| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Clifford R Jack, Heather J Wiste, Christopher G Schwarz, Val J Lowe, Matthew L Senjem, Prashanthi Vemuri, Stephen D Weigand, Terry M Therneau, Dave S Knopman, Jeffrey L Gunter, David T Jones, Jonathan Graff-Radford, Kejal Kantarci, Rosebud O Roberts, Michelle M Mielke, Mary M Machulda, Ronald C Peterse. Longitudinal tau PET in ageing and Alzheimer's disease. Brain : a journal of neurology. vol 141. issue 5. 2019-07-08. PMID:29538647. |
among all tau pet meta-regions of interest, sample size estimates were smallest for a temporal lobe composite within cognitively unimpaired abnormal amyloid and for the late alzheimer's disease meta-region of interest within cognitively impaired abnormal amyloid. |
2019-07-08 |
2023-08-13 |
Not clear |
| Tomoya Kon, Fumiaki Mori, Akira Arai, Yasuo Miki, Kunikazu Tanji, Hidekachi Kurotaki, Masahiko Tomiyama, Koichi Wakabayash. Atypical globular glial tauopathy with a combination of types I and II pathology. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 39. issue 2. 2019-05-07. PMID:30723950. |
by contrast, the tau pathology in the temporal lobe was chiefly globular oligodendroglial inclusions in the white matter, corresponding to ggt type i. |
2019-05-07 |
2023-08-13 |
Not clear |
| Wolfgang J Streit, Heiko Braak, Kelly Del Tredici, Judith Leyh, Julia Lier, Habibeh Khoshbouei, Christian Eisenlöffel, Wolf Müller, Ingo Bechman. Microglial activation occurs late during preclinical Alzheimer's disease. Glia. vol 66. issue 12. 2019-04-15. PMID:30417428. |
we evaluated the medial temporal lobe of 66 nondemented subjects, aged 42-93, in terms of tau pathology, aβ deposition, and microglial activation. |
2019-04-15 |
2023-08-13 |
human |
| Joshua Kriegel, Zachary Papadopoulos, Ann C McKe. Chronic Traumatic Encephalopathy: Is Latency in Symptom Onset Explained by Tau Propagation? Cold Spring Harbor perspectives in medicine. vol 8. issue 2. 2019-03-11. PMID:28096246. |
the pathology of cte is characterized by a progression from isolated focal perivascular hyperphosphorylated tau lesions in the cerebral cortex to a widespread tauopathy that involves diffuse cortical and medial temporal lobe regions. |
2019-03-11 |
2023-08-13 |
Not clear |
| Anne Maass, Samuel N Lockhart, Theresa M Harrison, Rachel K Bell, Taylor Mellinger, Kaitlin Swinnerton, Suzanne L Baker, Gil D Rabinovici, William J Jagus. Entorhinal Tau Pathology, Episodic Memory Decline, and Neurodegeneration in Aging. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 3. 2019-02-28. PMID:29192126. |
the medial temporal lobe (mtl) is an early site of tau accumulation and mtl dysfunction may underlie episodic-memory decline in aging and dementia. |
2019-02-28 |
2023-08-13 |
Not clear |
| Elias Granadillo, Pongsatorn Paholpak, Mario F Mendez, Edmond Ten. Visual Ratings of Medial Temporal Lobe Atrophy Correlate with CSF Tau Indices in Clinical Variants of Early-Onset Alzheimer Disease. Dementia and geriatric cognitive disorders. vol 44. issue 1-2. 2018-06-15. PMID:28675901. |
visual ratings of medial temporal lobe atrophy correlate with csf tau indices in clinical variants of early-onset alzheimer disease. |
2018-06-15 |
2023-08-13 |
Not clear |
| Elias Granadillo, Pongsatorn Paholpak, Mario F Mendez, Edmond Ten. Visual Ratings of Medial Temporal Lobe Atrophy Correlate with CSF Tau Indices in Clinical Variants of Early-Onset Alzheimer Disease. Dementia and geriatric cognitive disorders. vol 44. issue 1-2. 2018-06-15. PMID:28675901. |
prior studies of late-onset alzheimer disease (ad) have reported that cerebrospinal fluid (csf) tau levels correlate with hippocampal/medial temporal lobe atrophy. |
2018-06-15 |
2023-08-13 |
Not clear |
| Elias Granadillo, Pongsatorn Paholpak, Mario F Mendez, Edmond Ten. Visual Ratings of Medial Temporal Lobe Atrophy Correlate with CSF Tau Indices in Clinical Variants of Early-Onset Alzheimer Disease. Dementia and geriatric cognitive disorders. vol 44. issue 1-2. 2018-06-15. PMID:28675901. |
these findings suggest that csf tau indices in ad may reflect tau-related neurodegeneration in the medial temporal lobe. |
2018-06-15 |
2023-08-13 |
Not clear |
| Jennifer R Gatchel, Nancy J Donovan, Joseph J Locascio, Aaron P Schultz, J Alex Becker, Jasmeer Chhatwal, Kathryn V Papp, Rebecca E Amariglio, Dorene M Rentz, Deborah Blacker, Reisa A Sperling, Keith A Johnson, Gad A Marshal. Depressive Symptoms and Tau Accumulation in the Inferior Temporal Lobe and Entorhinal Cortex in Cognitively Normal Older Adults: A Pilot Study. Journal of Alzheimer's disease : JAD. vol 59. issue 3. 2018-04-10. PMID:28697559. |
depressive symptoms and tau accumulation in the inferior temporal lobe and entorhinal cortex in cognitively normal older adults: a pilot study. |
2018-04-10 |
2023-08-13 |
Not clear |
| David C Perry, Jesse A Brown, Katherine L Possin, Samir Datta, Andrew Trujillo, Anneliese Radke, Anna Karydas, John Kornak, Ana C Sias, Gil D Rabinovici, Maria Luisa Gorno-Tempini, Adam L Boxer, Mary De May, Katherine P Rankin, Virginia E Sturm, Suzee E Lee, Brandy R Matthews, Aimee W Kao, Keith A Vossel, Maria Carmela Tartaglia, Zachary A Miller, Sang Won Seo, Manu Sidhu, Stephanie E Gaus, Alissa L Nana, Jose Norberto S Vargas, Ji-Hye L Hwang, Rik Ossenkoppele, Alainna B Brown, Eric J Huang, Giovanni Coppola, Howard J Rosen, Daniel Geschwind, John Q Trojanowski, Lea T Grinberg, Joel H Kramer, Bruce L Miller, William W Seele. Clinicopathological correlations in behavioural variant frontotemporal dementia. Brain : a journal of neurology. vol 140. issue 12. 2017-12-13. PMID:29053860. |
patients with ftld were distributed between ftld-tau (34 patients: 10 corticobasal degeneration, nine progressive supranuclear palsy, eight pick's disease, three frontotemporal dementia with parkinsonism associated with chromosome 17, three unclassifiable tauopathy, and one argyrophilic grain disease); ftld-tdp (55 patients: nine type a including one with motor neuron disease, 27 type b including 21 with motor neuron disease, eight type c with right temporal lobe presentations, and 11 unclassifiable including eight with motor neuron disease), ftld-fus (eight patients), and one patient with ftld-ubiquitin proteasome system positive inclusions (ftld-ups) that stained negatively for tau, tdp-43, and fus. |
2017-12-13 |
2023-08-13 |
Not clear |
| Matthew R Brier, Brian Gordon, Karl Friedrichsen, John McCarthy, Ari Stern, Jon Christensen, Christopher Owen, Patricia Aldea, Yi Su, Jason Hassenstab, Nigel J Cairns, David M Holtzman, Anne M Fagan, John C Morris, Tammie L S Benzinger, Beau M Ance. Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease. Science translational medicine. vol 8. issue 338. 2017-12-07. PMID:27169802. |
cerebrospinal fluid measures of tau, often used to stage preclinical ad, correlated with tau deposition in the temporal lobe. |
2017-12-07 |
2023-08-13 |
Not clear |
| Matthew R Brier, Brian Gordon, Karl Friedrichsen, John McCarthy, Ari Stern, Jon Christensen, Christopher Owen, Patricia Aldea, Yi Su, Jason Hassenstab, Nigel J Cairns, David M Holtzman, Anne M Fagan, John C Morris, Tammie L S Benzinger, Beau M Ance. Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease. Science translational medicine. vol 8. issue 338. 2017-12-07. PMID:27169802. |
tau deposition in the temporal lobe more closely tracked dementia status and was a better predictor of cognitive performance than aβ deposition in any region of the brain. |
2017-12-07 |
2023-08-13 |
Not clear |
| Zhuang Song, Ian M McDonough, Peiying Liu, Hanzhang Lu, Denise C Par. Cortical amyloid burden and age moderate hippocampal activity in cognitively-normal adults. NeuroImage. Clinical. vol 12. 2017-11-17. PMID:27408792. |
tau tangles, however, do often aggregate in the medial temporal lobe in parallel with amyloid deposition in the neocortex in ad. |
2017-11-17 |
2023-08-13 |
human |
| Scott E Counts, Milos D Ikonomovic, Natosha Mercado, Irving E Vega, Elliott J Mufso. Biomarkers for the Early Detection and Progression of Alzheimer's Disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 14. issue 1. 2017-09-25. PMID:27738903. |
in this regard, positive amyloid or tau tracer retention on positron emission tomography imaging, low csf concentrations of the amyloid-β 1-42 peptide, high csf concentrations in total tau and phospho-tau, mesial temporal lobe atrophy on magnetic resonance imaging, and temporoparietal/precuneus hypometabolism or hypoperfusion on 18f-fluorodeoxyglucose positron emission tomography have all emerged as biomarkers for the progression to ad. |
2017-09-25 |
2023-08-13 |
human |
| David J Koss, Glynn Jones, Anna Cranston, Heidi Gardner, Nicholas M Kanaan, Bettina Plat. Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer's disease and track disease progression and cognitive decline. Acta neuropathologica. vol 132. issue 6. 2017-09-20. PMID:27770234. |
here, lateral temporal lobe samples (brodmann area 21) of 46 human cases were profiled via tau and aβ western blot and native state dot blot protocols. |
2017-09-20 |
2023-08-13 |
human |
| Emily J Mason, Erin P Hussey, Robert J Molitor, Philip C Ko, Manus J Donahue, Brandon A All. Family History of Alzheimer's Disease is Associated with Impaired Perceptual Discrimination of Novel Objects. Journal of Alzheimer's disease : JAD. vol 57. issue 3. 2017-08-25. PMID:28304286. |
tau pathology follows a stereotypical route through the medial temporal lobe beginning in the entorhinal and perirhinal cortices. |
2017-08-25 |
2023-08-13 |
human |
| Shawn M Marks, Samuel N Lockhart, Suzanne L Baker, William J Jagus. Tau and β-Amyloid Are Associated with Medial Temporal Lobe Structure, Function, and Memory Encoding in Normal Aging. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 12. 2017-08-18. PMID:28213439. |
tau and β-amyloid are associated with medial temporal lobe structure, function, and memory encoding in normal aging. |
2017-08-18 |
2023-08-13 |
Not clear |
| Shawn M Marks, Samuel N Lockhart, Suzanne L Baker, William J Jagus. Tau and β-Amyloid Are Associated with Medial Temporal Lobe Structure, Function, and Memory Encoding in Normal Aging. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 12. 2017-08-18. PMID:28213439. |
normal aging is associated with a decline in episodic memory and also with aggregation of the β-amyloid (aβ) and tau proteins and atrophy of medial temporal lobe (mtl) structures crucial to memory formation. |
2017-08-18 |
2023-08-13 |
Not clear |
| Jorge Sepulcre, Aaron P Schultz, Mert Sabuncu, Teresa Gomez-Isla, Jasmeer Chhatwal, Alex Becker, Reisa Sperling, Keith A Johnso. In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 28. 2017-07-18. PMID:27413148. |
moreover, tau and amyloid-β accumulations have strong network interdigitations in heteromodal and associative areas of the cortical mantle, particularly the inferior-lateral temporal lobe. |
2017-07-18 |
2023-08-13 |
human |
| Brian A Gordon, Karl Friedrichsen, Matthew Brier, Tyler Blazey, Yi Su, Jon Christensen, Patricia Aldea, Jonathan McConathy, David M Holtzman, Nigel J Cairns, John C Morris, Anne M Fagan, Beau M Ances, Tammie L S Benzinge. The relationship between cerebrospinal fluid markers of Alzheimer pathology and positron emission tomography tau imaging. Brain : a journal of neurology. vol 139. issue Pt 8. 2017-06-05. PMID:27286736. |
after controlling for levels of amyloid-β42, the correlations with tau uptake were r = 0.490 (p < 0.001) for t-tau and r = 0.492 (p < 0.001) for p-tau181 within the cognitively normal cohort, levels of amyloid-β42, but not t-tau or p-tau181, were associated with elevated tracer binding that was confined primarily to the medial temporal lobe and adjacent neocortical regions. |
2017-06-05 |
2023-08-13 |
Not clear |