| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria-Alexandra Martu, George-Alexandru Maftei, Ionut Luchian, Ovidiu Mihail Stefanescu, Mihaela Monica Scutariu, Sorina Mihaela Solomo. The Effect of Acknowledged and Novel Anti-Rheumatic Therapies on Periodontal Tissues-A Narrative Review. Pharmaceuticals (Basel, Switzerland). vol 14. issue 12. 2021-12-28. PMID:34959607. |
several alternatives are currently being tested, such as matrix metalloproteinases (mmp) inhibitors, toll-like receptors (tlr) blockers, pro-resolution mediators, anti-hypoxia inducing factors, stem cell therapy, nlrp3 inhibitors and even natural derived compounds. |
2021-12-28 |
2023-08-13 |
Not clear |
| Narayanappa Amruta, Gregory Bi. ATN-161 Ameliorates Ischemia/Reperfusion-induced Oxidative Stress, Fibro-inflammation, Mitochondrial damage, and Apoptosis-mediated Tight Junction Disruption in bEnd.3 Cells. Inflammation. vol 44. issue 6. 2021-11-26. PMID:34420157. |
atn-161 treatment (10 µm) effectively inhibited ogd/r-induced extracellular matrix (ecm) deposition by reducing integrin α5, mmp-9, and fibronectin expression, as well as reducing oxidative stress by reducing mitochondrial superoxide radicals, intracellular ros, inflammation by reducing nlrp3 inflammasome, tight junction loss by reducing claudin-5 and zo-1 expression levels, mitochondrial damage by inhibiting mitochondrial depolarization, and apoptosis via regulation of p-fak and p-akt levels. |
2021-11-26 |
2023-08-13 |
mouse |
| Qing Wang, Lujing Ying, Bing Wei, Yikui Ji, Yi X. Effects of quercetin on apoptosis and extracellular matrix degradation of chondrocytes induced by oxidative stress-mediated pyroptosis. Journal of biochemical and molecular toxicology. 2021-11-18. PMID:34791735. |
results showed that quercetin could reduce lps-induced c28/i2 cell apoptosis, extracellular matrix (ecm) degradation, and cell pyroptosis, and overexpression of nucleotide-binding domain and leucine-rich-repeat-containing (nlr) family, pyrin domain-containing 3 (nlrp3) revealed that quercetin reduced chondrocyte apoptosis and ecm degradation by inhibiting nlrp3-mediated pyroptosis. |
2021-11-18 |
2023-08-13 |
rat |
| Jiancong Chen, Jiansen Yan, Shuangxing Li, Jianxiong Zhu, Jie Zhou, Jun Li, Yangyang Zhang, Zhengqi Huang, Liang Yuan, Kang Xu, Weijian Chen, Wei Y. Atorvastatin inhibited TNF-α induced matrix degradation in rat nucleus pulposus cells by suppressing NLRP3 inflammasome activity and inducing autophagy through NF-κB signaling. Cell cycle (Georgetown, Tex.). vol 20. issue 20. 2021-11-05. PMID:34494933. |
atorvastatin inhibited tnf-α induced matrix degradation in rat nucleus pulposus cells by suppressing nlrp3 inflammasome activity and inducing autophagy through nf-κb signaling. |
2021-11-05 |
2023-08-13 |
rat |
| Jiancong Chen, Jiansen Yan, Shuangxing Li, Jianxiong Zhu, Jie Zhou, Jun Li, Yangyang Zhang, Zhengqi Huang, Liang Yuan, Kang Xu, Weijian Chen, Wei Y. Atorvastatin inhibited TNF-α induced matrix degradation in rat nucleus pulposus cells by suppressing NLRP3 inflammasome activity and inducing autophagy through NF-κB signaling. Cell cycle (Georgetown, Tex.). vol 20. issue 20. 2021-11-05. PMID:34494933. |
the results revealed that atorvastatin might suppress matrix degradation induced by tnf-α by suppressing nlrp3 inflammasome activity and inducing autophagic flux. |
2021-11-05 |
2023-08-13 |
rat |
| Jiancong Chen, Jiansen Yan, Shuangxing Li, Jianxiong Zhu, Jie Zhou, Jun Li, Yangyang Zhang, Zhengqi Huang, Liang Yuan, Kang Xu, Weijian Chen, Wei Y. Atorvastatin inhibited TNF-α induced matrix degradation in rat nucleus pulposus cells by suppressing NLRP3 inflammasome activity and inducing autophagy through NF-κB signaling. Cell cycle (Georgetown, Tex.). vol 20. issue 20. 2021-11-05. PMID:34494933. |
overall, the present study demonstrated that atorvastatin might suppress matrix degradation induced by tnf-α and further revealed the crosstalk among nlrp3 inflammasome activity, autophagy and nf-κb signaling. |
2021-11-05 |
2023-08-13 |
rat |
| Susanne Gaul, Karen Marie Schaeffer, Lena Opitz, Christina Maeder, Alexander Kogel, Luisa Uhlmann, Hermann Kalwa, Ulf Wagner, Jan Haas, Amirhossein Behzadi, Pablo Pelegrin, Jes-Niels Boeckel, Ulrich Lauf. Extracellular NLRP3 inflammasome particles are internalized by human coronary artery smooth muscle cells and induce pro-atherogenic effects. Scientific reports. vol 11. issue 1. 2021-11-03. PMID:34312415. |
extracellular nlrp3-yfp inflammasome particles promoted the secretion of pro-atherogenic and inflammatory cytokines such as ccl2/mcp1, cxcl1 and il-17e, and increased hcasmc migration (1.8-fold) and extracellular matrix production, such as fibronectin (5.8-fold) which was dependent on nfκb and nlrp3 activation. |
2021-11-03 |
2023-08-13 |
human |
| Wiwin Is Effendi, Tatsuya Nagan. The Crucial Role of NLRP3 Inflammasome in Viral Infection-Associated Fibrosing Interstitial Lung Diseases. International journal of molecular sciences. vol 22. issue 19. 2021-10-27. PMID:34638790. |
during viral infection, activation of the nlrp3 inflammasome by integrating multiple cellular and molecular signaling implicates robust inflammation, fibroblast proliferation, activation of myofibroblast, matrix deposition, and aberrant epithelial-mesenchymal function. |
2021-10-27 |
2023-08-13 |
Not clear |
| Hwan Hee Lee, Dongoh Kim, Joohee Jung, Hyojeung Kang, Hyosun Ch. NLRP3 Deficiency in Hepatocellular Carcinoma Enhances Surveillance of NK-92 through a Modulation of MICA/B. International journal of molecular sciences. vol 22. issue 17. 2021-10-18. PMID:34502191. |
when the expression of nlrp3 in hcc cells was ablated, mica/b on the surface of hcc cells was upregulated through the lowered expression of matrix metalloproteinase. |
2021-10-18 |
2023-08-13 |
mouse |
| Yanan Wang, Hexiao Huang, Weihong He, Shihong Zhang, Ming Liu, Simiao W. Association between serum NLRP3 and malignant brain edema in patients with acute ischemic stroke. BMC neurology. vol 21. issue 1. 2021-10-15. PMID:34493232. |
we aimed to explore the association of serum level of the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (nlrp3) and its related inflammatory biomarkers (hypoxia inducible factor-1α, cathepsin b, caspase-1 and matrix metalloproteinase-9) with malignant brain edema (mbe) in patients with acute ischemic stroke. |
2021-10-15 |
2023-08-13 |
Not clear |
| Jing Wang, Qibiao Wu, Lu Ding, Siyu Song, Yaxin Li, Li Shi, Tan Wang, Daqing Zhao, Zeyu Wang, Xiangyan L. Therapeutic Effects and Molecular Mechanisms of Bioactive Compounds Against Respiratory Diseases: Traditional Chinese Medicine Theory and High-Frequency Use. Frontiers in pharmacology. vol 12. 2021-09-14. PMID:34512360. |
we found that 31 bioactive compounds from the selected 10 common chinese herbs, such as epigallocatechin-3-gallate (egcg), kaempferol, isorhamnetin, quercetin, and β-sitosterol, can mainly regulate nf-κb, nrf2/ho-1, nlrp3, tgf-β/smad, mapk, and pi3k/akt/mtor pathways to inhibit infection, inflammation, extracellular matrix deposition, and tumor growth in a series of lung-related diseases. |
2021-09-14 |
2023-08-13 |
Not clear |
| Xabier Unamuno, Javier Gómez-Ambrosi, Beatriz Ramírez, Amaia Rodríguez, Sara Becerril, Víctor Valentí, Rafael Moncada, Camilo Silva, Javier Salvador, Gema Frühbeck, Victoria Catalá. NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling. Cellular & molecular immunology. vol 18. issue 4. 2021-08-17. PMID:31551515. |
nlrp3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling. |
2021-08-17 |
2023-08-13 |
human |
| Xabier Unamuno, Javier Gómez-Ambrosi, Beatriz Ramírez, Amaia Rodríguez, Sara Becerril, Víctor Valentí, Rafael Moncada, Camilo Silva, Javier Salvador, Gema Frühbeck, Victoria Catalá. NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling. Cellular & molecular immunology. vol 18. issue 4. 2021-08-17. PMID:31551515. |
we aimed to determine the impact of nlrp3 on obesity and its associated metabolic alterations as well as its role in adipocyte inflammation and extracellular matrix (ecm) remodeling. |
2021-08-17 |
2023-08-13 |
human |
| Yao Zhang, Zihao Lin, Deheng Chen, Yaohua H. CY-09 attenuates the progression of osteoarthritis via inhibiting NLRP3 inflammasome-mediated pyroptosis. Biochemical and biophysical research communications. vol 553. 2021-07-06. PMID:33765556. |
cy-09 can maintain extracellular matrix (ecm) homeostasis and regulate inflammation in tnf-α treated chondrocytes via inhibition of nlrp3 inflammasome-mediated pyroptosis. |
2021-07-06 |
2023-08-13 |
Not clear |
| Pinfang Kang, Jiahui Wang, Dian Fang, Tingting Fang, Ying Yu, Weiping Zhang, Lin Shen, Zhenghong Li, Hongju Wang, Hongwei Ye, Qin Ga. Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis. Free radical biology & medicine. vol 146. 2021-06-18. PMID:31689484. |
in contrast to normal glucose group, in hg group, with the decreases of aldh2 activity, mrna and protein levels, the cardiomyocytes viability was decreased, reactive oxygen species (ros), the inflammation factors - tumor necrosis factor-α (tnf-α), interleukin-6 (il-6), interleukin-1β (il-1β) levels, collagen i (col i) and col iii mrna expressions and tissue inhibitors of matrix metalloproteinase 4 (timp4) protein expression were increased, while matrix metalloproteinase 14 (mmp14) protein level, the ratio of mmp14/timp4 were decreased, and the necroptosis key factors - the receptor interacting protein 1 (rip1), rip3 and mixed lineage kinase domain-like protein (mlkl) at mrna and protein expressions were increased, the inflammasome core proteins - nlrp3 and asc protein expressions were also increased, the apoptosis rate and necrosis rate were also increased. |
2021-06-18 |
2023-08-13 |
rat |
| G Chao-Yang, C Peng, Z Hai-Hon. Roles of NLRP3 inflammasome in intervertebral disc degeneration. Osteoarthritis and cartilage. vol 29. issue 6. 2021-06-14. PMID:33609693. |
with the exploration of the mechanism of ivdd, recent studies have shown that activation of the nlrp3 inflammasome is associated with intervertebral disc (ivd) inflammation, pyroptosis, extracellular matrix degradation and apoptosis of ivd cells. |
2021-06-14 |
2023-08-13 |
Not clear |
| Ivan Luzardo-Ocampo, Guadalupe Loarca-Piña, Elvira Gonzalez de Meji. Gallic and butyric acids modulated NLRP3 inflammasome markers in a co-culture model of intestinal inflammation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 146. 2021-06-11. PMID:33130239. |
this is the first report of the nlrp3 inflammasome modulation by digested food matrix components, using a co-culture approach. |
2021-06-11 |
2023-08-13 |
Not clear |
| Xiaowei Chen, Xu Xiang, Teng Xie, Zhijun Chen, Yu Mou, Zixu Gao, Xun Xie, Min Song, Hui Huang, Ziyun Gao, Min Che. Memantine protects blood-brain barrier integrity and attenuates neurological deficits through inhibiting nitric oxide synthase ser1412 phosphorylation in intracerebral hemorrhage rats: involvement of peroxynitrite-related matrix metalloproteinase-9/NLRP3 inflammasome activation. Neuroreport. vol 32. issue 3. 2021-04-19. PMID:33470757. |
behavioral changes, brain edema, levels of nnos ser1412 phosphorylation, peroxynitrite, matrix metalloproteinase (mmp)-9, nlrp3, il-1β and numbers of dying neurons, as well as the cellular localization of gelatinolytic activity, were detected among the groups. |
2021-04-19 |
2023-08-13 |
rat |
| Yingjie Huang, Yan Peng, Jianchao Sun, Shuangxing Li, Junmin Hong, Jie Zhou, Jianchong Chen, Jiansen Yan, Zhengqi Huang, Xiaofei Wang, Weijian Chen, Wei Y. Nicotinamide Phosphoribosyl Transferase Controls NLRP3 Inflammasome Activity Through MAPK and NF-κB Signaling in Nucleus Pulposus Cells, as Suppressed by Melatonin. Inflammation. vol 43. issue 3. 2021-04-02. PMID:31900828. |
previous studies revealed that nlrp3 inflammasome plays a vital role in idd and nicotinamide phosphoribosyl transferase (nampt) is involved in matrix degradation induced by il-1β. |
2021-04-02 |
2023-08-13 |
Not clear |
| Yingjie Huang, Yan Peng, Jianchao Sun, Shuangxing Li, Junmin Hong, Jie Zhou, Jianchong Chen, Jiansen Yan, Zhengqi Huang, Xiaofei Wang, Weijian Chen, Wei Y. Nicotinamide Phosphoribosyl Transferase Controls NLRP3 Inflammasome Activity Through MAPK and NF-κB Signaling in Nucleus Pulposus Cells, as Suppressed by Melatonin. Inflammation. vol 43. issue 3. 2021-04-02. PMID:31900828. |
the results revealed that nampt downregulation or overexpression controlled the matrix degradation induced by tnf-α by modulating nlrp3 inflammasome activity. |
2021-04-02 |
2023-08-13 |
Not clear |