| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liang-Jen Wang, Sheng-Yu Lee, Shiou-Lan Chen, Yun-Hsuan Chang, Po See Chen, San-Yuan Huang, Nian-Sheng Tzeng, Kao Chin Chen, I Hui Lee, Tzu-Yun Wang, Yen Kuang Yang, Ru-Band L. A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder. Scientific reports. vol 5. 2015-11-25. PMID:25744938. |
because dopaminergic disturbance is thought to be involved in the development of bipolar disorder (bpd), it seems essential to investigate dopamine-related genes like the catechol-o-methyltransferase (comt) gene, which are involved in dopamine metabolism, and the methylenetetrahydrofolate reductase (mthfr) gene, which may affect comt methylation and comt function. |
2015-11-25 |
2023-08-13 |
human |
| Liang-Jen Wang, Sheng-Yu Lee, Shiou-Lan Chen, Yun-Hsuan Chang, Po See Chen, San-Yuan Huang, Nian-Sheng Tzeng, Kao Chin Chen, I Hui Lee, Tzu-Yun Wang, Yen Kuang Yang, Ru-Band L. A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder. Scientific reports. vol 5. 2015-11-25. PMID:25744938. |
our findings support preliminary evidence that the comt and mthfr genes interact in bp-ii, and they imply the connection of both dopaminergic pathways and methylation pathways in the pathogenesis of bp-ii. |
2015-11-25 |
2023-08-13 |
human |
| Stefanie C Biehl, Kathrin M Gschwendtner, Anne Guhn, Laura D Müller, Susanne Reichert, Julia Heupel, Andreas Reif, Jürgen Deckert, Martin J Herrmann, Christian P Jaco. Does adult ADHD interact with COMT val (158) met genotype to influence working memory performance? Attention deficit and hyperactivity disorders. vol 7. issue 1. 2015-11-23. PMID:25007787. |
both attention-deficit/hyperactivity disorder (adhd) and catechol-o-methyltransferase (comt) genotype have been linked to altered dopaminergic transmission and possible impairment in frontal lobe functioning. |
2015-11-23 |
2023-08-13 |
Not clear |
| Tim Klucken, Onno Kruse, Sina Wehrum-Osinsky, Juergen Hennig, Jan Schweckendiek, Rudolf Star. Impact of COMT Val158Met-polymorphism on appetitive conditioning and amygdala/prefrontal effective connectivity. Human brain mapping. vol 36. issue 3. 2015-10-21. PMID:25394948. |
it has been suggested that the val(158) met-polymorphism in the catechol-o-methyl-transferase (comt) is associated with the alteration of neural processes of appetitive conditioning due to the central role of the dopaminergic system in reward processing. |
2015-10-21 |
2023-08-13 |
Not clear |
| Ming-Li Li, Bo Xiang, Yin-Fei Li, Xun Hu, Qiang Wang, Wan-Jun Guo, Wei Lei, Chao-Hua Huang, Lian-Sheng Zhao, Na Li, Hong-Yan Ren, Hui-Yao Wang, Xiao-Hong Ma, Wei Deng, Tao L. Morphological changes in gray matter volume correlate with catechol-O-methyl transferase gene Val158Met polymorphism in first-episode treatment-naïve patients with schizophrenia. Neuroscience bulletin. vol 31. issue 1. 2015-09-18. PMID:25564193. |
these findings suggest that the comtmet variant is associated with the disruption of dopaminergic influence on gray matter in schizophrenia, and the effect of the comt gene on gmv in schizophrenia is mainly due to changes in cortical thickness rather than in cortical surface area. |
2015-09-18 |
2023-08-13 |
Not clear |
| Erik M Mueller, Christin Burgdorf, Mira-Lynn Chavanon, Desiree Schweiger, Jürgen Hennig, Jan Wacker, Gerhard Stemmle. The COMT Val158Met polymorphism regulates the effect of a dopamine antagonist on the feedback-related negativity. Psychophysiology. vol 51. issue 8. 2015-08-28. PMID:24773408. |
consistent with dopamine accounts of internal and external feedback processing, prior work showed that the dopamine d2 receptor antagonist sulpiride modulates the relationship between the dopaminergic comt val158met polymorphism and the error-related negativity (ern). |
2015-08-28 |
2023-08-13 |
human |
| Linh C Dang, James P O'Neil, William J Jagus. Genetic effects on behavior are mediated by neurotransmitters and large-scale neural networks. NeuroImage. vol 66. 2015-08-06. PMID:23142068. |
the integration of these results yields a model whereby comt affects prefrontal function by a mechanism involving dopaminergic modulation of the default mode network. |
2015-08-06 |
2023-08-12 |
Not clear |
| Pia Baldinger, Andreas Hahn, Markus Mitterhauser, Georg S Kranz, Marion Friedl, Wolfgang Wadsak, Christoph Kraus, Johanna Ungersböck, Annette Hartmann, Ina Giegling, Dan Rujescu, Siegfried Kasper, Rupert Lanzenberge. Impact of COMT genotype on serotonin-1A receptor binding investigated with PET. Brain structure & function. vol 219. issue 6. 2015-07-07. PMID:23928748. |
given the close interactions between serotonergic and dopaminergic neurotransmission, we investigated whether a common single-nucleotide-polymorphism of the catechol-o-methyltransferase (comt) gene (val158met or rs4680) coding for a key enzyme of the dopamine network that is associated with the pathogenesis of mood disorders and antidepressant treatment response, directly affects 5-ht1a receptor binding potential. |
2015-07-07 |
2023-08-12 |
human |
| Valentina Mione, Sonia Canterini, Emiliano Brunamonti, Pierpaolo Pani, Federica Donno, Maria Teresa Fiorenza, Stefano Ferrain. Both the COMT Val158Met single-nucleotide polymorphism and sex-dependent differences influence response inhibition. Frontiers in behavioral neuroscience. vol 9. 2015-06-04. PMID:26042010. |
to further identify sex-dependent characteristics in the cognitive control of actions, in this study, we have assessed whether/how differences in performance are modulated by the comt val158met single-nucleotide polymorphism (snp), a genetic factor known to influence the functionality of the dopaminergic system-in particular, at the level of the prefrontal cortex. |
2015-06-04 |
2023-08-13 |
human |
| Edna Grünblatt, Tobias U Hauser, Susanne Walitz. Imaging genetics in obsessive-compulsive disorder: linking genetic variations to alterations in neuroimaging. Progress in neurobiology. vol 121. 2015-06-02. PMID:25046835. |
the most promising findings of this systematic review point to the involvement of variants in genes involved in the serotonergic (5-httlpr, htr2a), dopaminergic (comt, dat), and glutamatergic (slc1a1, sapap) systems. |
2015-06-02 |
2023-08-13 |
Not clear |
| Polina Zozulinsky, Lior Greenbaum, Noa Brande-Eilat, Yair Braun, Idan Shalev, Rachel Tome. Dopamine system genes are associated with orienting bias among healthy individuals. Neuropsychologia. vol 62. 2015-05-19. PMID:25038551. |
the current study examined the hypothesis that functional genetic variants within dopaminergic genes (dat1 3' vntr, dopamine d2 receptor taq1a (rs1800497) and comt val158met (rs4680)) contribute to individual differences in orienting bias, as measured by the greyscales paradigm, in a sample of 197 young healthy israeli jewish participants. |
2015-05-19 |
2023-08-13 |
human |
| C W N Saville, T M Lancaster, M E Stefanou, G Salunkhe, I Lourmpa, A Nadkarni, S G Boehm, S Bender, N Smyrnis, U Ettinger, B Feige, M Biscaldi, K K Mantripragada, D E J Linden, C Klei. COMT Val158Met genotype is associated with fluctuations in working memory performance: converging evidence from behavioural and single-trial P3b measures. NeuroImage. vol 100. 2015-05-12. PMID:24936684. |
based on evidence that isv is associated with dopaminergic functioning, we apply a recently developed method of single-trial p3b analysis to investigate the association of comt val(158)met genotype with measures of isv on the behavioural and neural levels at different working memory loads. |
2015-05-12 |
2023-08-13 |
Not clear |
| Elisa Ira, Katia De Santi, Antonio Lasalvia, Chiara Bonetto, Gioia Zanatta, Doriana Cristofalo, Mariaelena Bertani, Sarah Saviana Bissoli, Rossana Riolo, Francesco Gardellin, Idana Morandin, Luana Ramon, Michele Tansella, Mirella Ruggeri, Sarah Tosat. Positive symptoms in first-episode psychosis patients experiencing low maternal care and stressful life events: a pilot study to explore the role of the COMT gene. Stress (Amsterdam, Netherlands). vol 17. issue 5. 2015-05-12. PMID:25068285. |
homozygosity for the comt val(158) allele seems to confer a biological predisposition to the stress-related hyperactivity of the mesolimbic dopaminergic system. |
2015-05-12 |
2023-08-13 |
Not clear |
| P Grant, F Gabriel, Y Kuepper, C Wielpuetz, J Henni. Psychosis-proneness correlates with expression levels of dopaminergic genes. European psychiatry : the journal of the Association of European Psychiatrists. vol 29. issue 5. 2015-02-20. PMID:24630741. |
we found significant negative correlations regarding the expression of the genes comt, maob, drd4, drd5 and fos, indicating that increased schizotypy coincides with higher levels of dopaminergic dysregulation on the mrna-level. |
2015-02-20 |
2023-08-12 |
human |
| Sarah Wilker, Thomas Elbert, Iris-Tatjana Kolass. The downside of strong emotional memories: how human memory-related genes influence the risk for posttraumatic stress disorder--a selective review. Neurobiology of learning and memory. vol 112. 2015-02-09. PMID:24012801. |
here, we focus on genes involved in noradrenergic (adra2b), serotonergic (slc6a4), and dopaminergic signaling (comt) as well as in the molecular cascades of memory formation (prkca and wwc1). |
2015-02-09 |
2023-08-12 |
human |
| Elisabeth M Weiss, Günter Schulter, Andreas Fink, Eva M Reiser, Erich Mittenecker, Harald Niederstätter, Simone Nagl, Walther Parson, Ilona Papouse. Influences of COMT and 5-HTTLPR polymorphisms on cognitive flexibility in healthy women: inhibition of prepotent responses and memory updating. PloS one. vol 9. issue 1. 2015-01-23. PMID:24465579. |
the current study examined the associations between the polymorphisms of dopaminergic (comt met158val) and serotoninergic (5-httlpr) genes and the sequential pattern of responses in a motor random generation task providing well-established indexes for executive functioning in a large sample of 255 healthy women. |
2015-01-23 |
2023-08-12 |
human |
| Daniel Krause, Frieder Beck, Manfred Agethen, Klaus Blischk. Effect of catechol-O-methyltransferase-val158met-polymorphism on the automatization of motor skills - a post hoc view on an experimental data. Behavioural brain research. vol 266. 2014-12-12. PMID:24607512. |
the purpose of this study was to evaluate if the catechol-o-methyltransferase-val158met (comt)-polymorphism, which is known to affect prefrontal dopaminergic metabolism, affects the automatization of motor skills. |
2014-12-12 |
2023-08-12 |
human |
| Iracema Leroi, Michelle Barraclough, Shane McKie, Neal Hinvest, Jonathan Evans, Rebecca Elliott, Kathryn McDonal. Dopaminergic influences on executive function and impulsive behaviour in impulse control disorders in Parkinson's disease. Journal of neuropsychology. vol 7. issue 2. 2014-10-09. PMID:23901888. |
dopaminergic state may be influenced by pharmacologic or genotypic (catechol-o-methyltransferase; comt) factors. |
2014-10-09 |
2023-08-12 |
Not clear |
| Eric Set, Ignacio Saez, Lusha Zhu, Daniel E Houser, Noah Myung, Songfa Zhong, Richard P Ebstein, Soo Hong Chew, Ming Hs. Dissociable contribution of prefrontal and striatal dopaminergic genes to learning in economic games. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 26. 2014-09-23. PMID:24979760. |
we found that this was also the case with comt, but not for other dopaminergic genes. |
2014-09-23 |
2023-08-13 |
Not clear |
| Henry Lin, Leonard H Epstei. Living in the moment: effects of time perspective and emotional valence of episodic thinking on delay discounting. Behavioral neuroscience. vol 128. issue 1. 2014-09-22. PMID:24512061. |
working memory capacity, inhibitory control, the genotypes of 3 functional dopaminergic polymorphisms (drd1 rs686, drd2 rs1800497, and comt rs4680), as well as an additive dopamine genetic risk score were assessed as potential moderators. |
2014-09-22 |
2023-08-12 |
human |