| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruben Smith, Andreas Puschmann, Michael Schöll, Tomas Ohlsson, John van Swieten, Michael Honer, Elisabet Englund, Oskar Hansso. 18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology in MAPT mutation carriers. Brain : a journal of neurology. vol 139. issue Pt 9. 2017-06-05. PMID:27357347. |
this mutation results in 3- and 4-repeat tau aggregates similar to those in alzheimer's disease, and many of the mutation carriers initially suffer from memory impairment and temporal lobe atrophy. |
2017-06-05 |
2023-08-13 |
Not clear |
| Xin You Tai, Matthias Koepp, John S Duncan, Nick Fox, Pamela Thompson, Sallie Baxendale, Joan Y W Liu, Cheryl Reeves, Zuzanna Michalak, Maria Tho. Hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: a study of temporal lobe resections. Brain : a journal of neurology. vol 139. issue Pt 9. 2017-06-05. PMID:27497924. |
hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: a study of temporal lobe resections. |
2017-06-05 |
2023-08-13 |
Not clear |
| Michael J Pontecorvo, Michael D Devous, Michael Navitsky, Ming Lu, Stephen Salloway, Frederick W Schaerf, Danna Jennings, Anupa K Arora, Anne McGeehan, Nathaniel C Lim, Hui Xiong, Abhinay D Joshi, Andrew Siderowf, Mark A Mintu. Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition. Brain : a journal of neurology. vol 140. issue 3. 2017-05-29. PMID:28077397. |
these results suggest development of tau beyond the mesial temporal lobe is associated with, and may be dependent on, amyloid accumulation. |
2017-05-29 |
2023-08-13 |
human |
| Victor L Villemagne, Vincent Doré, Pierrick Bourgeat, Samantha C Burnham, Simon Laws, Olivier Salvado, Colin L Masters, Christopher C Row. Aβ-amyloid and Tau Imaging in Dementia. Seminars in nuclear medicine. vol 47. issue 1. 2017-05-08. PMID:27987560. |
the recent addition of selective tau imaging will allow to elucidate if these effects are directly associated with Αβ deposition or if they are mediated, in toto or in parte, by tau as it spreads out of the mesial temporal lobe into neocortical association areas. |
2017-05-08 |
2023-08-13 |
human |
| Gabor G Kovacs, Jasmin Rahimi, Thomas Ströbel, Mirjam I Lutz, Günther Regelsberger, Nathalie Streichenberger, Armand Perret-Liaudet, Romana Höftberger, Pawel P Liberski, Herbert Budka, Beata Sikorsk. Tau pathology in Creutzfeldt-Jakob disease revisited. Brain pathology (Zurich, Switzerland). vol 27. issue 3. 2017-04-24. PMID:27377321. |
fifty-two (69.3%) showed additional tau pathology in the medial temporal lobe compatible with primary age related tauopathy (part). |
2017-04-24 |
2023-08-13 |
human |
| Gabor G Kovacs, Isidro Ferrer, Lea T Grinberg, Irina Alafuzoff, Johannes Attems, Herbert Budka, Nigel J Cairns, John F Crary, Charles Duyckaerts, Bernardino Ghetti, Glenda M Halliday, James W Ironside, Seth Love, Ian R Mackenzie, David G Munoz, Melissa E Murray, Peter T Nelson, Hitoshi Takahashi, John Q Trojanowski, Olaf Ansorge, Thomas Arzberger, Atik Baborie, Thomas G Beach, Kevin F Bieniek, Eileen H Bigio, Istvan Bodi, Brittany N Dugger, Mel Feany, Ellen Gelpi, Stephen M Gentleman, Giorgio Giaccone, Kimmo J Hatanpaa, Richard Heale, Patrick R Hof, Monika Hofer, Tibor Hortobágyi, Kurt Jellinger, Gregory A Jicha, Paul Ince, Julia Kofler, Enikö Kövari, Jillian J Kril, David M Mann, Radoslav Matej, Ann C McKee, Catriona McLean, Ivan Milenkovic, Thomas J Montine, Shigeo Murayama, Edward B Lee, Jasmin Rahimi, Roberta D Rodriguez, Annemieke Rozemüller, Julie A Schneider, Christian Schultz, William Seeley, Danielle Seilhean, Colin Smith, Fabrizio Tagliavini, Masaki Takao, Dietmar Rudolf Thal, Jon B Toledo, Markus Tolnay, Juan C Troncoso, Harry V Vinters, Serge Weis, Stephen B Wharton, Charles L White, Thomas Wisniewski, John M Woulfe, Masahito Yamada, Dennis W Dickso. Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta neuropathologica. vol 131. issue 1. 2016-09-29. PMID:26659578. |
we recommend four steps for evaluation of artag: (1) identification of five types based on the location of either morphologies of tau astrogliopathy: subpial, subependymal, perivascular, white matter, gray matter; (2) documentation of the regional involvement: medial temporal lobe, lobar (frontal, parietal, occipital, lateral temporal), subcortical, brainstem; (3) documentation of the severity of tau astrogliopathy; and (4) description of subregional involvement. |
2016-09-29 |
2023-08-13 |
Not clear |
| Michael J Yetman, Stephanie W Fowler, Joanna L Jankowsk. Humanized Tau Mice with Regionalized Amyloid Exhibit Behavioral Deficits but No Pathological Interaction. PloS one. vol 11. issue 4. 2016-08-22. PMID:27070146. |
these findings suggest that robust amyloid pathology within the medial temporal lobe has little effect on the metabolism of wild type human tau in this model. |
2016-08-22 |
2023-08-13 |
mouse |
| Kenji Matsumura, Masahiro Ono, Ayane Kitada, Hiroyuki Watanabe, Masashi Yoshimura, Shimpei Iikuni, Hiroyuki Kimura, Yoko Okamoto, Masafumi Ihara, Hideo Saj. Structure-Activity Relationship Study of Heterocyclic Phenylethenyl and Pyridinylethenyl Derivatives as Tau-Imaging Agents That Selectively Detect Neurofibrillary Tangles in Alzheimer's Disease Brains. Journal of medicinal chemistry. vol 58. issue 18. 2015-12-29. PMID:26327138. |
particularly, a phenylethenyl benzimidazole derivative ([(125)i]64) showed marked radioactivity accumulation in the temporal lobe which corresponded with the distribution of tau deposits. |
2015-12-29 |
2023-08-13 |
mouse |
| Meifeng Yang, Junye Miao, Joshua Rizak, Rongwei Zhai, Zhengbo Wang, Tanzeel Huma, Ting Li, Na Zheng, Shihao Wu, Yingwei Zheng, Xiaona Fan, Jianzhen Yang, Jianhong Wang, Shangchuan Yang, Yuanye Ma, Longbao Lü, Rongqiao He, Xintian H. Alzheimer's disease and methanol toxicity (part 2): lessons from four rhesus macaques (Macaca mulatta) chronically fed methanol. Journal of Alzheimer's disease : JAD. vol 41. issue 4. 2015-03-30. PMID:24787917. |
this change coincided with increases in tau protein phosphorylation at residues t181 and s396 in cerebrospinal fluid during feeding as well as with increases in tau phosphorylated aggregates and amyloid plaques in four brain regions postmortem: the frontal lobe, parietal lobe, temporal lobe, and the hippocampus. |
2015-03-30 |
2023-08-13 |
mouse |
| Thor D Stein, Victor E Alvarez, Ann C McKe. Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel. Alzheimer's research & therapy. vol 6. issue 1. 2014-06-24. PMID:24423082. |
the hyperphosphorylated tau abnormalities begin focally, as perivascular neurofibrillary tangles and neurites at the depths of the cerebral sulci, and then spread to involve superficial layers of adjacent cortex before becoming a widespread degeneration affecting medial temporal lobe structures, diencephalon and brainstem. |
2014-06-24 |
2023-08-12 |
Not clear |
| Thor D Stein, Victor E Alvarez, Ann C McKe. Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel. Alzheimer's research & therapy. vol 6. issue 1. 2014-06-24. PMID:24423082. |
as cte is characterized pathologically by frontal and temporal lobe atrophy, by abnormal deposits of phosphorylated tau and by 43 kda tar dna binding protein and is associated clinically with behavioral and personality changes, as well as cognitive impairments, cte is increasingly categorized as an acquired frontotemporal lobar degeneration. |
2014-06-24 |
2023-08-12 |
Not clear |
| Vanessa A Guzman, Owen T Carmichael, Christopher Schwarz, Giuseppe Tosto, Molly E Zimmerman, Adam M Brickma. White matter hyperintensities and amyloid are independently associated with entorhinal cortex volume among individuals with mild cognitive impairment. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 9. issue 5 Suppl. 2014-05-28. PMID:23375566. |
current hypothetical models of alzheimer's disease (ad) pathogenesis emphasize the role of β-amyloid (aβ), tau deposition, and neurodegenerative changes in the mesial temporal lobe, particularly the entorhinal cortex and hippocampus. |
2014-05-28 |
2023-08-12 |
Not clear |
| P Martinez-Marti. Is AD a homogeneous nosologic entity? Yes. Journal of neural transmission (Vienna, Austria : 1996). vol 120. issue 10. 2014-04-23. PMID:23828739. |
therefore, a disorder primarily affecting structures in medial temporal lobe, with accumulation of amyloid β and abnormal tau, neuritic plaques and tangles, progressive loss of memory and/or other cognitive deficits, ultimately resulting in dementia should be classified as ad. |
2014-04-23 |
2023-08-12 |
Not clear |
| Geoffrey A Kerchner, Jeffrey D Bernstein, Michelle C Fenesy, Gayle K Deutsch, Manojkumar Saranathan, Michael M Zeineh, Brian K Rut. Shared vulnerability of two synaptically-connected medial temporal lobe areas to age and cognitive decline: a seven tesla magnetic resonance imaging study. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 42. 2013-12-10. PMID:24133269. |
the medial temporal lobe (mtl) is the first brain area to succumb to neurofibrillary tau pathology in alzheimer's disease (ad). |
2013-12-10 |
2023-08-12 |
human |
| Ann C McKee, Robert A Stern, Christopher J Nowinski, Thor D Stein, Victor E Alvarez, Daniel H Daneshvar, Hyo-Soon Lee, Sydney M Wojtowicz, Garth Hall, Christine M Baugh, David O Riley, Caroline A Kubilus, Kerry A Cormier, Matthew A Jacobs, Brett R Martin, Carmela R Abraham, Tsuneya Ikezu, Robert Ross Reichard, Benjamin L Wolozin, Andrew E Budson, Lee E Goldstein, Neil W Kowall, Robert C Cant. The spectrum of disease in chronic traumatic encephalopathy. Brain : a journal of neurology. vol 136. issue Pt 1. 2013-04-23. PMID:23208308. |
in chronic traumatic encephalopathy, the spectrum of hyperphosphorylated tau pathology ranged in severity from focal perivascular epicentres of neurofibrillary tangles in the frontal neocortex to severe tauopathy affecting widespread brain regions, including the medial temporal lobe, thereby allowing a progressive staging of pathology from stages i-iv. |
2013-04-23 |
2023-08-12 |
human |
| Ismael Santa-Maria, Aya Haggiagi, Xinmin Liu, Jessica Wasserscheid, Peter T Nelson, Ken Dewar, Lorraine N Clark, John F Crar. The MAPT H1 haplotype is associated with tangle-predominant dementia. Acta neuropathologica. vol 124. issue 5. 2013-03-25. PMID:22802095. |
tangle-predominant dementia (tpd) patients exhibit cognitive decline that is clinically similar to early to moderate-stage alzheimer disease (ad), yet autopsy reveals neurofibrillary tangles in the medial temporal lobe composed of the microtubule-associated protein tau without significant amyloid-beta (aβ)-positive plaques. |
2013-03-25 |
2023-08-12 |
human |
| G Lace, P G Ince, C Brayne, G M Savva, F E Matthews, R de Silva, J E Simpson, S B Wharto. Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort. Dementia and geriatric cognitive disorders. vol 34. issue 1. 2013-02-07. PMID:22868294. |
we determined its frequency in ageing mesial temporal lobe and its relationship to other tau pathologies in the mrc-cfas population-representative neuropathology cohort. |
2013-02-07 |
2023-08-12 |
Not clear |
| Frank Jessen, Piotr Lewczuk, Okan Gür, Wolfgang Block, Gabriele Ende, Lutz Frölich, Thilo Hammen, Sönke Arlt, Johannes Kornhuber, Thomas Kucinski, Julius Popp, Oliver Peters, Wolfgang Maier, Frank Träber, Jens Wiltfan. Association of N-acetylaspartate and cerebrospinal fluid Aβ42 in dementia. Journal of Alzheimer's disease : JAD. vol 27. issue 2. 2012-08-16. PMID:21841259. |
we tested the association of the putative marker of mitochondrial function n-acetylaspartate (naa) as measured by proton magnetic resonance spectroscopy within the medial temporal lobe and cerebrospinal fluid amyoid-β42 (aβ42), total tau and ptau181. |
2012-08-16 |
2023-08-12 |
Not clear |
| Claire Boutoleau-Bretonnière, Thibaud Lebouvier, Odile Delaroche, Estelle Lamy, Christelle Evrard, Tiphaine Charriau, Cédric Bretonnière, Philippe Damier, Pascal Derkinderen, Martine Vercellett. Value of neuropsychological testing, imaging, and CSF biomarkers for the differential diagnosis and prognosis of clinically ambiguous dementia. Journal of Alzheimer's disease : JAD. vol 28. issue 2. 2012-05-24. PMID:22008265. |
medial temporal lobe atrophy score on mri, distinctive patterns on 99 mtc-hmpao-spect, and csf levels of amyloid-β peptide, total tau protein, and p-tau181p were used together with neuropsychological testing to assess se (sensitivity) and sp (specificity) of separate and combined markers. |
2012-05-24 |
2023-08-12 |
Not clear |
| Colin J Mahoney, Jon Beck, Jonathan D Rohrer, Tammaryn Lashley, Kin Mok, Tim Shakespeare, Tom Yeatman, Elizabeth K Warrington, Jonathan M Schott, Nick C Fox, Martin N Rossor, John Hardy, John Collinge, Tamas Revesz, Simon Mead, Jason D Warre. Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: clinical, neuroanatomical and neuropathological features. Brain : a journal of neurology. vol 135. issue Pt 3. 2012-04-09. PMID:22366791. |
the neuroimaging profile of the c9orf72 expansion was significantly more symmetrical than progranulin mutations with significantly less temporal lobe involvement than microtubule-associated protein tau mutations. |
2012-04-09 |
2023-08-12 |
Not clear |