| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yalan Chen, Junxin Kuang, Yimei Niu, Hongyao Zhu, Xiaoxia Chen, Kwok-Fai So, Anding Xu, Lingling Sh. Multiple factors to assist human-derived induced pluripotent stem cells to efficiently differentiate into midbrain dopaminergic neurons. Neural regeneration research. vol 19. issue 4. 2023-10-16. PMID:37843228. |
this increased the proportion of dopaminergic neurons, up to 75% tyrosine hydroxylase-positive neurons, with 15% tyrosine hydroxylase and forkhead box protein a2 (foxa2) co-expressing neurons. |
2023-10-16 |
2023-11-08 |
human |
| Yalan Chen, Junxin Kuang, Yimei Niu, Hongyao Zhu, Xiaoxia Chen, Kwok-Fai So, Anding Xu, Lingling Sh. Multiple factors to assist human-derived induced pluripotent stem cells to efficiently differentiate into midbrain dopaminergic neurons. Neural regeneration research. vol 19. issue 4. 2023-10-16. PMID:37843228. |
we further optimized the induction protocol by applying the small molecule inhibitor, chir99021 (chir).this helped facilitate the generation of midbrain dopaminergic neurons, and we obtained 31-74% midbrain dopaminergic neurons based on tyrosine hydroxylase and foxa2 staining. |
2023-10-16 |
2023-11-08 |
human |
| Yalan Chen, Junxin Kuang, Yimei Niu, Hongyao Zhu, Xiaoxia Chen, Kwok-Fai So, Anding Xu, Lingling Sh. Multiple factors to assist human-derived induced pluripotent stem cells to efficiently differentiate into midbrain dopaminergic neurons. Neural regeneration research. vol 19. issue 4. 2023-10-16. PMID:37843228. |
based on tyrosine hydroxylase and foxa2 immunostaining analysis, the chir, shh, and fgf8 combined protocol produces a much higher proportion of midbrain dopaminergic neurons, which could be an ideal resource for tackling midbrain-related diseases. |
2023-10-16 |
2023-11-08 |
human |
| Li He, Huihui Zheng, Jilong Qiu, Hong Chen, Huan Li, Yuejiao Ma, Yingying Wang, Qianjin Wang, Yuzhu Hao, Yueheng Liu, Qian Yang, Xin Wang, Manyun Li, Huixue Xu, Pu Peng, Zejun Li, Yanan Zhou, Qiuxia Wu, Shubao Chen, Xiaojie Zhang, Tieqiao Li. Effects of Multiple High-Dose Methamphetamine Administration on Enteric Dopaminergic Neurons and Intestinal Motility in the Rat Model. Neurotoxicity research. 2023-09-27. PMID:37755670. |
the edns were assessed by measuring the expression of two dopaminergic neuronal markers, dopamine transporter (dat) and tyrosine hydroxylase (th), at the transcriptional and protein levels. |
2023-09-27 |
2023-10-07 |
rat |
| Sibylle Frase, Julius Steddin, Enya Paschen, Maximilian Lenz, Pasquale Conforti, Carola A Haas, Andreas Vlachos, Christian Schachtrup, Jonas A Hos. Dense dopaminergic innervation of the peri-infarct cortex despite dopaminergic cell loss after a pure motor-cortical stroke in rats. Journal of neurochemistry. 2023-09-22. PMID:37735852. |
thus, dopaminergic midbrain neurons projecting into the pic were identified based on mr signal and immunoreactivity against tyrosine hydroxylase (th), a marker for dopaminergic neurons. |
2023-09-22 |
2023-10-07 |
rat |
| Lily Sarrafha, Drew R Neavin, Gustavo M Parfitt, Ilya A Kruglikov, Kristen Whitney, Ricardo Reyes, Elena Coccia, Tatyana Kareva, Camille Goldman, Regine Tipon, Gist Croft, John F Crary, Joseph E Powell, Joel Blanchard, Tim Ahfeld. Novel human pluripotent stem cell-derived hypothalamus organoids demonstrate cellular diversity. iScience. vol 26. issue 9. 2023-08-30. PMID:37646018. |
using an hpsc line with a tyrosine hydroxylase (th)-tdtomato reporter for dopaminergic neurons (dns) and other th-expressing cells, we interrogated dn-specific pathways and functions in electrophysiologically active hypothalamus organoids. |
2023-08-30 |
2023-09-07 |
human |
| Cintia Klaudia Finszter, Róbert Kemecsei, Gergely Zachar, Sophie Holtkamp, Diego Echevarría, István Adorján, Ágota Ádám, András Csilla. Early cellular and synaptic changes in dopaminoceptive forebrain regions of juvenile mice following gestational exposure to valproate. Frontiers in neuroanatomy. vol 17. 2023-08-21. PMID:37603782. |
the proteomic findings suggest reduction of tyrosine hydroxylase in the crude synaptosome fraction of nac, but not in the cpu, without simultaneous decrease of the synaptic protein, synaptophysin, indicating selective impairment of dopaminergic synapses. |
2023-08-21 |
2023-09-07 |
mouse |
| Xue-Yun Chen, Si-Ning Feng, Yin Bao, Yu-Xin Zhou, Fang B. Identification of Clec7a as the therapeutic target of rTMS in alleviating Parkinson's disease: targeting neuroinflammation. Biochimica et biophysica acta. Molecular basis of disease. 2023-07-26. PMID:37495085. |
adeno-associated virus (aav)-mediated specific knockdown of clec7a in microglial alleviated 6-ohda induced motor deficits and nigrostriatal dopaminergic neuron damage of rats, as evidenced by the increase of tyrosine hydroxylase (th) -positive neurons in sn, as well as dopaminergic nerve fibers in the striatum. |
2023-07-26 |
2023-08-14 |
rat |
| Tülay Akan, Yasemin Aydın, Orhan Tansel Korkmaz, Emel Ulupınar, Faruk Sayda. The Effects of Carvacrol on Transient Receptor Potential (TRP) Channels in an Animal Model of Parkinson's Disease. Neurotoxicity research. 2023-07-15. PMID:37452911. |
ca treatment significantly increased the density of dopaminergic neurons immunolabeled with tyrosine hydroxylase and transient receptor potential canonical 1 (trpc1) channel in the snpc of pd animals. |
2023-07-15 |
2023-08-14 |
rat |
| Xu Cao, Zhong-Rui Du, Xin Liu, Xiong Wang, Chong Li, Sai-Nan Zhou, Jia-Rui Liu, Ping-Yi Xu, Jun-Li Ye, Qing Zhao, Fang Zhao, Ka-Hing Wong, Xiao-Li Don. Low and high doses of oral maslinic acid protect against Parkinson's disease via distinct gut microbiota-related mechanisms. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-07. PMID:37418977. |
the present study found both low and high dose ma treatment significantly prevented dopaminergic neuronal loss in a classical chronic pd mouse model by ameliorating motor functions and improving tyrosine hydroxylase expressions in the substantia nigra pars compacta (snpc) and increasing dopamine and its metabolite homovanillic acid levels in the striatum. |
2023-07-07 |
2023-08-14 |
mouse |
| Marisa Alves de Oliveira-Higa, Paula da Silva Rodrigues, Ana Claudia Silva Sampaio, Alex de Camargo Coque, Thiago Berti Kirsten, Silvia Maria Gomes Massironi, Sandra Regina Alexandre-Ribeiro, Claudia Madalena Cabrera Mori, Rodrigo Augusto da Silva, Maria Martha Bernard. THE DOPAMINERGIC D1 RECEPTOR MODULATES THE HYPERACTIVITY OF BAPA MUTANT MICE. Behavioural brain research. 2023-07-02. PMID:37394124. |
a previous study showed that bapa mice present increased motor/exploratory behaviors during the prepubertal period due to increased striatal tyrosine hydroxylase expression, suggesting striatal dopaminergic system hyperactivity. |
2023-07-02 |
2023-08-14 |
mouse |
| Heba M Mansour, Ahmed F Mohamed, Mahmoud M Khattab, Aiman S El-Khati. Lapatinib ditosylate rescues motor deficits in rotenone-intoxicated rats: Potential repurposing of anti-cancer drug as a disease-modifying agent in Parkinson's disease. European journal of pharmacology. 2023-06-29. PMID:37385578. |
in the current study, administration of 100 mg/kg lap in rotenone-treated rats for 21 days ameliorates motor impairment, debilitated histopathological alterations, and revived dopaminergic neurons by increasing tyrosine hydroxylase (th) expression in sn, along with increased dopamine level. |
2023-06-29 |
2023-08-14 |
rat |
| Charlotte Helf, Maria Kober, Franz Markert, Jennifer Lanto, Leonie Overhoff, Kathrin Badstübner-Meeske, Alexander Storch, Mareike Fause. Subthalamic nucleus deep brain stimulation induces nigrostriatal dopaminergic plasticity in a stable rat model of Parkinson's disease. Neuroreport. vol 34. issue 10. 2023-06-04. PMID:37270842. |
in the context of identifying disease-modifying effects of stn-dbs by prompting cellular plasticity in midbrain dopaminergic systems, we analyzed neuronal tyrosine hydroxylase and c-fos expression in the substantia nigra pars compacta (snpc) and ventral tegmental area (vta). |
2023-06-04 |
2023-08-14 |
rat |
| Shaohua Ma, Hao Zhong, Xuemei Liu, Liping Wan. Spatial Distribution of Neurons Expressing Single, Double, and Triple Molecular Characteristics of Glutamatergic, Dopaminergic, or GABAergic Neurons in the Mouse Ventral Tegmental Area. Journal of molecular neuroscience : MN. 2023-05-27. PMID:37243808. |
we present a topographical distribution map of three main neuronal populations expressing a single molecular characteristic of dopaminergic, gabaergic, or glutamatergic neurons, and four neuronal populations co-expressing double or triple molecular characteristics in combinatorial manners, in the mouse vta, following analysis of triple fluorescent in situ hybridization for the simultaneous detection of tyrosine hydroxylase (th, marker for dopaminergic neurons), vesicular glutamate transporter 2 (vglut2, marker for glutamatergic neurons), and glutamic acid decarboxylase 2 (gad2, marker for gabaergic neurons) mrna. |
2023-05-27 |
2023-08-14 |
mouse |
| Shane J F Cronin, Weonjin Yu, Ashley Hale, Simon Licht-Mayer, Mark J Crabtree, Joanna A Korecka, Evgenii O Tretiakov, Marco Sealey-Cardona, Mate Somlyay, Masahiro Onji, Meilin An, Jesse D Fox, Bruna Lenfers Turnes, Carlos Gomez-Diaz, Débora da Luz Scheffer, Domagoj Cikes, Vanja Nagy, Adelheid Weidinger, Alexandra Wolf, Harald Reither, Antoine Chabloz, Anoop Kavirayani, Shuan Rao, Nick Andrews, Alban Latremoliere, Michael Costigan, Gillian Douglas, Fernando Cini Freitas, Christian Pifl, Roger Walz, Robert Konrat, Don J Mahad, Andrey V Koslov, Alexandra Latini, Ole Isacson, Tibor Harkany, Penelope J Hallett, Stefan Bagby, Clifford J Woolf, Keith M Channon, Hyunsoo Shawn Je, Josef M Penninge. Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons. bioRxiv : the preprint server for biology. 2023-05-23. PMID:37214873. |
mechanistically, bh4 not only serves as an essential cofactor for dopamine synthesis, but also independently regulates tyrosine hydroxylase levels, protects against ferroptosis, scavenges mitochondrial ros, maintains neuronal excitability and promotes mitochondrial atp production, thereby enhancing mitochondrial fitness and cellular respiration in multiple preclinical pd animal models, human dopaminergic midbrain-like organoids and primary cells from pd-affected individuals. |
2023-05-23 |
2023-08-14 |
mouse |
| Khai Huynh Ngoc, Angéla Kecskés, Eszter Kepe, Liza Nabi, Julie Keeble, Éva Borbély, Zsuzsanna Helye. Expression of the Transient Receptor Potential Vanilloid 1 ion channel in the supramammillary nucleus and the antidepressant effects of its antagonist AMG9810 in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 73. 2023-05-08. PMID:37156112. |
trpv1 mrna is selectively expressed in the supramammillary nucleus (sum) co-localized with vglut2 mrna, but not with tyrosine hydroxylase immunopositivity demonstrating its presence in glutamatergic, but not dopaminergic neurons. |
2023-05-08 |
2023-08-14 |
mouse |
| Emily C Mahoney-Rafferty, Heidi R Tucker, Kainat Akhtar, Rachael Herlihy, Aliyah Audil, Dia Shah, Megan Gupta, Eliyahu M Kochman, Paul J Feustel, Eric S Molho, Julie G Pilitsis, Damian S Shi. Assessing the Location, Relative Expression and Subclass of Dopamine Receptors in the Cerebellum of Hemi-Parkinsonian Rats. Neuroscience. 2023-04-28. PMID:37116741. |
limited research suggests that dopaminergic signaling exists in the cerebellum with functional dopamine receptors, tyrosine hydroxylase (th) and dopamine transporters (dats); however, much of this information is largely derived from healthy animals and humans. |
2023-04-28 |
2023-08-14 |
rat |
| I N Rozhkova, S V Okotrub, E Yu Brusentsev, K E Uldanova, E А Chuyko, V A Naprimerov, T V Lipina, T G Amstislavskaya, S Ya Amstislavsk. Alterations in the social-conditioned place preference and density of dopaminergic neurons in the ventral tegmental area in Clsnt2-KO mice. Vavilovskii zhurnal genetiki i selektsii. vol 27. issue 2. 2023-04-17. PMID:37063509. |
thus, a change in social-conditioned place preference in clstn2-ko mice as well as a higher number of neurons expressing type 2 dopamine receptors and tyrosine hydroxylase in the vta, the key structure of the mesolimbic dopaminergic pathway, were observed. |
2023-04-17 |
2023-08-14 |
mouse |
| Fabio Casciano, Nicoletta Bianchi, Mirta Borin, Vittorio Vellani, Paola Secchiero, Carlo M Bergamini, Simona Capsoni, Angela Pignatell. Characterization by Gene Expression Analysis of Two Groups of Dopaminergic Cells Isolated from the Mouse Olfactory Bulb. Biology. vol 12. issue 3. 2023-03-29. PMID:36979058. |
we took advantage of a peculiar property of dopaminergic neurons in transgenic mice expressing egfp under the tyrosine hydroxylase (th) promoter: while da neurons located in the glomerular layer (gl) display full electrophysiological maturation, egfp+ cells in the mitral layer (ml) show characteristics of immature cells. |
2023-03-29 |
2023-08-14 |
mouse |
| Mobina Alemi, Ana Raquel Pereira, Mariana Cerqueira-Nunes, Clara Monteiro, Vasco Galhardo, Helder Cardoso-Cru. Role of Glutamatergic Projections from Lateral Habenula to Ventral Tegmental Area in Inflammatory Pain-Related Spatial Working Memory Deficits. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979799. |
we evaluated the impact of the inflammatory pain in the vta synapses by performing immunohistochemical characterization of specific markers for gabaergic (gad65/67) and dopaminergic neurons (dopamine transporter (dat), dopamine d2 receptor (d2r) and tyrosine hydroxylase (th)). |
2023-03-29 |
2023-08-14 |
rat |