| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A L C S Nascimento, R P Fernandes, A C S Carvalho, I Frigieri, R C Alves, M Chorill. Insights for Alzheimer's disease pharmacotherapy and current clinical trials. Neurochemistry international. 2022-07-16. PMID:35842055. |
the strongest link between symptoms occurs with tau aggregation, which antecede aβ deposits in the medial temporal lobe, however, the protein can be found in cognitively healthy older people. |
2022-07-16 |
2023-08-14 |
human |
| Denis S Smirnov, David P Salmon, Douglas Galasko, Steven D Edland, Donald P Pizzo, Vanessa Goodwill, Annie Hinike. TDP-43 Pathology Exacerbates Cognitive Decline in Primary Age-Related Tauopathy. Annals of neurology. 2022-06-13. PMID:35696592. |
primary age-related tauopathy (part) refers to tau neurofibrillary tangles restricted largely to the medial temporal lobe in the absence of significant beta-amyloid plaques. |
2022-06-13 |
2023-08-14 |
Not clear |
| Molly R LaPoint, Suzanne L Baker, Susan M Landau, Theresa M Harrison, William J Jagus. Rates of β-amyloid deposition indicate widespread simultaneous accumulation throughout the brain. Neurobiology of aging. vol 115. 2022-04-21. PMID:35447369. |
furthermore, in all regions excluding the temporal lobe, faster amyloid accumulation was associated with greater tau burden. |
2022-04-21 |
2023-08-13 |
Not clear |
| Natasha Krishnadas, Vincent Doré, Colin Groot, Fiona Lamb, Pierrick Bourgeat, Samantha C Burnham, Kun Huang, Anita M Y Goh, Colin L Masters, Victor L Villemagne, Christopher C Row. Mesial temporal tau in amyloid-β-negative cognitively normal older persons. Alzheimer's research & therapy. vol 14. issue 1. 2022-04-09. PMID:35395950. |
tau deposition in the mesial temporal lobe (mtl) in the absence of amyloid-β (aβ-) occurs with aging. |
2022-04-09 |
2023-08-13 |
Not clear |
| Raffaele Cacciaglia, Gemma Salvadó, José Luis Molinuevo, Mahnaz Shekari, Carles Falcon, Gregory Operto, Marc Suárez-Calvet, Marta Milà-Alomà, Arianna Sala, Elena Rodriguez-Vieitez, Gwendlyn Kollmorgen, Ivonne Suridjan, Kaj Blennow, Henrik Zetterberg, Juan Domingo Gisper. Age, sex and APOE-ε4 modify the balance between soluble and fibrillar β-amyloid in non-demented individuals: topographical patterns across two independent cohorts. Molecular psychiatry. 2022-03-03. PMID:35236958. |
while age and sex mapped onto neocortical areas, the effect of apoe-ε4 was prominent in the medial temporal lobe, which represents a target of early tau deposition. |
2022-03-03 |
2023-08-13 |
Not clear |
| Dustin R Wakeman, Michael R Weed, Sylvia E Perez, Erika N Cline, Kirsten L Viola, Kyle C Wilcox, David S Moddrelle, Ernell Z Nisbett, Anish M Kurian, Amanda F Bell, Ricaldo Pike, Peer B Jacobson, William L Klein, Elliott J Mufson, Matthew S Lawrence, John D Elswort. Intrathecal amyloid-beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: a nonhuman primate model of Alzheimer's disease. Neuropathology and applied neurobiology. 2022-02-14. PMID:35156715. |
intrathecal amyloid-beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the african green monkey: a nonhuman primate model of alzheimer's disease. |
2022-02-14 |
2023-08-13 |
monkey |
| Alexandra J Weigand, Kelsey R Thomas, Katherine J Bangen, Graham M L Eglit, Adam M Brickman, Mark W Bond. Evidence for the progression of tau and neurodegeneration beyond the medial temporal lobe in amyloid-negative older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109203. |
evidence for the progression of tau and neurodegeneration beyond the medial temporal lobe in amyloid-negative older adults. |
2022-02-03 |
2023-08-13 |
Not clear |
| Jenna N Adams, Theresa M Harrison, Anne Maass, Suzanne L Baker, William J Jagus. Distinct factors drive the spatiotemporal progression of tau pathology in older adults. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2021-12-30. PMID:34965972. |
we examined whether baseline factors including age, amyloid-β, and neural activity predicted longitudinal tau accumulation in temporal lobe regions that reflect distinct stages of tau pathogenesis. |
2021-12-30 |
2023-08-13 |
human |
| Alireza Salami, Rolf Adolfsson, Micael Andersson, Kaj Blennow, Anders Lundquist, Annelie Nordin Adolfsson, Michael Schöll, Henrik Zetterberg, Lars Nyber. Association of APOE ɛ4 and Plasma p-tau181 with Preclinical Alzheimer's Disease and Longitudinal Change in Hippocampus Function. Journal of Alzheimer's disease : JAD. 2021-12-20. PMID:34924376. |
previous studies showed that tau pathology begins early in areas of the medial temporal lobe. |
2021-12-20 |
2023-08-13 |
Not clear |
| Allan I Levey, Deqiang Qiu, Liping Zhao, William T Hu, Duc M Duong, Lenora Higginbotham, Eric B Dammer, Nicholas T Seyfried, Thomas S Wingo, Chadwick M Hales, Malú Gámez Tansey, David S Goldstein, Anees Abrol, Vince D Calhoun, Felicia C Goldstein, Ihab Hajjar, Anne M Fagan, Doug Galasko, Steven D Edland, John Hanfelt, James J Lah, David Weinshenke. A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment. Brain : a journal of neurology. 2021-12-17. PMID:34919634. |
atomoxetine significantly reduced csf tau and ptau, normalized csf protein biomarker panels linked to synaptic function, brain metabolism, and glial immunity, and increased brain activity and metabolism in key temporal lobe circuits. |
2021-12-17 |
2023-08-13 |
human |
| David Berron, Jacob W Vogel, Philip S Insel, Joana B Pereira, Long Xie, Laura E M Wisse, Paul A Yushkevich, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Erik Stomrud, Ruben Smith, Olof Strandberg, Oskar Hansso. Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:33725124. |
here we used tau-pet imaging to investigate the sequence of tau pathology progression within the human medial temporal lobe and across regions in the posterior-medial system. |
2021-12-09 |
2023-08-13 |
human |
| David Berron, Jacob W Vogel, Philip S Insel, Joana B Pereira, Long Xie, Laura E M Wisse, Paul A Yushkevich, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Erik Stomrud, Ruben Smith, Olof Strandberg, Oskar Hansso. Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:33725124. |
second, in cognitively unimpaired individuals, increased tau load was related to local atrophy in the entorhinal cortex, brodmann area 35 and the anterior hippocampus and tau load in several anterior medial temporal lobe subregions was associated with distant atrophy of the posterior hippocampus. |
2021-12-09 |
2023-08-13 |
human |
| David Berron, Jacob W Vogel, Philip S Insel, Joana B Pereira, Long Xie, Laura E M Wisse, Paul A Yushkevich, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Erik Stomrud, Ruben Smith, Olof Strandberg, Oskar Hansso. Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:33725124. |
in summary, our findings highlight the progression of tau pathology across medial temporal lobe subregions and its disease stage-specific association with memory performance. |
2021-12-09 |
2023-08-13 |
human |
| Bora Yoon, Tengfei Guo, Karine Provost, Deniz Korman, Tyler J Ward, Susan M Landau, William J Jagus. Abnormal tau in amyloid PET negative individuals. Neurobiology of aging. vol 109. 2021-11-26. PMID:34715443. |
tau uptake patterns in a-t+ individuals were heterogeneous, but approximately 29% showed tau deposition in the medial temporal lobe only, consistent with primary age-related tauopathy and an additional 32% showed a pattern consistent with ad. |
2021-11-26 |
2023-08-13 |
human |
| Laura Em Wisse, Long Xie, Sandhitsu R Das, Robin de Flores, Oskar Hansson, Mohamad Habes, Jimit Doshi, Christos Davatzikos, Paul A Yushkevich, David A Wol. Tau pathology mediates age effects on medial temporal lobe structure. Neurobiology of aging. vol 109. 2021-11-26. PMID:34740075. |
tau pathology mediates age effects on medial temporal lobe structure. |
2021-11-26 |
2023-08-13 |
Not clear |
| Jacob Ziontz, Jenna N Adams, Theresa M Harrison, Suzanne L Baker, William J Jagus. Hippocampal Connectivity with Retrosplenial Cortex is Linked to Neocortical Tau Accumulation and Memory Function. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 42. 2021-11-23. PMID:34531286. |
the mechanisms underlying accumulation of alzheimer's disease (ad)-related tau pathology outside of the medial temporal lobe (mtl) in older adults are unknown but crucial to understanding cognitive decline. |
2021-11-23 |
2023-08-13 |
human |
| Jenna N Adams, Anne Maass, David Berron, Theresa M Harrison, Suzanne L Baker, Wesley P Thomas, Morgan Stanfill, William J Jagus. Reduced Repetition Suppression in Aging is Driven by Tau-Related Hyperactivity in Medial Temporal Lobe. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 17. 2021-11-19. PMID:33731446. |
tau deposition begins in the medial temporal lobe (mtl) in aging and alzheimer's disease (ad), and mtl neural dysfunction is commonly observed in these groups. |
2021-11-19 |
2023-08-13 |
human |
| Sadhana Ravikumar, Laura E M Wisse, Sydney Lim, Ranjit Ittyerah, Long Xie, Madigan L Bedard, Sandhitsu R Das, Edward B Lee, M Dylan Tisdall, Karthik Prabhakaran, Jacqueline Lane, John A Detre, Gabor Mizsei, John Q Trojanowski, John L Robinson, Theresa Schuck, Murray Grossman, Emilio Artacho-Pérula, Maria Mercedes Iñiguez de Onzoño Martin, María Del Mar Arroyo Jiménez, Monica Muñoz, Francisco Javier Molina Romero, Maria Del Pilar Marcos Rabal, Sandra Cebada Sánchez, José Carlos Delgado González, Carlos de la Rosa Prieto, Marta Córcoles Parada, David J Irwin, David A Wolk, Ricardo Insausti, Paul A Yushkevic. Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology. Acta neuropathologica communications. vol 9. issue 1. 2021-11-05. PMID:34689831. |
ex vivo mri atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology. |
2021-11-05 |
2023-08-13 |
human |
| Sadhana Ravikumar, Laura E M Wisse, Sydney Lim, Ranjit Ittyerah, Long Xie, Madigan L Bedard, Sandhitsu R Das, Edward B Lee, M Dylan Tisdall, Karthik Prabhakaran, Jacqueline Lane, John A Detre, Gabor Mizsei, John Q Trojanowski, John L Robinson, Theresa Schuck, Murray Grossman, Emilio Artacho-Pérula, Maria Mercedes Iñiguez de Onzoño Martin, María Del Mar Arroyo Jiménez, Monica Muñoz, Francisco Javier Molina Romero, Maria Del Pilar Marcos Rabal, Sandra Cebada Sánchez, José Carlos Delgado González, Carlos de la Rosa Prieto, Marta Córcoles Parada, David J Irwin, David A Wolk, Ricardo Insausti, Paul A Yushkevic. Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology. Acta neuropathologica communications. vol 9. issue 1. 2021-11-05. PMID:34689831. |
tau neurofibrillary tangle (nft) pathology in the medial temporal lobe (mtl) is closely linked to neurodegeneration, and is the early pathological change associated with alzheimer's disease (ad). |
2021-11-05 |
2023-08-13 |
human |
| Eun Hyun Seo, Ho Jae Lim, Hyung-Jun Yoon, Kyu Yeong Choi, Jang Jae Lee, Jun Young Park, Seong Hye Choi, Hoowon Kim, Byeong C Kim, Kun Ho Le. Visuospatial memory impairment as a potential neurocognitive marker to predict tau pathology in Alzheimer's continuum. Alzheimer's research & therapy. vol 13. issue 1. 2021-10-28. PMID:34627371. |
we investigated the association between phosphorylated tau (p-tau) level and cognitive impairment across the ad continuum and the mediating role of medial temporal lobe (mtl) atrophy. |
2021-10-28 |
2023-08-13 |
Not clear |