| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Baihui Song, Gaoyuan Zhang, Yitegele Bao, Mohan Zhan. Involvement of oxidative stress-AMPK-Cx43-NLRP3 pathway in extracellular matrix remodeling of gastric smooth muscle cells in rats with diabetic gastroparesis. Cell stress & chaperones. 2024-04-23. PMID:38653383. |
this study aimed to investigate the changes in oxidative stress, adenosine monophosphate-activated protein kinase (ampk), connexin43 (cx43), nucleotide-binding oligomerization domain-like receptor protein 3 (nlrp3) expression, and extracellular matrix (ecm) in the gastric smooth muscle tissues of rats with diabetic gastroparesis (dgp) and high glucose-cultured gastric smooth muscle cells, determine the existence of oxidative stress-ampk-cx43-nlrp3 pathway under high glucose condition, and the involvement of this pathway in ecm remodeling in dgp rats. |
2024-04-23 |
2024-04-26 |
rat |
| Li Zhang, Mengmeng Duan, Xiaohua Pu, Huiling Zheng, Xinjie Ning, Ying Tu, Chunming Xu, Demao Zhang, Chengcheng Liu, Jing Xi. GroEL triggers NLRP3 inflammasome activation through the TLR/NF-κB p-p65 axis in human periodontal ligament stem cells. Acta biochimica et biophysica Sinica. 2024-04-10. PMID:38596842. |
in the present study, we verify that groel can trigger the activation of nlrp3 inflammasome and its downstream effector molecules, il-1β and il-18, in human periodontal ligament stem cells (hpdlscs) and resultantly induce high activation of gelatinases (mmp-2 and mmp-9) to promote the degradation of extracellular matrix (ecm). |
2024-04-10 |
2024-04-12 |
human |
| Xuanhong Jin, Liangkun You, Jincheng Qiao, Weidong Han, Hongming Pa. Autophagy in colitis-associated colon cancer: exploring its potential role in reducing initiation and preventing IBD-Related CAC development. Autophagy. vol 20. issue 2. 2024-01-25. PMID:37723664. |
a. muciniphila: akkermansia muciniphila; aiec: adherent invasive escherichia coli; aom/dss: azoxymethane-dextran sodium sulfate; atg: autophagy related; becn1: beclin1, autophagy related; cac: colitis-associated colon cancer; ccdc50: coiled-coil domain containing 50; cldn2: claudin 2; copec: colibactin-producing escherichia coli; crc: colorectal cancer; damps: danger/damage-associated molecular patterns; dc: dendritic cell; dss: dextran sulfate sodium; dtp: drug-resistant persistent; er: endoplasmic reticulum; ern1/ire1α: endoplasmic reticulum to nucleus signaling 1; ibd: inflammatory bowel disease; iecs: intestinal epithelial cells; ikk: ikappab kinase; il: interleukin; irgm1: immunity-related gtpase family m member 1; isc: intestinal stem cell; lps: lipopolysaccharide; map1lc3/lc3: microtubule-associated protein 1 light chain 3; mapk: mitogen-activated protein kinase; mdp: muramyl dipeptide; melk: maternal embryonic leucine zipper kinase; mhc: major histocompatibility complex; mirna: microrna; mtor: mechanistic target of rapamycin kinase; nlrp3: nlr family, pyrin domain containing 3; nod2: nucleotide-binding oligomerization domain containing 2; nrbf2: nuclear receptor binding factor 2; pamps: pathogen-associated molecular patterns; pi3k: class i phosphoinositide 3-kinase; ptdins3k: class iii phosphatidylinositol 3-kinase; pycard/asc: pyd and card domain containing; ralgapa2/ralgapα2: ral gtpase activating protein protein, alpha subunit 2 (catalytic); ripk2/card3: receptor (tnfrsf)-interacting serine-threonine kinase 2; ripk3: receptor-interacting serine-threonine kinase 3; ros: reactive oxygen species; scrc: sporadic colorectal cancer; smarca4/brg1: swi/snf related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; sqstm1: sequestosome 1; stat3: signal transducer and activator of transcription 3; tnf/tnfa: tumor necrosis factor; ulk1: unc-51 like autophagy activating kinase 1; upr: unfolded protein response; wt: wild-type. |
2024-01-25 |
2024-01-27 |
Not clear |
| Ziaur Rahman, Arbaz Sujat Shaikh, K Venkata Rao, Manoj P Dandeka. Oxyberberine Protects Middle Cerebral Artery Occlusion Triggered Cerebral Injury Through TLR4/NLRP3 Pathway in Rats. Journal of chemical neuroanatomy. 2024-01-21. PMID:38246265. |
we also observed the decline in plasma levels/mrna transcription of tnf-α, il-1β, nlrp3, il-6, and matrix metalloproteinase-9 and increased expression of occludin and claudin in obb-treated rats. |
2024-01-21 |
2024-01-24 |
rat |
| Xiaotong Wu, Fengshi Zhang, Xiaolin Mao, Fujian Xu, Xiaokang Ding, Xiuli Sun, Jianliu Wan. The mechanism of adipose mesenchymal stem cells to stabilize the immune microenvironment of pelvic floor injury by regulating pyroptosis and promoting tissue repair. Materials today. Bio. vol 24. 2024-01-11. PMID:38204481. |
ros stimulated macrophages to produce nlrp3 inflammatory complex, induced the release of interleukin (il-1β) and pyroptosis and exacerbated the inflammatory state of damaged tissues, persisting chronic inflammation of fibroblasts in supporting tissues, thus causing the pelvic floor's extracellular matrix (ecm) collagen metabolic disorder. |
2024-01-11 |
2024-01-13 |
rat |
| Sher Bahadur Poudel, Ryan R Ruff, Gozde Yildirim, Richard A Miller, David E Harrison, Randy Strong, Thorsten Kirsch, Shoshana Yaka. Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice. bioRxiv : the preprint server for biology. 2024-01-03. PMID:38168298. |
significant direct correlations were found between ac scores and inflammatory markers in chondrocytes, including matrix metalloproteinase-13 (mmp-13), inducible nitric oxide synthase (inos), and the nlr family pyrin domain containing-3 (nlrp3) inflammasome in both sexes, indicating a link between oa severity and inflammation. |
2024-01-03 |
2024-01-06 |
mouse |
| Zahra Babazade. Involvement of NLRP3 Inflammasome in SARS-Cov-2-Induced Multiorgan Dysfunction in Patients with COVID-19: A Review of Molecular Mechanisms. Tanaffos. vol 22. issue 1. 2023-11-03. PMID:37920322. |
besides, invading host cells via sars-cov-2 further activates the nlrp3 inflammasome and induces pyroptosis in immune cells, resulting in the secretion of higher levels of proinflammatory cytokines into the extracellular matrix. |
2023-11-03 |
2023-11-08 |
Not clear |
| Xiangjing Meng, Sumei Guo, Xiaoxia Zhang, Bo Jiao, Xiaohan Yang, Ming Li, Chao Li, Jin He, Shangya Chen, Cheng Peng, Hua Shao, Qiang Ji. HMGB1 inhibition reduces TDI-induced occupational asthma through ROS/AMPK/autophagy pathway. Ecotoxicology and environmental safety. vol 266. 2023-10-15. PMID:37839183. |
at the molecular level, inhibition of hmgb1 decreased the expressions of hmgb1, toll-like receptor 4, vimentin and matrix metalloproteinase-9 proteins, activated nf-κb and nod-like receptor protein 3 (nlrp3) inflammasome, and increased e-cadherin expression. |
2023-10-15 |
2023-11-08 |
mouse |
| Yan Chen, Xiankun Cao, Bin Pan, Han Du, Baixing Li, Xiao Yang, Xuzhuo Chen, Xin Wang, Tangjun Zhou, An Qin, Changqing Zhao, Jie Zha. Verapamil attenuates intervertebral disc degeneration by suppressing ROS overproduction and pyroptosis via targeting the Nrf2/TXNIP/NLRP3 axis in four-week puncture-induced rat models both in vivo and in vitro. International immunopharmacology. vol 123. 2023-08-14. PMID:37579541. |
administration of verapamil, a classic clinical drug, mitigated the tbhp-induced overproduction of reactive oxygen species and activation of the nlrp3 inflammasome, thus protecting cells from pyroptosis, apoptosis, and extracellular matrix degradation. |
2023-08-14 |
2023-09-07 |
rat |
| Yaoyu Liu, Xiaojie Li, Minglan Zhao, Yifan Wu, Yuan Xu, Xiuming Li, Lizhe Fu, Liqiao Han, Zhou Wei, Qinghong Hu, Junqi Chen, Jiuyao Zhou, Xusheng Liu, Hua Lin, Junbiao W. Macrophage-derived exosomes promote activation of NLRP3 inflammasome and autophagy deficiency of mesangial cells in diabetic nephropathy. Life sciences. 2023-07-31. PMID:37524161. |
here, we found that dn mice appeared renal pathological damage, including dilation of mesangial matrix and significant infiltration of macrophages, accompanied by increased inflammatory response, nlrp3 inflammasome activation and autophagy deficiency. |
2023-07-31 |
2023-08-14 |
mouse |
| Jing Chen, Qi Li, Yifan Hong, Xiazhu Zhou, Chengjun Yu, Xiaomao Tian, Jie Zhao, Chunlan Long, Lianju Shen, Shengde Wu, Guanghui We. Inhibition of the NF-κB Signaling Pathway Alleviates Pyroptosis in Bladder Epithelial Cells and Neurogenic Bladder Fibrosis. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446339. |
moreover, using the nlrp3 inhibitor mcc950 rescued tgf-β1-induced fibrosis, and the nf-κb signaling pathway inhibitor bay 11-7082 effectively rescued tgf-β1-induced pyroptosis and the deposition of extracellular matrix by sv-huc-1 cells. |
2023-07-14 |
2023-08-14 |
rat |
| Ziaur Rahman, Shubham Ghuge, Manoj P Dandeka. Partial blood replacement ameliorates middle cerebral artery occlusion generated neurological aberrations by intervening TLR4 and NLRP3 cascades in rats. Metabolic brain disease. 2023-07-04. PMID:37402080. |
moreover, elevated levels of toll-like receptor 4 (tlr4) and mrna expression of il-1β, tnf-α, matrix metalloproteinase-9 and nlrp3, and decreased levels of zonula occludens-1 in mcao rats, were reversed following brt. |
2023-07-04 |
2023-08-14 |
rat |
| Baoshan Hu, Shan Lin, Shengrong Lin, Gang Ru. Ginkgetin Alleviates Intervertebral Disc Degeneration by Inhibiting Apoptosis, Inflammation, and Disturbance of Extracellular Matrix Synthesis and Catabolism via Inactivation of NLRP3 Inflammasome. Immunological investigations. 2023-05-08. PMID:37154418. |
ginkgetin alleviates intervertebral disc degeneration by inhibiting apoptosis, inflammation, and disturbance of extracellular matrix synthesis and catabolism via inactivation of nlrp3 inflammasome. |
2023-05-08 |
2023-08-14 |
Not clear |
| Jialing Xiao, Yali Li, Jie Zhang, Guochao Xu, Jianxing Zhan. Pannexin 3 activates P2X7 receptor to mediate inflammation and cartilage matrix degradation in temporomandibular joint osteoarthritis. Cell biology international. 2023-04-06. PMID:37021698. |
panx3 silencing alleviated the damage of condyle cartilage tissue in tmjoa rats, and reduced expressions of panx3, p2x7r, cartilage matrix degradation related-enzymes, and nlrp3 in condyle cartilage tissue. |
2023-04-06 |
2023-08-14 |
rat |
| Jennifer Adjei-Mosi, Qing Sun, Steven Blake Smithson, Gavyn Lee Shealy, Krupa Dhruvitha Amerineni, Zerong Liang, Hanqing Chen, Mei Wang, Qinggong Ping, Jingyan Han, Masahiro Morita, Amrita Kamat, Nicolas Musi, Mengwei Zan. Age-dependent loss of hepatic SIRT1 enhances NLRP3 inflammasome signaling and impairs capacity for liver fibrosis resolution. Aging cell. 2023-03-31. PMID:36999514. |
in a model of hepatotoxin-induced liver fibrosis, old mice displayed more severe and persistent liver fibrosis than young mice during liver injury and after injury cessation, as characterized by inhibition of sirt1, induction of nlrp3, infiltration of macrophages and neutrophils, activation of hepatic stellate cells (hscs), and excessive deposition and remodeling of the extracellular matrix. |
2023-03-31 |
2023-08-14 |
mouse |
| Armand N Yazdani, Vikrant Rai, Devendra K Agrawa. Rotator Cuff Health, Pathology, and Repair in the Perspective of Hyperlipidemia. Journal of orthopaedics and sports medicine. vol 4. issue 4. 2022-11-16. PMID:36381991. |
subsequent inflammatory pathways including the jak2/stat3 pathway and nlrp3 inflammasome pathway led to persistent inflammation and extracellular matrix (ecm) degradation within the rotator cuff. |
2022-11-16 |
2023-08-14 |
Not clear |
| Nanxing Yi, Yilin Mi, Xiaotong Xu, Naping Li, Baiyi Chen, Ke Yan, Kaiyun Tan, Bo Zhang, Linhua Wang, Gaoyan Kuang, Min L. Nodakenin attenuates cartilage degradation and inflammatory responses in a mice model of knee osteoarthritis by regulating mitochondrial Drp1/ROS/NLRP3 axis. International immunopharmacology. vol 113. issue Pt A. 2022-10-27. PMID:36302323. |
moreover, nod inhibited the mrna levels of inflammatory cytokines (cox 2, il-1β, and tnf-α), nod-like receptor family pyrin domain-containing 3 (nlrp3) inflammasome, and matrix metalloproteinase 13 expression in activated chondrocytes. |
2022-10-27 |
2023-08-14 |
mouse |
| Jiangbo Yan, Gangning Feng, Yong Yang, Dong Ding, Long Ma, Xin Zhao, Xiaolei Chen, Hui Wang, Zhirong Chen, Qunhua Ji. Autophagy attenuates osteoarthritis in mice by inhibiting chondrocyte pyroptosis and improving subchondral bone remodeling. Bosnian journal of basic medical sciences. 2022-07-26. PMID:35880352. |
mechanistically, activation of autophagy in cartilage increased the expression of type ii collagen (col ii), decreased the expression of matrix metalloproteinase 13 (mmp 13) and decreased the pyroptosis mediated by nod-like receptor protein 3 (nlrp3) inflammasome by decreasing the expression of nlrp3, caspase-1, gasdermin d (gsdmd), and il-1β. |
2022-07-26 |
2023-08-14 |
mouse |
| Jiangbo Yan, Dong Ding, Gangning Feng, Yong Yang, Yong Zhou, Long Ma, Haohui Guo, Zhidong Lu, Qunhua Ji. Metformin reduces chondrocyte pyroptosis in an osteoarthritis mouse model by inhibiting NLRP3 inflammasome activation. Experimental and therapeutic medicine. vol 23. issue 3. 2022-02-28. PMID:35222699. |
immunohistochemical staining was used to detect type ii collagen (col ii), matrix metalloproteinase 13 (mmp-13), nod-like receptor protein 3 (nlrp3), caspase-1, gasdermin d (gsdmd) and il-1β protein expression. |
2022-02-28 |
2023-08-13 |
mouse |
| Regina Sakalyte, Jaroslav Denkovskij, Eiva Bernotiene, Sigita Stropuviene, Silvija Ona Mikulenaite, Giedrius Kvederas, Narunas Porvaneckas, Vytautas Tutkus, Algirdas Venalis, Irena Butrimien. The Expression of Inflammasomes NLRP1 and NLRP3, Toll-Like Receptors, and Vitamin D Receptor in Synovial Fibroblasts From Patients With Different Types of Knee Arthritis. Frontiers in immunology. vol 12. 2022-02-07. PMID:35126351. |
in this study, we investigated the expression of nucleotide-binding, oligomerization domain (nod)-like receptor family, pyrin domain containing (nlrp)1, nlrp3 inflammasomes, toll-like receptor (tlr)1, tlr2, tlr4, vitamin d receptor (vdr), and secretion of matrix metalloproteinases (mmps) in sfs isolated from patients with ra, osteoarthritis (oa), ea, and control individuals (cn) after knee surgical intervention. |
2022-02-07 |
2023-08-13 |
Not clear |