| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giulia Costa, Marcello Serra, Riccardo Maccioni, Maria Antonietta Casu, Sanjay B Kasture, Elio Acquas, Micaela Morell. Withania somnifera influences MDMA-induced hyperthermic, cognitive, neurotoxic and neuroinflammatory effects in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 161. 2023-03-11. PMID:36905810. |
thereafter, immunohistochemistry was performed to evaluate in the substantia nigra pars compacta (snc) and striatum the levels of tyrosine hydroxylase (th), as marker of dopaminergic degeneration, and of glial fibrillary acidic protein (gfap) and tmem119, as markers of astrogliosis or microgliosis, respectively. |
2023-03-11 |
2023-08-14 |
mouse |
| Qi Li, Nian Chen, Jin-Ding Luo, Hui-Lin Wu, Zi-Han Wang, Meng-Wei Li, Shui-Dong Feng, Hong-Yan Lin. [Dihydromyricetin improves Parkinson's disease-like lesions in T2DM rats by activating AMPK/ULK1 pathway]. Sheng li xue bao : [Acta physiologica Sinica]. vol 75. issue 1. 2023-03-02. PMID:36859835. |
the motor ability of the rats was measured by balance beam experiment, the changes of dopaminergic (da) neurons and the expression of autophagy initiation related protein ulk1 in the midbrains of the rats were detected by immunohistochemistry, and the protein expression levels of α-synuclein (α-syn), tyrosine hydroxylase (th), as well as ampk activation level, in the midbrains of the rats were detected by western blot. |
2023-03-02 |
2023-08-14 |
rat |
| G Ramirez-Mejia, E Gil-Lievana, O Urrego-Morales, D Galvez-Marquez, E Hernández-Ortiz, J A Carrillo-Lorenzo, F Bermúdez-Ratton. Salience to remember: VTA-IC dopaminergic pathway activity is necessary for object recognition memory formation. Neuropharmacology. 2023-02-22. PMID:36804534. |
using a cre-recombinase under the tyrosine hydroxylase (th+) promoter mouse model, we photostimulated the vta-ic dopaminergic pathway during short training or photoinhibited the same pathway during long training while mice explored objects. |
2023-02-22 |
2023-08-14 |
mouse |
| Dong-Chan Seo, Yeon Ha Ju, Jin-Ju Seo, Soo-Jin Oh, C Justin Lee, Seung Eun Lee, Min-Ho Na. DDC-Promoter-Driven Chemogenetic Activation of SNpc Dopaminergic Neurons Alleviates Parkinsonian Motor Symptoms. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768816. |
recent studies have suggested that excessive gaba from reactive astrocytes tonically inhibits dopaminergic neurons and reduces the expression of tyrosine hydroxylase (th), the key dopamine-synthesizing enzyme, in the substantia nigra pars compacta (snpc). |
2023-02-11 |
2023-08-14 |
rat |
| Alba Tristán-Noguero, Irene Fernández-Carasa, Carles Calatayud, Cristina Bermejo-Casadesús, Meritxell Pons-Espinal, Arianna Colini Baldeschi, Leticia Campa, Francesc Artigas, Analia Bortolozzi, Rosario Domingo-Jiménez, Salvador Ibáñez, Mercè Pineda, Rafael Artuch, Ángel Raya, Àngels García-Cazorla, Antonella Consigli. iPSC-based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation. EMBO molecular medicine. 2023-02-06. PMID:36740977. |
tyrosine hydroxylase deficiency (thd) is a rare genetic disorder leading to dopaminergic depletion and early-onset parkinsonism. |
2023-02-06 |
2023-08-14 |
Not clear |
| Hyojung Kim, Yu-Jin Huh, Ji Hun Kim, Minkyung Jo, Joo-Heon Shin, Sang Chul Park, Jee-Yin Ahn, Yun-Il Lee, Yunjong Le. Identification and evaluation of midbrain specific longevity-related genes in exceptionally long-lived but healthy mice. Frontiers in aging neuroscience. vol 14. 2023-01-30. PMID:36711211. |
strikingly, these long-lived mice maintained tyrosine hydroxylase expression and dopaminergic fiber densities, even in the presence of persistent neuroinflammation and expression of aging markers. |
2023-01-30 |
2023-08-14 |
mouse |
| Shipra Kartik, Rishi Pal, Manju J Chaudhary, Rajendra Nath, Madhu Kumar, Monika Binwal, D U Bawankul. Neuroprotective role of chloroquine via modulation of autophagy and neuroinflammation in MPTP-induced Parkinson's disease. Inflammopharmacology. 2023-01-30. PMID:36715843. |
cq therapy preserves dopamine levels stable, inhibits tyrosine hydroxylase (th) positive dopaminergic cell death, and lowers oxidative stress. |
2023-01-30 |
2023-08-14 |
mouse |
| Yuka Nago-Iwashita, Yuki Moriya, Satoshi Hara, Ryohei Ogawa, Rina Aida, Katsuya Miyajima, Takenobu Shimura, Shin-Ichi Muramatsu, Soichiro Ide, Kazutaka Ikeda, Hiroshi Ichinos. Overexpression of tyrosine hydroxylase in dopaminergic neurons increased sensitivity to methamphetamine. Neurochemistry international. 2023-01-28. PMID:36709046. |
overexpression of tyrosine hydroxylase in dopaminergic neurons increased sensitivity to methamphetamine. |
2023-01-28 |
2023-08-14 |
mouse |
| Yuka Nago-Iwashita, Yuki Moriya, Satoshi Hara, Ryohei Ogawa, Rina Aida, Katsuya Miyajima, Takenobu Shimura, Shin-Ichi Muramatsu, Soichiro Ide, Kazutaka Ikeda, Hiroshi Ichinos. Overexpression of tyrosine hydroxylase in dopaminergic neurons increased sensitivity to methamphetamine. Neurochemistry international. 2023-01-28. PMID:36709046. |
dopaminergic neurons are deeply involved in addiction, and tyrosine hydroxylase (th) catalyzes the first and rate-limiting step of the biosynthesis of dopamine (da). |
2023-01-28 |
2023-08-14 |
mouse |
| Daniel Kalinowski, Krystyna Bogus-Nowakowska, Anna Kozłowska, Maciej Równia. Dopaminergic and cholinergic modulation of the amygdala is altered in female mice with oestrogen receptor β deprivation. Scientific reports. vol 13. issue 1. 2023-01-17. PMID:36650256. |
the results show that among dopaminergic markers, the expression of tyrosine hydroxylase (th), dopamine transporter (dat) and dopamine d |
2023-01-17 |
2023-08-14 |
mouse |
| Mahbubeh Saeedfar, Abolfazl Ardjmand, Behrang Alani, Amir Ghaderi, Hamid Reza Banafshe, Mohammad Esmaeil Shahaboddin, Gholamreza Ghavipanje. The effect of vitamin D on morphine preference in rats: Possible biochemical and DRD2-GDNF signaling. Brain and behavior. 2023-01-11. PMID:36630182. |
d in the evolution of dopaminergic neurons in the nucleus accumbens, an increase in the expression of tyrosine hydroxylase, and the regulation of dopaminergic processes. |
2023-01-11 |
2023-08-14 |
rat |
| Dmitry Troshev, Victor Blokhin, Valeria Ukrainskaya, Anna Kolacheva, Michael Ugrumo. Isolation of living dopaminergic neurons labeled with a fluorescent ligand of the dopamine transporter from mouse substantia nigra as a new tool for basic and applied research. Frontiers in molecular neuroscience. vol 15. 2022-12-26. PMID:36568278. |
we have developed a method for selecting a population of dns from the sn of mice, as evidenced by: (i) immunopositivity of 95% of the sorted cells for tyrosine hydroxylase, the first enzyme of dopamine synthesis; (ii) the sorted cells expressing the genes for specific proteins of the dopaminergic phenotype, tyrosine hydroxylase, the dopamine transporter, and vesicular monoamine transporter 2 and non-specific proteins, such as aromatic l-amino acid decarboxylase, non-specific enzyme of dopamine synthesis. |
2022-12-26 |
2023-08-14 |
mouse |
| Yara T Mohamed, Abeer Salama, Mostafa A Rabie, Mai A Abd El Fatta. Neuroprotective effect of secukinumab against rotenone induced Parkinson's disease in rat model: Involvement of IL-17, HMGB-1/TLR4 axis and BDNF/TrKB cascade. International immunopharmacology. vol 114. 2022-12-17. PMID:36527875. |
furthermore, secukinumab increased striatal tyrosine hydroxylase immunoexpression, the rate limiting step in dopamine biosynthesis, to guard against dopaminergic neuronal loss. |
2022-12-17 |
2023-08-14 |
rat |
| Yongjun Wang, Zhengjia Pu, Yiran Zhang, Zhaohui Du, Zeming Guo, Qunhua Ba. Exercise training has a protective effect in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model with improved neural and intestinal pathology and modified intestinal flora. Behavioural brain research. 2022-12-01. PMID:36455673. |
the results showed in these pd mice, exercise training improved their motility, increased the dopamine (da) content in the striatum, along with promoted the gene expression of tyrosine hydroxylase and brain-derived neurotrophic factor in the striatum, which suggests this exercise training might protect striatal dopaminergic neurons from mptp damage; the results also showed exercise training promoted recovery from ileal pathology, reduced the gene expression of intestinal inflammatory factors, and significantly altered the composition and structure of the intestinal flora in these mice. |
2022-12-01 |
2023-08-14 |
mouse |
| Richard L Jayaraj, Sheikh Azimullah, Khatija A Parekh, Shreesh K Ojha, Rami Beira. Effect of citronellol on oxidative stress, neuroinflammation and autophagy pathways in an Heliyon. vol 8. issue 11. 2022-11-17. PMID:36387498. |
tyrosine hydroxylase (th) immunoreactivity showed that citronellol preserved tyrosine hydroxylase (th) positive dopaminergic neurons and enhanced th striatal expression levels significantly compared to rotenone alone group. |
2022-11-17 |
2023-08-14 |
rat |
| Sergio G Cuevas-Carbonell, Lizbeth Vásquez-Celaya, Daniel García-López, Diego Granados-Patrón, María Del R García-Miss, Fernando J Álvarez-Cervera, Mirza Mut-Martín, Irving Parra, Liliana Mendieta, Humberto Salgado, Javier Alamilla, Reyna Cruz-Bojórquez, María Luisa Ávila-Escalante, Irma I Aranda-González, José L Góngora-Alfar. Chronic treatment with the probiotics Lacticaseibacillus rhamnosus GG and Bifidobacterium lactis BB12 attenuates motor impairment, striatal microglial activation, and dopaminergic loss in rats with 6-hydroxydopamine-induced hemiparkinsonism. Neuroscience. 2022-11-12. PMID:36370934. |
dopaminergic (da) denervation and microglia recruitment were assessed with tyrosine hydroxylase (th |
2022-11-12 |
2023-08-14 |
rat |
| Mingyue Jin, Sakiko Matsumoto, Takashi Ayaki, Hodaka Yamakado, Tomoyuki Taguchi, Natsuko Togawa, Ayumu Konno, Hirokazu Hirai, Hiroshi Nakajima, Shoji Komai, Ryuichi Ishida, Syuhei Chiba, Ryosuke Takahashi, Toshifumi Takao, Shinji Hirotsun. DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers. Nature communications. vol 13. issue 1. 2022-11-12. PMID:36371400. |
parkinson's disease is a progressive neurodegenerative disorder characterized by the preferential loss of tyrosine hydroxylase (th)-expressing dopaminergic neurons in the substantia nigra. |
2022-11-12 |
2023-08-14 |
mouse |
| Shima Tavakol, Elham Hoveizi, Hani Tavakol, Amin Almasi, Mansoureh Soleimani, Shadi Rabiee Motmaen, Fereshteh Azedi, Mohammad Taghi Joghatae. Strong binding of phytochemicals to the catalytic domain of tyrosine hydroxylase as a Trojan horse decreases dopamine in dopaminergic cells: Pharmaceutical considerations in schizophrenia and Parkinson's disease. Current pharmaceutical design. 2022-11-04. PMID:36330626. |
strong binding of phytochemicals to the catalytic domain of tyrosine hydroxylase as a trojan horse decreases dopamine in dopaminergic cells: pharmaceutical considerations in schizophrenia and parkinson's disease. |
2022-11-04 |
2023-08-14 |
Not clear |
| Ryo Yamamoto, Takafumi Furuyama, Qin Zhao, Takayoshi Masuoka, Yoshie Hori, Tetsufumi Ito, Munenori Ono, Nobuo Kat. [Characterization of the dorsal raphe-periaqueductal grey DAT neurons innervating onto the extended amygdala]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 157. issue 6. 2022-11-03. PMID:36328558. |
it has been known that a number of tyrosine hydroxylase (th)-positive neurons, which are regarded as dopaminergic (da) neurons, exist in the dorsal raphe (dr). |
2022-11-03 |
2023-08-14 |
Not clear |
| Yutaka Itokazu, Robert K Y. Ganglioside Microdomains on Cellular and Intracellular Membranes Regulate Neuronal Cell Fate Determination. Advances in neurobiology. vol 29. 2022-10-18. PMID:36255679. |
interestingly, gm1 could induce epigenetic activation of the tyrosine hydroxylase (th) gene, with recruitment of nuclear receptor related 1 (nurr1, also known as nr4a2), a dopaminergic neuron-associated transcription factor, to the th promoter region. |
2022-10-18 |
2023-08-14 |
Not clear |