| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Salina Gairhe, Natalie N Bauer, Sarah A Gebb, Ivan F McMurtr. Serotonin passes through myoendothelial gap junctions to promote pulmonary arterial smooth muscle cell differentiation. American journal of physiology. Lung cellular and molecular physiology. vol 303. issue 9. 2013-01-03. PMID:22923644. |
inhibition of serotonin synthesis pharmacologically or by small interfering rnas to tph1 in paecs inhibited the paec-induced activation of tgf-β signaling and differentiation of pasmcs. |
2013-01-03 |
2023-08-12 |
rat |
| Dante Cicchetti, Fred A Rogosch, Eric L Thibodea. The effects of child maltreatment on early signs of antisocial behavior: genetic moderation by tryptophan hydroxylase, serotonin transporter, and monoamine oxidase A genes. Development and psychopathology. vol 24. issue 3. 2012-12-04. PMID:22781862. |
variants in three genes were examined: tryptophan hydroxylase 1 (tph1), serotonin transporter linked polymorphic region (5-httlpr), and monoamine oxidase a (maoa) upstream variable number tandem repeat. |
2012-12-04 |
2023-08-12 |
Not clear |
| Jae-Hwi Jang, Andreas Rickenbacher, Bostjan Humar, Achim Weber, Dimitri Aristotle Raptis, Kuno Lehmann, Bruno Stieger, Wolfgang Moritz, Christopher Soll, Panco Georgiev, David Fischer, Endre Laczko, Rolf Graf, Pierre-Alain Clavie. Serotonin protects mouse liver from cholestatic injury by decreasing bile salt pool after bile duct ligation. Hepatology (Baltimore, Md.). vol 56. issue 1. 2012-10-17. PMID:22290718. |
we induced cholestasis by ligation of the bile duct (bdl) in either wild-type (wt) mice or mice lacking peripheral serotonin (tph1(-/-) and immune thrombocytopenic [itp] mice). |
2012-10-17 |
2023-08-12 |
mouse |
| Jae-Hwi Jang, Andreas Rickenbacher, Bostjan Humar, Achim Weber, Dimitri Aristotle Raptis, Kuno Lehmann, Bruno Stieger, Wolfgang Moritz, Christopher Soll, Panco Georgiev, David Fischer, Endre Laczko, Rolf Graf, Pierre-Alain Clavie. Serotonin protects mouse liver from cholestatic injury by decreasing bile salt pool after bile duct ligation. Hepatology (Baltimore, Md.). vol 56. issue 1. 2012-10-17. PMID:22290718. |
serotonin reloading of tph1(-/-) mice reversed this phenotype, resulting in a reduction of circulating bile salts and liver injury. |
2012-10-17 |
2023-08-12 |
mouse |
| Carla M R Lacerda, Holly B Maclea, John D Kisiday, E Christopher Orto. Static and cyclic tensile strain induce myxomatous effector proteins and serotonin in canine mitral valves. Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology. vol 14. issue 1. 2012-09-25. PMID:22364693. |
we also explored whether tensile strain could induce the serotonin synthetic enzyme tryptophan hydroxylase 1 (tph1), serotonin synthesis, and markers of chondrogenesis. |
2012-09-25 |
2023-08-12 |
Not clear |
| Carla M R Lacerda, John Kisiday, Brennan Johnson, E Christopher Orto. Local serotonin mediates cyclic strain-induced phenotype transformation, matrix degradation, and glycosaminoglycan synthesis in cultured sheep mitral valves. American journal of physiology. Heart and circulatory physiology. vol 302. issue 10. 2012-07-26. PMID:22345569. |
expression of the serotonin synthetic enzyme tryptophan hydroxylase 1 (tph1) increased in strained mitral valves. |
2012-07-26 |
2023-08-12 |
Not clear |
| Carla M R Lacerda, John Kisiday, Brennan Johnson, E Christopher Orto. Local serotonin mediates cyclic strain-induced phenotype transformation, matrix degradation, and glycosaminoglycan synthesis in cultured sheep mitral valves. American journal of physiology. Heart and circulatory physiology. vol 302. issue 10. 2012-07-26. PMID:22345569. |
pharmacologic inhibition of the serotonin 2b/2c receptor or tph1 diminished expression of phenotype markers (α-sma and smemb) and matrix catabolic enzyme (mmp1, mmp13, and cathepsin k) expression in 10- and 30%-strained mitral valves. |
2012-07-26 |
2023-08-12 |
Not clear |
| Laura L Hernandez, Bernadette E Grayson, Ekta Yadav, Randy J Seeley, Nelson D Horsema. High fat diet alters lactation outcomes: possible involvement of inflammatory and serotonergic pathways. PloS one. vol 7. issue 3. 2012-07-09. PMID:22403677. |
expression of tryptophan hydroxylase 1 (tph1), the rate-limiting enzyme in serotonin (5-ht) biosynthesis, and the 5-ht(7) receptor (htr7), which regulates mammary gland involution, were significantly increased in mammary glands of hfd animals. |
2012-07-09 |
2023-08-12 |
rat |
| A Chin, B Svejda, B I Gustafsson, A B Granlund, A K Sandvik, A Timberlake, B Sumpio, R Pfragner, I M Modlin, M Kid. The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion. American journal of physiology. Gastrointestinal and liver physiology. vol 302. issue 3. 2012-04-23. PMID:22038827. |
mechanical stimulation using a rhythmic flex model induced transcription and activation of tph1 (tryptophan hydroxylase) and vmat₁ (vesicular monoamine transporter 1) and the release of 5-ht, which could be inhibited by mrs1754 and amplified by neca. |
2012-04-23 |
2023-08-12 |
human |
| Soo Heon Kwak, Byoung Lae Park, Hail Kim, Michael S German, Min Jin Go, Hye Seung Jung, Bo Kyong Koo, Young Min Cho, Sung Hee Choi, Yoon Shin Cho, Hyoung Doo Shin, Hak C Jang, Kyong Soo Par. Association of variations in TPH1 and HTR2B with gestational weight gain and measures of obesity. Obesity (Silver Spring, Md.). vol 20. issue 1. 2012-04-12. PMID:21836641. |
recently, it has been reported that 5-hydroxytryptamine receptor 2b (htr2b) and tryptophan hydroxylase 1 (tph1) play major role in β-cell proliferation in mouse during pregnancy. |
2012-04-12 |
2023-08-12 |
mouse |
| R Asghari, M S Y Lung, P M Pilowsky, M Conno. Sex differences in the expression of serotonin-synthesizing enzymes in mouse trigeminal ganglia. Neuroscience. vol 199. 2012-04-06. PMID:22056601. |
the trigeminal ganglion (tg) has been proposed as a site for 5-ht synthesis based on the expression of the rate limiting enzyme in peripheral 5-ht synthesis, tryptophan hydroxylase 1 (tph1), in female rodent trigeminal ganglia. |
2012-04-06 |
2023-08-12 |
mouse |
| R Asghari, M S Y Lung, P M Pilowsky, M Conno. Sex differences in the expression of serotonin-synthesizing enzymes in mouse trigeminal ganglia. Neuroscience. vol 199. 2012-04-06. PMID:22056601. |
c57/bl6 mice of both sexes expressed tph1 and aromatic amino acid decarboxylase (aadc), the key enzymes involved in 5-ht synthesis. |
2012-04-06 |
2023-08-12 |
mouse |
| Se Joo Kim, Jee In Kang, Kee Namkoong, Dong-Ho Son. The effects of serotonin transporter promoter and monoamine oxidase A gene polymorphisms on trait emotional intelligence. Neuropsychobiology. vol 64. issue 4. 2012-01-20. PMID:21912191. |
the purpose of this study was to evaluate the influences of major serotonin-related genetic variants of the serotonin transporter-linked promoter region (5-httlpr), tryptophan hydroxylase 1 gene (tph1) and monoamine oxidase a gene (maoa-ecorv) on trait emotional intelligence (ei). |
2012-01-20 |
2023-08-12 |
Not clear |
| Sara Trowbridge, Nicolas Narboux-Nême, Patricia Gaspa. Genetic models of serotonin (5-HT) depletion: what do they tell us about the developmental role of 5-HT? Anatomical record (Hoboken, N.J. : 2007). vol 294. issue 10. 2012-01-17. PMID:20818612. |
serotonin (5-ht) depletion has been obtained via targeting of genes involved in 5-ht synthesis (tph1 and tph2), specification and determination of the 5-ht phenotype during development (gata3, pet1, and lmx1b), and 5-ht storage or clearance (vmat2 and sert). |
2012-01-17 |
2023-08-12 |
Not clear |
| Hiroyuki Inose, Bin Zhou, Vijay K Yadav, X Edward Guo, Gerard Karsenty, Patricia Duc. Efficacy of serotonin inhibition in mouse models of bone loss. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 26. issue 9. 2011-12-14. PMID:21608033. |
in a proof-of-concept study it was shown that decreasing synthesis of gut serotonin through a small molecule inhibitor of tph1 could prevent and treat ovariectomy-induced osteoporosis in young mice and rats. |
2011-12-14 |
2023-08-12 |
mouse |
| b' Pascal Amireault, Sarah Hatia, Elisa Bayard, Florence Bernex, Corinne Collet, Jacques Callebert, Jean-Marie Launay, Olivier Hermine, Elke Schneider, Jacques Mallet, Michel Dy, Francine C\\xc3\\xb4t\\xc3\\xa. Ineffective erythropoiesis with reduced red blood cell survival in serotonin-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 32. 2011-10-18. PMID:21788492.' |
availability of 5-ht depends on the expression of the enzyme tryptophan hydroxylase (tph), and the recent discovery of a dual system for 5-ht synthesis in the brain (tph2) and periphery (tph1) has renewed interest in studying the potential functions played by 5-ht in nonnervous tissues. |
2011-10-18 |
2023-08-12 |
mouse |
| b' Pascal Amireault, Sarah Hatia, Elisa Bayard, Florence Bernex, Corinne Collet, Jacques Callebert, Jean-Marie Launay, Olivier Hermine, Elke Schneider, Jacques Mallet, Michel Dy, Francine C\\xc3\\xb4t\\xc3\\xa. Ineffective erythropoiesis with reduced red blood cell survival in serotonin-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 32. 2011-10-18. PMID:21788492.' |
moreover, characterization of the tph1 knockout mouse model (tph1(-/-)) led to the identification of unsuspected roles for peripheral 5-ht, revealing the importance of this monoamine in regulating key physiological functions outside the brain. |
2011-10-18 |
2023-08-12 |
mouse |
| b' Pascal Amireault, Sarah Hatia, Elisa Bayard, Florence Bernex, Corinne Collet, Jacques Callebert, Jean-Marie Launay, Olivier Hermine, Elke Schneider, Jacques Mallet, Michel Dy, Francine C\\xc3\\xb4t\\xc3\\xa. Ineffective erythropoiesis with reduced red blood cell survival in serotonin-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 32. 2011-10-18. PMID:21788492.' |
our thorough analysis of tph1(-/-) mice provides a unique model of morphological and functional aberrations of erythropoiesis and identifies 5-ht as a key factor for red blood cell production and survival. |
2011-10-18 |
2023-08-12 |
mouse |
| Zhishan Li, Alcmène Chalazonitis, Yung-Yu Huang, J John Mann, Kara Gross Margolis, Qi Melissa Yang, Dolly O Kim, Francine Côté, Jacques Mallet, Michael D Gersho. Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 24. 2011-08-22. PMID:21677183. |
5-ht biosynthesis depends on tryptophan hydroxylase 1 (tph1) in ec cells and on tph2 in neurons; therefore, mice lacking tph1 and/or tph2 distinguish ec-derived from neuronal 5-ht. |
2011-08-22 |
2023-08-12 |
mouse |
| Richard B Rothman, Jean L Cadet, Christina M Dersch, Michael T McCoy, Elin Lehrmann, Kevin G Becker, Michael Bader, Natalia Alenina, Michael H Bauman. Altered gene expression in pulmonary tissue of tryptophan hydroxylase-1 knockout mice: implications for pulmonary arterial hypertension. PloS one. vol 6. issue 3. 2011-07-18. PMID:21464983. |
a recent study reported that female mice lacking the gene for tryptophan hydroxylase-1 (tph1(-/-) mice) were protected from pah caused by chronic dexfenfluramine, suggesting a pivotal role for peripheral serotonin (5-ht) in the disease process. |
2011-07-18 |
2023-08-12 |
mouse |