| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Niklas Mattsson-Carlgren, Shorena Janelidze, Randall J Bateman, Ruben Smith, Erik Stomrud, Geidy E Serrano, Eric M Reiman, Sebastian Palmqvist, Jeffrey L Dage, Thomas G Beach, Oskar Hansso. Soluble P-tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau. EMBO molecular medicine. vol 13. issue 6. 2021-10-25. PMID:33949133. |
finally, p-tau217 mediated the association between β-amyloid and tau in both cohorts, especially for tau outside of the medial temporal lobe. |
2021-10-25 |
2023-08-13 |
Not clear |
| Keenan A Walker, Sahil Chawla, Carlos Nogueras-Ortiz, Josef Coresh, A Richey Sharrett, Dean F Wong, Clifford R Jack, Anthony J Spychalla, Rebecca F Gottesman, Dimitrios Kapogianni. Neuronal insulin signaling and brain structure in nondemented older adults: the Atherosclerosis Risk in Communities Study. Neurobiology of aging. vol 97. 2021-09-01. PMID:33160263. |
secondary analyses found the levels of downstream protein kinases involved in cell survival (p70s6k) and tau phosphorylation/neuroinflammation (gsk-3β) to be most strongly associated with wmh and temporal lobe volume, respectively. |
2021-09-01 |
2023-08-13 |
human |
| Farshid Sepehrband, Giuseppe Barisano, Nasim Sheikh-Bahaei, Jeiran Choupan, Ryan P Cabeen, Kirsten M Lynch, Malcolm S Crawford, Haoyu Lan, Wendy J Mack, Helena C Chui, John M Ringman, Arthur W Tog. Volumetric distribution of perivascular space in relation to mild cognitive impairment. Neurobiology of aging. vol 99. 2021-09-01. PMID:33422892. |
surprisingly, we noted lower pvs presence in the anterosuperior medial temporal lobe (asmtl) (1.29 times lower pvs volume fraction in cognitively impaired individuals, p < 0.0001), which was associated with entorhinal neurofibrillary tau tangle deposition (beta (standard error) = -0.98 (0.4); p = 0.014), one of the hallmarks of early alzheimer's disease pathology. |
2021-09-01 |
2023-08-13 |
human |
| Nathalie Bodd Halaas, Kristi Henjum, Kaj Blennow, Shams Dakhil, Ane-Victoria Idland, Lars Ng Nilsson, Donatas Sederevicius, Didac Vidal-Piñeiro, Kristine B Walhovd, Torgeir Brunn Wyller, Henrik Zetterberg, Leiv Otto Watne, Anders M Fjel. CSF sTREM2 and Tau Work Together in Predicting Increased Temporal Lobe Atrophy in Older Adults. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 4. 2021-08-18. PMID:31812991. |
csf strem2 and tau work together in predicting increased temporal lobe atrophy in older adults. |
2021-08-18 |
2023-08-13 |
human |
| Amelia Strom, Leonardo Iaccarino, Lauren Edwards, Orit H Lesman-Segev, David N Soleimani-Meigooni, Julie Pham, Suzanne L Baker, Susan Landau, William J Jagust, Bruce L Miller, Howard J Rosen, Maria Luisa Gorno-Tempini, Gil D Rabinovici, Renaud La Joi. Cortical hypometabolism reflects local atrophy and tau pathology in symptomatic Alzheimer's disease. Brain : a journal of neurology. 2021-08-10. PMID:34373896. |
we assessed cross-sectionally the relative contributions of three potential mechanisms causing hypometabolism in the retrosplenial and inferior parietal cortices: local molecular (amyloid and tau) pathology and atrophy, distant factors including contributions from the degenerating medial temporal lobe or molecular pathology in functionally connected regions, and the presence of the apolipoprotein e (apoe) ε4 allele. |
2021-08-10 |
2023-08-13 |
human |
| Justin S Sanchez, J Alex Becker, Heidi I L Jacobs, Bernard J Hanseeuw, Shu Jiang, Aaron P Schultz, Michael J Properzi, Samantha R Katz, Alexa Beiser, Claudia L Satizabal, Adrienne O'Donnell, Charles DeCarli, Ron Killiany, Georges El Fakhri, Marc D Normandin, Teresa Gómez-Isla, Yakeel T Quiroz, Dorene M Rentz, Reisa A Sperling, Sudha Seshadri, Jean Augustinack, Julie C Price, Keith A Johnso. The cortical origin and initial spread of medial temporal tauopathy in Alzheimer's disease assessed with positron emission tomography. Science translational medicine. vol 13. issue 577. 2021-07-12. PMID:33472953. |
initial tau deposition occurs many years before aβ in a specific area of the medial temporal lobe. |
2021-07-12 |
2023-08-13 |
human |
| Justin S Sanchez, J Alex Becker, Heidi I L Jacobs, Bernard J Hanseeuw, Shu Jiang, Aaron P Schultz, Michael J Properzi, Samantha R Katz, Alexa Beiser, Claudia L Satizabal, Adrienne O'Donnell, Charles DeCarli, Ron Killiany, Georges El Fakhri, Marc D Normandin, Teresa Gómez-Isla, Yakeel T Quiroz, Dorene M Rentz, Reisa A Sperling, Sudha Seshadri, Jean Augustinack, Julie C Price, Keith A Johnso. The cortical origin and initial spread of medial temporal tauopathy in Alzheimer's disease assessed with positron emission tomography. Science translational medicine. vol 13. issue 577. 2021-07-12. PMID:33472953. |
building on recent work that enabled focus of molecular pet measurements on specific tau-vulnerable convolutional temporal lobe anatomy, we applied an automated anatomic sampling method to quantify tau pet signal in 443 adult participants from several observational studies of aging and ad, spanning a wide range of ages, aβ burdens, and degrees of clinical impairment. |
2021-07-12 |
2023-08-13 |
human |
| Vincent Doré, Natasha Krishnadas, Pierrick Bourgeat, Kun Huang, Shenpeng Li, Samantha Burnham, Colin L Masters, Jurgen Fripp, Victor L Villemagne, Christopher C Row. Relationship between amyloid and tau levels and its impact on tau spreading. European journal of nuclear medicine and molecular imaging. vol 48. issue 7. 2021-06-25. PMID:33495928. |
previous studies have shown that aβ-amyloid (aβ) likely promotes tau to spread beyond the medial temporal lobe. |
2021-06-25 |
2023-08-13 |
Not clear |
| Sheina Emrani, Hirra A Arain, Cassandra DeMarshall, Tal Nurie. APOE4 is associated with cognitive and pathological heterogeneity in patients with Alzheimer's disease: a systematic review. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:33148345. |
specifically, apoe4+ ad patients appear to possess more tau accumulation and brain atrophy in the medial temporal lobe, resulting in greater memory impairment, compared to apoe4- ad patients. |
2021-06-24 |
2023-08-13 |
Not clear |
| Nicole D Anderson, Elsa Beana, Haopei Yang, Stefan Köhle. Deficits in recent but not lifetime familiarity in amnestic mild cognitive impairment. Neuropsychologia. vol 151. 2021-06-24. PMID:33359882. |
accumulation of neurofibrillary tau in preclinical alzheimer's disease begins in perirhinal cortex, a medial temporal lobe region linked to familiarity. |
2021-06-24 |
2023-08-13 |
Not clear |
| Robin de Flores, Laura E M Wisse, Sandhitsu R Das, Long Xie, Corey T McMillan, John Q Trojanowski, John L Robinson, Murray Grossman, Edward Lee, David J Irwin, Paul A Yushkevich, David A Wol. Contribution of mixed pathology to medial temporal lobe atrophy in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 6. 2021-06-03. PMID:32323446. |
it is unclear how different proteinopathies (tau, transactive response dna-binding protein 43 [tdp-43], amyloid β [aβ], and α-synuclein) contribute to atrophy within medial temporal lobe (mtl) subregions in alzheimer's disease (ad). |
2021-06-03 |
2023-08-13 |
Not clear |
| Philip S Insel, Elizabeth C Mormino, Paul S Aisen, Wesley K Thompson, Michael C Donohu. Neuroanatomical spread of amyloid β and tau in Alzheimer's disease: implications for primary prevention. Brain communications. vol 2. issue 1. 2021-04-28. PMID:32140682. |
early elevation in tau pet uptake was found in the inferior temporal lobe, amygdala, banks of the superior temporal sulcus, entorhinal cortex, middle temporal lobe, inferior parietal lobe and the fusiform gyrus. |
2021-04-28 |
2023-08-13 |
human |
| Petrice M Cogswell, Heather J Wiste, Matthew L Senjem, Jeffrey L Gunter, Stephen D Weigand, Christopher G Schwarz, Arvin Arani, Terry M Therneau, Val J Lowe, David S Knopman, Hugo Botha, Jonathan Graff-Radford, David T Jones, Kejal Kantarci, Prashanthi Vemuri, Bradley F Boeve, Michelle M Mielke, Ronald C Petersen, Clifford R Jac. Associations of quantitative susceptibility mapping with Alzheimer's disease clinical and imaging markers. NeuroImage. vol 224. 2021-03-08. PMID:33035667. |
higher susceptibility was significantly associated with higher amyloid pet suvr in the pallidum and putamen (betas: 0.0029 and 0.0012 ppm for a 20% increase in amyloid pet, p = 0.05 and 0.02, respectively), higher tau pet in the basal ganglia with the largest effect size in the pallidum (0.0082 ppm for a 20% increase in tau pet, p<0.001), and with lower cortical gray matter volume in the medial temporal lobe (0.0006 ppm for a 20% decrease in volume, p = 0.03). |
2021-03-08 |
2023-08-13 |
human |
| Clifford R Jack, Heather J Wiste, Stephen D Weigand, Terry M Therneau, Val J Lowe, David S Knopman, Hugo Botha, Jonathan Graff-Radford, David T Jones, Tanis J Ferman, Bradley F Boeve, Kejal Kantarci, Prashanthi Vemuri, Michelle M Mielke, Jennifer Whitwell, Keith Josephs, Christopher G Schwarz, Matthew L Senjem, Jeffrey L Gunter, Ronald C Peterse. Predicting future rates of tau accumulation on PET. Brain : a journal of neurology. vol 143. issue 10. 2021-02-16. PMID:33094327. |
a temporal lobe tau pet meta-region of interest was used. |
2021-02-16 |
2023-08-13 |
human |
| Irene Sintini, Jonathan Graff-Radford, Matthew L Senjem, Christopher G Schwarz, Mary M Machulda, Peter R Martin, David T Jones, Bradley F Boeve, David S Knopman, Kejal Kantarci, Ronald C Petersen, Clifford R Jack, Val J Lowe, Keith A Josephs, Jennifer L Whitwel. Longitudinal neuroimaging biomarkers differ across Alzheimer's disease phenotypes. Brain : a journal of neurology. vol 143. issue 7. 2020-12-30. PMID:32572464. |
the topography of longitudinal tau accumulation and atrophy differed across phenotypes, with key regions of tau accumulation in the frontal and temporal lobes for all phenotypes and key regions of atrophy in the occipitotemporal regions for posterior cortical atrophy, left temporal lobe for logopenic progressive aphasia and medial and lateral temporal lobe for typical alzheimer's disease. |
2020-12-30 |
2023-08-13 |
human |
| Daniel Tward, Timothy Brown, Yusuke Kageyama, Jaymin Patel, Zhipeng Hou, Susumu Mori, Marilyn Albert, Juan Troncoso, Michael Mille. Diffeomorphic Registration With Intensity Transformation and Missing Data: Application to 3D Digital Pathology of Alzheimer's Disease. Frontiers in neuroscience. vol 14. 2020-11-19. PMID:32116503. |
by using a standard convolutional neural network to detect tau tangles in histology slices, this registration method enabled us to quantify the 3d density distribution of tauopathy throughout the medial temporal lobe of an alzheimer's disease postmortem specimen. |
2020-11-19 |
2023-08-13 |
Not clear |
| Julia Neitzel, Rachel Nuttall, Christian Sor. Perspectives on How Human Simultaneous Multi-Modal Imaging Adds Directionality to Spread Models of Alzheimer's Disease. Frontiers in neurology. vol 9. 2020-10-01. PMID:29434570. |
specifically, tau pathology has been suggested to propagate in an infection-like mode along axons, from transentorhinal cortices to medial temporal lobe cortices and consequently to other cortical regions, while amyloid-beta (aβ) pathology seems to spread in an activity-dependent manner among and from isocortical regions into limbic and then subcortical regions. |
2020-10-01 |
2023-08-13 |
human |
| Bhaskar C Das, Somsankar Dasgupta, Swapan K Ra. Potential therapeutic roles of retinoids for prevention of neuroinflammation and neurodegeneration in Alzheimer's disease. Neural regeneration research. vol 14. issue 11. 2020-09-30. PMID:31290437. |
impaired retinoic acid signaling results in neuroinflammation, oxidative stress, mitochondrial malfunction, and neurodegeneration leading to progressive alzheimer's disease, which is pathologically characterized by extra-neuronal accumulation of amyloid plaques (aggregated amyloid-beta) and intra-neurofibrillary tangles (hyperphosphorylated tau protein) in the temporal lobe of the brain. |
2020-09-30 |
2023-08-13 |
mouse |
| Shuko Taked. Tau Propagation as a Diagnostic and Therapeutic Target for Dementia: Potentials and Unanswered Questions. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31920473. |
a unique clinical course of alzheimer's disease (ad), beginning with memory deficit as the earliest symptom, is well-correlated with a progressive pattern of intracellular aggregates of tau (neurofibrillary tangles), which spread from the medial temporal lobe to other brain areas in a stereotypical manner. |
2020-09-30 |
2023-08-13 |
Not clear |
| Alexandra J Weigand, Katherine J Bangen, Kelsey R Thomas, Lisa Delano-Wood, Paul E Gilbert, Adam M Brickman, Mark W Bond. Is tau in the absence of amyloid on the Alzheimer's continuum?: A study of discordant PET positivity. Brain communications. vol 2. issue 1. 2020-09-28. PMID:32051933. |
however, medial temporal lobe tau pathology in the absence of amyloid beta is frequently observed at autopsy in cognitively normal individuals, a phenomenon that may reflect a consequence of aging and has been labelled 'primary age-related tauopathy'. |
2020-09-28 |
2023-08-13 |
Not clear |