| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sujin Jeong, Yoseob Kim, Sanggil Choe, Hyunwook Kang, Hyung Min Kim, Jong Seong Kan. A fatal case of desvenlafaxine and paroxetine poisoning. Journal of pharmaceutical and biomedical analysis. vol 245. 2024-04-23. PMID:38652939. |
desvenlafaxine (o-desmethylvenlafaxine) and paroxetine are antidepressants that inhibit serotonin reuptake. |
2024-04-23 |
2024-04-26 |
Not clear |
| Helen M Collins, L Sophie Gullino, Dersu Ozdemir, Caroline Lazarenco, Yulia Sudarikova, Elizabeth Daly, Fuencisla Pilar Cuéllar, Raquel Pinacho, David M Bannerman, Trevor Shar. Rebound activation of 5-HT neurons following SSRI discontinuation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-04-12. PMID:38609530. |
here we determined the effect on 5-ht neurochemistry of discontinuation from the ssri paroxetine. |
2024-04-12 |
2024-04-15 |
mouse |
| Helen M Collins, L Sophie Gullino, Dersu Ozdemir, Caroline Lazarenco, Yulia Sudarikova, Elizabeth Daly, Fuencisla Pilar Cuéllar, Raquel Pinacho, David M Bannerman, Trevor Shar. Rebound activation of 5-HT neurons following SSRI discontinuation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-04-12. PMID:38609530. |
whereas brain tissue levels of 5-ht and/or its metabolite 5-hiaa tended to decrease during continuous paroxetine, levels increased above controls after discontinuation, notably in hippocampus. |
2024-04-12 |
2024-04-15 |
mouse |
| Helen M Collins, L Sophie Gullino, Dersu Ozdemir, Caroline Lazarenco, Yulia Sudarikova, Elizabeth Daly, Fuencisla Pilar Cuéllar, Raquel Pinacho, David M Bannerman, Trevor Shar. Rebound activation of 5-HT neurons following SSRI discontinuation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-04-12. PMID:38609530. |
in microdialysis experiments continuous paroxetine elevated hippocampal extracellular 5-ht and this effect fell to saline control levels on discontinuation. |
2024-04-12 |
2024-04-15 |
mouse |
| Helen M Collins, L Sophie Gullino, Dersu Ozdemir, Caroline Lazarenco, Yulia Sudarikova, Elizabeth Daly, Fuencisla Pilar Cuéllar, Raquel Pinacho, David M Bannerman, Trevor Shar. Rebound activation of 5-HT neurons following SSRI discontinuation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-04-12. PMID:38609530. |
however, depolarisation (high potassium)-evoked 5-ht release was reduced by continuous paroxetine but increased above controls post-discontinuation. |
2024-04-12 |
2024-04-15 |
mouse |
| Helen M Collins, L Sophie Gullino, Dersu Ozdemir, Caroline Lazarenco, Yulia Sudarikova, Elizabeth Daly, Fuencisla Pilar Cuéllar, Raquel Pinacho, David M Bannerman, Trevor Shar. Rebound activation of 5-HT neurons following SSRI discontinuation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-04-12. PMID:38609530. |
next, immunohistochemistry experiments found that paroxetine discontinuation increased c-fos expression in midbrain 5-ht (tph2 positive) neurons, adding further evidence for a hyperexcitable 5-ht system. |
2024-04-12 |
2024-04-15 |
mouse |
| Xiang-Ming Cai, Xiao-Yu Sun, Rui Li, Pei-Juan Wang, Jian-Cheng Qi, Yu-Xin Ge, Lei Yan. The hippocampal Salt-Inducible Kinase 2-CREB-Regulated Transcription Co-activator 1 system mediates the antidepressant actions of paroxetine in mice. Behavioural brain research. 2024-03-29. PMID:38552744. |
like fluoxetine, paroxetine is also a widely used selective serotonin (5-ht) reuptake inhibitor (ssri). |
2024-03-29 |
2024-04-01 |
mouse |
| Gemma Mestre-Bach, Marc N Potenz. Current Understanding of Compulsive Sexual Behavior Disorder and Co-occurring Conditions: What Clinicians Should Know about Pharmacological Options. CNS drugs. 2024-03-15. PMID:38485889. |
the main pharmacological approaches to treating csbd have included opioid antagonists (naltrexone and nalmefene), selective serotonin reuptake inhibitors (paroxetine, citalopram, fluoxetine, and sertraline), mood stabilizers (topiramate), tricyclic antidepressants (clomipramine), serotonin antagonist and reuptake inhibitors (nefazodone), and n-acetylcysteine. |
2024-03-15 |
2024-03-17 |
Not clear |
| Qianrui Huang, Mengling Wu, Yamin Pu, Junyou Zhou, Yiqian Zhang, Ru Li, Yong Xia, Yiwen Zhang, Yimei M. Inhibition of TNBC Cell Growth by Paroxetine: Induction of Apoptosis and Blockage of Autophagy Flux. Cancers. vol 16. issue 5. 2024-03-13. PMID:38473249. |
paroxetine (px), a selective serotonin reuptake inhibitor typically utilized in the treatment of depression, has demonstrated promise as an agent for combating cancer. |
2024-03-13 |
2024-03-15 |
Not clear |
| Yuhua Jin, Lamei Yu, Yan L. Paroxetine Effect on Nerve Growth Factor, Human Neurotrophin-4, Brain-Derived Neurotrophic Factor Levels in Post-stroke Depression. Molecular neurobiology. 2024-03-05. PMID:38443730. |
for post-stroke depression, paroxetine treatment can effectively improve ngf, nt-4, bdnf, 5-ht, hcy, and ne levels and effectively reduce the degree of neurological damage and depression, which has high clinical application value. |
2024-03-05 |
2024-03-08 |
human |
| Fumiya Inoue, Yuji Okazaki, Toshihisa Ichiba, Kenichiro Kashiwa, Akira Namer. Unexpectedly Prolonged Serotonin Syndrome and Fatal Complications Following a Massive Overdose of Paroxetine Controlled-Release. Cureus. vol 15. issue 12. 2024-01-17. PMID:38229825. |
unexpectedly prolonged serotonin syndrome and fatal complications following a massive overdose of paroxetine controlled-release. |
2024-01-17 |
2024-01-19 |
Not clear |
| Fumiya Inoue, Yuji Okazaki, Toshihisa Ichiba, Kenichiro Kashiwa, Akira Namer. Unexpectedly Prolonged Serotonin Syndrome and Fatal Complications Following a Massive Overdose of Paroxetine Controlled-Release. Cureus. vol 15. issue 12. 2024-01-17. PMID:38229825. |
we describe a fatal case of severe serotonin syndrome and acute respiratory distress syndrome (ards) following an overdose of controlled-release paroxetine. |
2024-01-17 |
2024-01-19 |
Not clear |
| Letícia Rampazzo da Gama Viveiro, Amanda Rodrigues Rehem, Evelyn Luzia De Souza Santos, Paulo Henrique Fonseca do Carmo, Juliana Campos Junqueira, Liliana Scorzon. In vitro effects of selective serotonin reuptake inhibitors on Cryptococcus gattii Capsule and biofilm. Pathogens and disease. 2024-01-11. PMID:38204138. |
this study aimed to validate the efficacy of selective serotonin reuptake inhibitors (ssri) fluoxetine hydrochloride (flh) and paroxetine hydrochloride (pah) in vitro against c. gattii. |
2024-01-11 |
2024-01-13 |
Not clear |
| Mingfeng Fan, Laian Li, Xiangjun Xu, Cong Zhou, Peng Wang, Wanbin Yin, Wenju Pei, Shuai Wan. Psychological status of patients with functional anorectal pain and treatment efficacy of paroxetine in alleviating the symptoms: a retrospective study. Scientific reports. vol 13. issue 1. 2023-10-21. PMID:37865675. |
paroxetine, a typical serotonin reuptake inhibitor (ssri), was able to alleviate depression, anxiety, and pain symptoms in fap, which might have clinical application prospects. |
2023-10-21 |
2023-11-08 |
Not clear |
| Kathryn Justesen, Darien Jourdain. Peripartum Depression: Detection and Treatment. American family physician. vol 108. issue 3. 2023-09-19. PMID:37725459. |
the benefits of selective serotonin reuptake inhibitors generally outweigh the risks; however, fluoxetine and paroxetine should be avoided during pregnancy because they can cause an increased risk of birth defects. |
2023-09-19 |
2023-10-07 |
Not clear |
| Flávia Luciana Beltrame, Thiago Henrique Pereira Moysés, Mônica Pereira Coelho, Maria Clara Rossetto Steinvascher, Salmo Azambuja de Oliveira, André Acácio Souza da Silva, Paulo Sérgio Cerri, Estela Sasso-Cerr. Role of serotonin, estrogen, and TNF-α in the paroxetine-impaired steroidogenesis and testicular macrophages polarization. Andrology. 2023-09-07. PMID:37675929. |
paroxetine, a selective serotonin reuptake inhibitor (ssri) antidepressant, has caused male sexual dysfunction; however, the paroxetine mechanisms of action in testes are still unclear. |
2023-09-07 |
2023-10-07 |
Not clear |
| Francesca R Brugnoli, Marion Holy, Marco Niello, Julian Maier, Marcus Hanreich, Mario Menzel, Matthias Haberler, Niklas Zulus, Thomas Pickl, Christa Ivanova, Lisa D Muiznieks, Benjamin Garlan, Harald H Sitt. Development and validation of an automated microfluidic perfusion platform for parallelized screening of compounds in vitro. Basic & clinical pharmacology & toxicology. 2023-09-02. PMID:37658634. |
d-amphetamine, gbr12909 (norepinephrine transporter) and p-chloroamphetamine, paroxetine (serotonin transporter) were used as control compounds to validate the system. |
2023-09-02 |
2023-09-07 |
Not clear |
| Khalid AlHezaimi, Ilan Rotstein, Joseph Katz, Marc Nevins, Myron Nevin. Effect of selective serotonin reuptake inhibitor (paroxetine) on newly formed bone volume: Real time in vivo micro computed tomographic analysis. Journal of endodontics. 2023-08-18. PMID:37595681. |
effect of selective serotonin reuptake inhibitor (paroxetine) on newly formed bone volume: real time in vivo micro computed tomographic analysis. |
2023-08-18 |
2023-10-07 |
Not clear |
| Harika Topal Önal, Derya Yetkin, Furkan Aya. Paroxetine's effect on the proinflammatory cytokine stimulation and intracellular signaling pathways in J774.2 cells. Naunyn-Schmiedeberg's archives of pharmacology. 2023-08-17. PMID:37589738. |
paroxetine works by increasing serotonin levels in nerve cells in the brain. |
2023-08-17 |
2023-09-07 |
Not clear |
| G Tcherne. NITROSOGENESIS OF SKIN CANCER: THE NITROSAMINE CONTAMINATION IN THE CALCIUM CHANNEL BLOCKERS (AMLODIPINE), BETA BLOCKERS (BISOPROLOL), SARTANS (VALSARTAN/LOSARTAN), ACE INHIBITORS (PERINDOPRIL/ENALAPRIL), TRICYCLIC ANTIDEPRESSANTS (MELITRACEN), SSRIS (PAROXETINE), SNRIS (VENLAFAXINE) AND METFORMIN: THE MOST PROBABLE EXPLANATION FOR THE RISING SKIN CANCER INCIDENCE. Georgian medical news. issue 339. 2023-07-31. PMID:37522769. |
the possible contamination with nitrosamines of 1) other types of tricyclic antidepressant- melitracen; 2) antidepressant of the selective serotonin reuptake inhibitor (ssri) class: paroxetine; 3) antidepressant of the serotonin and noradrenaline reuptake inhibitor (snris) class: venlafaxine, as well as of the systemic anticoagulant: apixaban is highlighted for the first time in the world literature. |
2023-07-31 |
2023-08-14 |
human |