| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luca Colucci-D'Amato, Luisa Speranza, Floriana Volpicell. Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer. International journal of molecular sciences. vol 21. issue 20. 2021-04-16. PMID:33096634. |
bdnf plays an important role in proper growth, development, and plasticity of glutamatergic and gabaergic synapses and through modulation of neuronal differentiation, it influences serotonergic and dopaminergic neurotransmission. |
2021-04-16 |
2023-08-13 |
Not clear |
| Dagmar N van Deursen, Odile A van den Heuvel, Jan Booij, Henk W Berendse, Chris Vrien. Autonomic failure in Parkinson's disease is associated with striatal dopamine deficiencies. Journal of neurology. vol 267. issue 7. 2021-04-12. PMID:32162062. |
dopamine and serotonin are known to play a role in autonomic regulation, and, therefore, pd-related degeneration of serotonergic and dopaminergic neurons in these regions may be associated with autonomic dysfunction. |
2021-04-12 |
2023-08-13 |
Not clear |
| Antonio Carotenuto, Heather Wilson, Beniamino Giordano, Silvia P Caminiti, Zachary Chappell, Steven C R Williams, Alexander Hammers, Eli Silber, Peter Brex, Marios Politi. Impaired connectivity within neuromodulatory networks in multiple sclerosis and clinical implications. Journal of neurology. vol 267. issue 7. 2021-04-12. PMID:32219555. |
we applied resting-state functional connectivity and graph theory to investigate the changes in the functional connectivity within neuromodulatory networks including the serotonergic, noradrenergic, cholinergic, and dopaminergic systems in ms. twenty-nine ms patients and twenty-four age- and gender-matched healthy controls performed clinical and cognitive assessments including the expanded disability status score, symbol digit modalities test, and hamilton depression rating scale. |
2021-04-12 |
2023-08-13 |
Not clear |
| Pragathi Priyadharsini Balasubramani, V Srinivasa Chakravarth. Bipolar oscillations between positive and negative mood states in a computational model of Basal Ganglia. Cognitive neurodynamics. vol 14. issue 2. 2021-04-02. PMID:32226561. |
phenomenological and network models of the basal ganglia extend that logic, and interpret bipolar oscillations in terms of the activity of dopaminergic and serotonergic projections on the cortico-basal ganglia network dynamics. |
2021-04-02 |
2023-08-13 |
Not clear |
| Shu-Yue Qu, Xiao-Yue Li, Xia Heng, Yi-Yu Qi, Ping-Yuan Ge, Sai-Jia Ni, Zeng-Ying Yao, Rui Guo, Nian-Yun Yang, Yi Cao, Qi-Chun Zhang, Hua-Xu Zh. Analysis of Antidepressant Activity of Huang-Lian Jie-Du Decoction Through Network Pharmacology and Metabolomics. Frontiers in pharmacology. vol 12. 2021-03-23. PMID:33746756. |
grin2b, drd, prkca, htr, maoa, slc6a4, grin2a, and cacna1a are implicated in inhibition of depressive symptoms through modulating tryptophan metabolism, serotonergic and dopaminergic synaptic activities, camp signaling pathway, and calcium signaling pathway. |
2021-03-23 |
2023-08-13 |
mouse |
| Tsafrir Greenberg, Jay C Fournier, Richelle Stiffler, Henry W Chase, Jorge R Almeida, Haris Aslam, Thilo Deckersbach, Crystal Cooper, Marisa S Toups, Tom Carmody, Benji Kurian, Scott Peltier, Phillip Adams, Melvin G McInnis, Maria A Oquendo, Maurizio Fava, Ramin Parsey, Patrick J McGrath, Myrna Weissman, Madhukar Trivedi, Mary L Phillip. Reward related ventral striatal activity and differential response to sertraline versus placebo in depressed individuals. Molecular psychiatry. vol 25. issue 7. 2021-03-17. PMID:31462766. |
thus, a more abnormal pattern of pretreatment vs dynamic response to reward expectancy (expected outcome value) and prediction error (difference between expected and actual outcome), likely reflecting serotonergic and dopaminergic deficits, was associated with better response to sertraline than placebo. |
2021-03-17 |
2023-08-13 |
Not clear |
| Mohammad Naderi, Pankaj Puar, Mahtab Zonouzi-Marand, Douglas P Chivers, Som Niyogi, Raymond W M Kwon. A comprehensive review on the neuropathophysiology of selenium. The Science of the total environment. vol 767. 2021-02-26. PMID:33445002. |
a wealth of evidence has shown that exposure to excess se may compromise the normal functioning of various key proteins, neurotransmitter systems (the glutamatergic, dopaminergic, serotonergic, and cholinergic systems), and signaling molecules involved in the control and regulation of cognitive, behavioral, and neuroendocrine functions. |
2021-02-26 |
2023-08-13 |
Not clear |
| Nikolina Skandali, Joonas Majuri, Juho Joutsa, Kwangyeol Baek, Eveliina Arponen, Sarita Forsback, Valtteri Kaasinen, Valerie Voo. The neural substrates of risky rewards and losses in healthy volunteers and patient groups: a PET imaging study. Psychological medicine. 2021-02-11. PMID:33568248. |
several psychiatric disorders belonging to distinct diagnostic categories, including pathological gambling and addiction, show pathological risk-taking and implicate abnormal dopaminergic, opioidergic and serotonergic neurotransmission. |
2021-02-11 |
2023-08-13 |
human |
| Enaam Chleilat, Abhishek Pethe, Dietmar Pfeifer, Kerstin Krieglstein, Eleni Rouss. TGF-β Signaling Regulates SLC8A3 Expression and Prevents Oxidative Stress in Developing Midbrain Dopaminergic and Dorsal Raphe Serotonergic Neurons. International journal of molecular sciences. vol 21. issue 8. 2021-02-08. PMID:32326436. |
tgf-β signaling regulates slc8a3 expression and prevents oxidative stress in developing midbrain dopaminergic and dorsal raphe serotonergic neurons. |
2021-02-08 |
2023-08-13 |
Not clear |
| J M Carpenter, H E Gordon, H D Ludwig, J J Wagner, D A Harn, T Norberg, N M Filipo. Neurochemical and neuroinflammatory perturbations in two Gulf War Illness models: Modulation by the immunotherapeutic LNFPIII. Neurotoxicology. vol 77. 2021-01-22. PMID:31866310. |
serotonergic (5-ht) and dopaminergic (da) dyshomeostasis caused by gwi chemicals was apparent in multiple brain regions, primarily in the nucleus accumbens (5-ht) and hippocampus (5-ht, da) for both models. |
2021-01-22 |
2023-08-13 |
mouse |
| P Arechavala-Lopez, J C Caballero-Froilán, M Jiménez-García, X Capó, S Tejada, J L Saraiva, A Sureda, D Morant. Enriched environments enhance cognition, exploratory behaviour and brain physiological functions of Sparus aurata. Scientific reports. vol 10. issue 1. 2021-01-22. PMID:32647185. |
results from brain monoamines analyses may suggest increased recent dopaminergic activity in telencephalon, known to be involved in learning processes; and increased serotonergic activity in cerebellum, involved in the coordination of balance, movements and orientation. |
2021-01-22 |
2023-08-13 |
Not clear |
| Joseph Jankovic, Eng King Ta. Parkinson's disease: etiopathogenesis and treatment. Journal of neurology, neurosurgery, and psychiatry. vol 91. issue 8. 2021-01-19. PMID:32576618. |
the involvement of dopaminergic as well as noradrenergic, glutamatergic, serotonergic and adenosine pathways provide insights into the rich and variable clinical phenomenology associated with pd and the possibility of alternative therapeutic approaches beyond traditional dopamine replacement therapies.one of the biggest challenges in the development of potential neuroprotective therapies has been the lack of reliable and sensitive biomarkers of progression. |
2021-01-19 |
2023-08-13 |
Not clear |
| Minkyung Park, Mark J Niciu, Carlos A Zarat. Novel Glutamatergic Treatments for Severe Mood Disorders. Current behavioral neuroscience reports. vol 2. issue 4. 2021-01-09. PMID:26824031. |
all currently approved antidepressant medications for major depressive disorder (mdd) and bipolar disorder act primarily on the monoaminergic system and have varying affinities for serotonergic, norepinephrine-ergic, and/or dopaminergic receptors. |
2021-01-09 |
2023-08-13 |
Not clear |
| Mirko Grubor, Maja Zivkovic, Marina Sagud, Matea Nikolac Perkovic, Alma Mihaljevic-Peles, Nela Pivac, Dorotea Muck-Seler, Dubravka Svob Stra. International journal of molecular sciences. vol 21. issue 7. 2021-01-04. PMID:32231051. |
in addition to the dopaminergic system, serotonergic mechanisms, including serotonin (5-ht) receptors, might be involved in eps development. |
2021-01-04 |
2023-08-13 |
Not clear |
| Amnon A Berger, Ariel Winnick, Alexandra Welschmeyer, Alicia Kaneb, Kevin Berardino, Elyse M Cornett, Alan D Kaye, Omar Viswanath, Ivan Urit. Istradefylline to Treat Patients with Parkinson's Disease Experiencing "Off" Episodes: A Comprehensive Review. Neurology international. vol 12. issue 3. 2020-12-29. PMID:33302331. |
pd is caused by a loss of dopaminergic, cholinergic, serotonergic, and noradrenergic neurons in the central nervous system (cns), and peripherally; the syndromic parkinsonism symptoms of movement disorder, gait disorder, rigidity and tremor are mostly driven by the loss of these neurons in the basal ganglia. |
2020-12-29 |
2023-08-13 |
Not clear |
| Justin K Siemann, Piper Williams, Turnee N Malik, Chad R Jackson, Noah H Green, Ronald B Emeson, Pat Levitt, Douglas G McMaho. Photoperiodic effects on monoamine signaling and gene expression throughout development in the serotonin and dopamine systems. Scientific reports. vol 10. issue 1. 2020-12-15. PMID:32963273. |
hence, we evaluated, at multiple stages of postnatal development, the expression of key dopaminergic (th) and serotonergic (tph2, sert, and pet-1) genes, and midbrain monoamine content in mice raised under control equinox (ld 12:12), short winter-like (ld 8:16), or long summer-like (ld 16:8) photoperiods. |
2020-12-15 |
2023-08-13 |
mouse |
| Margarita R Ramis, Fiorella Sarubbo, Silvia Tejada, Manuel Jiménez, Susana Esteban, Antoni Miralles, David Morant. Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 Levels Improving Cognition in Aged Rats. Nutrients. vol 12. issue 2. 2020-11-27. PMID:31991916. |
statistically, results were correlated with significant improvements, mainly in hippocampal and striatal noradrenergic and serotonergic systems, but also with the striatal dopaminergic system. |
2020-11-27 |
2023-08-13 |
rat |
| Jon DelaCuesta-Barrutia, Olga Peñagarikano, Amaia M Erdozai. G Protein-Coupled Receptor Heteromers as Putative Pharmacotherapeutic Targets in Autism. Frontiers in cellular neuroscience. vol 14. 2020-11-17. PMID:33192330. |
among these, the dopaminergic, oxytocinergic, serotonergic, and cannabinoid systems have also been implicated in autism and thus represent putative therapeutic targets. |
2020-11-17 |
2023-08-13 |
Not clear |
| Meng Li, Jiaping Zhu, Hua Fang, Mengcen Wang, Qiangwei Wang, Bingsheng Zho. Coexposure to environmental concentrations of cis-bifenthrin and graphene oxide: Adverse effects on the nervous system during metamorphic development of Xenopus laevis. Journal of hazardous materials. vol 381. 2020-11-12. PMID:31425913. |
exposure to cis-bf and go caused further reduction in pre-metamorphic developmental rates and activated dopaminergic, noradrenergic, and serotonergic neurotransmitter systems. |
2020-11-12 |
2023-08-13 |
xenopus_laevis |
| John O'Brien, John Paul Taylor, Clive Ballard, Roger A Barker, Clare Bradley, Alistair Burns, Daniel Collerton, Sonali Dave, Rob Dudley, Paul Francis, Andrea Gibbons, Kate Harris, Vanessa Lawrence, Iracema Leroi, Ian McKeith, Michel Michaelides, Chaitali Naik, Claire O'Callaghan, Kirsty Olsen, Marco Onofrj, Rebecca Pinto, Gregor Russell, Peter Swann, Alan Thomas, Prabitha Urwyler, Rimona Sharon Weil, Dominic Ffytch. Visual hallucinations in neurological and ophthalmological disease: pathophysiology and management. Journal of neurology, neurosurgery, and psychiatry. vol 91. issue 5. 2020-11-12. PMID:32213570. |
not all hallucinations require intervention but for those that are clinically significant, current evidence supports pharmacological modification of cholinergic, gabaergic, serotonergic or dopaminergic systems, or reduction of cortical excitability. |
2020-11-12 |
2023-08-13 |
Not clear |