| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dmitry Troshev, Alyona Bannikova, Victor Blokhin, Anna Kolacheva, Tatiana Pronina, Michael Ugrumo. Striatal Neurons Partially Expressing a Dopaminergic Phenotype: Functional Significance and Regulation. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232359. |
in this study, it was shown that in transgenic mice expressing green fluorescent protein (gfp) under the tyrosine hydroxylase (th) gene promoter, (i) there are striatal neurons expressing only th, only aromatic l-amino acid decarboxylase (aadc), or both enzymes of dopamine synthesis; (ii) striatal neurons expressing dopamine-synthesizing enzymes are not dopaminergic since they lack a dopamine transporter; (iii) monoenzymatic neurons expressing individual complementary dopamine-synthesizing enzymes produce this neurotransmitter in cooperation; (iv) striatal nerve fibers containing only th, only aadc, or both enzymes project into the lateral ventricles, providing delivery pathways for l-3,4-dihydroxyphenylalanine and dopamine to the cerebrospinal fluid; and (v) striatal gfp neurons express receptor genes for various signaling molecules, i.e., classical neurotransmitters, neuropeptides, and steroids, indicating fine regulation of these neurons. |
2022-10-14 |
2023-08-14 |
mouse |
| Milca Abda Morais, Beatriz Silva Franco, Alessandro Spencer Souza Holanda, Laís Angélica de Paula Simino, Alana Carolina Costa Veras, Marcio Alberto Torsoni, Mauro Manconi, Adriana Souza Torsoni, Andrea Maculano Esteve. Protein tyrosine phosphatase receptor type delta (PTPRD) gene in an animal model of restless legs syndrome. Journal of sleep research. 2022-09-02. PMID:36053904. |
to evaluate the tyrosine hydroxylase enzyme, dopamine transporter (dat) and type 2 dopaminergic receptor, qpcr and western blotting techniques were used. |
2022-09-02 |
2023-08-14 |
rat |
| Xiaosan Tang, Heng Li, Baozeng An, Haibo Ma, Nana Huang, Xiaohong L. Transplantation of human cord blood-derived multipotent stem cells (CB-SCs) enhances the recovery of Parkinson in rats. Transplant immunology. 2022-08-29. PMID:36038047. |
after being transplanted into the striatum and substantia nigra of pd rats, most of cb-scs (>90%) developed a fate commitment to dopaminergic differentiation, expressed as the expression of tyrosine hydroxylase (th) and dopamine transporter (dat). |
2022-08-29 |
2023-08-14 |
human |
| Nana Saeki, Haruna Tamano, Azusa Takeuchi, Misa Katahira, Ryusuke Nishio, Haruna Tamura, Atsushi Taked. Heated Leaf Extract of Coriandrum sativum L. Protects Nigral Dopaminergic Degeneration in Rats. Plant foods for human nutrition (Dordrecht, Netherlands). 2022-08-03. PMID:35922685. |
after injection of 6-ohda into the rat substantia nigra pars compacta (snpc), dopaminergic degeneration, which was determined by tyrosine hydroxylase immunostaining, was rescued by co-injection of caedta, an extracellular zn |
2022-08-03 |
2023-08-14 |
rat |
| Emily Clarke, Pawel Stocki, Elizabeth H Sinclair, Aziz Gauhar, Edward J R Fletcher, Alicja Krawczun-Rygmaczewska, Susan Duty, Frank S Walsh, Patrick Doherty, Julia Lynn Rutkowsk. A Single Domain Shark Antibody Targeting the Transferrin Receptor 1 Delivers a TrkB Agonist Antibody to the Brain and Provides Full Neuroprotection in a Mouse Model of Parkinson's Disease. Pharmaceutics. vol 14. issue 7. 2022-07-27. PMID:35890231. |
only the txb4-trkb antibody fusion was detected within the brain and localized to trkb positive cells in the cortex and tyrosine hydroxylase (th) positive dopaminergic neurons in the substantia nigra pars compacta (snc), where it was associated with activated erk1/2 signaling. |
2022-07-27 |
2023-08-14 |
mouse |
| Carmen Avagliano, Lorena Coretti, Adriano Lama, Claudio Pirozzi, Carmen De Caro, Davide De Biase, Luigia Turco, Maria Pina Mollica, Orlando Paciello, Antonio Calignano, Rosaria Meli, Francesca Lembo, Giuseppina Mattace Ras. Dual-Hit Model of Parkinson's Disease: Impact of Dysbiosis on 6-Hydroxydopamine-Insulted Mice-Neuroprotective and Anti-Inflammatory Effects of Butyrate. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35742813. |
this effect was accompanied by a significant increase in neuronal dopaminergic loss (reduced tyrosine hydroxylase expression and increased bcl-2/bax ratio). |
2022-06-24 |
2023-08-14 |
mouse |
| Michael V Ugrumov, Ekaterina N Pavlova, Anna A Kolacheva, Liliya K Dil'mukhametova, Vsevolod V Bogdanov, Victor Blokhin, Tatiana S Pronin. The Periventricular Nucleus as a Brain Center Containing Dopaminergic Neurons and Neurons Expressing Individual Enzymes of Dopamine Synthesis. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35743179. |
it has been shown that, in addition to dopaminergic neurons, most of these centers contain neurons expressing one of the enzymes of dopamine synthesis: tyrosine hydroxylase (th) or aromatic l-amino acid decarboxylase (aadc). |
2022-06-24 |
2023-08-14 |
rat |
| Jaime Eugenin von Bernhardi, Daniela Biechl, Laura Miek, Ulrich Herget, Soojin Ryu, Mario F Wulliman. A versatile transcription factor: Multiple roles of orthopedia a (otpa) beyond its restricted localization in dopaminergic systems of developing and adult zebrafish (Danio rerio) brains. The Journal of comparative neurology. 2022-06-16. PMID:35708548. |
since otpa is also critical for the development of zebrafish basal diencephalic dopaminergic cells, colocalization of otpa with the catecholamine synthesizing enzyme tyrosine hydroxylase (th) is studied. |
2022-06-16 |
2023-08-14 |
mouse |
| Kiera E Grierson, Tyler T Hickman, M Charles Liberma. Dopaminergic and cholinergic innervation in the mouse cochlea after noise-induced or age-related synaptopathy. Hearing research. vol 422. 2022-06-07. PMID:35671600. |
here, we investigated if degeneration of the olivocochlear (oc) efferent innervation is also a major aspect of the synaptopathic ear, by quantifying the volume and spatial organization of its cholinergic and dopaminergic components, using antibodies to vesicular acetylcholine transporter (vat) and tyrosine hydroxylase (th), respectively. |
2022-06-07 |
2023-08-14 |
mouse |
| b' Kaja Kolman\\xc4\\x8di\\xc4\\x8d, Marko \\xc5\\xbdivin, Maja Zorovi\\xc4\\x8. Modulation by Estradiol of L-Dopa-Induced Dyskinesia in a Rat Model of Post-Menopausal Hemiparkinsonism. Life (Basel, Switzerland). vol 12. issue 5. 2022-05-28. PMID:35629308.' |
postmortem tyrosine hydroxylase immunostaining revealed an almost complete unilateral lesion of nigrostriatal dopaminergic neurons. |
2022-05-28 |
2023-08-13 |
rat |
| Olusegun G Adebayo, Jerome N Asiwe, Benneth Ben-Azu, Wadioni Aduema, Ijeoma Onyeleonu, Ajirioghene E Akpotu, Iheanyichukwu Wopara, Tolunigba A Kolawole, Elizabeth B Umoren, Vincent Igbokwe, Buduchim R Buduburisi, Favour C Onwuka, Providence I Brow. Ginkgo biloba protects striatal neurodegeneration and gut phagoinflammatory damage in rotenone-induced mice model of Parkinson's disease: Role of executioner caspase-3/Nrf2/ARE signaling. Journal of food biochemistry. 2022-05-24. PMID:35608987. |
treatment with gbs significantly repressed the motor behavioral and neuromuscular deficits and prevented loss of striatal dopaminergic loss by improving the level of tyrosine hydroxylase enzyme and suppressing synucleinopathy development. |
2022-05-24 |
2023-08-13 |
mouse |
| Qin Zhao, Tetsufumi Ito, Chika Soko, Yoshie Hori, Takafumi Furuyama, Hiroyuki Hioki, Kohtarou Konno, Miwako Yamasaki, Masahiko Watanabe, Satoshi Ohtsuka, Munenori Ono, Nobuo Kato, Ryo Yamamot. Histochemical characterization of the dorsal raphe-periaqueductal grey dopamine transporter neurons projecting to the extended amygdala. eNeuro. 2022-05-17. PMID:35580986. |
the dorsal raphe (dr) nucleus contains many tyrosine hydroxylase (th) positive neurons which are regarded as dopaminergic (da) neurons. |
2022-05-17 |
2023-08-13 |
Not clear |
| Nanthini Jayabalan, Katherine Kerry Roper, Helen M Woodhouse, Robert J Adam, John D O'Sullivan, Richard Gordo. A Novel Role for Glucocerebrosidase 1 (GBA1) in Parkinson's Disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555783. |
in vivo,6- ohda mice had significant loss of tyrosine hydroxylase (th), indicative of the substantial dopaminergic neuronal death which was rescued in lti-291 treated mice. |
2022-05-13 |
2023-08-13 |
mouse |
| Adrian Romero, Justin C Hunt, Brent R Bill, Ayman K Hamoud. Optimizing 6-Hydroxydopamine Concentrations for induction of a Parkinson's Disease Like Behavior in Zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555953. |
parkinson's disease is associated with the loss of tyrosine hydroxylase (th) expressing dopaminergic neurons. |
2022-05-13 |
2023-08-13 |
zebrafish |
| Shivangi Gupta, Virendra Tiwari, Priya Tiwari, Parul, Akanksha Mishra, Kashif Hanif, Shubha Shukl. Angiotensin-Converting Enzyme 2 Activation Mitigates Behavioral Deficits and Neuroinflammatory Burden in 6-OHDA Induced Experimental Models of Parkinson's Disease. ACS chemical neuroscience. 2022-05-09. PMID:35533351. |
further, the dize-mediated activation of ace2 led to increased tyrosine hydroxylase (th) and dopamine transporters (dat) expression in the rat brain, indicating the protection of dopaminergic (daergic) neurons from 6-ohda induced neurotoxicity. |
2022-05-09 |
2023-08-13 |
rat |
| Katie K N Tran, Vickie H Y Wong, Jeremiah K H Lim, Ali Shahandeh, Anh Hoang, David I Finkelstein, Bang V Bui, Christine T O Nguye. Characterization of retinal function and structure in the MPTP murine model of Parkinson's disease. Scientific reports. vol 12. issue 1. 2022-05-09. PMID:35534594. |
we use a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) mouse model of pd to characterize the neurotoxic effects of mptp on in vivo retinal function (electroretinography, erg), retinal structure (optical coherence tomography, oct) and retinal dopaminergic cell number (tyrosine hydroxylase immunohistochemistry, ihc) at two time points (21 and 45 days) post mptp model induction. |
2022-05-09 |
2023-08-13 |
mouse |
| Xian-Guo Zou, Meng-Ting Xu, Xiao-Li Dong, You-Min Ying, Rong-Fa Guan, Wei-Cheng Wu, Kai Yang, Pei-Long Su. Solid-state-cultured mycelium of Antrodia camphorata exerts potential neuroprotective activities against 6-hydroxydopamine-induced toxicity in PC12 cells. Journal of food biochemistry. 2022-04-25. PMID:35467031. |
the results showed that scmac extracts alleviated cell toxicity induced by 6-ohda and the loss of dopaminergic neurons, which was confirmed by the increase of cell viabilities, inhibition of cell apoptosis, the upregulation of tyrosine hydroxylase (th) and dopamine transporter (dat) levels and the downregulation of α-synuclein level. |
2022-04-25 |
2023-08-13 |
Not clear |
| Xin Liu, Zhong Rui Du, Xiong Wang, Xiang Rong Sun, Qing Zhao, Fang Zhao, Wing Tak Wong, Ka Hing Wong, Xiao-Li Don. Polymannuronic acid prebiotic plus Lacticaseibacillus rhamnosus GG probiotic as a novel synbiotic promoted their separate neuroprotection against Parkinson's disease. Food research international (Ottawa, Ont.). vol 155. 2022-04-11. PMID:35400445. |
our results found oral administration of prebiotic pm or lgg separately or in combination for 5 weeks could prevent dopaminergic neuronal loss via improving reduced walking distance and activity or weakened muscle strength in behavior tests by enhancing tyrosine hydroxylase (th) gene and/or protein expressions in the midbrain and striatum of pd mice. |
2022-04-11 |
2023-08-13 |
mouse |
| Aleksandar Rakovic, Dorothea Voß, Franca Vulinovic, Britta Meier, Ann-Katrin Hellberg, Carla Nau, Christine Klein, Enrico Leipol. Electrophysiological Properties of Induced Pluripotent Stem Cell-Derived Midbrain Dopaminergic Neurons Correlate With Expression of Tyrosine Hydroxylase. Frontiers in cellular neuroscience. vol 16. 2022-04-11. PMID:35401116. |
electrophysiological properties of induced pluripotent stem cell-derived midbrain dopaminergic neurons correlate with expression of tyrosine hydroxylase. |
2022-04-11 |
2023-08-13 |
Not clear |
| Yue Xu, Ya'nan Wang, Guang'an Tong, Lin Li, Juan Cheng, Lesha Zhang, Qi Xu, Liecheng Wang, Pingping Zhan. Expression of SH3 and Multiple Ankyrin Repeat Domains Protein 3 in Mouse Retina. Frontiers in cellular neuroscience. vol 16. 2022-04-11. PMID:35401120. |
dopaminergic acs (labeled by tyrosine hydroxylase) and cholinergic acs (labeled by choline acetyltransferase) were also found to contain shank3-positive signals. |
2022-04-11 |
2023-08-13 |
mouse |