| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fahad Aldosary, Sandhaya Norris, Philippe Tremblay, Jonathan S James, James C Ritchie, Pierre Blie. Differential potency of venlafaxine, paroxetine, and atomoxetine to inhibit serotonin and norepinephrine reuptake in patients with major depressive disorder. The international journal of neuropsychopharmacology. 2021-12-27. PMID:34958348. |
differential potency of venlafaxine, paroxetine, and atomoxetine to inhibit serotonin and norepinephrine reuptake in patients with major depressive disorder. |
2021-12-27 |
2023-08-13 |
Not clear |
| Fahad Aldosary, Sandhaya Norris, Philippe Tremblay, Jonathan S James, James C Ritchie, Pierre Blie. Differential potency of venlafaxine, paroxetine, and atomoxetine to inhibit serotonin and norepinephrine reuptake in patients with major depressive disorder. The international journal of neuropsychopharmacology. 2021-12-27. PMID:34958348. |
paroxetine is generally considered as a selective serotonin reuptake inhibitor but exhibits some affinity for net. |
2021-12-27 |
2023-08-13 |
Not clear |
| Ian D Tomlinson, Oleg Kovtun, Ruben Torres, Laurel G Bellocchio, Travis Josephs, Sandra J Rosentha. A Novel Biotinylated Homotryptamine Derivative for Quantum Dot Imaging of Serotonin Transporter in Live Cells. Frontiers in cellular neuroscience. vol 15. 2021-12-07. PMID:34867196. |
we demonstrated that idt785 enabled quantum dot (qd) labeling of membrane sert in transfected hek-293 cultures that could be blocked using the high affinity serotonin reuptake inhibitor paroxetine. |
2021-12-07 |
2023-08-13 |
Not clear |
| Selin Acar, Hilal Erol, Elif Keskin Arslan, Nusret Uysal, Barış Karadaş, Tijen Kaya Temiz, Yusuf Cem Kapla. Paroxetine overdose during pregnancy. Forensic sciences research. vol 6. issue 3. 2021-12-07. PMID:34868717. |
paroxetine is a selective serotonin reuptake inhibitor (ssri) used in the treatment of depression and anxiety disorders. |
2021-12-07 |
2023-08-13 |
Not clear |
| Tyler Thomas Henderson, Jacob R Thorstensen, Steven Morrison, Murray G Tucker, Justin J Kavanag. Physiological tremor is suppressed and force steadiness is enhanced with increased availability of serotonin regardless of muscle fatigue. Journal of neurophysiology. 2021-12-01. PMID:34851768. |
the selective serotonin reuptake inhibitor, paroxetine, suppressed physiological tremor and increased force steadiness when performing the isometric contractions. |
2021-12-01 |
2023-08-13 |
Not clear |
| Ahmed Hassen Elshafeey, Rania Moataz El-Dahm. Formulation and Development of Oral Fast-Dissolving Films Loaded with Nanosuspension to Augment Paroxetine Bioavailability: In Vitro Characterization, Ex Vivo Permeation, and Pharmacokinetic Evaluation in Healthy Human Volunteers. Pharmaceutics. vol 13. issue 11. 2021-11-29. PMID:34834284. |
paroxetine (px) is the most potent serotonin reuptake inhibitor utilized in depression and anxiety treatment. |
2021-11-29 |
2023-08-13 |
human |
| B Raccah-Tebeka, G Boutet, G Plu-Burea. [Non-hormonal alternatives for the management of menopausal hot flushes. Postmenopausal women management: CNGOF and GEMVi clinical practice guidelines]. Gynecologie, obstetrique, fertilite & senologie. vol 49. issue 5. 2021-11-24. PMID:33757925. |
hence, some selective serotonin reuptake inhibitors (paroxetine, citalopram and escitalopram), serotonin and norepinephrine reuptake inhibitors (venlafaxine, desvenlafaxine) gabapentin, pregabalin and clonidine have a statistically effect as compared with placebo in reducing, the frequency and/or severity of hf. |
2021-11-24 |
2023-08-13 |
Not clear |
| Soobeen Hwang, Jong-Hui Kim, Su-Hyun J. Inhibitory effect of the selective serotonin reuptake inhibitor paroxetine on human Kv1.3 channels. European journal of pharmacology. vol 912. 2021-11-22. PMID:34662565. |
inhibitory effect of the selective serotonin reuptake inhibitor paroxetine on human kv1.3 channels. |
2021-11-22 |
2023-08-13 |
human |
| Soobeen Hwang, Jong-Hui Kim, Su-Hyun J. Inhibitory effect of the selective serotonin reuptake inhibitor paroxetine on human Kv1.3 channels. European journal of pharmacology. vol 912. 2021-11-22. PMID:34662565. |
paroxetine is one of the most effective selective serotonin reuptake inhibitors used to treat depressive and panic disorders that reduce the viability of human t lymphocytes, in which kv1.3 channels are highly expressed. |
2021-11-22 |
2023-08-13 |
human |
| Gohei Yamada, Takanari Toyoda, Eiichi Katada, Noriyuki Matsukaw. Index finger pointing posture in a patient with drug-induced foot tremor. Clinical parkinsonism & related disorders. vol 5. 2021-10-26. PMID:34693272. |
co-administration of paroxetine and tramadol increases the risk of serotonin toxicity. |
2021-10-26 |
2023-08-13 |
Not clear |
| Yogesh S Singh, Lauren E Sawarynski, Heather M Michael, Robert E Ferrell, Michael A Murphey-Corb, Greg M Swain, Bhavik A Patel, Anne M Andrew. Boron-Doped Diamond Microelectrodes Reveal Reduced Serotonin Uptake Rates in Lymphocytes from Adult Rhesus Monkeys Carrying the Short Allele of the 5-HTTLPR. ACS chemical neuroscience. vol 1. issue 1. 2021-10-20. PMID:20352073. |
serotonin clearance by lymphocytes is na(+)-dependent and inhibited by the serotonin-selective reuptake inhibitor paroxetine (paxil®), indicative of active uptake by serotonin transporters. |
2021-10-20 |
2023-08-12 |
monkey |
| Hiltrud Brauch, Werner Schroth, Michel Eichelbaum, Matthias Schwab, Nadia Harbec. Clinical Relevance of CYP2D6 Genetics for Tamoxifen Response in Breast Cancer. Breast care (Basel, Switzerland). vol 3. issue 1. 2021-10-20. PMID:20824020. |
moreover, strong cyp2d6 inhibitors such as the selective serotonin reuptake inhibitor paroxetine should be avoided as co-medication. |
2021-10-20 |
2023-08-12 |
Not clear |
| Xuejing Sun, Mengli Zhou, Gaiyan Wen, Yun Huang, Junru Wu, Liping Peng, Weihong Jiang, Hong Yuan, Yao Lu, Jingjing Ca. Paroxetine Attenuates Cardiac Hypertrophy Via Blocking GRK2 and ADRB1 Interaction in Hypertension. Journal of the American Heart Association. vol 10. issue 1. 2021-10-18. PMID:33372534. |
meanwhile, we discovered a selective serotonin reuptake inhibitor paroxetine specifically blockades grk2 and adrb1 interaction. |
2021-10-18 |
2023-08-13 |
rat |
| Li Chen, Jincheng Wang, Tyllis Xu, Xinrui Feng, Chuixiu Huang, Xiantao She. Recent sample pretreatment methods for determination of selective serotonin reuptake inhibitors (SSRIs) in biological samples. Journal of pharmaceutical and biomedical analysis. vol 206. 2021-10-13. PMID:34543943. |
selective serotonin reuptake inhibitors (ssris) such as fluoxetine (flu), sertraline (ser), paroxetine (par), fluvoxamine (flv) and citalopram (cit) have been the first treatment drugs for pregnant and breastfeeding women. |
2021-10-13 |
2023-08-13 |
Not clear |
| Robert M Cabrera, Ying Linda Lin, Elizabeth Law, Jimi Kim, Bogdan J Wlodarczy. The teratogenic effects of sertraline in mice. Birth defects research. vol 112. issue 13. 2021-08-18. PMID:32077266. |
selective serotonin reuptake inhibitors (ssris), which include paroxetine (paxil), sertraline (zoloft), fluoxetine (prozac), citalopram (celexa), and escitalopram (lexapro), are the most common antidepressants prescribed to pregnant women. |
2021-08-18 |
2023-08-13 |
mouse |
| Ayesha Afzal, Ammara Khan, Asma Khan, Rashida Farooqi, Bushra Tayyaba Khan, Iffat Ar. Effect of paroxetine on intestinal motility in the presence of ondansetron. Pakistan journal of pharmaceutical sciences. vol 33. issue 3. 2021-08-03. PMID:33191244. |
the effects of increasing concentrations of serotonin, ondansetron and paroxetine alone were observed. |
2021-08-03 |
2023-08-13 |
Not clear |
| Thaís Cristine Pereira, Raquel Teles de Menezes, Haroldo Cesar de Oliveira, Luciane Dias de Oliveira, Liliana Scorzon. In vitro synergistic effects of fluoxetine and paroxetine in combination with amphotericin B against Cryptococcus neoformans. Pathogens and disease. vol 79. issue 2. 2021-07-19. PMID:33417701. |
the present study aimed to validate the efficacy of selective serotonin reuptake inhibitors, fluoxetine hydrochloride (flh) and paroxetine hydrochloride (pah), alone and in combination with amphotericin b (amb) against c. neoformans. |
2021-07-19 |
2023-08-13 |
Not clear |
| Magdalena Kowalska, Łukasz Fijałkowski, Alicja Nowaczy. Assessment of Paroxetine Molecular Interactions with Selected Monoamine and γ-Aminobutyric Acid Transporters. International journal of molecular sciences. vol 22. issue 12. 2021-07-14. PMID:34208199. |
due to the confirmed dependence of depression on serotonin, norepinephrine, dopamine and γ-aminobutyric acid levels, studies have been undertaken into paroxetine interactions with these primary neurotransmitters using in silico and in vitro methods. |
2021-07-14 |
2023-08-13 |
Not clear |
| Magdalena Kowalska, Łukasz Fijałkowski, Alicja Nowaczy. Assessment of Paroxetine Molecular Interactions with Selected Monoamine and γ-Aminobutyric Acid Transporters. International journal of molecular sciences. vol 22. issue 12. 2021-07-14. PMID:34208199. |
however, studies of the potency inhibitors and binding affinity values indicate that the neurogenic mechanism of paroxetine's action may be determined mainly by its interactions with serotonin transporters. |
2021-07-14 |
2023-08-13 |
Not clear |
| Stacy A Henry, Selina Crivello, Tina M Nguyen, Magdalena Cybulska, Ngoc S Hoang, Mary Nguyen, Tajinder Badial, Nazgol Emami, Nasma Awada, Johnathen F Woodward, Christopher H S. G protein-coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress. Cell stress & chaperones. vol 26. issue 1. 2021-07-06. PMID:33064264. |
treating c. elegans with a grk2 inhibitor, the selective serotonin reuptake inhibitor paroxetine, resulted in increased acute oxidative stress resistance compared with another selective serotonin reuptake inhibitor, fluoxetine. |
2021-07-06 |
2023-08-13 |
caenorhabditis_elegans |