| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junmin Hong, Shuangxing Li, Dessislava Z Markova, Anjing Liang, Christopher K Kepler, Yingjie Huang, Jie Zhou, Jiansen Yan, Weijian Chen, Dongsheng Huang, Kang Xu, Wei Y. Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31975410. |
simply, brd4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing nlrp3 inflammasome activity through nf-κb signaling in np cells. |
2021-03-10 |
2023-08-13 |
human |
| Ying Han, Hai-Jian Sun, Ying Tong, Yun-Zhi Chen, Chao Ye, Yun Qiu, Feng Zhang, Ai-Dong Chen, Xiao-Hong Qi, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zh. Curcumin attenuates migration of vascular smooth muscle cells via inhibiting NFκB-mediated NLRP3 expression in spontaneously hypertensive rats. The Journal of nutritional biochemistry. vol 72. 2020-11-04. PMID:31473513. |
intragastric administration of curcumin in shr attenuated hypertension and reduced nfκb activation, nlrp3 and matrix metalloproteinase-9 expressions and aortic media thickness. |
2020-11-04 |
2023-08-13 |
rat |
| Ava Faridi, Yunxiang Sun, Monika Mortimer, Ritchlynn R Aranha, Aparna Nandakumar, Yuhuan Li, Ibrahim Javed, Aleksandr Kakinen, Qingqing Fan, Anthony W Purcell, Thomas P Davis, Feng Ding, Pouya Faridi, Pu Chun K. Graphene quantum dots rescue protein dysregulation of pancreatic β-cells exposed to human islet amyloid polypeptide. Nano research. vol 12. issue 11. 2020-11-01. PMID:31695851. |
while iapp can activate the nlrp3 inflammasome and modulate cellular autophagy, apoptosis and extracellular matrix metabolism, no data is available concerning intracellular protein expression upon exposure to the polypeptide. |
2020-11-01 |
2023-08-13 |
human |
| Wen-Cao Liu, Xiaona Wang, Xinyu Zhang, Xi Chen, Xinchun Ji. Melatonin Supplementation, a Strategy to Prevent Neurological Diseases through Maintaining Integrity of Blood Brain Barrier in Old People. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:28596733. |
melatonin has been shown to preserves bbb integrity and permeability via a variety of pathways: inhibition of matrix metalloproteinase-9 (mmp-9), inhibition of nadph oxidase-2, and impact on silent information regulator 1 (sirt1) and nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (nlrp3) inflammasome. |
2020-10-01 |
2023-08-13 |
mouse |
| Gang Xu, Jian Wang, Long Ma, Xin Zhao, Wen Luo, Qunhua Ji. Local intra-articular injection of rapamycin inhibits NLRP3 activity and prevents osteoarthritis in mouse DMM models. Autoimmunity. vol 52. issue 4. 2020-05-14. PMID:31407595. |
the expression of oa associated biomarkers namely matrix metalloproteinase (mmp-13), nod-, lrr- and pyrin domain-containing 3 (nlrp3) induced by destabilizing the medial meniscus operation (dmm) were also investigated. |
2020-05-14 |
2023-08-13 |
mouse |
| Gurupreet S Sethi, Sukriti Sharma, Amarjit S Naur. PARP inhibition by olaparib alleviates chronic asthma-associated remodeling features via modulating inflammasome signaling in mice. IUBMB life. vol 71. issue 7. 2020-04-16. PMID:30964965. |
interestingly, the protection offered by olaparib was further linked with the altered level of nlrp3 inflammasome-mediated il-1β release and consequent expression of its downstream targets matrix metalloproteinase-9 and transforming growth factor beta. |
2020-04-16 |
2023-08-13 |
mouse |
| Bria M Coates, Kelly L Staricha, Nandini Ravindran, Clarissa M Koch, Yuan Cheng, Jennifer M Davis, Dale K Shumaker, Karen M Ridg. Inhibition of the NOD-Like Receptor Protein 3 Inflammasome Is Protective in Juvenile Influenza A Virus Infection. Frontiers in immunology. vol 8. 2019-11-20. PMID:28740490. |
the iav matrix 2 proton channel (m2) has been shown to be an important activator of the nlrp3 inflammasome during iav infection. |
2019-11-20 |
2023-08-13 |
mouse |
| Lu Chen, Qian You, Liang Hu, Jian Gao, Qianqian Meng, Wentao Liu, Xuefeng Wu, Qiang X. The Antioxidant Procyanidin Reduces Reactive Oxygen Species Signaling in Macrophages and Ameliorates Experimental Colitis in Mice. Frontiers in immunology. vol 8. 2019-11-20. PMID:29354126. |
some inflammatory conditions, such as matrix metalloproteinases (mmps) and the nuclear factor-κb (nf-κb) and nod-like receptor protein 3 (nlrp3) inflammasome signaling pathways, are reported to contribute to the development and maintenance of ibd. |
2019-11-20 |
2023-08-13 |
mouse |
| M J McAllister, M Chemaly, A J Eakin, D S Gibson, V E McGilliga. NLRP3 as a potentially novel biomarker for the management of osteoarthritis. Osteoarthritis and cartilage. vol 26. issue 5. 2019-11-06. PMID:29499288. |
the nucleotide-binding and oligomerization domain-like receptor containing protein 3 (nlrp3) inflammasome has been implicated in the pathogenesis of a number of arthritic disorders, producing proinflammatory cytokines and degradative enzymes such as interleukin-1 beta (il-1β), tumour necrosis factor alpha (tnf-α) and matrix metalloproteinase-3 (mmp-3) which drive cartilage degeneration and synovial inflammation. |
2019-11-06 |
2023-08-13 |
Not clear |
| Shan Song, Duojun Qiu, Fengwei Luo, Jinying Wei, Ming Wu, Haijiang Wu, Chunyang Du, Yunxia Du, Yunzhuo Ren, Nan Chen, Huijun Duan, Yonghong Sh. Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells Journal of molecular endocrinology. vol 61. issue 3. 2019-10-28. PMID:30307163. |
knockdown of nlrp3 alleviates high glucose or tgfb1-induced emt in human renal tubular cells tubular injury is one of the crucial determinants of progressive renal failure in diabetic nephropathy (dn), while epithelial-to-mesenchymal transition (emt) of tubular cells contributes to the accumulation of matrix protein in the diabetic kidney. |
2019-10-28 |
2023-08-13 |
human |
| John Henderson, Swati Bhattacharyya, John Varga, Steven O'Reill. Targeting TLRs and the inflammasome in systemic sclerosis. Pharmacology & therapeutics. vol 192. 2019-09-23. PMID:30081049. |
although still widely debated, significant evidence points to upregulation of the innate immune response via the activity of toll-like receptors (tlrs) and the nlrp3 inflammasome as the start points in a cascade of signaling events which drives excessive extracellular matrix protein production, causing fibrosis. |
2019-09-23 |
2023-08-13 |
Not clear |
| Xiaohui Bian, Xiaoxiao Su, Yanqiu Wang, Guifeng Zhao, Beiru Zhang, Detian L. Periostin contributes to renal and cardiac dysfunction in rats with chronic kidney disease: Reduction of PPARα. Biochimie. vol 160. 2019-07-08. PMID:30890453. |
postn knockdown inhibits the formation of nlrp3 inflammasome in rat myocardium.periostin (postn), an extracellular matrix protein, and peroxisome proliferator-activated receptor alpha (pparα), a ligand-activated nuclear transcription factor, are reported to be involved in renal and cardiac dysfunction associated with chronic kidney disease (ckd), respectively. |
2019-07-08 |
2023-08-13 |
rat |
| Yael Alippe, Chun Wang, Biancamaria Ricci, Jianqiu Xiao, Chao Qu, Wei Zou, Deborah V Novack, Yousef Abu-Amer, Roberto Civitelli, Gabriel Mbalaviel. Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation. Scientific reports. vol 7. issue 1. 2019-02-04. PMID:28747793. |
bone matrix components activate the nlrp3 inflammasome and promote osteoclast differentiation. |
2019-02-04 |
2023-08-13 |
mouse |
| Yael Alippe, Chun Wang, Biancamaria Ricci, Jianqiu Xiao, Chao Qu, Wei Zou, Deborah V Novack, Yousef Abu-Amer, Roberto Civitelli, Gabriel Mbalaviel. Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation. Scientific reports. vol 7. issue 1. 2019-02-04. PMID:28747793. |
the nlrp3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (damps), including those triggered by crystalline particulates or degradation products of extracellular matrix. |
2019-02-04 |
2023-08-13 |
mouse |
| Yael Alippe, Chun Wang, Biancamaria Ricci, Jianqiu Xiao, Chao Qu, Wei Zou, Deborah V Novack, Yousef Abu-Amer, Roberto Civitelli, Gabriel Mbalaviel. Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation. Scientific reports. vol 7. issue 1. 2019-02-04. PMID:28747793. |
since some damps confer tissue-specific activation of the inflammasomes, we tested the hypothesis that bone matrix components function as damps for the nlrp3 inflammasome and regulate osteoclast differentiation. |
2019-02-04 |
2023-08-13 |
mouse |
| Yael Alippe, Chun Wang, Biancamaria Ricci, Jianqiu Xiao, Chao Qu, Wei Zou, Deborah V Novack, Yousef Abu-Amer, Roberto Civitelli, Gabriel Mbalaviel. Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation. Scientific reports. vol 7. issue 1. 2019-02-04. PMID:28747793. |
thus, signals originating from bone matrix activate the nlrp3 inflammasome in the osteoclast lineage, and may represent a bone-restricted positive feedback mechanism that amplifies bone resorption in pathologic conditions of accelerated bone turnover. |
2019-02-04 |
2023-08-13 |
mouse |
| Dietmar Spengler, Supandi Winoto-Morbach, Sarah Kupsch, Christina Vock, Katharina Blöchle, Susanna Frank, Nele Rintz, Marie Diekötter, Harshavardhan Janga, Markus Weckmann, Sabine Fuchs, Andra B Schromm, Heinz Fehrenbach, Stefan Schütze, Martin F Kraus. Novel therapeutic roles for surfactant-inositols and -phosphatidylglycerols in a neonatal piglet ARDS model: a translational study. American journal of physiology. Lung cellular and molecular physiology. vol 314. issue 1. 2019-01-10. PMID:28860142. |
the inositol derivatives (mainly s+ip3) exerted their actions by suppressing acid sphingomyelinase activity and dependent ceramide production, linked with the suppression of the inflammasome nucleotide-binding domain, leucine-rich repeat-containing protein-3 (nlrp3)-apoptosis-associated speck-like protein containing a caspase recruitment domain (asc)-caspase-1 complex, and the profibrotic response represented by the cytokines transforming growth factor-β1 and ifn-γ, matrix metalloproteinase (mmp)-1/8, and elastin. |
2019-01-10 |
2023-08-13 |
Not clear |
| Xiaoguang Zhu, Jun Shi, Huicong L. Liquiritigenin attenuates high glucose-induced mesangial matrix accumulation, oxidative stress, and inflammation by suppression of the NF-κB and NLRP3 inflammasome pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-12-18. PMID:30119269. |
liquiritigenin attenuates high glucose-induced mesangial matrix accumulation, oxidative stress, and inflammation by suppression of the nf-κb and nlrp3 inflammasome pathways. |
2018-12-18 |
2023-08-13 |
Not clear |
| Chongfeng Bai, Tao Li, Qing Sun, Qun Xin, Tongyi Xu, Jinjian Yu, Yun Wang, Li We. Protective effect of baicalin against severe burn‑induced remote acute lung injury in rats. Molecular medicine reports. vol 17. issue 2. 2018-07-17. PMID:29207058. |
as a result, baicalin significantly suppressed nucleotide‑binding oligomerization, nacht, lrr and pyd domains‑containing protein 3 (nlrp3), caspase‑1, nuclear factor‑κb and matrix metalloproteinase‑9 protein expression in the rat model of ali. |
2018-07-17 |
2023-08-13 |
rat |
| Ana S Falcão, Luís A R Carvalho, Gonçalo Lidónio, Ana R Vaz, Susana D Lucas, Rui Moreira, Dora Brite. Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation. ACS chemical neuroscience. vol 8. issue 1. 2017-10-30. PMID:27797173. |
vs also suppressed aβ-induced expression of inflammatory mediators in microglia, such as matrix metalloproteinase (mmp)-2 and mmp-9, as well as high-mobility group box protein-1 (hmgb1), nod-like receptor protein 3 (nlrp3)-inflammasome, and interleukin (il)-1β. |
2017-10-30 |
2023-08-13 |
mouse |