and senile plaques]. No to shinkei = Brain and nerve. vol 45. issue 3. 1993-08-06. PMID:8323818. |
in order to elucidate the progression of aging process in the brains of methylmercury intoxication in humans, neurofibrillary tangles (nft) and senile plaques (sp) were examined quantitatively in the temporal lobe and calcarine cortex of 16 patients with methylmercury intoxication and 12 control subjects by using tau and beta-peptide immunostained preparations. |
1993-08-06 |
2023-08-12 |
human |
| K A Harris, G A Oyler, G M Doolittle, I Vincent, R A Lehman, R L Kincaid, M L Billingsle. Okadaic acid induces hyperphosphorylated forms of tau protein in human brain slices. Annals of neurology. vol 33. issue 1. 1993-06-16. PMID:8494335. |
tau phosphorylation in temporal lobe slices was determined using mobility shifts after sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunodetection with the monoclonal antibodies alz-50, 5e2, and tau-1. |
1993-06-16 |
2023-08-12 |
human |