| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Rennie, Urban Ekman, John Wallert, J-Sebastian Muehlboeck, Maria Eriksdotter, Lars-Olof Wahlund, Daniel Ferreira, Eric Westma. Comparing three neuropsychological subgrouping approaches in subjective and mild cognitive impairment from a naturalistic multicenter study. Neurobiology of aging. vol 129. 2023-06-03. PMID:37269645. |
biomarkers included cerebrospinal fluid measures of beta-amyloid-42 and phosphorylated tau, as well as visual ratings of medial temporal lobe atrophy and white matter hyperintensities on magnetic resonance imaging. |
2023-06-03 |
2023-08-14 |
Not clear |
| Jaime Fernández Arias, Joseph Therriault, Emilie Thomas, Firoza Z Lussier, Gleb Bezgin, Cécile Tissot, Stijn Servaes, Sulantha S Mathotaarachchi, Dorothée Schoemaker, Jenna Stevenson, Nesrine Rahmouni, Min Su Kang, Vanessa Pallen, Nina Margherita Poltronetti, Yi-Ting Wang, Peter Kunach, Mira Chamoun, Kely M Quispialaya S, Paolo Vitali, Gassan Massarweh, Serge Gauthier, Maria N Rajah, Tharick Pascoal, Pedro Rosa-Net. Verbal memory formation across PET-based Braak stages of tau accumulation in Alzheimer's disease. Brain communications. vol 5. issue 3. 2023-05-30. PMID:37252014. |
a classical early sign of typical alzheimer's disease is memory decline, which has been linked to the aggregation of tau in the medial temporal lobe. |
2023-05-30 |
2023-08-14 |
Not clear |
| Antoinette O'Connor, David M Cash, Teresa Poole, Pawel J Markiewicz, Maggie R Fraser, Ian B Malone, Jieqing Jiao, Philip S J Weston, Shaney Flores, Russ Hornbeck, Eric McDade, Michael Schöll, Brian A Gordon, Randall J Bateman, Tammie L S Benzinger, Nick C Fo. Tau accumulation in autosomal dominant Alzheimer's disease: a longitudinal [ Alzheimer's research & therapy. vol 15. issue 1. 2023-05-25. PMID:37231491. |
in cases where early uptake was seen, there was often a predilection for posterior regions (the precuneus and post-cingulate) as opposed to the medial temporal lobe, highlighting the importance of examining in vivo tau uptake beyond the confines of traditional braak staging. |
2023-05-25 |
2023-08-14 |
human |
| Anika Wuestefeld, Alexa Pichet Binette, David Berron, Nicola Spotorno, Danielle van Westen, Erik Stomrud, Niklas Mattsson-Carlgren, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Trevor Glenn, Svenja Moes, Michael Honer, Konstantinos Arfanakis, Lisa L Barnes, David A Bennett, Julie A Schneider, Laura E M Wisse, Oskar Hansso. Age-related and amyloid-beta-independent tau deposition and its downstream effects. Brain : a journal of neurology. 2023-04-21. PMID:37082959. |
amyloid-beta is hypothesized to facilitate the spread of tau pathology beyond the medial temporal lobe. |
2023-04-21 |
2023-08-14 |
Not clear |
| Anika Wuestefeld, Alexa Pichet Binette, David Berron, Nicola Spotorno, Danielle van Westen, Erik Stomrud, Niklas Mattsson-Carlgren, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Trevor Glenn, Svenja Moes, Michael Honer, Konstantinos Arfanakis, Lisa L Barnes, David A Bennett, Julie A Schneider, Laura E M Wisse, Oskar Hansso. Age-related and amyloid-beta-independent tau deposition and its downstream effects. Brain : a journal of neurology. 2023-04-21. PMID:37082959. |
however, there is evidence that, independently of amyloid-beta, age-related tau pathology might be present outside of the medial temporal lobe. |
2023-04-21 |
2023-08-14 |
Not clear |
| Anika Wuestefeld, Alexa Pichet Binette, David Berron, Nicola Spotorno, Danielle van Westen, Erik Stomrud, Niklas Mattsson-Carlgren, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Trevor Glenn, Svenja Moes, Michael Honer, Konstantinos Arfanakis, Lisa L Barnes, David A Bennett, Julie A Schneider, Laura E M Wisse, Oskar Hansso. Age-related and amyloid-beta-independent tau deposition and its downstream effects. Brain : a journal of neurology. 2023-04-21. PMID:37082959. |
we therefore aimed to study age-related amyloid-beta-independent tau deposition outside the medial temporal lobe in two large cohorts and to investigate potential downstream effects of this on cognition and structural measures. |
2023-04-21 |
2023-08-14 |
Not clear |
| Anika Wuestefeld, Alexa Pichet Binette, David Berron, Nicola Spotorno, Danielle van Westen, Erik Stomrud, Niklas Mattsson-Carlgren, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Trevor Glenn, Svenja Moes, Michael Honer, Konstantinos Arfanakis, Lisa L Barnes, David A Bennett, Julie A Schneider, Laura E M Wisse, Oskar Hansso. Age-related and amyloid-beta-independent tau deposition and its downstream effects. Brain : a journal of neurology. 2023-04-21. PMID:37082959. |
in vivo age-related tau deposition was observed in the medial temporal lobe and in frontal and parietal cortical regions, which was statistically significant when adjusting for amyloid-beta. |
2023-04-21 |
2023-08-14 |
Not clear |
| Anika Wuestefeld, Alexa Pichet Binette, David Berron, Nicola Spotorno, Danielle van Westen, Erik Stomrud, Niklas Mattsson-Carlgren, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Trevor Glenn, Svenja Moes, Michael Honer, Konstantinos Arfanakis, Lisa L Barnes, David A Bennett, Julie A Schneider, Laura E M Wisse, Oskar Hansso. Age-related and amyloid-beta-independent tau deposition and its downstream effects. Brain : a journal of neurology. 2023-04-21. PMID:37082959. |
results were validated in the ex vivo cohort showing age-related and amyloid-beta-independent increases in tau aggregates in and outside the medial temporal lobe. |
2023-04-21 |
2023-08-14 |
Not clear |
| Anika Wuestefeld, Alexa Pichet Binette, David Berron, Nicola Spotorno, Danielle van Westen, Erik Stomrud, Niklas Mattsson-Carlgren, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Trevor Glenn, Svenja Moes, Michael Honer, Konstantinos Arfanakis, Lisa L Barnes, David A Bennett, Julie A Schneider, Laura E M Wisse, Oskar Hansso. Age-related and amyloid-beta-independent tau deposition and its downstream effects. Brain : a journal of neurology. 2023-04-21. PMID:37082959. |
these results have implications for our understanding of the spreading of tau outside the medial temporal lobe, also in the context of alzheimer's disease. |
2023-04-21 |
2023-08-14 |
Not clear |
| Laura J Mahady, Sylvia E Perez, Michael Malek-Ahmadi, Elliott J Mufso. Oligomeric, phosphorylated, and truncated tau and spliceosome pathology within the entorhinal-hippocampal connectome across stages of Alzheimer's disease. The Journal of comparative neurology. 2023-03-29. PMID:36989381. |
neurofibrillary tangles (nfts) contain abnormally phosphorylated tau proteins, which spread within components of the medial temporal lobe (mtl) memory circuit in alzheimer's disease (ad). |
2023-03-29 |
2023-08-14 |
human |
| Kaitlin M Stouffer, Claire Chen, Sue Kulason, Eileen Xu, Menno P Witter, Can Ceritoglu, Marilyn S Albert, Susumu Mori, Juan Troncoso, Daniel J Tward, Michael I Mille. Early amygdala and ERC atrophy linked to 3D reconstruction of rostral neurofibrillary tau tangle pathology in Alzheimer's disease. NeuroImage. Clinical. vol 38. 2023-03-19. PMID:36934675. |
previous research has emphasized the unique impact of alzheimer's disease (ad) pathology on the medial temporal lobe (mtl), a reflection that tau pathology is particularly striking in the entorhinal and transentorhinal cortex (erc, tec) early in the course of disease. |
2023-03-19 |
2023-08-14 |
Not clear |
| Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal Synaptic Alterations Associated with Tau Pathology in Primary Age-Related Tauopathy. medRxiv : the preprint server for health sciences. 2023-03-03. PMID:36865237. |
primary age-related tauopathy (part) is characterized by the aggregation of tau in the mesial temporal lobe in older individuals. |
2023-03-03 |
2023-08-14 |
Not clear |
| Yue Cai, Jing Du, Anqi Li, Yalin Zhu, Linsen Xu, Kun Sun, Shaohua Ma, Tengfei Gu. Initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in Alzheimer's disease. Alzheimer's research & therapy. vol 15. issue 1. 2023-02-08. PMID:36750884. |
to better assist with the design of future clinical trials for alzheimer's disease (ad) and aid in our understanding of the disease's symptomatology, it is essential to clarify what roles β-amyloid (aβ) plaques and tau tangles play in longitudinal tau accumulation inside and outside the medial temporal lobe (mtl) as well as how age, sex, apolipoprotein e (apoe) ε4 (apoe-ε4), and klotho-vs heterozygosity (kl-vs |
2023-02-08 |
2023-08-14 |
Not clear |
| Raffaella Franciotti, Davide Nardini, Mirella Russo, Marco Onofrj, Stefano L Sens. Comparison of Machine Learning-based approaches to predict the conversion to Alzheimer's disease from Mild Cognitive Impairment. Neuroscience. 2023-02-03. PMID:36736612. |
finally, the feature selection procedure indicated that the most critical variables in the respective classes were the adas-cog-13 scale, the medial temporal lobe and hippocampus atrophy, and the ratio between phosphorylated tau and aβ42 proteins. |
2023-02-03 |
2023-08-14 |
human |
| Chloé Savignac, Sylvia Villeneuve, AmanPreet Badhwar, Karin Saltoun, Kimia Shafighi, Chris Zajner, Vaibhav Sharma, Sarah A Gagliano Taliun, Sali Farhan, Judes Poirier, Danilo Bzdo. APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer's disease and related dementia. PLoS biology. vol 20. issue 12. 2022-12-13. PMID:36512526. |
alzheimer's disease is marked by intracellular tau aggregates in the medial temporal lobe (mtl) and extracellular amyloid aggregates in the default network (dn). |
2022-12-13 |
2023-08-14 |
human |
| Kaitlin M Stouffer, Zhenzhen Wang, Eileen Xu, Karl Lee, Paige Lee, Michael I Miller, Daniel J Twar. From Picoscale Pathology to Decascale Disease: Image Registration with a Scattering Transform and Varifolds for Manipulating Multiscale Data. Multimodal learning for clinical decision support : 11th International Workshop, ML-CDS 2021, held in conjunction with MICCAI 2021, Strasbourg, France, October 1, 2021, Proceedings. ML-CDS (Workshop) (11th : 2021 : Online). vol 13050. 2022-10-25. PMID:36283001. |
we use our methods to quantify microscopic tau pathology across macroscopic 3d regions of the medial temporal lobe to address a major challenge in the diagnosis of alzheimer's disease-the reliance on invasive methods to detect microscopic pathology. |
2022-10-25 |
2023-08-14 |
Not clear |
| Shelley L Forrest, Stephanie Wagner, Ain Kim, Gabor G Kovac. Association of glial tau pathology and LATE-NC in the ageing brain. Neurobiology of aging. vol 119. 2022-08-17. PMID:35977443. |
results from this study suggest overlapping pathogenic mechanisms between late-nc and glial tau pathologies in the medial temporal lobe. |
2022-08-17 |
2023-08-14 |
Not clear |
| Timo Jan Oberstein, Manuel Alexander Schmidt, Anna Florvaag, Anna Lena Haas, Eva Maria Siegmann, Pauline Olm, Janine Utz, Philipp Spitzer, Arnd Doerfler, Piotr Lewczuk, Johannes Kornhuber, Juan Manuel Male. Amyloid-β levels and cognitive trajectories in non-demented pTau181-positive subjects without amyloidopathy. Brain : a journal of neurology. 2022-08-16. PMID:35973034. |
in the absence of amyloidopathy, individuals with increased total tau levels and/or temporal lobe atrophy experience no or only mild cognitive decline compared with biomarker-negative controls, leading to the proposal to categorize this constellation as suspected non-alzheimer disease pathophysiology (snap). |
2022-08-16 |
2023-08-14 |
human |
| Raffaella Migliaccio, Federica Cacciaman. The temporal lobe in typical and atypical Alzheimer disease. Handbook of clinical neurology. vol 187. 2022-08-14. PMID:35964987. |
in typical amnestic late-onset alzheimer's disease (>65 years old; load), tau pathology gradually spreads to the brain from the medial temporal lobe (mtl). |
2022-08-14 |
2023-08-14 |
Not clear |
| Philip S Insel, Christina B Young, Paul S Aisen, Keith A Johnson, Reisa A Sperling, Elizabeth C Mormino, Michael C Donohu. Tau positron emission tomography in preclinical Alzheimer's disease. Brain : a journal of neurology. 2022-08-13. PMID:35962782. |
the focus of early tau accumulation on the medial temporal lobe has resulted from the observation that the entorhinal cortex is the initial site to show abnormal levels of tau with age. |
2022-08-13 |
2023-08-14 |
human |