| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D J O'Boyle, J S Freeman, F W Cod. The accuracy and precision of timing of self-paced, repetitive movements in subjects with Parkinson's disease. Brain : a journal of neurology. vol 119 ( Pt 1). 1996-06-25. PMID:8624694. |
the theoretical import of these results is discussed in the light of several important procedural, statistical and computational issues and we conclude that tv, cv, and mdv may all vary significantly as a function of the efficacy of dopaminergic transmission in the basal ganglia. |
1996-06-25 |
2023-08-12 |
human |
| A Berardelli, S Rona, M Inghilleri, M Manfred. Cortical inhibition in Parkinson's disease. A study with paired magnetic stimulation. Brain : a journal of neurology. vol 119 ( Pt 1). 1996-06-25. PMID:8624695. |
the positive effect of l-dopa suggests that dopaminergic modulation of cortical activity, most probably at basal ganglia level, is involved in the pathogenesis of this phenomenon. |
1996-06-25 |
2023-08-12 |
human |
| B K Lipska, G E Jaskiw, A R Braun, D R Weinberge. Prefrontal cortical and hippocampal modulation of haloperidol-induced catalepsy and apomorphine-induced stereotypic behaviors in the rat. Biological psychiatry. vol 38. issue 4. 1996-02-20. PMID:8547448. |
effects of prefrontal cortical or hippocampal excitotoxic lesions on behavioral parameters related to dopaminergic transmission in the basal ganglia were investigated in the rat. |
1996-02-20 |
2023-08-12 |
rat |
| J W Kebabian, P J Blanchet, P Bedar. The D-1 dopamine receptor: past, present and future an idiosyncratic review. Progress in neuro-psychopharmacology & biological psychiatry. vol 19. issue 5. 1996-02-07. PMID:8539418. |
the loss of the dopaminergic innervation and the subsequent repeated exposure to dopamine (derived from the exogenous dopa administered to the subjects) alters the response properties of the basal ganglia circuitry so that stimulation of dopamine receptors now elicits the dyskinetic movements. |
1996-02-07 |
2023-08-12 |
human |
| Z Elazar, N Peleg, M Paz, G Rin. The striatal dopaminergic catalepsy mechanism is not necessary for the expression of pontine catalepsy produced by carbachol injections into the pontine reticular formation. Naunyn-Schmiedeberg's archives of pharmacology. vol 352. issue 2. 1995-12-27. PMID:7477442. |
these results suggest that the pontine catalepsy produced by microinjections of carbachol in prf is generated independently of the dopaminergic cataleptogenic mechanism in basal ganglia. |
1995-12-27 |
2023-08-12 |
rat |
| J M Delfs, V M Ciaramitaro, T J Parry, M F Chessele. Subthalamic nucleus lesions: widespread effects on changes in gene expression induced by nigrostriatal dopamine depletion in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 10. 1995-12-04. PMID:7472418. |
this suggests that polysynaptic pathways regulated by the subthalamic nucleus contribute to the effects of dopaminergic lesions in many regions of the basal ganglia. |
1995-12-04 |
2023-08-12 |
rat |
| J P de Mattos, A L de Ross. [Tics and Gilles de la Tourette syndrome]. Arquivos de neuro-psiquiatria. vol 53. issue 1. 1995-11-07. PMID:7575199. |
however, three factors have been considered: the neurochemical factor, related to the increased dopaminergic activity at the basal ganglia; the genetic factor and the non-genetic factors, for which environment more than genetic factors are involved. |
1995-11-07 |
2023-08-12 |
Not clear |
| D L Bliwise, R L Watts, N Watts, D B Rye, D Irbe, M Hughe. Disruptive nocturnal behavior in Parkinson's disease and Alzheimer's disease. Journal of geriatric psychiatry and neurology. vol 8. issue 2. 1995-08-03. PMID:7794473. |
these findings raise the possibility that sundowning in pd patients may be a manifestation of dopaminergic depletion within the basal ganglia or other abnormalities involving the cholinergic, serotoninergic and/or noradrenergic systems in the brainstem. |
1995-08-03 |
2023-08-12 |
Not clear |
| G B Frisoni, G Pizzolato, O Zanetti, A Bianchetti, F Chierichetti, M Trabucch. Corticobasal degeneration: neuropsychological assessment and dopamine D2 receptor SPECT analysis. European neurology. vol 35. issue 1. 1995-06-02. PMID:7737248. |
ibzm spect, which gives information about postsynaptic dopaminergic d2 receptors, showed severe reduction of tracer uptake in the right basal ganglia. |
1995-06-02 |
2023-08-12 |
Not clear |
| G B Frisoni, G Pizzolato, O Zanetti, A Bianchetti, F Chierichetti, M Trabucch. Corticobasal degeneration: neuropsychological assessment and dopamine D2 receptor SPECT analysis. European neurology. vol 35. issue 1. 1995-06-02. PMID:7737248. |
our findings suggest that a postsynaptic lesion in the basal ganglia might account for the lack of response of extrapyramidal motor symptoms to dopaminergic agonists in corticobasal degeneration. |
1995-06-02 |
2023-08-12 |
Not clear |
| S A Factor, G D Podskalny, K D Barro. Persistent neuroleptic-induced rigidity and dystonia in AIDS dementia complex: a clinico-pathological case report. Journal of the neurological sciences. vol 127. issue 1. 1995-04-28. PMID:7699386. |
it has been hypothesized, based on clinical evidence, that hypersensitivity to these drugs in adc is probably related to direct invasion of the basal ganglia by the hiv virus and a secondary alteration in dopaminergic mechanisms. |
1995-04-28 |
2023-08-12 |
Not clear |
| R M Ridle. The psychology of perserverative and stereotyped behaviour. Progress in neurobiology. vol 44. issue 2. 1995-02-17. PMID:7831478. |
in experimental studies in animals, stereotyped behaviour seems to be related mainly to excess dopaminergic activity in the basal ganglia while perserverative behaviour can be produced by lesions of the frontal lobes. |
1995-02-17 |
2023-08-12 |
Not clear |
| C C Chiueh, R M Wu, K P Mohanakumar, L M Sternberger, G Krishna, T Obata, D L Murph. In vivo generation of hydroxyl radicals and MPTP-induced dopaminergic toxicity in the basal ganglia. Annals of the New York Academy of Sciences. vol 738. 1995-02-17. PMID:7832434. |
in vivo generation of hydroxyl radicals and mptp-induced dopaminergic toxicity in the basal ganglia. |
1995-02-17 |
2023-08-12 |
Not clear |
| C C Chiueh, R M Wu, K P Mohanakumar, L M Sternberger, G Krishna, T Obata, D L Murph. In vivo generation of hydroxyl radicals and MPTP-induced dopaminergic toxicity in the basal ganglia. Annals of the New York Academy of Sciences. vol 738. 1995-02-17. PMID:7832434. |
in conclusion, this in vivo free-radical trapping procedure provides evidence to support a current working hypothesis that a site-specific formation of cytotoxic .oh free radicals in the basal ganglia may be one of the neurotoxic mechanisms underlying nigrostriatal degeneration and parkinsonism caused by the dopaminergic neurotoxin mptp. |
1995-02-17 |
2023-08-12 |
Not clear |
| M J Twery, L A Thompson, J R Walter. Intracellularly recorded response of rat striatal neurons in vitro to fenoldopam and SKF 38393 following lesions of midbrain dopamine cells. Synapse (New York, N.Y.). vol 18. issue 1. 1995-02-16. PMID:7825125. |
similar regulation of striatal neurons in vivo may contribute to dopaminergic regulation of basal ganglia output and the ability of dopaminomimetic agents to ameliorate symptoms of dopaminergic deficiency in parkinson's disease. |
1995-02-16 |
2023-08-12 |
rat |
| J C Hedreen, S E Folstei. Early loss of neostriatal striosome neurons in Huntington's disease. Journal of neuropathology and experimental neurology. vol 54. issue 1. 1995-02-08. PMID:7815073. |
analysis of the functional circuitry of the basal ganglia suggests that early degeneration of striosomal neurons may produce hyperactivity of the nigrostriatal dopaminergic pathway, causing chorea and other early clinical manifestations of hd. |
1995-02-08 |
2023-08-12 |
Not clear |
| K W Lange, P Riederer, M B Youdi. Biochemical actions of l-deprenyl (selegiline). Clinical pharmacology and therapeutics. vol 56. issue 6 Pt 2. 1995-01-18. PMID:7995015. |
because parkinson's disease is characterized by a decrease in dopaminergic neurotransmission in the basal ganglia, the selective inhibition of mao-b should lead to diminished metabolism of dopamine in the nigrostriatal system and a significant increase in the concentration of the neurotransmitter. |
1995-01-18 |
2023-08-12 |
human |
| K X Huang, J R Walter. Electrophysiological effects of SKF 38393 in rats with reserpine treatment and 6-hydroxydopamine-induced nigrostriatal lesions reveal two types of plasticity in D1 dopamine receptor modulation of basal ganglia output. The Journal of pharmacology and experimental therapeutics. vol 271. issue 3. 1995-01-17. PMID:7996456. |
to examine the role of d1 dopamine receptors in modulating basal ganglia output and how this role may be altered by changes in dopaminergic transmission, the effects of a d1 dopamine agonist on firing rates of substantia nigra pars reticulata (snpr) neurons were determined in reserpine-treated rats and compared with effects observed in nigrostriatal-lesioned and normal rats. |
1995-01-17 |
2023-08-12 |
rat |
| M Xu, R Moratalla, L H Gold, N Hiroi, G F Koob, A M Graybiel, S Tonegaw. Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Cell. vol 79. issue 4. 1994-12-27. PMID:7954836. |
the brain dopaminergic system is a critical modulator of basal ganglia function and plasticity. |
1994-12-27 |
2023-08-12 |
mouse |
| R H Porter, J G Greene, D S Higgins, J T Greenamyr. Polysynaptic regulation of glutamate receptors and mitochondrial enzyme activities in the basal ganglia of rats with unilateral dopamine depletion. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 11 Pt 2. 1994-12-02. PMID:7965108. |
after nigrostriatal dopaminergic denervation, the output nuclei of the basal ganglia, the medial globus pallidus and substantia nigra pars reticulata (snr), become overactive, in part, because of increased activity of excitatory afferents from the subthalamic nucleus (stn). |
1994-12-02 |
2023-08-12 |
rat |