| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carla S S Ferreira, Cátia Venâncio, Peter Kille, Miguel Oliveir. Are early and young life stages of fish affected by paroxetine? A case study with Danio rerio. The Science of the total environment. 2023-07-27. PMID:37499832. |
paroxetine (par) is a selective serotonin reuptake inhibitor (ssri) antidepressant increasingly detected in surface waters worldwide. |
2023-07-27 |
2023-08-14 |
zebrafish |
| Yasemin Hoşgören Alıcı, Müge Kuzu Kumc. Potential Effect of Vortioxetine on Restless Leg Syndrome. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 21. issue 3. 2023-07-10. PMID:37424427. |
it has been reported that serotonin-noradrenaline reuptake inhibitors such as venlafaxine and selective serotonin reuptake inhibitors such as citalopram, fluoxetine, paroxetine, and sertraline can cause rls symptoms. |
2023-07-10 |
2023-08-14 |
Not clear |
| Tian-Shun Shi, Wei-Yu Li, Yan-Mei Chen, Jie Huang, Wei Guan, Da-Wei Xu, Bo Jian. The antidepressant-like effects of escitalopram in mice require salt-inducible kinase 1 and CREB-regulated transcription co-activator 1 in the paraventricular nucleus of the hypothalamus. Journal of affective disorders. 2023-05-31. PMID:37257779. |
like fluoxetine and paroxetine, escitalopram is also a well-known selective serotonin (5-ht) reuptake inhibitor (ssri). |
2023-05-31 |
2023-08-14 |
mouse |
| Jiawei Zhang, Xianzheng Zhang, Mingdian Lu, Yan Chang, Qingtong Wang, Jiajie Tu, Huaxun Wu, Chun Wang, Zhongyang Hong, Maoming Xiong, Lihua Song, Wei We. GRK2 Mediates Macrophage Polarization by Regulating EP4-cAMP-pCREB Signaling in Ulcerative Colitis and the Therapeutic Effect of Paroxetine on Mice with DSS-Induced Colitis. Pharmaceuticals (Basel, Switzerland). vol 16. issue 5. 2023-05-27. PMID:37242446. |
paroxetine is acknowledged as one of the selective serotonin reuptake inhibitors (ssri), which is also considered as a potent grk2 inhibitor with a high selectivity for grk2. |
2023-05-27 |
2023-08-14 |
mouse |
| Chad A Bousman, James M Stevenson, Laura B Ramsey, Katrin Sangkuhl, J Kevin Hicks, Jeffrey R Strawn, Ajeet B Singh, Gualberto Ruaño, Daniel J Mueller, Evangelia Eirini Tsermpini, Jacob T Brown, Gillian C Bell, J Steven Leeder, Andrea Gaedigk, Stuart A Scott, Teri E Klein, Kelly E Caudle, Jeffrey R Bisho. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants. Clinical pharmacology and therapeutics. 2023-04-09. PMID:37032427. |
serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake inhibitors (ssris; i.e., citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline), serotonin and norepinephrine reuptake inhibitors (snris; i.e., desvenlafaxine, duloxetine, levomilnacipran, milnacipran, and venlafaxine), and serotonin modulators with ssri-like properties (i.e., vilazodone and vortioxetine) are primary pharmacologic treatments for major depressive and anxiety disorders. |
2023-04-09 |
2023-08-14 |
Not clear |
| Kristine Hole, Tore Haslemo, Espen Molde. Impact of CYP2D6 Genotype on Paroxetine Serum Concentration. Therapeutic drug monitoring. 2023-04-04. PMID:37012633. |
paroxetine is a selective serotonin reuptake inhibitor metabolized by cytochrome p450 (cyp)2d6. |
2023-04-04 |
2023-08-14 |
Not clear |
| Zachary Sartor, Lance Kelley, Ryan Laschobe. Posttraumatic Stress Disorder: Evaluation and Treatment. American family physician. vol 107. issue 3. 2023-03-15. PMID:36920821. |
selective serotonin reuptake inhibitors (i.e., fluoxetine, paroxetine, and sertraline) and the serotonin-norepinephrine reuptake inhibitor venlafaxine effectively treat primary ptsd symptoms. |
2023-03-15 |
2023-08-14 |
Not clear |
| Ananda Baskaran Venkatachalam, Bailey Levesque, John C Achenbach, Jane J Pappas, Lee D Elli. Long and Short Duration Exposures to the Selective Serotonin Reuptake Inhibitors (SSRIs) Fluoxetine, Paroxetine and Sertraline at Environmentally Relevant Concentrations Lead to Adverse Effects on Zebrafish Behaviour and Reproduction. Toxics. vol 11. issue 2. 2023-02-28. PMID:36851026. |
long and short duration exposures to the selective serotonin reuptake inhibitors (ssris) fluoxetine, paroxetine and sertraline at environmentally relevant concentrations lead to adverse effects on zebrafish behaviour and reproduction. |
2023-02-28 |
2023-08-14 |
human |
| Luke R Cavanah, Jessica L Goldhirsh, Leighton Y Huey, Brian J Pipe. Specialty-type and state-level variation in paroxetine use among older adult patients. medRxiv : the preprint server for health sciences. 2023-02-24. PMID:36824839. |
paroxetine is an older "selective" serotonin reuptake inhibitor (ssri) that is notable for its lack of selectivity, resulting in a cholinergic adverse-effect profile, especially among older adults (65+). |
2023-02-24 |
2023-08-14 |
Not clear |
| Anna Portugalov, Hiba Zaidan, Inna Gaisler-Salomon, Cecilia J Hillard, Irit Akira. FAAH Inhibition Restores Early Life Stress-Induced Alterations in PFC microRNAs Associated with Depressive-Like Behavior in Male and Female Rats. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555739. |
we compared the effects of treatment with the fatty acid amide hydrolase (faah) inhibitor urb597, and the selective serotonin reuptake inhibitor paroxetine, on els-induced depressive-like behavior and the expression of micrornas (mirs) associated with depression in the medial prefrontal cortex (mpfc), hippocampal ca1 area, lateral habenula and dorsal raphe in rats. |
2022-12-23 |
2023-08-14 |
rat |
| Mark Abie Horowitz, Adele Framer, Michael P Hengartner, Anders Sørensen, David Taylo. Estimating Risk of Antidepressant Withdrawal from a Review of Published Data. CNS drugs. 2022-12-13. PMID:36513909. |
serotonin and noradrenaline reuptake inhibitors and paroxetine are associated with higher risks than other antidepressants, though data for some antidepressants are lacking. |
2022-12-13 |
2023-08-14 |
Not clear |
| Reyhane Aghajani, Marziyeh Tavalaee, Niloofar Sadeghi, Mazdak Razi, Parviz Gharagozloo, Maryam Arbabian, Joël R Drevet, Mohammad Hossein Nasr-Esfahan. Paroxetine treatment in an animal model of depression improves sperm quality. PloS one. vol 17. issue 12. 2022-12-08. PMID:36480503. |
we further show that administration of a conventional antidepressant of the serotonin reuptake inhibitor class (paroxetine) impairs male reproductive performance in terms of sperm production and quality when administered to healthy animals. |
2022-12-08 |
2023-08-14 |
mouse |
| Farzaneh Motafeghi, Romina Shahsavari, Parham Mortazavi, Mohammad Shokrzade. Anticancer effect of paroxetine and amitriptyline on HT29 and A549 cell lines. Toxicology in vitro : an international journal published in association with BIBRA. 2022-12-02. PMID:36460226. |
paroxetine is functionally classified as a selective serotonin reuptake inhibitor. |
2022-12-02 |
2023-08-14 |
Not clear |
| Faruk Ugu. The Relationship Between Maternal Antidepressants and Neonatal Hypoglycemia: A Systematic Review. Alpha psychiatry. vol 22. issue 5. 2022-11-30. PMID:36447450. |
the searched keywords were as follows: antidepressants, pregnancy, selective serotonin reuptake inhibitors (ssris), citalopram, fluoxetine, paroxetine, escitalopram, sertraline, fluvoxamine, selective serotonin-norepinephrine reuptake inhibitors (snris), venlafaxine, tricyclic antidepressants (tcas), neonatal outcomes, neonatal hypoglycemia, imipramine, clomipramine, amitriptyline, bupropion, trazodone, and mirtazapine. |
2022-11-30 |
2023-08-14 |
Not clear |
| Elizabeth Mostel, Savan Patel, Brian G Wiene. A 70-Year-Old Woman Presenting with Confusion and Muscle Spasms Due to Serotonin Syndrome Associated with Paroxetine and Quetiapine Treatment. The American journal of case reports. vol 23. 2022-11-11. PMID:36366736. |
a 70-year-old woman presenting with confusion and muscle spasms due to serotonin syndrome associated with paroxetine and quetiapine treatment. |
2022-11-11 |
2023-08-14 |
Not clear |
| Elizabeth Mostel, Savan Patel, Brian G Wiene. A 70-Year-Old Woman Presenting with Confusion and Muscle Spasms Due to Serotonin Syndrome Associated with Paroxetine and Quetiapine Treatment. The American journal of case reports. vol 23. 2022-11-11. PMID:36366736. |
this report is of a 70-year-old woman who presented with confusion and muscle spasms due to serotonin toxicity associated with paroxetine and quetiapine treatment. |
2022-11-11 |
2023-08-14 |
Not clear |
| Elizabeth Mostel, Savan Patel, Brian G Wiene. A 70-Year-Old Woman Presenting with Confusion and Muscle Spasms Due to Serotonin Syndrome Associated with Paroxetine and Quetiapine Treatment. The American journal of case reports. vol 23. 2022-11-11. PMID:36366736. |
a presumptive diagnosis of serotonin toxicity was made early on during her stay, with the etiology attributed to use of paroxetine and quetiapine. |
2022-11-11 |
2023-08-14 |
Not clear |
| Rafia Nimal, Didem Nur Unal, Cem Erkmen, Sevinc Kurbanoglu, Muhammad Siddiq, Gokcen Eren, Afzal Shah, Bengi Usl. Elucidating the interaction of antidepressant drug paroxetine with ct-dsDNA: A comparative study by electrochemical, spectroscopic, and molecular docking approaches. Bioelectrochemistry (Amsterdam, Netherlands). vol 149. 2022-10-14. PMID:36240548. |
this study is designed to investigate the interaction of phenylpiperidine derivative drug paroxetine, which is an effective serotonin reuptake inhibitor and biomolecules through electrochemical, fluorescence spectroscopy, and molecular docking methods. |
2022-10-14 |
2023-08-14 |
Not clear |
| Xuan Guan, Zai-Quan Dong, Yan-Ni Hao, Xiao-Ling Shen, Qing-Lian Xie, Jian-Min Che. Plasma levels of interleukin-8 and response to paroxetine in patients with major depressive disorder. Human psychopharmacology. 2022-10-04. PMID:36194639. |
this study was performed to investigate the correlation between plasma interleukin-8 (il-8) levels and treatment outcome of paroxetine (a selective serotonin reuptake inhibitor) in patients with mdd. |
2022-10-04 |
2023-08-14 |
Not clear |
| Xiao-Lin Li, Shan-Qing Huang, Tao Xiao, Xi-Pei Wang, Wan Kong, Shu-Jing Liu, Zi Zhang, Ye Yang, Shan-Shan Huang, Xiao-Jia Ni, Hao-Yang Lu, Ming Zhang, Yu-Guan Wen, De-Wei Shan. Pharmacokinetics of immediate and sustained-release formulations of paroxetine: Population pharmacokinetic approach to guide paroxetine personalized therapy in chinese psychotic patients. Frontiers in pharmacology. vol 13. 2022-09-29. PMID:36172189. |
paroxetine is one of the most potent selective serotonin reuptake inhibitors (ssris) approved for treating depression, panic disorder, and obsessive-compulsive disorder. |
2022-09-29 |
2023-08-14 |
Not clear |