| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongxin Wang, Guangyan Yao, Lei Li, Zhaoyin Ma, Jing Chen, Wen Che. LncRNA-UCA1 inhibits the astrocyte activation in the temporal lobe epilepsy via regulating the JAK/STAT signaling pathway. Journal of cellular biochemistry. vol 121. issue 10. 2021-07-12. PMID:31909503. |
uca1 inhibited hippocampal astrocyte activation and jak/stat/glast expression in tle rats and improved the adverse reactions caused by epilepsy. |
2021-07-12 |
2023-08-13 |
rat |
| Yun Fan, Mei-Chuan Chou, Yen-Chin Liu, Ching-Kuan Liu, Chu-Huang Chen, Shiou-Lan Che. Intermittent Hypoxia Activates N-Methyl-D-Aspartate Receptors to Induce Anxiety Behaviors in a Mouse Model of Sleep-Associated Apnea. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33660202. |
increased glutamate n-methyl-d-aspartate (nmda) receptor subunits 2b (glun2b) and phosphorylated-erk1/2 were seen in the mpfc, striatum, and hippocampus of ih mice, but no significant microglial and astrocyte activation was found in these brain areas. |
2021-07-06 |
2023-08-13 |
mouse |
| Marta Balog, Senka Blažetić, Vedrana Ivić, Irena Labak, Bartosz Krajnik, Raquel Marin, Ana Canerina-Amaro, Daniel Pereda de Pablo, Ana Bardak, Robert Gaspar, Kálmán Ferenc Szűcs, Sandor G Vari, Marija Heffe. Disarranged neuroplastin environment upon aging and chronic stress recovery in female Sprague Dawley rats. The European journal of neuroscience. 2021-07-05. PMID:33909305. |
stress recovery was followed by a microglial decrease and an increase in astrocyte count in the hippocampal immune system. |
2021-07-05 |
2023-08-13 |
rat |
| Leelavathi N Madhu, Maheedhar Kodali, Sahithi Attaluri, Bing Shuai, Laila Melissari, Xiaolan Rao, Ashok K Shett. Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus. Redox biology. vol 43. 2021-07-05. PMID:33933884. |
behavioral tests revealed cognitive and mood dysfunction in gwi rats receiving vehicle, which were associated with elevated oxidative stress, reduced nrf2, catalase and mitochondrial complex proteins, astrocyte hypertrophy, activated microglia with nlrp3 inflammasomes, elevated proinflammatory cytokines, waned neurogenesis, and synapse loss in the hippocampus. |
2021-07-05 |
2023-08-13 |
rat |
| Zhenshu Li, Dezheng Zhou, Dalong Zhang, Jing Zhao, Wen Li, Yue Sun, Yongjie Chen, Huan Liu, John X Wilson, Zhiyong Qian, Guowei Huan. Folic Acid Inhibits Aging-Induced Telomere Attrition and Apoptosis in Astrocytes In Vivo and In Vitro. Cerebral cortex (New York, N.Y. : 1991). 2021-07-05. PMID:34223882. |
the results showed that fa supplementation inhibited aging-induced astrocytosis, astrocyte apoptosis, neurodegeneration, and prevented telomere attrition in hippocampus and cortex of samp8 mice. |
2021-07-05 |
2023-08-13 |
mouse |
| Lucineia Gainski Danielski, Amanda Della Giustina, Sandra Bonfante, Mariana Pereira de Souza Goldim, Larissa Joaquim, Kiuanne Lobo Metzker, Erica Bernardo Biehl, Thaynan Vieira, Fabiana Durante de Medeiros, Naiana da Rosa, Jaqueline Generoso, Lutiana Simoes, Hémelin Resende Farias, Isabela da Silva Lemos, Vijayasree Giridharan, Gislaine Tezza Rezin, Jucelia Jeremias Fortunato, Rafael Mariano Bitencourt, Emilio Luiz Streck, Felipe Dal-Pizzol, Tatiana Barichello, Fabricia Petronilh. NLRP3 Activation Contributes to Acute Brain Damage Leading to Memory Impairment in Sepsis-Surviving Rats. Molecular neurobiology. vol 57. issue 12. 2021-07-01. PMID:32870491. |
prefrontal cortex and hippocampus were isolated for cytokine analysis, microglial and astrocyte activation, oxidative stress measurements, nitric oxide formation, and mitochondrial respiratory chain activity at 24 h after clp. |
2021-07-01 |
2023-08-13 |
rat |
| Lucineia Gainski Danielski, Amanda Della Giustina, Sandra Bonfante, Mariana Pereira de Souza Goldim, Larissa Joaquim, Kiuanne Lobo Metzker, Erica Bernardo Biehl, Thaynan Vieira, Fabiana Durante de Medeiros, Naiana da Rosa, Jaqueline Generoso, Lutiana Simoes, Hémelin Resende Farias, Isabela da Silva Lemos, Vijayasree Giridharan, Gislaine Tezza Rezin, Jucelia Jeremias Fortunato, Rafael Mariano Bitencourt, Emilio Luiz Streck, Felipe Dal-Pizzol, Tatiana Barichello, Fabricia Petronilh. NLRP3 Activation Contributes to Acute Brain Damage Leading to Memory Impairment in Sepsis-Surviving Rats. Molecular neurobiology. vol 57. issue 12. 2021-07-01. PMID:32870491. |
nlrp3 receptor levels increased in the prefrontal cortex and hippocampus at 24 h after sepsis, associated with microglial, but not astrocyte, activation. |
2021-07-01 |
2023-08-13 |
rat |
| Zohreh Abbasi, Mohammad Mahdi Ghahramani Seno, Masoud Fereidon. A Neonatal Mild Defect in Brain Insulin Signaling Predisposes a Subclinical Model of Sporadic Alzheimer's to Develop the Disease. Journal of molecular neuroscience : MN. vol 71. issue 7. 2021-06-28. PMID:33492616. |
these impairments were associated with altered gene expression of insulin receptor, tau and choline acetyltransferase, along with increased astrocyte and dark neuron densities in the hippocampus. |
2021-06-28 |
2023-08-13 |
rat |
| Yue Li, Yanmin Luo, Jing Tang, Xin Liang, Jin Wang, Qian Xiao, Peilin Zhu, Kai Xiao, Lin Jiang, Xiaoyun Dou, Chunxia Huang, Yuhan Xie, Yong Tan. The positive effects of running exercise on hippocampal astrocytes in a rat model of depression. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33526783. |
mounting evidence suggests that changes in astrocyte number in the hippocampus are closely associated with depression. |
2021-06-28 |
2023-08-13 |
rat |
| Xiaohui Jiang, Lina Chen, Zhongyuan Zheng, Ying Chen, Xiaogang Weng, Yuan Guo, Kai Li, Ting Yang, Shuiqing Qu, Hui Liu, Yujie Li, Xiaoxin Zh. Synergistic Effect of Combined Artesunate and Tetramethylpyrazine in Experimental Cerebral Malaria. ACS infectious diseases. vol 6. issue 9. 2021-06-23. PMID:32786270. |
this combination downregulated the expression of adhesion molecules and sequestration of parasitized red blood cells (prbcs), increased cerebral blood flow, nerve growth factor (b-ngf), vascular endothelial growth factor a (vegf-a), and neurotrophin (brain-derived neurotrophic factor (bdnf), neurotrophic factor-3 (nt-3)) levels, and alleviated hippocampal neuronal damage and astrocyte activation. |
2021-06-23 |
2023-08-13 |
mouse |
| Hossein Hassanpoor, Maryam Said. An investigation into the effective role of astrocyte in the hippocampus pattern separation process: A computational modeling study. Journal of theoretical biology. vol 487. 2021-06-21. PMID:31836505. |
an investigation into the effective role of astrocyte in the hippocampus pattern separation process: a computational modeling study. |
2021-06-21 |
2023-08-13 |
Not clear |
| Yong Xu, Yating Zhang, Jian-Hua Zhang, Kang Han, Xinwei Zhang, Xue Bai, Lin-Hao You, Peng Yu, Zhenhua Shi, Yan-Zhong Chang, Guofen Ga. Astrocyte hepcidin ameliorates neuronal loss through attenuating brain iron deposition and oxidative stress in APP/PS1 mice. Free radical biology & medicine. vol 158. 2021-06-18. PMID:32707154. |
our results showed that the elevated expression of astrocyte hepcidin in app/ps1 mice significantly improved their cognitive decline, and partially alleviated the formation of aβ plaques in cortex and hippocampus. |
2021-06-18 |
2023-08-13 |
mouse |
| Guoyuan Qi, Yashi Mi, Xiaojian Shi, Haiwei Gu, Roberta Diaz Brinton, Fei Yi. ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism. Cell reports. vol 34. issue 1. 2021-06-18. PMID:33406436. |
further, apoe4 lowers fa oxidation and leads to lipid accumulation in both astrocyte and the hippocampus. |
2021-06-18 |
2023-08-13 |
Not clear |
| Emi Taniguchi, Ayako Tashiro, Ayumi Hattori, Mitsuhiro Furuse, Shinobu Yasu. Photoperiodic changes in hippocampal neurogenesis and plasma metabolomic profiles in relation to depression-like behavior in mice. Behavioural brain research. vol 403. 2021-06-18. PMID:33482168. |
mice that were maintained under long-day conditions (ld) exhibited a higher number of 5-bromo-2'-deoxyuridine-positive cells and higher levels of astrocyte marker in the dentate gyrus of the hippocampus compared to that of mice under short-day conditions (sd). |
2021-06-18 |
2023-08-13 |
mouse |
| Yangyang Lin, Jian Jin, Rongke Lv, Yuan Luo, Weiping Dai, Wenchang Li, Yamei Tang, Yuling Wang, Xiaojing Ye, Wei-Jye Li. Repetitive transcranial magnetic stimulation increases the brain's drainage efficiency in a mouse model of Alzheimer's disease. Acta neuropathologica communications. vol 9. issue 1. 2021-06-07. PMID:34078467. |
significant reduction of aβ deposits, suppression of microglia and astrocyte activation, and prevention of decline of neuronal activity as indicated by the elevated c-fos expression, were observed in the prefrontal cortex and hippocampus of the rtms-treated 5xfad mice. |
2021-06-07 |
2023-08-13 |
mouse |
| Andrea Du Preez, Diletta Onorato, Inez Eiben, Ksenia Musaelyan, Martin Egeland, Patricia A Zunszain, Cathy Fernandes, Sandrine Thuret, Carmine M Pariant. Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in male mice. Brain, behavior, and immunity. vol 91. 2021-05-27. PMID:32755644. |
chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in male mice. |
2021-05-27 |
2023-08-13 |
mouse |
| Andrea Du Preez, Diletta Onorato, Inez Eiben, Ksenia Musaelyan, Martin Egeland, Patricia A Zunszain, Cathy Fernandes, Sandrine Thuret, Carmine M Pariant. Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in male mice. Brain, behavior, and immunity. vol 91. 2021-05-27. PMID:32755644. |
however, ucmsi animals showed increased microglial activation in the ventral dentate gyrus (dg) of the hippocampus and astrocyte activation in both the dorsal and ventral dg, with increased gfap-positive cell immunoreactivity, gfap-positive cell hypertrophy and process extension, and increased s100β-positive cell density. |
2021-05-27 |
2023-08-13 |
mouse |
| Andrea Du Preez, Diletta Onorato, Inez Eiben, Ksenia Musaelyan, Martin Egeland, Patricia A Zunszain, Cathy Fernandes, Sandrine Thuret, Carmine M Pariant. Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in male mice. Brain, behavior, and immunity. vol 91. 2021-05-27. PMID:32755644. |
our work gives clinically relevant insights into the role that microglial and astrocyte functioning, and hippocampal neurogenesis may play in the context of stress, social isolation and depression, offering a potentially new avenue for therapeutic target. |
2021-05-27 |
2023-08-13 |
mouse |
| Calla M Goeke, Joel G Hashimoto, Marina Guizzetti, Annabella Vitalon. Effects of ethanol-and choline-treated astrocytes on hippocampal neuron neurite outgrowth in vitro. Science progress. vol 104. issue 2. 2021-05-25. PMID:34019432. |
we have previously reported that astrocyte pre-treatment with 75 mm ethanol, in vitro, reduces neurite outgrowth in hippocampal neurons co-cultured with the pre-treated astrocytes. |
2021-05-25 |
2023-08-13 |
human |
| Calla M Goeke, Joel G Hashimoto, Marina Guizzetti, Annabella Vitalon. Effects of ethanol-and choline-treated astrocytes on hippocampal neuron neurite outgrowth in vitro. Science progress. vol 104. issue 2. 2021-05-25. PMID:34019432. |
culture media was then removed, replaced with fresh media containing no ethanol or choline treatments and primary rat hippocampal neurons were plated on top of the astrocyte monolayer and cultured for 16 h. |
2021-05-25 |
2023-08-13 |
human |