| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Esther D A van Duin, Liesbet Goossens, Dennis Hernaus, Fabiana da Silva Alves, Nicole Schmitz, Koen Schruers, Therese van Amelsvoor. Neural correlates of reward processing in adults with 22q11 deletion syndrome. Journal of neurodevelopmental disorders. vol 8. 2016-07-19. PMID:27429661. |
the gene coding for catechol-o-methyl-transferase (comt) is located at the deleted region, resulting in disrupted dopaminergic neurotransmission in 22q11ds, which may contribute to the increased vulnerability for psychosis. |
2016-07-19 |
2023-08-13 |
Not clear |
| Z Naumovska, A K Nestorovska, A Filipce, Z Sterjev, K Brezovska, A Dimovski, L J Suturkov. Pharmacogenetics and antipsychotic treatment response. Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki). vol 36. issue 1. 2016-07-15. PMID:26076775. |
it highlights the most important findings about the impact of functional polymorphisms in genes coding the cyp450 metabolizing enzymes, abcb1 transporter gene, dopaminergic and serotonergic drug targets (drd2, drd3, drd4, 5-ht1, 5ht-2a, 5ht-2c, 5ht6) as well as genes responsible for metabolism of neurotransmitters and g signalling pathways (5-httlpr, bdnf, comt, rgs4) and points their role as potential biomarkers in everyday clinical practice. |
2016-07-15 |
2023-08-13 |
Not clear |
| Jean-Pierre Lindenmayer, Anzalee Khan, Herbert Lachman, Susan R McGurk, Abraham Goldring, Amod Thanju, Saurabh Kaushi. COMT genotype and response to cognitive remediation in schizophrenia. Schizophrenia research. vol 168. issue 1-2. 2016-07-06. PMID:26255563. |
a functional polymorphism of the catechol-o-methyltransferase (comt) gene (val158met) partially appears to influence cognitive performance in schizophrenia subjects and healthy controls by modulating prefrontal dopaminergic activity. |
2016-07-06 |
2023-08-13 |
human |
| Carolina B Meloto, Samantha K Segall, Shad Smith, Marc Parisien, Svetlana A Shabalina, Célia M Rizzatti-Barbosa, Josée Gauthier, Douglas Tsao, Marino Convertino, Marjo H Piltonen, Gary Dmitri Slade, Roger B Fillingim, Joel D Greenspan, Richard Ohrbach, Charles Knott, William Maixner, Dmitri Zaykin, Nikolay V Dokholyan, Ilkka Reenilä, Pekka T Männistö, Luda Diatchenk. COMT gene locus: new functional variants. Pain. vol 156. issue 10. 2016-06-27. PMID:26207649. |
they also established that the pain-protective a allele of rs165774 coincides with lower comt activity, suggesting contribution to decreased pain sensitivity through increased dopaminergic rather than decreased adrenergic tone, characteristic of reference isoforms. |
2016-06-27 |
2023-08-13 |
human |
| Eric L Thibodeau, Dante Cicchetti, Fred A Rogosc. Child maltreatment, impulsivity, and antisocial behavior in African American children: Moderation effects from a cumulative dopaminergic gene index. Development and psychopathology. vol 27. issue 4 Pt 2. 2016-06-17. PMID:26535948. |
five genotypes in four dopaminergic genes (dopamine receptors d4, d2, known as drd4, drd2; dopamine active transporter 1, known as dat1; and catechol-o-methyltransferase, known as comt) conferring heightened environmental sensitivity were combined into one polygenic index. |
2016-06-17 |
2023-08-13 |
Not clear |
| Ansley Stanfill, Donna Hathaway, Ann Cashion, Ramin Homayouni, Patricia Cowan, Carol Thompson, Behrouz Madahian, Yvette Conle. A Pilot Study of Demographic and Dopaminergic Genetic Contributions to Weight Change in Kidney Transplant Recipients. PloS one. vol 10. issue 9. 2016-05-27. PMID:26406335. |
the purpose of this pilot study is to first examine the feasibility and methodology, and then to examine the associations of age, race, sex, and genotype for 13 snps and 3 vntrs in 9 dopaminergic pathway genes (ankk1, drd2, drd3, drd4, slc6a3/dat1, maoa, maob, comt, cpe) for associations with percent weight change at 12 months post-transplantation. |
2016-05-27 |
2023-08-13 |
Not clear |
| Yeimy González-Giraldo, Rodrigo E González-Reyes, Shane T Mueller, Brian J Piper, Ana Adan, Diego A Forer. Differences in planning performance, a neurocognitive endophenotype, are associated with a functional variant in PER3 gene. Chronobiology international. vol 32. issue 5. 2016-05-09. PMID:25798540. |
several genes related to dopaminergic systems, such as comt, have been explored as candidates for influencing planning performance. |
2016-05-09 |
2023-08-13 |
human |
| Julia Muellner, Iman Gharrad, Marie-Odile Habert, Aurélie Kas, Jean-Baptiste Martini, Florence Cormier-Dequaire, Khadija Tahiri, Marie Vidailhet, Niklaus Meier, Alexis Brice, Michael Schuepbach, Alain Mallet, Andreas Hartmann, Jean-Christophe Corvo. Dopaminergic denervation severity depends on COMT Val158Met polymorphism in Parkinson's disease. Parkinsonism & related disorders. vol 21. issue 5. 2016-04-18. PMID:25753458. |
dopaminergic denervation severity depends on comt val158met polymorphism in parkinson's disease. |
2016-04-18 |
2023-08-13 |
Not clear |
| Julia Muellner, Iman Gharrad, Marie-Odile Habert, Aurélie Kas, Jean-Baptiste Martini, Florence Cormier-Dequaire, Khadija Tahiri, Marie Vidailhet, Niklaus Meier, Alexis Brice, Michael Schuepbach, Alain Mallet, Andreas Hartmann, Jean-Christophe Corvo. Dopaminergic denervation severity depends on COMT Val158Met polymorphism in Parkinson's disease. Parkinsonism & related disorders. vol 21. issue 5. 2016-04-18. PMID:25753458. |
we investigated dopaminergic denervation in the striatum in pd patients according to comt rs4680 genotype. |
2016-04-18 |
2023-08-13 |
Not clear |
| Pauliina Lindholm, Salla Lamusuo, Tero Taiminen, Ullamari Pesonen, Ari Lahti, Arja Virtanen, Heli Forssell, Jarmo Hietala, Nora Hagelberg, Antti Pertovaara, Riitta Parkkola, Satu Jääskeläine. Right secondary somatosensory cortex-a promising novel target for the treatment of drug-resistant neuropathic orofacial pain with repetitive transcranial magnetic stimulation. Pain. vol 156. issue 7. 2016-04-11. PMID:25830924. |
furthermore, as dopaminergic mechanisms modulate pain responses, we assessed the influence of the functional drd2 gene polymorphism (957c>t) and the catechol-o-methyltransferase (comt) val158met polymorphism on the analgesic effect of rtms. |
2016-04-11 |
2023-08-13 |
human |
| Yves Dauvilliers, Mehdi Tafti, Hans Peter Landol. Catechol-O-methyltransferase, dopamine, and sleep-wake regulation. Sleep medicine reviews. vol 22. 2016-04-08. PMID:25466290. |
individuals homozygous for the val allele show higher comt activity, and lower dopaminergic signaling in prefrontal cortex (pfc) than subjects homozygous for the met allele. |
2016-04-08 |
2023-08-13 |
human |
| Ming-Chuan Hu, Sheng-Yu Lee, Tzu-Yun Wang, Yun-Hsuan Chang, Shiou-Lan Chen, Shih-Heng Chen, Chun-Hsien Chu, Chen-Lin Wang, I Hui Lee, Po See Chen, Yen Kuang Yang, Ru-Band L. Interaction of DRD2TaqI, COMT, and ALDH2 genes associated with bipolar II disorder comorbid with anxiety disorders in Han Chinese in Taiwan. Metabolic brain disease. vol 30. issue 3. 2016-04-01. PMID:25430946. |
it is hypothesized that dopaminergic genes-dopamine type-2 receptor (drd2), aldehyde dehydrogenase 2 (aldh2), and catechol-o-methyltransferase (comt)-are associated with bipolar disorder (bp) and anxiety disorder (ad). |
2016-04-01 |
2023-08-13 |
human |
| Ming-Chuan Hu, Sheng-Yu Lee, Tzu-Yun Wang, Yun-Hsuan Chang, Shiou-Lan Chen, Shih-Heng Chen, Chun-Hsien Chu, Chen-Lin Wang, I Hui Lee, Po See Chen, Yen Kuang Yang, Ru-Band L. Interaction of DRD2TaqI, COMT, and ALDH2 genes associated with bipolar II disorder comorbid with anxiety disorders in Han Chinese in Taiwan. Metabolic brain disease. vol 30. issue 3. 2016-04-01. PMID:25430946. |
this study supports the hypothesis the interaction of the dopaminergic genes between bp-ii(+ad) and bp-ii(-ad) is significant different,, and provides additional evidence that the drd2taqia a1/a1, aldh2*1/*1 and comt genes interact in bp-ii(-ad) but not in bp-ii(+ad). |
2016-04-01 |
2023-08-13 |
human |
| A E Gareeva, K O Kinyasheva, D Yu Galaktionova, E T Sabirov, R G Valinourov, A V Chudinov, A S Zasedatelev, T V Nasedkina, E K Khusnutdinov. [Brain neurotransmitter systems gene Polymorphism: the Search for pharmacogenetic markers of efficacy of haloperidol in Russians and Tatars]. Molekuliarnaia biologiia. vol 49. issue 6. 2016-02-23. PMID:26710776. |
in this paper, we analyzed the association of nine polymorphic variants of five genes of dopaminergic and serotonergic systems drd4, htr2a, tph1, slc18a1, comt in russian and tatars patients living in the republic of bashkortostan (rb) with the efficiency of a typical antipsychotic haloperidol on the scale of positive and negative systems of panss. |
2016-02-23 |
2023-08-13 |
Not clear |
| A E Gareeva, K O Kinyasheva, D Yu Galaktionova, E T Sabirov, R G Valinourov, A V Chudinov, A S Zasedatelev, T V Nasedkina, E K Khusnutdinov. [Brain neurotransmitter systems gene Polymorphism: the Search for pharmacogenetic markers of efficacy of haloperidol in Russians and Tatars]. Molekuliarnaia biologiia. vol 49. issue 6. 2016-02-23. PMID:26710776. |
the results of this study confirm the importance of changes in the nucleotide sequences of the studied genes of the serotoninergic and dopaminergic systems (htr2a, tph1, slc18a1 comt, drd4) in the formation of individual sensitivity to haloperidol. |
2016-02-23 |
2023-08-13 |
Not clear |
| Ignacio Sáez, Lusha Zhu, Eric Set, Andrew Kayser, Ming Hs. Dopamine modulates egalitarian behavior in humans. Current biology : CB. vol 25. issue 7. 2016-01-05. PMID:25802148. |
specifically, using the brain penetrant catechol-o-methyl transferase (comt) inhibitor tolcapone [4, 5], we investigated the causal relationship between dopaminergic mechanisms and two prosocial concerns at the core of a number of widely used economic games: (1) the extent to which individuals directly value the material payoffs of others, i.e., generosity, and (2) the extent to which they are averse to differences between their own payoffs and those of others, i.e., inequity. |
2016-01-05 |
2023-08-13 |
human |
| Ignacio Sáez, Lusha Zhu, Eric Set, Andrew Kayser, Ming Hs. Dopamine modulates egalitarian behavior in humans. Current biology : CB. vol 25. issue 7. 2016-01-05. PMID:25802148. |
we found that dopaminergic augmentation via comt inhibition increased egalitarian tendencies in participants who played an extended version of the dictator game [6]. |
2016-01-05 |
2023-08-13 |
human |
| Weidong Ji, Ning Li, Kang Ju, Hong Zheng, Chuang Yang, Ping Xu, Silu Chen, Aiai Cao, Xue Chen, Lanting Gu. Association of Catechol-O-methyltransferase val/met polymorphism with cognitive function in Gilles de la Tourette syndrome patients. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 36. issue 4. 2015-12-09. PMID:25367405. |
the mechanism of cognitive functions was associated with dopaminergic system, thus we access the associations between polymorphism of some dopaminergic system-related genes including catechol-o-methyltransferase (comt) met/val, dopamine receptor d4 (drd4) exon iii 48 bp vntr (variable number of tandem repeats), interleukin 1 (il-1) ra 86 bp and il-1β exon 5, and cognitive functions in gts patients. |
2015-12-09 |
2023-08-13 |
Not clear |
| Maria Laura De Marchis, Piero Barbanti, Raffaele Palmirotta, Gabriella Egeo, Cinzia Aurilia, Luisa Fofi, Serena Piroso, Cristiano Ialongo, David Della-Morte, Giovanni D'Andrea, Patrizia Ferroni, Fiorella Guadagn. Look beyond Catechol-O-Methyltransferase genotype for cathecolamines derangement in migraine: the BioBIM rs4818 and rs4680 polymorphisms study. The journal of headache and pain. vol 16. 2015-12-01. PMID:25929431. |
the study of comt gene polymorphisms in migraine could be of particular interest since impaired catecholaminergic neurotransmission, namely chronic dopaminergic and noradrenergic hypofunction, is a peculiar migraine trait. |
2015-12-01 |
2023-08-13 |
Not clear |
| Katharina Domschke, Bernward Winter, Agnieszka Gajewska, Stefan Unterecker, Bodo Warrings, Andrea Dlugos, Swantje Notzon, Kathrin Nienhaus, Falko Markulin, Astrid Gieselmann, Christian Jacob, Martin J Herrmann, Volker Arolt, Andreas Mühlberger, Andreas Reif, Paul Pauli, Jürgen Deckert, Peter Zwanzge. Multilevel impact of the dopamine system on the emotion-potentiated startle reflex. Psychopharmacology. vol 232. issue 11. 2015-11-30. PMID:25510857. |
particular evidence has accumulated for alterations in the dopaminergic system-partly conferred by catechol-o-methyltransferase (comt) gene variation-and for distorted emotional processing to constitute risk factors for anxiety and anxiety-related disorders. |
2015-11-30 |
2023-08-13 |
Not clear |