| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andreas Gutzeit, Johannes M Froehlich, Klaus Hergan, Nicole Graf, Christoph A Binkert, Dieter Meier, Mike Brügger, Carolin Reischauer, Reto Sutter, Marcus Herdener, Tillmann Schubert, Sebastian Kos, Martin Grosshans, Matus Straka, Jochen Mutschle. Insula-specific H magnetic resonance spectroscopy reactions in heavy smokers under acute nicotine withdrawal and after oral nicotine substitution. European addiction research. vol 19. issue 4. 2014-11-06. PMID:23257512. |
the results are consistent with the expression of an addiction-specific neurometabolic shift in the brain and confirm the fact that the insular cortex seems to play a possible role in nicotine dependence. |
2014-11-06 |
2023-08-12 |
human |
| Lauren V Moran, Hemalatha Sampath, Peter Kochunov, L Elliot Hon. Brain circuits that link schizophrenia to high risk of cigarette smoking. Schizophrenia bulletin. vol 39. issue 6. 2014-06-23. PMID:23236076. |
several of these functional circuits were also associated with nicotine addiction severity; the largest cluster included limbic areas such as the parahippocampal, extended amygdala, ventral striatal, and posterior insula regions, indicating an overlap of schizophrenia and nicotine addiction on to this circuit. |
2014-06-23 |
2023-08-12 |
Not clear |
| Eric D Claus, Sara K Blaine, Francesca M Filbey, Andrew R Mayer, Kent E Hutchiso. Association between nicotine dependence severity, BOLD response to smoking cues, and functional connectivity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 12. 2014-06-03. PMID:23708507. |
finally, relationships with nicotine dependence scores showed enhanced response in insula and dorsal anterior cingulate cortex in the smoking vs food comparison, and increased connectivity between insula and circuits involved in motivated behavior. |
2014-06-03 |
2023-08-12 |
Not clear |
| Nils B Kroemer, Alvaro Guevara, Sabine Vollstädt-Klein, Michael N Smolk. Nicotine alters food-cue reactivity via networks extending from the hypothalamus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 11. 2014-05-05. PMID:23778853. |
furthermore, nicotine reduced coupling with the nucleus accumbens and the ogtt reduced coupling with an 'interoceptive network' (ie, insula, operculum) instead. |
2014-05-05 |
2023-08-12 |
human |
| Matthew T Sutherland, Allison J Carroll, Betty Jo Salmeron, Thomas J Ross, L Elliot Hong, Elliot A Stei. Down-regulation of amygdala and insula functional circuits by varenicline and nicotine in abstinent cigarette smokers. Biological psychiatry. vol 74. issue 7. 2014-03-25. PMID:23506999. |
down-regulation of amygdala and insula functional circuits by varenicline and nicotine in abstinent cigarette smokers. |
2014-03-25 |
2023-08-12 |
Not clear |
| Matthew T Sutherland, Allison J Carroll, Betty Jo Salmeron, Thomas J Ross, L Elliot Hong, Elliot A Stei. Down-regulation of amygdala and insula functional circuits by varenicline and nicotine in abstinent cigarette smokers. Biological psychiatry. vol 74. issue 7. 2014-03-25. PMID:23506999. |
although the amygdala and insula are regarded as critical neural substrates perpetuating cigarette smoking, little is known about their circuit-level interactions with interconnected regions during nicotine withdrawal or following pharmacotherapy administration. |
2014-03-25 |
2023-08-12 |
Not clear |
| R Mychasiuk, A Muhammad, C Carroll, B Kol. Does prenatal nicotine exposure alter the brain's response to nicotine in adolescence? A neuroanatomical analysis. The European journal of neuroscience. vol 38. issue 4. 2014-02-19. PMID:23679187. |
this study examined changes in dendritic morphology and spine density in multiple brain regions [zilles' areas: (i) the cg3 region of the anterior cingulate cortex or the medial prefrontal cortex, layer iii (cg3); (ii) the dorsal agranular insular cortex, layer iii (aid); (iii) the par i region of the parietal cortex, layer iii (par1) and (iv) the nucleus accumbens (nac)]of long-evans rats following exposure to nicotine prenatally, in late adolescence, or both prenatally and in adolescence. |
2014-02-19 |
2023-08-12 |
rat |
| Abhiram Pushparaj, Clement Hamani, Wilson Yu, Damian S Shin, Bin Kang, José N Nobrega, Bernard Le Fol. Electrical stimulation of the insular region attenuates nicotine-taking and nicotine-seeking behaviors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 4. 2013-10-29. PMID:23249816. |
evaluation of the effect of stimulation in the insular region was performed on nicotine self-administration under fr-5 and pr schedules, as well on reinstatement of nicotine-seeking behavior induced by nicotine-associated cues or nicotine-priming injections. |
2013-10-29 |
2023-08-12 |
rat |
| Marina Goldman, Regina P Szucs-Reed, Kanchana Jagannathan, Ronald N Ehrman, Ze Wang, Yin Li, Jesse J Suh, Kyle Kampman, Charles P O'Brien, Anna Rose Childress, Teresa R Frankli. Reward-related brain response and craving correlates of marijuana cue exposure: a preliminary study in treatment-seeking marijuana-dependent subjects. Journal of addiction medicine. vol 7. issue 1. 2013-05-27. PMID:23188041. |
laboratory neuroimaging studies have demonstrated differential activation of limbic and motivational circuitry (eg, amygdala, hippocampus, ventral striatum, insula, and orbitofrontal cortex) triggered by cocaine, heroin, nicotine, and alcohol cues. |
2013-05-27 |
2023-08-12 |
human |
| Lauren V Moran, Hemalatha Sampath, Elliot A Stein, L Elliot Hon. Insular and anterior cingulate circuits in smokers with schizophrenia. Schizophrenia research. vol 142. issue 1-3. 2013-05-07. PMID:23021898. |
since the insula is implicated in nicotine dependence, we hypothesized that sz smokers will have greater dysfunction in smoking-related insular and dacc circuits than normal control smokers (nc) independent of smoking severity, consistent with an inherent disease-related weakening of smoking-related circuits. |
2013-05-07 |
2023-08-12 |
Not clear |
| Lauren V Moran, Hemalatha Sampath, Elliot A Stein, L Elliot Hon. Insular and anterior cingulate circuits in smokers with schizophrenia. Schizophrenia research. vol 142. issue 1-3. 2013-05-07. PMID:23021898. |
reduced rsfc strength between the insula, dacc and striatum is associated with nicotine addiction severity in both non-psychiatrically ill and in sz smokers. |
2013-05-07 |
2023-08-12 |
Not clear |
| Matthew T Sutherland, Meredith J McHugh, Vani Pariyadath, Elliot A Stei. Resting state functional connectivity in addiction: Lessons learned and a road ahead. NeuroImage. vol 62. issue 4. 2013-01-02. PMID:22326834. |
emerging evidence supports a critical role for the insula in nicotine addiction. |
2013-01-02 |
2023-08-12 |
Not clear |
| Matthew T Sutherland, Meredith J McHugh, Vani Pariyadath, Elliot A Stei. Resting state functional connectivity in addiction: Lessons learned and a road ahead. NeuroImage. vol 62. issue 4. 2013-01-02. PMID:22326834. |
we suggest that a better understanding of how the insula modulates the interaction between these networks is critical for elucidating both the cognitive impairments often associated with withdrawal and the performance-enhancing effects of nicotine administration. |
2013-01-02 |
2023-08-12 |
Not clear |
| Antonio Verdejo-Garcia, Luke Clark, Barnaby D Dun. The role of interoception in addiction: a critical review. Neuroscience and biobehavioral reviews. vol 36. issue 8. 2012-12-27. PMID:22659642. |
recent work has begun to explore the relevance of this construct to drug addiction: drugs of abuse and drug-related stimuli induce pronounced peripheral changes, and damage to a brain region known to support interoception (the insula) disrupts nicotine dependence. |
2012-12-27 |
2023-08-12 |
Not clear |
| Daniel G Ehlinger, Hadley C Bergstrom, Craig G McDonald, Robert F Smit. Nicotine-induced dendritic remodeling in the insular cortex. Neuroscience letters. vol 516. issue 1. 2012-08-24. PMID:22487730. |
the insular cortex has emerged as a novel target for nicotine addiction research. |
2012-08-24 |
2023-08-12 |
rat |
| Daniel G Ehlinger, Hadley C Bergstrom, Craig G McDonald, Robert F Smit. Nicotine-induced dendritic remodeling in the insular cortex. Neuroscience letters. vol 516. issue 1. 2012-08-24. PMID:22487730. |
one unresolved question about the insular cortex is whether its neurons exhibit nicotine-induced dendritic remodeling similar to other brain regions implicated in nicotine addiction. |
2012-08-24 |
2023-08-12 |
rat |
| Daniel G Ehlinger, Hadley C Bergstrom, Craig G McDonald, Robert F Smit. Nicotine-induced dendritic remodeling in the insular cortex. Neuroscience letters. vol 516. issue 1. 2012-08-24. PMID:22487730. |
thirty-seven days following the end of nicotine dosing, rats were sacrificed for golgi-cox staining and pyramidal neurons from the rostral agranular insular cortex were digitally reconstructed in three dimensions. |
2012-08-24 |
2023-08-12 |
rat |
| Daniel G Ehlinger, Hadley C Bergstrom, Craig G McDonald, Robert F Smit. Nicotine-induced dendritic remodeling in the insular cortex. Neuroscience letters. vol 516. issue 1. 2012-08-24. PMID:22487730. |
results from morphometric analyses revealed an increased complexity of dendrites in the insular cortex following nicotine. |
2012-08-24 |
2023-08-12 |
rat |
| Daniel G Ehlinger, Hadley C Bergstrom, Craig G McDonald, Robert F Smit. Nicotine-induced dendritic remodeling in the insular cortex. Neuroscience letters. vol 516. issue 1. 2012-08-24. PMID:22487730. |
together, these results show the insular cortex is a target for neuroplasticity following nicotine exposure. |
2012-08-24 |
2023-08-12 |
rat |
| Teresa R Franklin, Ze Wang, Yin Li, Jesse J Suh, Marina Goldman, Falk W Lohoff, Jeffrey Cruz, Rebecca Hazan, Will Jens, John A Detre, Wade Berrettini, Charles P O'Brien, Anna Rose Childres. Dopamine transporter genotype modulation of neural responses to smoking cues: confirmation in a new cohort. Addiction biology. vol 16. issue 2. 2011-07-20. PMID:21299752. |
in secondary analyses, we found that the fagerström test for nicotine dependence scores correlated with enhanced sc-induced perfusion in 10/10-repeats in the insula, mofc, medial temporal and superior frontal gyri (r=0.50-0.82), while correlations were absent in 9-repeat carriers. |
2011-07-20 |
2023-08-12 |
Not clear |