| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunying Guo, Ting Wang, Haiyan Huang, Xiaolu Wang, Yugui Jiang, Jinan L. Plasminogen degrades α-synuclein, Tau and TDP-43 and decreases dopaminergic neurodegeneration in mouse models of Parkinson's disease. Scientific reports. vol 14. issue 1. 2024-04-13. PMID:38615036. |
the in vitro, ex vivo and in vivo results showed that the administered plasminogen crossed the blood‒brain barrier (bbb), entered cells, and migrated to the nucleus, increased plasmin activity intracellularly, bound to α-syn through lysine binding sites, significantly promoted α-syn, tau and tdp-43 clearance intracellularly and even intranuclearly in the brain, decreased dopaminergic neurodegeneration and increased the tyrosine hydroxylase levels in the substantia nigra and striatum, and improved motor function in pd mouse models. |
2024-04-13 |
2024-04-16 |
mouse |
| Chiara Prodani, Elaine E Irvine, Alessandro Sardini, Hannah J Gleneadie, Andrew Dimond, Mathew Van de Pette, Rosalind John, Michelle Kokkinou, Oliver Howes, Dominic J Withers, Mark A Ungless, Matthias Merkenschlager, Amanda G Fishe. Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes. Scientific reports. vol 14. issue 1. 2024-04-12. PMID:38609446. |
exposure to lpd in utero resulted in significantly more tyrosine hydroxylase positive (dopaminergic) neurons in the midbrain of adult offspring as compared to age-matched, control-diet equivalents. |
2024-04-12 |
2024-04-15 |
mouse |
| Cui Liu, Wen-Hong Liu, Wu Yang, Lei Chen, Yan Xue, Xin-Yi Che. GLP-1 modulated the firing activity of nigral dopaminergic neurons in both normal and parkinsonian mice. Neuropharmacology. 2024-04-10. PMID:38599494. |
the spontaneous firing activity of nigral dopaminergic neurons is associated with some important roles including modulation of dopamine release, expression of tyrosine hydroxylase (th), as well as neuronal survival. |
2024-04-10 |
2024-04-13 |
mouse |
| Juan U Mascotte-Cruz, Arturo Vera, Lorenzo Leija, Francisco E Lopez-Salas, Michael Gradzielski, Joachim Koetz, Bismark Gatica-García, C P Rodríguez-Oviedo, Irais E Valenzuela-Arzeta, Lourdes Escobedo, David Reyes-Corona, M E Gutierrez-Castillo, Minerva Maldonado-Berny, Armando J Espadas-Alvarez, Carlos E Orozco-Barrios, Daniel Martinez-Fon. Focused ultrasound on the substantia nigra enables safe neurotensin-polyplex nanoparticle-mediated gene delivery to dopaminergic neurons intranasally and by blood circulation. Discover nano. vol 19. issue 1. 2024-04-02. PMID:38564106. |
accordingly, 35 μl of neurotensin-polyplex nanoparticles encompassing the green fluorescent protein plasmid (79.6 nm mean size and + 1.3 mv zeta-potential) caused its expression in tyrosine hydroxylase(+) cells (dopaminergic neurons) of both substantiae nigrae upon delivery via internal carotid artery, retro-orbital venous sinus, or nasal mucosa 30 min after fus. |
2024-04-02 |
2024-04-04 |
rat |
| A Amini, F Esmaeili, M Golpic. Possible role of lncRNAs in amelioration of Parkinson's disease symptoms by transplantation of dopaminergic cells. NPJ Parkinson's disease. vol 10. issue 1. 2024-03-13. PMID:38472261. |
moreover, the expression of lncrnas malat1, meg3, and snhg1, alongside specific neuronal (synaptophysin) and dopaminergic (tyrosine hydroxylase) markers was evaluated by qrt-pcr. |
2024-03-13 |
2024-03-15 |
rat |
| Adeola Oluwatosin Adedara, Getúlio Nicola Bressan, Matheus Mulling Dos Santos, Roselei Fachinetto, Amos Olalekan Abolaji, Nilda Vargas Barbos. Antioxidant responses driven by Hesperetin and Hesperidin Counteract Parkinson's Disease-like Phenotypes in Drosophila melanogaster. Neurotoxicology. 2024-02-29. PMID:38423185. |
in addition to in vivo parameters, we assayed some markers of oxidative stress (lipid peroxidation, protein carbonylation, thiol content, hydrogen peroxide, and nitrate/nitrite levels, mrna expression of keap-1 (kelch-like ech associated protein 1)/nrf2 (nuclear factor erythroid 2 related factor 2), catalase (cat), glutathione-s-transferase (gst) activities), and cholinergic (acetyl cholinesterase activity (ache) and dopaminergic signaling (content and the mrna expression of tyrosine hydroxylase (th), monoamine oxidase (mao) activity). |
2024-02-29 |
2024-03-03 |
cat |
| Rahul Chaurasia, Mohamad Ayajuddin, Girish S Ratnaparkhi, Shashidhara S Lingadahalli, Sarat C Yenisett. A Simple Immunofluorescence Method to Characterize Neurodegeneration and Tyrosine Hydroxylase Reduction in Whole Brain of a Bio-protocol. vol 14. issue 4. 2024-02-26. PMID:38405079. |
a simple immunofluorescence method to characterize neurodegeneration and tyrosine hydroxylase reduction in whole brain of a dopaminergic (daergic) neurodegeneration in the substantia nigra pars compacta of the human brain is the pathological feature associated with parkinson's disease (pd). |
2024-02-26 |
2024-02-28 |
human |
| Emad Albadawi, Ahmed El-Tokhy, Muayad Albadrani, Mohammed Adel, Randa El-Gamal, Wael Zaarina, Mosaab Salah El-Din El-Agawy, Hassan Reda Hassan Elsaye. The role of stinging nettle (Urtica dioica L.) in the management of rotenone-induced Parkinson's disease in rats. Tissue & cell. vol 87. 2024-02-22. PMID:38387425. |
the midbrains were investigated for histopathological alteration and immunohistochemical reaction for tyrosine hydroxylase in the dopaminergic neurons, α-synuclein for lewy bodies, caspase 3 for apoptotic neurons, lc3 and p62 for autophagic activity. |
2024-02-22 |
2024-02-25 |
rat |
| David L Bernstein, Stacia I Lewandowski, Christina Besada, Delaney Place, Rodrigo A España, Ole V Mortense. Inactivation of ERK1/2 Signaling in Dopaminergic Neurons by Map Kinase Phosphatase MKP3 Regulates Dopamine Signaling and Motivation for Cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 44. issue 5. 2024-01-31. PMID:38296649. |
to enable specific modulation of erk1/2 signaling in dopaminergic neurons of the ventral tegmental area, we utilize a viral construct that cre dependently expresses map kinase phosphatase 3 (mkp3) to reduce the activity of erk1/2, in combination with transgenic rats that express cre in tyrosine hydroxylase (th)-positive cells. |
2024-01-31 |
2024-02-03 |
rat |
| Yea-Hyun Leem, Jin-Sun Park, Jung-Eun Park, Do-Yeon Kim, Hee-Sun Ki. Creatine supplementation with exercise reduces α-synuclein oligomerization and necroptosis in Parkinson's disease mouse model. The Journal of nutritional biochemistry. 2024-01-23. PMID:38262563. |
we found that 2% creatine supplementation and/or exercise intervention for 4 weeks elicited neurobehavioral recovery and neuroprotective effects regarding dopaminergic cell loss in mptp-treated mice; this effect implies functional preservation of dopaminergic cells in the substantia nigra, as reflected by tyrosine hydroxylase expression recovery. |
2024-01-23 |
2024-01-26 |
mouse |
| Hua Rong, Xiaoming Li, Chunlei Yu, Wenbao Wang, Libo Li, Tianjiao Xu, Yisong Ding, Yingshi Su, Xiaoli Wan. Targeting the Nrf2-dependent mechanism of b-Ecdysterone in attenuating the motor dysfunction in the MPTP/Pro-induced Parkinson's disease mice model. Folia neuropathologica. 2024-01-04. PMID:38174686. |
using open field, rotarod, and pole climbing tests, we have found that b-ecd alleviates motor disorder in mptp/pro-induced mice and ultimately reduces the impairment of tyrosine hydroxylase (th)-positive dopaminergic neurons in the substantia nigra (sn). |
2024-01-04 |
2024-01-06 |
mouse |
| Hend A Sabry, Mai M Zahr. Icariin Attenuates Dopaminergic Neural Loss in Haloperidol-Induced Parkinsonism in Rats via GSK-3β and Tyrosine Hydroxylase Regulation Mechanism. Journal of chemical neuroanatomy. 2023-12-31. PMID:38160784. |
icariin attenuates dopaminergic neural loss in haloperidol-induced parkinsonism in rats via gsk-3β and tyrosine hydroxylase regulation mechanism. |
2023-12-31 |
2024-01-05 |
rat |
| Wanran Huang, Yanni Wang, Wei Huan. Mangiferin alleviates 6-OHDA-induced Parkinson's disease by inhibiting AKR1C3 to activate Wnt signaling pathway. Neuroscience letters. 2023-12-24. PMID:38142926. |
our results demonstrated that treatment with mangiferin significantly attenuated 6-ohda-induced cell damage in pc12 cells, reducing intracellular oxidative stress, improving mitochondrial membrane potential, and restoring the expression of tyrosine hydroxylase (th), a characteristic protein of dopaminergic neurons. |
2023-12-24 |
2023-12-27 |
mouse |
| Ichiro Kawahata, Kohji Fukunag. Pathogenic Impact of Fatty Acid-Binding Proteins in Parkinson's Disease-Potential Biomarkers and Therapeutic Targets. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38069360. |
in particular, fabp3, abundant in nigrostriatal dopaminergic neurons, is responsible for α-synuclein propagation into neurons and intracellular accumulation, affecting the loss of mesencephalic tyrosine hydroxylase protein, a rate-limiting enzyme of dopamine biosynthesis. |
2023-12-09 |
2023-12-17 |
Not clear |
| Rachael A Herlihy, Francisco Alicandri, Hudy Berger, Huda Rehman, Yifan Kao, Kainat Akhtar, Elizabeth Dybas, Emily Mahoney-Rafferty, Kassie Von Stein, Raven Kirby, Angela Tawfik, Rachel Skumurski, Paul J Feustel, Eric S Molho, Damian S Shi. Investigation of non-invasive focused ultrasound efficacy on depressive-like behavior in hemiparkinsonian rats. Experimental brain research. 2023-12-07. PMID:38059986. |
after, tyrosine hydroxylase immuno-staining was employed to visualize and quantify dopaminergic degeneration in the substantia nigra pars compacta, ventral tegmental area, and striatum. |
2023-12-07 |
2023-12-10 |
rat |
| Jong Mi Park, Masoud Rahmati, Sang Chul Lee, Jae Il Shin, Yong Wook Ki. Effects of mesenchymal stem cell on dopaminergic neurons, motor and memory functions in animal models of Parkinson's disease: a systematic review and meta-analysis. Neural regeneration research. vol 19. issue 7. 2023-12-05. PMID:38051903. |
the stem cell treatment group had significantly more tyrosine hydroxylase positive dopaminergic neurons in the striatum ([95% ci] = 1.04 [0.59 to 1.49], p = 0.0001, i2 = 65.1 %) and substantia nigra (smd [95% ci] = 1.38 [0.89 to 1.87], p = 0.0001, i2 = 75.3 %), indicating a protective effect on dopaminergic neurons. |
2023-12-05 |
2023-12-10 |
Not clear |
| Haneen Y Khidr, Noha F Hassan, S S Abdelrahman, Mona R El-Ansary, Mohammed F El-Yamany, Mostafa A Rabi. Formoterol attenuated mitochondrial dysfunction in rotenone-induced Parkinson's disease in a rat model: Role of PINK-1/PARKIN and PI3K/Akt/CREB/BDNF/TrKB axis. International immunopharmacology. vol 125. issue Pt B. 2023-11-13. PMID:37956489. |
formoterol treatment succeeded in upregulating β2-adrenoreceptor expression in pd rats and preserving the function and integrity of dopaminergic neurons as witnessed by enhancement of muscular performance in tests, open field, grip strength-meter, and rotarod, besides the increment in substantia nigra and striatal tyrosine hydroxylase immunoexpression. |
2023-11-13 |
2023-11-20 |
rat |
| Sian-Tai Liu, Jiun-Lin Horng, Li-Yih Lin, Ming-Yi Cho. Fenpropathrin causes alterations in locomotion and social behaviors in zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). vol 265. 2023-11-12. PMID:37952273. |
the immunocytochemical results showed the tyrosine hydroxylase antibody-labeled dopaminergic neurons in the teleost posterior tuberculum decreased in the zebrafish brain. |
2023-11-12 |
2023-11-20 |
zebrafish |
| Nicole Burkert, Shoumik Roy, Max Häusler, Dominik Wuttke, Sonja Müller, Johanna Wiemer, Helene Hollmann, Marvin Oldrati, Jorge Ramirez-Franco, Julia Benkert, Michael Fauler, Johanna Duda, Jean-Marc Goaillard, Christina Pötschke, Moritz Münchmeyer, Rosanna Parlato, Birgit Lis. Deep learning-based image analysis identifies a DAT-negative subpopulation of dopaminergic neurons in the lateral Substantia nigra. Communications biology. vol 6. issue 1. 2023-11-10. PMID:37950046. |
we utilised dlap to analyse subtypes of tyrosine hydroxylase (th)-positive dopaminergic midbrain neurons in mouse and human brain-sections. |
2023-11-10 |
2023-11-20 |
mouse |
| Bingyun Li, Yujia Jiang, Ting Wang, Weiwei Liu, Xiaojuan Chen, Jinyi He, Zeyu Du, Ruijiao Yang, Danxiu Miao, Yanshu L. MicroRNA-217-5p triggers dopaminergic neuronal degeneration via autophagy activation under Atrazine exposure. Environmental pollution (Barking, Essex : 1987). vol 340. issue Pt 1. 2023-10-31. PMID:37890694. |
moreover, atr causes damage to dopaminergic neurons, as indicated by the altered expression of tyrosine hydroxylase and α-synuclein. |
2023-10-31 |
2023-11-08 |
Not clear |