| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joe H Pogson, Rachael M Ivatt, Alexander J Whitwort. Molecular mechanisms of PINK1-related neurodegeneration. Current neurology and neuroscience reports. vol 11. issue 3. 2011-08-05. PMID:21331528. |
pink1 is a mitochondrially targeted kinase that has been linked to a rare monogenic form of parkinson's disease (pd), a common neurodegenerative disease characterized by the degeneration of selected dopaminergic neurons. |
2011-08-05 |
2023-08-12 |
Not clear |
| Kumar Sapkota, Seung Kim, Se-Eun Park, Sung-Jun Ki. Detoxified extract of Rhus verniciflua stokes inhibits rotenone-induced apoptosis in human dopaminergic cells, SH-SY5Y. Cellular and molecular neurobiology. vol 31. issue 2. 2011-07-18. PMID:21061154. |
these results suggest that rvs may protect dopaminergic neurons against rotenone-induced apoptosis by multiple functions and contribute to neuroprotection in neurodegenerative diseases, such as pd. |
2011-07-18 |
2023-08-12 |
human |
| Hyongjong Koh, Jongkyeong Chun. PINK1 and Parkin to control mitochondria remodeling. Anatomy & cell biology. vol 43. issue 3. 2011-07-14. PMID:21212857. |
parkinson's disease (pd), one of the most common neurodegenerative diseases, is characterized by movement disorders and a loss of dopaminergic (da) neurons. |
2011-07-14 |
2023-08-12 |
drosophila_melanogaster |
| Yue Yong, Hanqing Ding, Zhiqin Fan, Jia Luo, Zun-Ji K. Lithium fails to protect dopaminergic neurons in the 6-OHDA model of Parkinson's disease. Neurochemical research. vol 36. issue 3. 2011-05-19. PMID:21203835. |
parkinson's disease (pd) is the second most common neurodegenerative disease, characterized by the pathological loss of dopaminergic neurons in the substantia nigra pars compacta (snpc). |
2011-05-19 |
2023-08-12 |
human |
| Dario Domenico Lofrumento, Concetta Saponaro, Antonia Cianciulli, Francesco De Nuccio, Vincenzo Mitolo, Giuseppe Nicolardi, Maria Antonietta Panar. MPTP-induced neuroinflammation increases the expression of pro-inflammatory cytokines and their receptors in mouse brain. Neuroimmunomodulation. vol 18. issue 2. 2011-04-06. PMID:20938211. |
parkinson's disease (pd) is a common neurodegenerative disease characterised by a slow and progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2011-04-06 |
2023-08-12 |
mouse |
| Aleksandra Glavaski-Joksimovic, Tamas Virag, Thomas A Mangatu, Michael McGrogan, Xue Song Wang, Martha C Boh. Glial cell line-derived neurotrophic factor-secreting genetically modified human bone marrow-derived mesenchymal stem cells promote recovery in a rat model of Parkinson's disease. Journal of neuroscience research. vol 88. issue 12. 2011-03-11. PMID:20544825. |
parkinson's disease (pd) is a neurodegenerative disease characterized by progressive degeneration of nigrostriatal dopaminergic (da) neurons. |
2011-03-11 |
2023-08-12 |
human |
| Maarit Hellman, Johan Peränen, Mart Saarma, Perttu Perm. 1H, 13C and 15N resonance assignments of the human mesencephalic astrocyte-derived neurotrophic factor. Biomolecular NMR assignments. vol 4. issue 2. 2011-03-04. PMID:20617400. |
parkinson's disease (pd) is a chronic, progressive neurodegenerative disease, where dopaminergic cells die most prominently in the area of substantia nigra. |
2011-03-04 |
2023-08-12 |
human |
| Arianna Tucci, Mike A Nalls, Henry Houlden, Tamas Revesz, Andrew B Singleton, Nicholas W Wood, John Hardy, Coro Paisán-Rui. Genetic variability at the PARK16 locus. European journal of human genetics : EJHG. vol 18. issue 12. 2011-02-28. PMID:20683486. |
parkinson's disease (pd) is a complex neurodegenerative disease which is clinically heterogeneous and pathologically consists of loss of dopaminergic neurons in the substantia nigra and intracytoplasmic neuronal inclusions containing alpha-synuclein aggregations known as lewy bodies. |
2011-02-28 |
2023-08-12 |
Not clear |
| L Jaworska-Feil, D Jantas, M Leskiewicz, B Budziszewska, M Kubera, A Basta-Kaim, A W Lipkowski, W Laso. Protective effects of TRH and its analogues against various cytotoxic agents in retinoic acid (RA)-differentiated human neuroblastoma SH-SY5Y cells. Neuropeptides. vol 44. issue 6. 2011-02-28. PMID:20869113. |
furthermore, the data obtained on human cell line with a dopaminergic phenotype suggest potential utility of trh and its analogues in the treatment of some neurodegenerative diseases including parkinson's disease. |
2011-02-28 |
2023-08-12 |
human |
| Seongsoo Lee, Hsin-Ping Liu, Wei-Yong Lin, Huifu Guo, Bingwei L. LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 50. 2011-02-09. PMID:21159966. |
mutations in leucine-rich repeat kinase 2 (lrrk2) are linked to familial as well as sporadic forms of parkinson's disease (pd), a neurodegenerative disease characterized by dysfunction and degeneration of dopaminergic and other types of neurons. |
2011-02-09 |
2023-08-12 |
human |
| Jaime N Guzman, Javier Sanchez-Padilla, David Wokosin, Jyothisri Kondapalli, Ema Ilijic, Paul T Schumacker, D James Surmeie. Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature. vol 468. issue 7324. 2011-01-11. PMID:21068725. |
parkinson's disease is a pervasive, ageing-related neurodegenerative disease the cardinal motor symptoms of which reflect the loss of a small group of neurons, the dopaminergic neurons in the substantia nigra pars compacta (snc). |
2011-01-11 |
2023-08-12 |
mouse |
| Julia Mahler, Alida Filippi, Wolfgang Drieve. DeltaA/DeltaD regulate multiple and temporally distinct phases of notch signaling during dopaminergic neurogenesis in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 49. 2011-01-07. PMID:21148001. |
despite their relevance in neurodegenerative diseases and the interests in reconstitutive therapies from stem cells, mechanisms of the neurogenic switch from precursor populations to dopaminergic neurons are not well understood. |
2011-01-07 |
2023-08-12 |
zebrafish |
| Marie-Pierre Hinault, America Farina Henriquez Cuendet, Rayees U H Mattoo, Mounir Mensi, Giovanni Dietler, Hilal A Lashuel, Pierre Goloubinof. Stable alpha-synuclein oligomers strongly inhibit chaperone activity of the Hsp70 system by weak interactions with J-domain co-chaperones. The Journal of biological chemistry. vol 285. issue 49. 2010-12-30. PMID:20847048. |
together, our findings suggest that inhibition of the hsp70/hsp40 chaperone system by α-syn oligomers may contribute to the disruption of protein homeostasis in dopaminergic neurons, leading to apoptosis and tissue loss in parkinson disease and related neurodegenerative diseases. |
2010-12-30 |
2023-08-12 |
human |
| Renan P Souza, Gary Remington, Nabilah I Chowdhury, Matthew K Lau, Aristotle N Voineskos, Jeffrey A Lieberman, Herbert Y Meltzer, James L Kenned. Association study of the GSK-3B gene with tardive dyskinesia in European Caucasians. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 10. 2010-12-22. PMID:20605420. |
dopaminergic signaling modulates the glycogen synthase kinase 3b (gsk-3b), a kinase that may play a critical role in the pathogenesis of neurodegenerative diseases. |
2010-12-22 |
2023-08-12 |
human |
| Jie Wu, Jiao Sun, Yang Xu. Involvement of JNK and P53 activation in G2/M cell cycle arrest and apoptosis induced by titanium dioxide nanoparticles in neuron cells. Toxicology letters. vol 199. issue 3. 2010-12-17. PMID:20863874. |
pc12 cell is a type of cells, which have been used as an in vitro model of dopaminergic neurons for neurodegenerative diseases research. |
2010-12-17 |
2023-08-12 |
Not clear |
| Jonathan Wills, Jessica Jones, Thomas Haggerty, Valeriy Duka, Jeffrey N Joyce, Anita Sidh. Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Experimental neurology. vol 225. issue 1. 2010-10-20. PMID:20599975. |
parkinson's disease (pd), a progressive neurodegenerative disease, results in abnormal accumulation of insoluble alpha-synuclein (alpha-syn) in dopaminergic neurons. |
2010-10-20 |
2023-08-12 |
Not clear |
| Tatsuya Ohnuki, Atsushi Nakamura, Shigeru Okuyama, Shoji Nakamur. Gene expression profiling in progressively MPTP-lesioned macaques reveals molecular pathways associated with sporadic Parkinson's disease. Brain research. vol 1346. 2010-10-19. PMID:20513370. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by progressive loss of midbrain dopaminergic neurons. |
2010-10-19 |
2023-08-12 |
monkey |
| Javier Diaz-Nid. NLX-P101, an adeno-associated virus gene therapy encoding glutamic acid decarboxylase, for the potential treatment of Parkinson's disease. Current opinion in investigational drugs (London, England : 2000). vol 11. issue 7. 2010-10-05. PMID:20571977. |
parkinson's disease (pd) is a neurodegenerative disease affecting nigrostriatal dopaminergic neurons. |
2010-10-05 |
2023-08-12 |
Not clear |
| Ji Won Um, Eunju Im, Hyun Jung Lee, Boram Min, Lang Yoo, Jiho Yoo, Hermann Lübbert, Christine Stichel-Gunkel, Hyun-Soo Cho, Jong Bok Yoon, Kwang Chul Chun. Parkin directly modulates 26S proteasome activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 35. 2010-09-20. PMID:20810900. |
parkinson's disease (pd) is a common neurodegenerative disease that involves the deterioration of dopaminergic neurons in the substantia nigra pars compacta. |
2010-09-20 |
2023-08-12 |
Not clear |
| Young Cheul Chung, Hyuk Wan Ko, Eugene Bok, Eun Soo Park, Sue Hee Huh, Jin Han Nam, Byung Kwan Ji. The role of neuroinflammation on the pathogenesis of Parkinson's disease. BMB reports. vol 43. issue 4. 2010-07-21. PMID:20423606. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by the progressive degeneration of nigrostriatal dopaminergic (da) neurons. |
2010-07-21 |
2023-08-12 |
Not clear |