| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yingjie Huang, Yan Peng, Jianchao Sun, Shuangxing Li, Junmin Hong, Jie Zhou, Jianchong Chen, Jiansen Yan, Zhengqi Huang, Xiaofei Wang, Weijian Chen, Wei Y. Nicotinamide Phosphoribosyl Transferase Controls NLRP3 Inflammasome Activity Through MAPK and NF-κB Signaling in Nucleus Pulposus Cells, as Suppressed by Melatonin. Inflammation. vol 43. issue 3. 2021-04-02. PMID:31900828. |
herein, real-time pcr, western blot analysis, and immunofluorescence staining experiments revealed that melatonin showed protective effects against tnf-α-induced matrix degradation by downregulating nampt and reducing nlrp3 inflammasome activity in np cells. |
2021-04-02 |
2023-08-13 |
Not clear |
| Yingjie Huang, Yan Peng, Jianchao Sun, Shuangxing Li, Junmin Hong, Jie Zhou, Jianchong Chen, Jiansen Yan, Zhengqi Huang, Xiaofei Wang, Weijian Chen, Wei Y. Nicotinamide Phosphoribosyl Transferase Controls NLRP3 Inflammasome Activity Through MAPK and NF-κB Signaling in Nucleus Pulposus Cells, as Suppressed by Melatonin. Inflammation. vol 43. issue 3. 2021-04-02. PMID:31900828. |
the current investigation verified that melatonin could alleviate matrix degradation induced by tnf-α by suppressing nampt and nlrp3 inflammasome activity. |
2021-04-02 |
2023-08-13 |
Not clear |
| Yingjie Huang, Yan Peng, Jianchao Sun, Shuangxing Li, Junmin Hong, Jie Zhou, Jianchong Chen, Jiansen Yan, Zhengqi Huang, Xiaofei Wang, Weijian Chen, Wei Y. Nicotinamide Phosphoribosyl Transferase Controls NLRP3 Inflammasome Activity Through MAPK and NF-κB Signaling in Nucleus Pulposus Cells, as Suppressed by Melatonin. Inflammation. vol 43. issue 3. 2021-04-02. PMID:31900828. |
moreover, nampt downregulation controlled the matrix degradation induced by tnf-α by suppressing nlrp3 inflammasome activity through mapk and nf-κb signaling in np cells. |
2021-04-02 |
2023-08-13 |
Not clear |
| Chengcong Wei, Shenquan Guo, Wenchao Liu, Fa Jin, Boyang Wei, Haiyan Fan, Hengxian Su, Jiahui Liu, Nan Zhang, Dazhao Fang, Guangxu Li, Shixing Shu, Xifeng Li, Xuying He, Xin Zhang, Chuanzhi Dua. Resolvin D1 ameliorates Inflammation-Mediated Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in rats by Modulating A20 and NLRP3 Inflammasome. Frontiers in pharmacology. vol 11. 2021-03-20. PMID:33732145. |
rvd1 treatment upregulated the expression of a20, occludin, claudin-5, and zona occludens-1, as well as downregulated nuclear factor-κbp65, nlrp3, matrix metallopeptidase 9, and intercellular cell adhesion molecule-1 expression. |
2021-03-20 |
2023-08-13 |
rat |
| Junmin Hong, Shuangxing Li, Dessislava Z Markova, Anjing Liang, Christopher K Kepler, Yingjie Huang, Jie Zhou, Jiansen Yan, Weijian Chen, Dongsheng Huang, Kang Xu, Wei Y. Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31975410. |
bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing nlrp3 inflammasome activity in np cells. |
2021-03-10 |
2023-08-13 |
human |
| Junmin Hong, Shuangxing Li, Dessislava Z Markova, Anjing Liang, Christopher K Kepler, Yingjie Huang, Jie Zhou, Jiansen Yan, Weijian Chen, Dongsheng Huang, Kang Xu, Wei Y. Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31975410. |
the present study aims to observe whether brd4 inhibition regulates matrix metabolism by controlling autophagy and nlrp3 inflammasome activity. |
2021-03-10 |
2023-08-13 |
human |
| Junmin Hong, Shuangxing Li, Dessislava Z Markova, Anjing Liang, Christopher K Kepler, Yingjie Huang, Jie Zhou, Jiansen Yan, Weijian Chen, Dongsheng Huang, Kang Xu, Wei Y. Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31975410. |
moreover, p65 knockdown or treatment with jq1 and bay11-7082 demonstrated that brd4 inhibition attenuated nlrp3 inflammasome activity through nf-κb signaling, while autophagy inhibition by bafilomycin a1 promoted matrix degradation and nlrp3 inflammasome activity in np cells. |
2021-03-10 |
2023-08-13 |
human |
| Junmin Hong, Shuangxing Li, Dessislava Z Markova, Anjing Liang, Christopher K Kepler, Yingjie Huang, Jie Zhou, Jiansen Yan, Weijian Chen, Dongsheng Huang, Kang Xu, Wei Y. Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31975410. |
simply, brd4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing nlrp3 inflammasome activity through nf-κb signaling in np cells. |
2021-03-10 |
2023-08-13 |
human |
| Ying Han, Hai-Jian Sun, Ying Tong, Yun-Zhi Chen, Chao Ye, Yun Qiu, Feng Zhang, Ai-Dong Chen, Xiao-Hong Qi, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zh. Curcumin attenuates migration of vascular smooth muscle cells via inhibiting NFκB-mediated NLRP3 expression in spontaneously hypertensive rats. The Journal of nutritional biochemistry. vol 72. 2020-11-04. PMID:31473513. |
intragastric administration of curcumin in shr attenuated hypertension and reduced nfκb activation, nlrp3 and matrix metalloproteinase-9 expressions and aortic media thickness. |
2020-11-04 |
2023-08-13 |
rat |
| Ava Faridi, Yunxiang Sun, Monika Mortimer, Ritchlynn R Aranha, Aparna Nandakumar, Yuhuan Li, Ibrahim Javed, Aleksandr Kakinen, Qingqing Fan, Anthony W Purcell, Thomas P Davis, Feng Ding, Pouya Faridi, Pu Chun K. Graphene quantum dots rescue protein dysregulation of pancreatic β-cells exposed to human islet amyloid polypeptide. Nano research. vol 12. issue 11. 2020-11-01. PMID:31695851. |
while iapp can activate the nlrp3 inflammasome and modulate cellular autophagy, apoptosis and extracellular matrix metabolism, no data is available concerning intracellular protein expression upon exposure to the polypeptide. |
2020-11-01 |
2023-08-13 |
human |
| Wen-Cao Liu, Xiaona Wang, Xinyu Zhang, Xi Chen, Xinchun Ji. Melatonin Supplementation, a Strategy to Prevent Neurological Diseases through Maintaining Integrity of Blood Brain Barrier in Old People. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:28596733. |
melatonin has been shown to preserves bbb integrity and permeability via a variety of pathways: inhibition of matrix metalloproteinase-9 (mmp-9), inhibition of nadph oxidase-2, and impact on silent information regulator 1 (sirt1) and nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (nlrp3) inflammasome. |
2020-10-01 |
2023-08-13 |
mouse |
| Gang Xu, Jian Wang, Long Ma, Xin Zhao, Wen Luo, Qunhua Ji. Local intra-articular injection of rapamycin inhibits NLRP3 activity and prevents osteoarthritis in mouse DMM models. Autoimmunity. vol 52. issue 4. 2020-05-14. PMID:31407595. |
the expression of oa associated biomarkers namely matrix metalloproteinase (mmp-13), nod-, lrr- and pyrin domain-containing 3 (nlrp3) induced by destabilizing the medial meniscus operation (dmm) were also investigated. |
2020-05-14 |
2023-08-13 |
mouse |
| Gurupreet S Sethi, Sukriti Sharma, Amarjit S Naur. PARP inhibition by olaparib alleviates chronic asthma-associated remodeling features via modulating inflammasome signaling in mice. IUBMB life. vol 71. issue 7. 2020-04-16. PMID:30964965. |
interestingly, the protection offered by olaparib was further linked with the altered level of nlrp3 inflammasome-mediated il-1β release and consequent expression of its downstream targets matrix metalloproteinase-9 and transforming growth factor beta. |
2020-04-16 |
2023-08-13 |
mouse |
| Bria M Coates, Kelly L Staricha, Nandini Ravindran, Clarissa M Koch, Yuan Cheng, Jennifer M Davis, Dale K Shumaker, Karen M Ridg. Inhibition of the NOD-Like Receptor Protein 3 Inflammasome Is Protective in Juvenile Influenza A Virus Infection. Frontiers in immunology. vol 8. 2019-11-20. PMID:28740490. |
the iav matrix 2 proton channel (m2) has been shown to be an important activator of the nlrp3 inflammasome during iav infection. |
2019-11-20 |
2023-08-13 |
mouse |
| Lu Chen, Qian You, Liang Hu, Jian Gao, Qianqian Meng, Wentao Liu, Xuefeng Wu, Qiang X. The Antioxidant Procyanidin Reduces Reactive Oxygen Species Signaling in Macrophages and Ameliorates Experimental Colitis in Mice. Frontiers in immunology. vol 8. 2019-11-20. PMID:29354126. |
some inflammatory conditions, such as matrix metalloproteinases (mmps) and the nuclear factor-κb (nf-κb) and nod-like receptor protein 3 (nlrp3) inflammasome signaling pathways, are reported to contribute to the development and maintenance of ibd. |
2019-11-20 |
2023-08-13 |
mouse |
| M J McAllister, M Chemaly, A J Eakin, D S Gibson, V E McGilliga. NLRP3 as a potentially novel biomarker for the management of osteoarthritis. Osteoarthritis and cartilage. vol 26. issue 5. 2019-11-06. PMID:29499288. |
the nucleotide-binding and oligomerization domain-like receptor containing protein 3 (nlrp3) inflammasome has been implicated in the pathogenesis of a number of arthritic disorders, producing proinflammatory cytokines and degradative enzymes such as interleukin-1 beta (il-1β), tumour necrosis factor alpha (tnf-α) and matrix metalloproteinase-3 (mmp-3) which drive cartilage degeneration and synovial inflammation. |
2019-11-06 |
2023-08-13 |
Not clear |
| Shan Song, Duojun Qiu, Fengwei Luo, Jinying Wei, Ming Wu, Haijiang Wu, Chunyang Du, Yunxia Du, Yunzhuo Ren, Nan Chen, Huijun Duan, Yonghong Sh. Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells Journal of molecular endocrinology. vol 61. issue 3. 2019-10-28. PMID:30307163. |
knockdown of nlrp3 alleviates high glucose or tgfb1-induced emt in human renal tubular cells tubular injury is one of the crucial determinants of progressive renal failure in diabetic nephropathy (dn), while epithelial-to-mesenchymal transition (emt) of tubular cells contributes to the accumulation of matrix protein in the diabetic kidney. |
2019-10-28 |
2023-08-13 |
human |
| John Henderson, Swati Bhattacharyya, John Varga, Steven O'Reill. Targeting TLRs and the inflammasome in systemic sclerosis. Pharmacology & therapeutics. vol 192. 2019-09-23. PMID:30081049. |
although still widely debated, significant evidence points to upregulation of the innate immune response via the activity of toll-like receptors (tlrs) and the nlrp3 inflammasome as the start points in a cascade of signaling events which drives excessive extracellular matrix protein production, causing fibrosis. |
2019-09-23 |
2023-08-13 |
Not clear |
| Xiaohui Bian, Xiaoxiao Su, Yanqiu Wang, Guifeng Zhao, Beiru Zhang, Detian L. Periostin contributes to renal and cardiac dysfunction in rats with chronic kidney disease: Reduction of PPARα. Biochimie. vol 160. 2019-07-08. PMID:30890453. |
postn knockdown inhibits the formation of nlrp3 inflammasome in rat myocardium.periostin (postn), an extracellular matrix protein, and peroxisome proliferator-activated receptor alpha (pparα), a ligand-activated nuclear transcription factor, are reported to be involved in renal and cardiac dysfunction associated with chronic kidney disease (ckd), respectively. |
2019-07-08 |
2023-08-13 |
rat |
| Yael Alippe, Chun Wang, Biancamaria Ricci, Jianqiu Xiao, Chao Qu, Wei Zou, Deborah V Novack, Yousef Abu-Amer, Roberto Civitelli, Gabriel Mbalaviel. Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation. Scientific reports. vol 7. issue 1. 2019-02-04. PMID:28747793. |
bone matrix components activate the nlrp3 inflammasome and promote osteoclast differentiation. |
2019-02-04 |
2023-08-13 |
mouse |