| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Térèse A Johansson, Gunnar Westin, Britt Skogsei. Identification of Achaete-scute complex-like 1 (ASCL1) target genes and evaluation of DKK1 and TPH1 expression in pancreatic endocrine tumours. BMC cancer. vol 9. 2009-12-02. PMID:19744316. |
notch signalling regulates expression of tph1, the rate limiting enzyme in the biosynthesis of serotonin. |
2009-12-02 |
2023-08-12 |
Not clear |
| B-T Lee, H-Y Lee, B-C Lee, C-U Pae, B-J Yoon, S-G Ryu, I-G Choi, M-S Lee, B-J Ha. Impact of the tryptophan hydroxylase 1 gene A218C polymorphism on amygdala activity in response to affective facial stimuli in patients with major depressive disorder. Genes, brain, and behavior. vol 8. issue 5. 2009-11-10. PMID:19500158. |
tryptophan hydroxylase-1 (tph1) is the rate-limiting enzyme in serotonin biosynthesis, and allelic variations at the tph1 locus have been implicated in the pathophysiology of depression. |
2009-11-10 |
2023-08-12 |
human |
| Ari Illi, Eija Setälä-Soikkeli, Merja Viikki, Outi Poutanen, Heini Huhtala, Nina Mononen, Terho Lehtimäki, Esa Leinonen, Olli Kampma. 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression. Neuroreport. vol 20. issue 12. 2009-09-29. PMID:19590397. |
in this study, we evaluated the association of seven serotonin signal transduction-linked single nucleotide polymorphisms [htr1a (rs6295), htr2a (rs6313, rs6311 and rs7997012), htr6 (rs1805054), tph1 (rs1800532) and tph2 (rs1386494)] with major depressive disorder and/or treatment outcome with serotonin reuptake inhibitors. |
2009-09-29 |
2023-08-12 |
Not clear |
| Anna Secher, Jens Bukh, Camilla Bock, Pernille Koefoed, Henrik Berg Rasmussen, Thomas Werge, Lars Vedel Kessing, Erling Melleru. Antidepressive-drug-induced bodyweight gain is associated with polymorphisms in genes coding for COMT and TPH1. International clinical psychopharmacology. vol 24. issue 4. 2009-09-15. PMID:19474754. |
polymorphisms in catechol-o-methyltransferase, tryptophan hydroxylase (tph1), serotonin receptor 2c (htr2c) and serotonin transporter (slc6a4) genes were identified and associated with bodyweight gain during treatment. |
2009-09-15 |
2023-08-12 |
human |
| Michał A Zmijewski, Trevor W Sweatman, Andrzej T Slominsk. The melatonin-producing system is fully functional in retinal pigment epithelium (ARPE-19). Molecular and cellular endocrinology. vol 307. issue 1-2. 2009-08-28. PMID:19409957. |
tph1 and aanat proteins were detected in arpe by western blotting, while sequential metabolism of tryptophan, serotonin and n-acetylserotonin to melatonin was shown by rp-hplc. |
2009-08-28 |
2023-08-12 |
human |
| Arun K Tiwari, Renan P Souza, Daniel J Mülle. Pharmacogenetics of anxiolytic drugs. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 6. 2009-08-18. PMID:19434367. |
other significant findings pointed to the serotonin 2a (5-ht2a) receptor and to the tryptophan hydroxylase (tph1) genes. |
2009-08-18 |
2023-08-12 |
Not clear |
| Margaret R MacLean, Yvonne Dempsi. Serotonin and pulmonary hypertension--from bench to bedside? Current opinion in pharmacology. vol 9. issue 3. 2009-08-04. PMID:19286424. |
the rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (tph1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (sert) and serotonin can induce pulmonary vasoconstriction via the 5-ht1b receptor in man. |
2009-08-04 |
2023-08-12 |
Not clear |
| b' Liisa T Ukkola, P\\xc3\\xa4ivi Onkamo, Pirre Raijas, Kai Karma, Irma J\\xc3\\xa4rvel\\xc3\\xa. Musical aptitude is associated with AVPR1A-haplotypes. PloS one. vol 4. issue 5. 2009-07-20. PMID:19461995.' |
in order to understand the neurobiological basis of music in human evolution and communication we analyzed polymorphisms of the arginine vasopressin receptor 1a (avpr1a), serotonin transporter (slc6a4), catecol-o-methyltranferase (comt), dopamin receptor d2 (drd2) and tyrosine hydroxylase 1 (tph1), genes associated with social bonding and cognitive functions in 19 finnish families (n = 343 members) with professional musicians and/or active amateurs. |
2009-07-20 |
2023-08-12 |
human |
| Natalia Alenina, Dana Kikic, Mihail Todiras, Valentina Mosienko, Fatimunnisa Qadri, Ralph Plehm, Philipp Boyé, Larissa Vilianovitch, Reinhard Sohr, Katja Tenner, Heide Hörtnagl, Michael Bade. Growth retardation and altered autonomic control in mice lacking brain serotonin. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 25. 2009-07-17. PMID:19520831. |
serotonin synthesis in mammals is initiated by 2 distinct tryptophan hydroxylases (tph), tph1 and tph2. |
2009-07-17 |
2023-08-12 |
mouse |
| B I Gustafsson, L Thommesen, A K Stunes, K Tommeras, I Westbroek, H L Waldum, K Slørdahl, M V Tamburstuen, J E Reseland, U Syverse. Serotonin and fluoxetine modulate bone cell function in vitro. Journal of cellular biochemistry. vol 98. issue 1. 2009-05-29. PMID:16408289. |
rt-pcr on the human osteoclasts demonstrated several serotonin receptors, the serotonin transporter, and the rate-limiting enzyme in serotonin synthesis, tryptophan hydroxylase 1 (tph1). |
2009-05-29 |
2023-08-12 |
human |
| B I Gustafsson, L Thommesen, A K Stunes, K Tommeras, I Westbroek, H L Waldum, K Slørdahl, M V Tamburstuen, J E Reseland, U Syverse. Serotonin and fluoxetine modulate bone cell function in vitro. Journal of cellular biochemistry. vol 98. issue 1. 2009-05-29. PMID:16408289. |
tph1 expression was also found in murine osteoblasts and osteoclasts, indicating an ability to produce serotonin. |
2009-05-29 |
2023-08-12 |
human |
| Lise Gutknecht, Claudia Kriegebaum, Jonas Waider, Angelika Schmitt, Klaus-Peter Lesc. Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 4. 2009-05-20. PMID:19181488. |
in support of tph2 specificity in brain 5-ht synthesis, raphe neurons of tph2 knockout mice were completely devoid of 5-ht, with no compensatory activation of tph1 expression. |
2009-05-20 |
2023-08-12 |
mouse |
| Sirilak Disatian, E Christopher Orto. Autocrine serotonin and transforming growth factor beta 1 signaling mediates spontaneous myxomatous mitral valve disease. The Journal of heart valve disease. vol 18. issue 1. 2009-04-30. PMID:19301552. |
tryptophan hydroxylase 1 (tph1) is the limiting enzyme for peripheral serotonin synthesis, and its expression in myxomatous valves could implicate an autocrine serotonin signaling mechanism. |
2009-04-30 |
2023-08-12 |
Not clear |
| Eric J Peters, Susan L Slager, Greg D Jenkins, Megan S Reinalda, Holly A Garriock, Stanley I Shyn, Jeffrey B Kraft, Patrick J McGrath, Steven P Hamilto. Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response. Pharmacogenetics and genomics. vol 19. issue 1. 2009-03-03. PMID:19077664. |
here, we attempt to expand upon and replicate these results by (i) resequencing the exonic and putatively regulatory regions of five serotonin-related candidate genes (htr1a, htr2a, tph1, tph2, and maoa) in our fluoxetine-treated sample to uncover novel variants; (ii) selecting tagging single nucleotide polymorphisms (snps) for these genes from the resequencing data; and (iii) evaluating these tagging snps for association with response to the selective serotonin reuptake inhibitor citalopram in an independent sample of participants who are enrolled in the sequenced treatment alternatives to relieve depression (star*d) clinical study (n=1953). |
2009-03-03 |
2023-08-12 |
human |
| b' Sean P David, Elaine C Johnstone, Michael F G Murphy, Paul Aveyard, Boliang Guo, Caryn Lerman, Marcus R Munaf\\xc3\\xb. Genetic variation in the serotonin pathway and smoking cessation with nicotine replacement therapy: new data from the Patch in Practice trial and pooled analyses. Drug and alcohol dependence. vol 98. issue 1-2. 2009-01-23. PMID:18562131.' |
therefore, 792 cigarette smokers from the patch in practice trial were genotyped for the tryptophan hydroxylase (tph1 a779c), serotonin transporter (slc6a45-httlpr), and 5-ht1a (htr1a c-1019g) polymorphisms. |
2009-01-23 |
2023-08-12 |
Not clear |
| Fumihiro Kaneko, Koji Masuda, Yukari Takeuchi, Yuji Mor. Identifying novel polymorphisms in the canine tryptophan hydroxylase 2 gene. The Journal of veterinary medical science. vol 70. issue 10. 2009-01-08. PMID:18981671. |
tryptophan hydroxylase (tph) serves as the rate-limiting enzyme in the biosynthesis of serotonin, and two forms of tph genes, tph1 and tph2, have been reported with specific nucleotide sequences and expression patterns. |
2009-01-08 |
2023-08-12 |
Not clear |
| William H J Norton, Anja Folchert, Laure Bally-Cui. Comparative analysis of serotonin receptor (HTR1A/HTR1B families) and transporter (slc6a4a/b) gene expression in the zebrafish brain. The Journal of comparative neurology. vol 511. issue 4. 2008-12-30. PMID:18839395. |
in cells in which 5-ht is synthesized by tph1, slc6a4b is used for re-uptake, whereas tph2-positive cells utilize slc6a4a. |
2008-12-30 |
2023-08-12 |
zebrafish |
| Zheping Huang, Tiecheng Liu, Asamanja Chattoraj, Samreen Ahmed, Michael M Wang, Jie Deng, Xing Sun, Jimo Borjigi. Posttranslational regulation of TPH1 is responsible for the nightly surge of 5-HT output in the rat pineal gland. Journal of pineal research. vol 45. issue 4. 2008-12-24. PMID:18705647. |
posttranslational regulation of tph1 is responsible for the nightly surge of 5-ht output in the rat pineal gland. |
2008-12-24 |
2023-08-12 |
rat |
| Zheping Huang, Tiecheng Liu, Asamanja Chattoraj, Samreen Ahmed, Michael M Wang, Jie Deng, Xing Sun, Jimo Borjigi. Posttranslational regulation of TPH1 is responsible for the nightly surge of 5-HT output in the rat pineal gland. Journal of pineal research. vol 45. issue 4. 2008-12-24. PMID:18705647. |
the synthesis of 5-ht in the pineal gland is rate limited by tryptophan hydroxylase 1 (tph1) whose activity displays a twofold increase at night. |
2008-12-24 |
2023-08-12 |
rat |
| Zheping Huang, Tiecheng Liu, Asamanja Chattoraj, Samreen Ahmed, Michael M Wang, Jie Deng, Xing Sun, Jimo Borjigi. Posttranslational regulation of TPH1 is responsible for the nightly surge of 5-HT output in the rat pineal gland. Journal of pineal research. vol 45. issue 4. 2008-12-24. PMID:18705647. |
in this study, we report that (a) 5-ht total output from the pineal gland and tph1 protein levels both display diurnal rhythms with a twofold increase at night; (b) stimulation of camp signaling elevates 5-ht output in vivo; (c) 5-ht total output and tph1 protein content in rat pineal gland are both acutely inhibited by light exposure at night. |
2008-12-24 |
2023-08-12 |
rat |