| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Seibyl, D Jennings, R Tabamo, K Mare. The role of neuroimaging in the early diagnosis and evaluation of Parkinson's disease. Minerva medica. vol 96. issue 5. 2005-12-28. PMID:16227950. |
nonetheless, current unresolved issues around the clinical role of neuroimaging in monitoring patients over time and validation of quantitative imaging measures of dopaminergic function are immediate issues for the field and the subject of current research efforts and the extension of the lessons learned in parkinson's to other neurodegenerative diseases including alzheimer's dementia. |
2005-12-28 |
2023-08-12 |
human |
| Stacy S Wu, Steven J Fruch. Treatment of Parkinson's disease : what's on the horizon? CNS drugs. vol 19. issue 9. 2005-11-07. PMID:16142989. |
although great strides have been made in the development of agents to treat this neurodegenerative disease, none yet address the underlying problem associated with it, the progressive loss of dopaminergic neurons. |
2005-11-07 |
2023-08-12 |
Not clear |
| Charleen T Chu, Jian-hui Zhu, Guodong Cao, Armando Signore, Suping Wang, Jun Che. Apoptosis inducing factor mediates caspase-independent 1-methyl-4-phenylpyridinium toxicity in dopaminergic cells. Journal of neurochemistry. vol 94. issue 6. 2005-10-27. PMID:16156740. |
parkinson's disease is a debilitating neurodegenerative disease characterized by loss of midbrain dopaminergic neurons. |
2005-10-27 |
2023-08-12 |
mouse |
| Dong-Youn Hwang, Sheila M Fleming, Paul Ardayfio, Taylor Moran-Gates, Hansoo Kim, Frank I Tarazi, Marie-Francoise Chesselet, Kwang-Soo Ki. 3,4-dihydroxyphenylalanine reverses the motor deficits in Pitx3-deficient aphakia mice: behavioral characterization of a novel genetic model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 8. 2005-10-26. PMID:15728853. |
parkinson's disease (pd) is a neurodegenerative disease characterized by a loss of dopaminergic neurons in the substantia nigra. |
2005-10-26 |
2023-08-12 |
mouse |
| Emiliana Borrell. Without DJ-1, the D2 receptor doesn't play. Neuron. vol 45. issue 4. 2005-04-25. PMID:15721232. |
parkinson's disease and parkinsonism are neurodegenerative diseases of dopaminergic neurons affecting the human brain. |
2005-04-25 |
2023-08-12 |
human |
| Pavan K Auluck, Marc C Meulener, Nancy M Bonin. Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila. The Journal of biological chemistry. vol 280. issue 4. 2005-03-08. PMID:15556931. |
parkinson's disease is a common neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta and the accumulation of the protein alpha-synuclein into aggregates called lewy bodies and lewy neurites. |
2005-03-08 |
2023-08-12 |
drosophila_melanogaster |
| Masato Asanuma, Ikuko Miyazaki, Francisco J Diaz-Corrales, Norio Ogaw. Quinone formation as dopaminergic neuron-specific oxidative stress in the pathogenesis of sporadic Parkinson's disease and neurotoxin-induced parkinsonism. Acta medica Okayama. vol 58. issue 5. 2005-02-08. PMID:15666991. |
parkinson's disease (pd) is a progressive neurodegenerative disease characterized by dopaminergic neuron-specific degeneration in the substantia nigra. |
2005-02-08 |
2023-08-12 |
Not clear |
| Marco Cosentino, Emanuela Rasini, Cristina Colombo, Franca Marino, Fabio Blandini, Marco Ferrari, Alberta Samuele, Sergio Lecchini, Giuseppe Nappi, Gianmario Frig. Dopaminergic modulation of oxidative stress and apoptosis in human peripheral blood lymphocytes: evidence for a D1-like receptor-dependent protective effect. Free radical biology & medicine. vol 36. issue 10. 2004-11-23. PMID:15110388. |
the present findings add knowledge about the sensitivity of pbl to da and strengthen the rationale for exploiting these cells as an easily accessible peripheral model for the ex vivo investigation of oxidative stress-related dopaminergic mechanisms underlying human neurodegenerative diseases. |
2004-11-23 |
2023-08-12 |
human |
| Sabine Peters, Eilhard Mix, Peter Bauer, Sabine Weinelt, Beke Schubert, Rupert Knoblich, Tobias Böttcher, Ulf Strauss, Jens Pahnke, Elena Cattaneo, Andreas Wree, Arndt Rolf. Wnt-5a expression in the rat neuronal progenitor cell line ST14A. Experimental brain research. vol 158. issue 2. 2004-11-22. PMID:15309358. |
however, they raise the possibility that neuronal progenitor cells that might be used to treat neurodegenerative diseases express wnt-5a, thus promoting their potential for dopaminergic differentiation. |
2004-11-22 |
2023-08-12 |
rat |
| Judit Soós, József I Engelhardt, László Siklós, László Havas, Katalin Majtény. The expression of PARP, NF-kappa B and parvalbumin is increased in Parkinson disease. Neuroreport. vol 15. issue 11. 2004-10-21. PMID:15257133. |
immunohistochemical techniques revealed a significant increase of poly(adp-ribose) polymerase (parp)-containing nuclei in the dopaminergic neurons of the substantia nigra (sn) in parkinson disease and in diffuse lewy body disease as compared with a group of patients with other neurodegenerative diseases and normal controls. |
2004-10-21 |
2023-08-12 |
Not clear |
| Jing Zhang, David R Goodlet. Proteomic approach to studying Parkinson's disease. Molecular neurobiology. vol 29. issue 3. 2004-09-16. PMID:15181239. |
parkinson's disease is a common age-related neurodegenerative disease characterized pathologically by a loss of dopaminergic neurons in the substantia nigra with resultant depletion of striatal dopamine and presence of lewy bodies in the remaining neurons. |
2004-09-16 |
2023-08-12 |
human |
| Dong-Wook Ki. Efficient induction of dopaminergic neurons from embryonic stem cells for application to Parkinson's disease. Yonsei medical journal. vol 45 Suppl. 2004-08-17. PMID:15250046. |
for cell replacement therapy of neurodegenerative diseases such as parkinson's disease (pd), methods for efficiently generating midbrain dopaminergic (da) neurons from embryonic stem (es) cells have been investigated. |
2004-08-17 |
2023-08-12 |
Not clear |
| J L W Bosboom, E Ch Wolter. Psychotic symptoms in Parkinson's disease: pathophysiology and management. Expert opinion on drug safety. vol 3. issue 3. 2004-07-13. PMID:15155149. |
parkinson's disease (pd) is a chronic neurodegenerative disease, in which mainly dopaminergic neurons in the substantia nigra in the brain degenerate, leading to a depletion of dopamine (da) in the striatum. |
2004-07-13 |
2023-08-12 |
Not clear |
| Annika F M Haywood, Brian E Stavele. Parkin counteracts symptoms in a Drosophila model of Parkinson's disease. BMC neuroscience. vol 5. 2004-07-09. PMID:15090075. |
parkinson's disease, a prevalent neurodegenerative disease, is characterized by the reduction of dopaminergic neurons resulting in the loss of motor control, resting tremor, the formation of neuronal inclusions and ultimately premature death. |
2004-07-09 |
2023-08-12 |
human |
| Cristina Colombo, Marco Cosentino, Franca Marino, Emanuela Rasini, Maria Ossola, Fabio Blandini, Anna Mangiagalli, Alberta Samuele, Marco Ferrari, Raffaella Bombelli, Sergio Lecchini, Giuseppe Nappi, Gianmario Frig. Dopaminergic modulation of apoptosis in human peripheral blood mononuclear cells: possible relevance for Parkinson's disease. Annals of the New York Academy of Sciences. vol 1010. 2004-06-15. PMID:15033811. |
dopamine (da) modulates apoptosis in neuronal and non-neuronal cells, and dopaminergic pathways contribute to neurodegenerative disease. |
2004-06-15 |
2023-08-12 |
human |
| Esti Liani, Allon Eyal, Eyal Avraham, Revital Shemer, Raymonde Szargel, Daniela Berg, Antje Bornemann, Olaf Riess, Christopher A Ross, Ruth Rott, Simone Engelende. Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 15. 2004-05-19. PMID:15064394. |
parkinson's disease (pd) is a neurodegenerative disease characterized by lewy body formation and death of dopaminergic neurons. |
2004-05-19 |
2023-08-12 |
Not clear |
| Ferhan Girgin Sagin, Eser Y Sozmen, Biltan Ersoz, Gulriz Mente. Link between monoamine oxidase and nitric oxide. Neurotoxicology. vol 25. issue 1-2. 2004-04-01. PMID:14697884. |
although, the role of dopaminergic, noradrenergic and serotonergic systems in central nervous system (cns) and neurodegenerative diseases have been mostly demonstrated, the intrinsic mechanisms in these systems with relation to other molecules in cns have received less attention. |
2004-04-01 |
2023-08-12 |
Not clear |
| Yossi Gilgun-Sherki, Eldad Melamed, Raphael Mechoulam, Daniel Offe. The CB1 cannabinoid receptor agonist, HU-210, reduces levodopa-induced rotations in 6-hydroxydopamine-lesioned rats. Pharmacology & toxicology. vol 93. issue 2. 2004-01-06. PMID:12899667. |
parkinson's disease is a chronic neurodegenerative disease of the extrapyramidal system associated with dopaminergic neuronal loss in the basal ganglia. |
2004-01-06 |
2023-08-12 |
rat |
| Takashi Ito, Jun-Ichi Niwa, Nozomi Hishikawa, Shinsuke Ishigaki, Manabu Doyu, Gen Sobu. Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1. The Journal of biological chemistry. vol 278. issue 31. 2003-09-10. PMID:12750386. |
parkinson's disease (pd) is a neurodegenerative disease characterized by loss of nigra dopaminergic neurons. |
2003-09-10 |
2023-08-12 |
Not clear |
| Hongjun Li, Zhanlong He, Ting Su, Yanbing Ma, Shuaiyao Lu, Changbai Dai, Maosheng Su. Protective action of recombinant neurturin on dopaminergic neurons in substantia nigra in a rhesus monkey model of Parkinson's disease. Neurological research. vol 25. issue 3. 2003-06-06. PMID:12739234. |
parkinson's disease (pd) is a neurodegenerative disease characterized by muscular trembling palsy due to lack of dopamine (da) in the substantia nigra-striatum (nigrostriatal) system resulting from the degeneration and necrosis of dopaminergic neurons. |
2003-06-06 |
2023-08-12 |
human |