| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hanoch Kaphzan, Dorit Ben-Shachar, Ehud Klei. Entacapone augmentation of antipsychotic treatment in schizophrenic patients with negative symptoms; a double-blind placebo-controlled study. The international journal of neuropsychopharmacology. vol 17. issue 2. 2014-08-26. PMID:24229565. |
hence, inhibition of comt activity with entacapone should reverse pfc dopaminergic transmission. |
2014-08-26 |
2023-08-12 |
Not clear |
| Christopher T Smith, Theresa Swift-Scanlan, Charlotte A Boettige. Genetic polymorphisms regulating dopamine signaling in the frontal cortex interact to affect target detection under high working memory load. Journal of cognitive neuroscience. vol 26. issue 2. 2014-08-18. PMID:24144248. |
these findings suggest that enhanced dopaminergic signaling via the darpp-32 t allele aids target detection in individuals with presumed low frontal da (comt(valval)) but impairs target detection in those with putatively higher frontal da levels (comt(met) carriers). |
2014-08-18 |
2023-08-12 |
Not clear |
| Nadella Kumudini, Addepally Umai, Yalavarthy Prameela Devi, Shaik Mohammad Naushad, Rukmini Mridula, Rupam Borgohain, Vijay Kumar Kutal. Impact of COMT H108L, MAOB int 13 A>G and DRD2 haplotype on the susceptibility to Parkinson's disease in South Indian subjects. Indian journal of biochemistry & biophysics. vol 50. issue 5. 2014-07-10. PMID:24772965. |
in view of documented evidence demonstrating the association of dopaminergic metabolism and neurotransmission with parkinson's disease (pd), a case-control study was conducted to investigate the impact of particular polymorphisms in the catechol o-methyl transferase (comt) h108l, monoamine oxidase b (maob) int 13 a>g, dopamine transporter 1 (dat1) a1215g, dopamine receptor d2 (drd2) taq1a, drd2 taq1b and drd2 taq1d genes on the susceptibility to pd. |
2014-07-10 |
2023-08-13 |
human |
| Maja Zivković, Alma Mihaljević-Peles, Nada Bozina, Marina Sagud, Matea Nikolac-Perkovic, Bjanka Vuksan-Cusa, Dorotea Muck-Sele. The association study of polymorphisms in DAT, DRD2, and COMT genes and acute extrapyramidal adverse effects in male schizophrenic patients treated with haloperidol. Journal of clinical psychopharmacology. vol 33. issue 5. 2014-04-01. PMID:23963056. |
the aim of this study was to determine the association between dopaminergic type 2 receptor (drd2) dopamine transporter (slc6a3) and catechol-o-methyltransferase (comt) gene polymorphisms and acute epss in 240 male schizophrenic patients treated with haloperidol (15-mg/d) over a period of 2 weeks. |
2014-04-01 |
2023-08-12 |
Not clear |
| Maja Zivković, Alma Mihaljević-Peles, Nada Bozina, Marina Sagud, Matea Nikolac-Perkovic, Bjanka Vuksan-Cusa, Dorotea Muck-Sele. The association study of polymorphisms in DAT, DRD2, and COMT genes and acute extrapyramidal adverse effects in male schizophrenic patients treated with haloperidol. Journal of clinical psychopharmacology. vol 33. issue 5. 2014-04-01. PMID:23963056. |
three dopaminergic gene polymorphisms, the drd2 taq1a, the slc6a3 vntr, and the comt val158met, were determined. |
2014-04-01 |
2023-08-12 |
Not clear |
| Sophia C Magalona, Roberta Rasetti, Jingshan Chen, Qiang Chen, Ian Gold, Heather Decot, Joseph H Callicott, Karen F Berman, José A Apud, Daniel R Weinberger, Venkata S Matta. Effect of tolcapone on brain activity during a variable attentional control task: a double-blind, placebo-controlled, counter-balanced trial in healthy volunteers. CNS drugs. vol 27. issue 8. 2014-02-19. PMID:23794107. |
evidence indicates that catechol-o-methyltransferase (comt) modulates dopaminergic tone in the pfc and dcc. |
2014-02-19 |
2023-08-12 |
human |
| Dennis Hernaus, Dina Collip, Johan Lataster, Jenny Ceccarini, Gunther Kenis, Linda Booij, Jens Pruessner, Koen Van Laere, Ruud van Winkel, Jim van Os, Inez Myin-Germey. COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge. PloS one. vol 8. issue 6. 2014-01-30. PMID:23799032. |
although a polymorphism in this gene, comt val(158)met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis. |
2014-01-30 |
2023-08-12 |
human |
| Dennis Hernaus, Dina Collip, Johan Lataster, Jenny Ceccarini, Gunther Kenis, Linda Booij, Jens Pruessner, Koen Van Laere, Ruud van Winkel, Jim van Os, Inez Myin-Germey. COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge. PloS one. vol 8. issue 6. 2014-01-30. PMID:23799032. |
we aimed to investigate the effect of variations in comt genotype on in vivo measures of stress-induced prefrontal cortex (pfc) dopaminergic processing and subjective stress responses. |
2014-01-30 |
2023-08-12 |
human |
| Jochen Mutschler, Elvira Abbruzzese, Christoph von der Goltz, Christina Dinter, Arian Mobascher, Holger Thiele, Amalia Diaz-Lacava, Norbert Dahmen, Jürgen Gallinat, Tomislav Majic, Nadine Petrovsky, Norbert Thuerauf, Johannes Kornhuber, Gerhard Gründer, Lena Rademacher, Juergen Brinkmeyer, Thomas Wienker, Michael Wagner, Georg Winterer, Falk Kiefe. Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 15. issue 7. 2014-01-27. PMID:23288874. |
the catechol-o-methyltransferase (comt) modulates dopaminergic neurotransmission in the prefrontal cortex as well as in the mesolimbic reward system. |
2014-01-27 |
2023-08-12 |
Not clear |
| Fabienne Sprenger, Werner Poew. Management of motor and non-motor symptoms in Parkinson's disease. CNS drugs. vol 27. issue 4. 2013-12-17. PMID:23515972. |
levodopa still remains the gold standard for the treatment of motor symptoms of pd but dopamine agonists (das), catechol-o-methyltransferase (comt) inhibitors and monoamine oxidase b (mao-b) inhibitors have also been developed to provide more continuous oral delivery of dopaminergic stimulation in order to improve motor outcomes and decrease the risk of levodopa-induced motor complications. |
2013-12-17 |
2023-08-12 |
Not clear |
| Matteo Lazzaretti, Dora Fabbro, Michela Sala, Kether Del Toso, Giulia de Vidovich, Elisa Marraffini, Niccolò Morandotti, Francesca Gambini, Francesco Barale, Matteo Balestrieri, Giuseppe Damante, Edgardo Caverzasi, Paolo Brambill. Association between low-activity allele of cathecolamine-O-methyl-transferase (COMT) and Borderline Personality Disorder in an Italian population. Behavioral medicine (Washington, D.C.). vol 39. issue 2. 2013-12-17. PMID:23668908. |
the allele encoding for the comt with low enzymatic efficiency was found to be over-represented in bpd, possibly resulting in excessive synaptic dopaminergic activity and ultimately affecting externalizing behaviours, such as impulsivity and aggressiveness. |
2013-12-17 |
2023-08-12 |
human |
| Stefan Brauns, Randy L Gollub, Esther Walton, Johanna Hass, Michael N Smolka, Tonya White, Thomas H Wassink, Vince D Calhoun, Stefan Ehrlic. Genetic variation in GAD1 is associated with cortical thickness in the parahippocampal gyrus. Journal of psychiatric research. vol 47. issue 7. 2013-12-09. PMID:23566421. |
because of the well known interactions between the gabaergic and dopaminergic systems, we examined whether associations between gad1 rs3749034 and cortical thickness are modulated by the catechol-o-methyltransferase (comt) val158met genotype. |
2013-12-09 |
2023-08-12 |
human |
| b' Nadia Schendzielorz, Juha-Pekka Oinas, Timo T My\\xc3\\xb6h\\xc3\\xa4nen, Ilkka Reenil\\xc3\\xa4, Atso Raasmaja, Pekka T M\\xc3\\xa4nnist\\xc3\\xb. Catechol-O-methyltransferase (COMT) protein expression and activity after dopaminergic and noradrenergic lesions of the rat brain. PloS one. vol 8. issue 4. 2013-11-14. PMID:23613844.' |
catechol-o-methyltransferase (comt) protein expression and activity after dopaminergic and noradrenergic lesions of the rat brain. |
2013-11-14 |
2023-08-12 |
rat |
| b' Nadia Schendzielorz, Juha-Pekka Oinas, Timo T My\\xc3\\xb6h\\xc3\\xa4nen, Ilkka Reenil\\xc3\\xa4, Atso Raasmaja, Pekka T M\\xc3\\xa4nnist\\xc3\\xb. Catechol-O-methyltransferase (COMT) protein expression and activity after dopaminergic and noradrenergic lesions of the rat brain. PloS one. vol 8. issue 4. 2013-11-14. PMID:23613844.' |
this study utilized dopaminergic and noradrenergic toxins to assess the presence of comt in the presynaptic neurons originating from the substantia nigra, ventral tegmental area or locus coeruleus. |
2013-11-14 |
2023-08-12 |
rat |
| b' Nadia Schendzielorz, Juha-Pekka Oinas, Timo T My\\xc3\\xb6h\\xc3\\xa4nen, Ilkka Reenil\\xc3\\xa4, Atso Raasmaja, Pekka T M\\xc3\\xa4nnist\\xc3\\xb. Catechol-O-methyltransferase (COMT) protein expression and activity after dopaminergic and noradrenergic lesions of the rat brain. PloS one. vol 8. issue 4. 2013-11-14. PMID:23613844.' |
despite successful lesioning of dopaminergic and noradrenergic neurons, no changes in comt protein expression or activity could be noted. |
2013-11-14 |
2023-08-12 |
rat |
| b' Nadia Schendzielorz, Juha-Pekka Oinas, Timo T My\\xc3\\xb6h\\xc3\\xa4nen, Ilkka Reenil\\xc3\\xa4, Atso Raasmaja, Pekka T M\\xc3\\xa4nnist\\xc3\\xb. Catechol-O-methyltransferase (COMT) protein expression and activity after dopaminergic and noradrenergic lesions of the rat brain. PloS one. vol 8. issue 4. 2013-11-14. PMID:23613844.' |
these results strongly suggest that comt is not present in presynaptic dopaminergic and noradrenergic neurons. |
2013-11-14 |
2023-08-12 |
rat |
| Joana Reis, Igor Encarnação, Alexandra Gaspar, Aliuska Morales, Nuno Milhazes, Fernanda Borge. Parkinson's disease management. Part II- discovery of MAO-B inhibitors based on nitrogen heterocycles and analogues. Current topics in medicinal chemistry. vol 12. issue 20. 2013-11-13. PMID:23231391. |
despite all the recent research, there are only a few classes of drugs approved for the treatment of motor related symptoms of pd which primarily act on the dopaminergic neurons system: l-dopa, dopamine agonists, monoamine oxidase-b (mao-b) and catechol-o-methyl transferase (comt) inhibitors. |
2013-11-13 |
2023-08-12 |
human |
| I Heitland, J L Kenemans, R S Oosting, J M P Baas, K B E Böcke. Auditory event-related potentials (P3a, P3b) and genetic variants within the dopamine and serotonin system in healthy females. Behavioural brain research. vol 249. 2013-10-21. PMID:23619133. |
in all, the present findings suggest involvement of frontal-cortical dopaminergic and serotoninergic mechanisms in bottom-up attentional capture (comt val158met, 5httlpr), with an additional top-down component sensitive to striatal signals (dat1). |
2013-10-21 |
2023-08-12 |
human |
| Elizabeth M Tunbridge, Sarah M Farrell, Paul J Harrison, Clare E Macka. Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest. NeuroImage. vol 68. 2013-08-01. PMID:23228511. |
the results suggest that genotype-related differences in prefrontal dopaminergic tone result in neuroadaptive changes in basal functional connectivity, potentially including subtle comt genotype-dependent differences in the relative coupling of task-positive and task-negative regions, which could in turn contribute to its effects on brain activation, connectivity, and behaviour. |
2013-08-01 |
2023-08-12 |
human |
| Xiaochu Zhang, Mary R Lee, Betty Jo Salmeron, Dan J Stein, L Elliot Hong, Xiujuan Geng, Thomas J Ross, Nan Li, Colin Hodgkinson, Pei-Hong Shen, Yihong Yang, David Goldman, Elliot A Stei. Prefrontal white matter impairment in substance users depends upon the catechol-o-methyl transferase (COMT) val158met polymorphism. NeuroImage. vol 69. 2013-07-26. PMID:23219927. |
the catechol-o-methyltransferase (comt) gene contains an evolutionarily recent and common functional variant at codon 108/158 (rs4680) that plays an important role in modulating prefrontal dopaminergic tone. |
2013-07-26 |
2023-08-12 |
Not clear |