| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Niki Antypa, Alessandro Serretti, Dan Rujesc. Serotonergic genes and suicide: a systematic review. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 10. 2014-04-24. PMID:23742855. |
in this paper, we review evidence from studies examining the association between various serotonergic genes (tryptophan hydroxylase genes: tph1; tph2, serotonin transporter gene: 5-httlpr in slc6a4, serotonin receptor genes: htr1a, htr2a, htr1b, htr2c and monoamine oxidase a gene: maoa) and suicidal behavior. |
2014-04-24 |
2023-08-12 |
Not clear |
| Raffaella Calati, Florence Gressier, Martina Balestri, Alessandro Serrett. Genetic modulation of borderline personality disorder: systematic review and meta-analysis. Journal of psychiatric research. vol 47. issue 10. 2014-04-04. PMID:23810197. |
meta-analyses were performed for three serotonergic polymorphisms: two common polymorphisms of the serotonin transporter gene (slc6a4), the promoter insertion/deletion (5-httlpr) and the intron 2 vntr (stin2 vntr), and the rs1800532 (a218c) polymorphism of the tryptophan hydroxylase 1 gene (tph1), all showing no association. |
2014-04-04 |
2023-08-12 |
Not clear |
| Richard Musil, Peter Zill, Florian Seemüller, Brigitta Bondy, Sebastian Meyer, Ilja Spellmann, Wolfram Bender, Mazda Adli, Isabella Heuser, Robert Fisher, Wolfgang Gaebel, Wolfgang Maier, Marcella Rietschel, Dan Rujescu, Rebecca Schennach, Hans-Jürgen Möller, Michael Riede. Genetics of emergent suicidality during antidepressive treatment--data from a naturalistic study on a large sample of inpatients with a major depressive episode. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 7. 2014-01-23. PMID:23063133. |
common polymorphisms involved in the tryptophan hydroxylase 1 (tph1) and 2 (tph2), serotonin transporter, monoamine oxidase a (maoa) and brain-derived neurotrophic factor (bdnf) were investigated in a naturalistic inpatient study of the german research network on depression. |
2014-01-23 |
2023-08-12 |
Not clear |
| Helmut Grasberger, Lin Chang, Wendy Shih, Angela P Presson, Gregory S Sayuk, Rodney D Newberry, Iordanis Karagiannides, Charalabos Pothoulakis, Emeran Mayer, Juanita L Merchan. Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes. The American journal of gastroenterology. vol 108. issue 11. 2013-12-30. PMID:24060757. |
tryptophan hydroxylase 1 (tph1) is the rate-limiting enzyme in enterochromaffin cell 5-ht biosynthesis. |
2013-12-30 |
2023-08-12 |
Not clear |
| Helmut Grasberger, Lin Chang, Wendy Shih, Angela P Presson, Gregory S Sayuk, Rodney D Newberry, Iordanis Karagiannides, Charalabos Pothoulakis, Emeran Mayer, Juanita L Merchan. Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes. The American journal of gastroenterology. vol 108. issue 11. 2013-12-30. PMID:24060757. |
we hypothesized that genetic variants affecting tph1 gene expression might alter intestinal 5-ht bioavailability and subsequently the propensity for distinct bowel habit subtypes in ibs. |
2013-12-30 |
2023-08-12 |
Not clear |
| Eveline Boudin, Karen Jennes, Fenna de Freitas, David Tegay, Geert Mortier, Wim Van Hu. No mutations in the serotonin related TPH1 and HTR1B genes in patients with monogenic sclerosing bone disorders. Bone. vol 55. issue 1. 2013-11-25. PMID:23563356. |
no mutations in the serotonin related tph1 and htr1b genes in patients with monogenic sclerosing bone disorders. |
2013-11-25 |
2023-08-12 |
mouse |
| Eveline Boudin, Karen Jennes, Fenna de Freitas, David Tegay, Geert Mortier, Wim Van Hu. No mutations in the serotonin related TPH1 and HTR1B genes in patients with monogenic sclerosing bone disorders. Bone. vol 55. issue 1. 2013-11-25. PMID:23563356. |
gene expression studies showed that mice lacking lrp5 have increased expression of tph1, the rate limiting enzyme for the production of serotonin in the gut. |
2013-11-25 |
2023-08-12 |
mouse |
| Eveline Boudin, Karen Jennes, Fenna de Freitas, David Tegay, Geert Mortier, Wim Van Hu. No mutations in the serotonin related TPH1 and HTR1B genes in patients with monogenic sclerosing bone disorders. Bone. vol 55. issue 1. 2013-11-25. PMID:23563356. |
furthermore mice lacking either tph1 or htr1b, the receptor for serotonin on the osteoblasts, were reported to have an increased bone mass due to increased bone formation. |
2013-11-25 |
2023-08-12 |
mouse |
| Of Khabour, Bh Amarneh, Ea Bani Hani, Im Lataife. Associations Between Variations in TPH1 , TPH2 and SLC6A4 Genes and Postpartum Depression: A Study in the Jordanian Population. Balkan journal of medical genetics : BJMG. vol 16. issue 1. 2013-11-22. PMID:24265583. |
in this study, we investigated the association between tryptophan hydroxylase-1 (tph1 ) (218a>c), tryptophan hydroxylase-2 ( tph2 ) (1463g>a) and serotonin carrier family 6, member 4 (slc6a4) [long (l) vs. short (s)] gene polymorphisms with post-partum depression (ppd) in women from jordan. |
2013-11-22 |
2023-08-12 |
Not clear |
| Georgette L Suidan, Daniel Duerschmied, Gregory M Dillon, Veronique Vanderhorst, Thomas G Hampton, Siu Ling Wong, Jaymie R Voorhees, Denisa D Wagne. Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities. PloS one. vol 8. issue 3. 2013-11-01. PMID:23516593. |
tryptophan hydroxylase-1 (tph1) is expressed by non-neuronal cells including enterochromaffin cells of the gut, mast cells and the pineal gland and is the rate-limiting enzyme involved in the biosynthesis of peripheral serotonin. |
2013-11-01 |
2023-08-12 |
mouse |
| Michael D Gersho. Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense. Transactions of the American Clinical and Climatological Association. vol 123. 2013-07-01. PMID:23303993. |
surprisingly, deletion of tryptophan hydroxylase-1 (tph1), upon which 5-ht biosynthesis in ec cells depends, does not alter constitutive gi motility, whereas deletion of tph2, upon which biosynthesis of neuronal 5-ht depends, slows intestinal transit and accelerates gastric emptying. |
2013-07-01 |
2023-08-12 |
mouse |
| Michael D Gersho. Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense. Transactions of the American Clinical and Climatological Association. vol 123. 2013-07-01. PMID:23303993. |
tph1 deletion, however, protects mice from experimental inflammation; 5-ht potentiation and tph2 deletion each make inflammation more severe. |
2013-07-01 |
2023-08-12 |
mouse |
| Francisco Jiménez-Trejo, Miguel Tapia-Rodríguez, Marco Cerbón, Donald M Kuhn, Gabriel Manjarrez-Gutiérrez, C Adriana Mendoza-Rodríguez, Ofir Picaz. Evidence of 5-HT components in human sperm: implications for protein tyrosine phosphorylation and the physiology of motility. Reproduction (Cambridge, England). vol 144. issue 6. 2013-04-26. PMID:23028123. |
we used both immunocytochemistry and western blot to detect serotoninergic markers such as 5-ht, tph1, mao(a), 5-ht(1b), 5-ht(3), and 5ht(t); hplc for tph enzymatic activity; computer assisted semen analysis assays to measure sperm motility parameters and pharmacological approaches to show the effect of 5-ht in sperm motility and tyrosine phosphorylation was assessed by western blot. |
2013-04-26 |
2023-08-12 |
human |
| Francisco Jiménez-Trejo, Miguel Tapia-Rodríguez, Marco Cerbón, Donald M Kuhn, Gabriel Manjarrez-Gutiérrez, C Adriana Mendoza-Rodríguez, Ofir Picaz. Evidence of 5-HT components in human sperm: implications for protein tyrosine phosphorylation and the physiology of motility. Reproduction (Cambridge, England). vol 144. issue 6. 2013-04-26. PMID:23028123. |
we found the presence of serotoninergic markers (5-ht, tph1, mao(a), 5-ht(1b), 5-ht(2a), 5-ht(3), 5-ht(t), and tph enzymatic activity) in human sperm. |
2013-04-26 |
2023-08-12 |
human |
| Daniel Duerschmied, Georgette L Suidan, Melanie Demers, Nadine Herr, Carla Carbo, Alexander Brill, Stephen M Cifuni, Maximilian Mauler, Sanja Cicko, Michael Bader, Marco Idzko, Christoph Bode, Denisa D Wagne. Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice. Blood. vol 121. issue 6. 2013-04-05. PMID:23243271. |
stimulation of endothelium with histamine, a secretagogue of wpbs, or injection of serotonin normalized the rolling in tph1(-/-) mice. |
2013-04-05 |
2023-08-12 |
mouse |
| Daniel Duerschmied, Georgette L Suidan, Melanie Demers, Nadine Herr, Carla Carbo, Alexander Brill, Stephen M Cifuni, Maximilian Mauler, Sanja Cicko, Michael Bader, Marco Idzko, Christoph Bode, Denisa D Wagne. Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice. Blood. vol 121. issue 6. 2013-04-05. PMID:23243271. |
four hours after inflammatory stimulation, neutrophil extravasation into lung, peritoneum, and skin wounds was reduced in tph1(-/-) mice, whereas in vitro neutrophil chemotaxis was independent of serotonin. |
2013-04-05 |
2023-08-12 |
mouse |
| Gabriel Manjarrez-Gutiérrez, Karina Martínez-Radilla, Alfonso Boyzo-Montes de Oca, Sandra Orozco-Suárez, Jorge Hernández-Rodrígue. Increased expression of tryptophan-5-hydroxylase 1, but not 2, in brainstem as a result of intrauterine malnutrition. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 6. 2013-02-05. PMID:22819790. |
it was confirmed that ium produces an increase in 5-ht in the brainstem and also showed increased expression of tph1 at birth, with decreased expression of tph2. |
2013-02-05 |
2023-08-12 |
Not clear |
| Gabriel Manjarrez-Gutiérrez, Karina Martínez-Radilla, Alfonso Boyzo-Montes de Oca, Sandra Orozco-Suárez, Jorge Hernández-Rodrígue. Increased expression of tryptophan-5-hydroxylase 1, but not 2, in brainstem as a result of intrauterine malnutrition. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 6. 2013-02-05. PMID:22819790. |
these findings together allow us to propose that chronic elevation of synthesis of 5-ht observed in the brain of the offspring with ium is probably due to a change in the expression and activity of tph1 induced from fetal life. |
2013-02-05 |
2023-08-12 |
Not clear |
| Armen K Goenjian, Julia N Bailey, David P Walling, Alan M Steinberg, Devon Schmidt, Uma Dandekar, Ernest P Nobl. Association of TPH1, TPH2, and 5HTTLPR with PTSD and depressive symptoms. Journal of affective disorders. vol 140. issue 3. 2013-01-31. PMID:22483952. |
to examine the potential contribution of the serotonin hydroxylase (tph1 and tph2) genes, and the serotonin transporter promoter polymorphism (5httlpr) to the unique and pleiotropic risk of ptsd symptoms and depressive symptoms. |
2013-01-31 |
2023-08-12 |
Not clear |
| Ian Morecroft, Katie White, Paola Caruso, Margaret Nilsen, Lynn Loughlin, Raul Alba, Paul N Reynolds, Sergei M Danilov, Andrew H Baker, Margaret R Maclea. Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension. Molecular therapy : the journal of the American Society of Gene Therapy. vol 20. issue 8. 2013-01-11. PMID:22525513. |
serotonin is produced by pulmonary arterial endothelial cells (paec) via tryptophan hydroxylase-1 (tph1). |
2013-01-11 |
2023-08-12 |
human |