| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katharina Domschke, Jürgen Decker. Genetics. Current topics in behavioral neurosciences. vol 2. 2011-03-07. PMID:21309106. |
a particular focus will be on the most robust findings in panic disorder to date in the serotonergic, noradrenergic, and dopaminergic system, such as the catechol-o-methyltransferase (comt) gene. |
2011-03-07 |
2023-08-12 |
Not clear |
| Jeroen Hoogland, Rob M A de Bie, Caroline H Williams-Gray, Dino Muslimović, Ben Schmand, Bart Pos. Catechol-O-methyltransferase val158met and cognitive function in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 25. issue 15. 2011-02-25. PMID:20878993. |
our results do not support a direct effect of comt val158met genotype on performance on neuropsychological measures of attention and executive function, but they suggest that genotype may interact with dopaminergic medication use to influence cognitive ability. |
2011-02-25 |
2023-08-12 |
Not clear |
| Estela Camara, Ulrike M Krämer, Toni Cunillera, Josep Marco-Pallarés, David Cucurell, Wido Nager, Anna Mestres-Missé, Peter Bauer, Rebecca Schüle, Ludger Schöls, Claus Tempelmann, Antoni Rodriguez-Fornells, Thomas F Münt. The effects of COMT (Val108/158Met) and DRD4 (SNP -521) dopamine genotypes on brain activations related to valence and magnitude of rewards. Cerebral cortex (New York, N.Y. : 1991). vol 20. issue 8. 2011-02-18. PMID:20038544. |
because of the established role of the dopaminergic system in the neural encoding of rewards and negative events, we investigated young healthy volunteers being homozygous for either the valine or methionine variant of the catechol-o-methyltransferase (comt) codon 158 polymorphism as well as homozygous for the c or t variant of the snp -521 polymorphism of the dopamine d4 receptor. |
2011-02-18 |
2023-08-12 |
human |
| G Brousse, F Vorspan, K Ksouda, V Bloch, K Peoc'h, J L Laplanche, S Mouly, J Schmidt, P M Llorca, J P Lepin. Could the inter-individual variability in cocaine-induced psychotic effects influence the development of cocaine addiction? Towards a new pharmacogenetic approach to addictions. Medical hypotheses. vol 75. issue 6. 2011-02-18. PMID:20801583. |
several studies have looked for a link between cocaine addiction and the genes of the dopaminergic system: the genes drd2, comt, slc6a3 (coding for the dopamine transporter dat) and dbh (coding for the dopamine beta hydroxylase) but unfortunately very few well established results. |
2011-02-18 |
2023-08-12 |
Not clear |
| G Brousse, F Vorspan, K Ksouda, V Bloch, K Peoc'h, J L Laplanche, S Mouly, J Schmidt, P M Llorca, J P Lepin. Could the inter-individual variability in cocaine-induced psychotic effects influence the development of cocaine addiction? Towards a new pharmacogenetic approach to addictions. Medical hypotheses. vol 75. issue 6. 2011-02-18. PMID:20801583. |
several functional alterations caused by different mutations of the genes involved in dopaminergic transmission (principally-1021c>t of the gene dbh, but also val158met of the gene comt, taqi a of the gene drd2 and vntr 9 repeat of the dat) could result in a cocaine-induced psychosis prone phenotype. |
2011-02-18 |
2023-08-12 |
Not clear |
| Nicola Simola, Annalisa Pinna, Sandro Fen. Pharmacological therapy of Parkinson's disease: current options and new avenues. Recent patents on CNS drug discovery. vol 5. issue 3. 2011-01-31. PMID:20726838. |
drugs acting on dopamine transmission, as l-dopa, direct dopaminergic agonists, inhibitors for either the mao or comt enzymes and drugs acting on neurotransmitters other than dopamine (e.g. |
2011-01-31 |
2023-08-12 |
Not clear |
| Josep Marco-Pallarés, Wido Nager, Ulrike M Krämer, Toni Cunillera, Estela Càmara, David Cucurell, Rebecca Schüle, Ludger Schöls, Antoni Rodriguez-Fornells, Thomas F Münt. Neurophysiological markers of novelty processing are modulated by COMT and DRD4 genotypes. NeuroImage. vol 53. issue 3. 2011-01-03. PMID:20156565. |
here we studied the impact of two polymorphisms affecting dopaminergic functioning (comt val108/158met and drd4 snp -521) on neurophysiological correlates of novelty processing. |
2011-01-03 |
2023-08-12 |
human |
| Francesco Benedetti, Sara Dallaspezia, Cristina Colombo, Cristina Lorenzi, Adele Pirovano, Enrico Smerald. Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder. Journal of affective disorders. vol 125. issue 1-3. 2010-12-30. PMID:20122740. |
catechol-o-methyltransferase (comt) inactivates catecholamines, and a g-a transition in the comt gene (rs4680) influences the enzyme activity and the interaction between cortical and subcortical dopaminergic neurotransmission. |
2010-12-30 |
2023-08-12 |
human |
| Sereina Bodenmann, Hans-Peter Landol. Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT. Sleep. vol 33. issue 8. 2010-09-23. PMID:20815183. |
modafinil may promote wakefulness by increasing cerebral dopaminergic neurotransmission, which importantly depends on activity of catechol-o-methyltransferase (comt) in prefrontal cortex. |
2010-09-23 |
2023-08-12 |
Not clear |
| Anna Szekely, Reka Kovacs-Nagy, Eva I Bányai, Anna C Gosi-Greguss, Katalin Varga, Zsuzsa Halmai, Zsolt Ronai, Maria Sasvari-Szekel. Association between hypnotizability and the catechol-O-methyltransferase (COMT) polymorphism. The International journal of clinical and experimental hypnosis. vol 58. issue 3. 2010-09-03. PMID:20509070. |
previous studies implicate involvement of dopaminergic systems in hypnotizability and report association with the comt val(158)met single nucleotide polymorphism (snp, rs4680) demonstrating the val/met heterozygotes as the most hypnotizable group using the stanford hypnotic susceptibility scale. |
2010-09-03 |
2023-08-12 |
Not clear |
| Monika Wiłkość, Joanna Hauser, Marta Tomaszewska, Monika Dmitrzak-Weglarz, Maria Skibińska, Aleksandra Szczepankiewicz, Alina Borkowsk. Influence of dopaminergic and serotoninergic genes on working memory in healthy subjects. Acta neurobiologiae experimentalis. vol 70. issue 1. 2010-07-28. PMID:20407490. |
the purpose of this study was to assess the association between the polymorphisms of dopaminergic (drd1, drd3, drd4, comt) and serotoninergic (sert--serotonin transporter, 5ht2a, 5ht2c) genes' polymorphisms and performance on wcst in 200 volunteers from the polish population. |
2010-07-28 |
2023-08-12 |
human |
| Nancy A Dennis, Anna C Need, Kevin S LaBar, Sheena Waters-Metenier, Elizabeth T Cirulli, James Kragel, David B Goldstein, Roberto Cabez. COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals. Cerebral cortex (New York, N.Y. : 1991). vol 20. issue 3. 2010-05-04. PMID:19641018. |
furthermore, based on the dopaminergic differences associated with the comt val108/158met genotype, neural differences during cognition may be present, regardless of genotypic differences in cognitive performance. |
2010-05-04 |
2023-08-12 |
Not clear |
| Hong Yuan, Zhen-Wen Zhang, Li-Wu Liang, Quan Shen, Xiang-Dang Wang, Su-Mei Ren, Hong-Jie Ma, Shu-Jun Jiao, Ping Li. Treatment strategies for Parkinson's disease. Neuroscience bulletin. vol 26. issue 1. 2010-04-15. PMID:20101274. |
current therapies include dopaminergic therapy, da agonists, mao-b inhibitor, comt inhibitors, anticholinergic drugs, surgical procedures such as pallidotomy and more specifically deep brain stimulation of the globus pallidus pars interna (gpi) or subthalamic nucleus (stn), and stem cell transplantation. |
2010-04-15 |
2023-08-12 |
Not clear |
| Bradley T Conner, Gerhard S Hellemann, Terry L Ritchie, Ernest P Nobl. Genetic, personality, and environmental predictors of drug use in adolescents. Journal of substance abuse treatment. vol 38. issue 2. 2010-04-09. PMID:19717274. |
variables included in the study were dopaminergic genes (ankk1 taqi a, drd2 c957t, drd4 7r, comt val/met substitution, and slc6a3 9r) and a gabaergic gene (gabrb3), all combinations of genes, a count of the number of hypodopaminergic genotypes, personality traits, neurocognitive factors, depressive symptoms, and environmental factors. |
2010-04-09 |
2023-08-12 |
Not clear |
| V Mylius, J C Möller, K Strauch, W H Oertel, K Stiasny-Kolste. No significance of the COMT val158met polymorphism in restless legs syndrome. Neuroscience letters. vol 473. issue 2. 2010-04-08. PMID:20184941. |
the catechol-o-methyltransferase (comt) val(158)met polymorphism, which codes for the substitution of valine (val) by methionine (met) leading to a reduced comt activity in homo- or heterozygous individuals, is associated with individual pain sensitivity and dopaminergic responses in parkinson's disease as well as with various chronic painful diseases. |
2010-04-08 |
2023-08-12 |
Not clear |
| Bai-Yun Zeng, Robert H Balfour, Mike J Jackson, Sarah Rose, Peter Jenne. Expression of catechol-O-methyltransferase in the brain and periphery of normal and MPTP-treated common marmosets. Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 1. 2010-03-24. PMID:19771390. |
catechol-o-methyltransferase (comt) inhibition is widely used to potentiate the effects of levodopa in parkinson's disease but the effects of nigral dopaminergic cell loss and levodopa treatment on comt activity are not known. |
2010-03-24 |
2023-08-12 |
marmoset |
| Bai-Yun Zeng, Robert H Balfour, Mike J Jackson, Sarah Rose, Peter Jenne. Expression of catechol-O-methyltransferase in the brain and periphery of normal and MPTP-treated common marmosets. Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 1. 2010-03-24. PMID:19771390. |
comt activity appears unaffected by loss of the dopaminergic nigro-striatal pathway and levodopa treatment. |
2010-03-24 |
2023-08-12 |
marmoset |
| Daniel Paul Eisenberg, Deepak Sarpal, Philip D Kohn, Andreas Meyer-Lindenberg, Dylan Wint, Bhaskar Kolachana, José Apud, Daniel R Weinberger, Karen Faith Berma. Catechol-o-methyltransferase valine(158)methionine genotype and resting regional cerebral blood flow in medication-free patients with schizophrenia. Biological psychiatry. vol 67. issue 3. 2010-02-25. PMID:19892319. |
a valine(158)methionine (val(158)met) polymorphism in catechol-o-methyltransferase (comt) modulates cortical dopaminergic catabolism and has been associated with schizophrenia. |
2010-02-25 |
2023-08-12 |
Not clear |
| Raphael Béné, Sonja Antić, Mislav Budisić, Marijana Lisak, Zlatko Trkanjec, Vida Demarin, Slava Podobnik-Sarkanj. Parkinson's disease. Acta clinica Croatica. vol 48. issue 3. 2010-01-29. PMID:20055267. |
the key therapeutic agent in the treatment of parkinson's disease is l-dopa, and the others are dopaminergic agents, monoamine oxidase-b (mao-b) inhibitors, catechol-o-methyltransferase (comt) inhibitors, amantadine and anticholinergic agents. |
2010-01-29 |
2023-08-12 |
Not clear |
| Irene E Nagel, Christian Chicherio, Shu-Chen Li, Timo von Oertzen, Thomas Sander, Arno Villringer, Hauke R Heekeren, Lars Bäckman, Ulman Lindenberge. Human aging magnifies genetic effects on executive functioning and working memory. Frontiers in human neuroscience. vol 2. 2009-12-16. PMID:18958202. |
the age-associated magnification of comt gene effects provides novel information on the inverted u-shaped relation linking dopaminergic neuromodulation in pfc to cognitive performance. |
2009-12-16 |
2023-08-12 |
human |