| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoxuan Sun, Lili Yin, Zhongjun Qiao, Muhammad Younus, Guoqing Chen, Xi Wu, Jie Li, Xinjiang Kang, Huadong Xu, Li Zhou, Yinglin Li, Min Gao, Xingyu Du, Yuqi Hang, Zhaohan Lin, Liyuan Sun, Qinglong Wang, Ruiying Jiao, Lun Wang, Meiqin Hu, Yuan Wang, Rong Huang, Yiman Li, Qihui Wu, Shujiang Shang, Shu Guo, Qian Lei, Haifeng Shu, Lianghong Zheng, Shirong Wang, Feipeng Zhu, Panli Zuo, Bing Liu, Changhe Wang, Quanfeng Zhang, Zhuan Zho. Action Potential Firing Patterns Regulate Dopamine Release via Voltage-Sensitive Dopamine D2 Autoreceptors in Mouse Striatum In Vivo. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-12-28. PMID:39731325. |
midbrain dopaminergic neurons generate both tonic and phasic action potential (ap) firing patterns in behavior mice. |
2024-12-28 |
2024-12-30 |
mouse |
| Talita Rodrigues, Getulio Nicola Bressan, Patrícia Zorzi Juliani, Maria Eduarda Brandli da Silva, Roselei Fachinett. Ketamine impairs the performance of male mice in novel recognition object test and reduces the immunoreactivity of GAD Pharmacology, biochemistry, and behavior. 2024-12-26. PMID:39725040. |
the peroxisome proliferator-activated receptors-gamma (ppar-γ) are expressed in dopaminergic neurons of the midbrain participating in the modulation of neurotransmitters release like dopamine. |
2024-12-26 |
2024-12-29 |
mouse |
| Qiaochu Jiang, Konstantin I Bakhurin, Ryan N Hughes, Bryan Lu, Shaolin Ruan, Henry H Yi. GABAergic neurons from the ventral tegmental area represent and regulate force vectors. bioRxiv : the preprint server for biology. 2024-12-23. PMID:39713374. |
the ventral tegmental area (vta), a midbrain region associated with motivated behaviors, consists predominantly of dopaminergic (da) neurons and gabaergic (gaba) neurons. |
2024-12-23 |
2024-12-25 |
mouse |
| Mitchell J Vaughn, Nandini Yellamelli, R Michael Burger, Julie S Haa. Dopamine receptors D1, D2, and D4 modulate electrical synapses and excitability in the thalamic reticular nucleus. Journal of neurophysiology. 2024-12-20. PMID:39706150. |
the trn receives dopaminergic innervation from the midbrain, and it is known to express high concentrations of d1 and d4 receptors. |
2024-12-20 |
2024-12-24 |
Not clear |
| Fiona Weiss, Laura Hughes, Yuhong Fu, Cedric Bardy, Glenda M Halliday, Nicolas Dzamk. Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson's model. Translational neurodegeneration. vol 13. issue 1. 2024-12-16. PMID:39681872. |
parkinson's disease (pd) is characterised by degeneration of ventral midbrain dopaminergic (da) neurons and abnormal deposition of α-synuclein (α-syn) in neurons. |
2024-12-16 |
2024-12-21 |
human |
| Zuzana Bacova, Tomas Havranek, Denisa Mihalj, Veronika Borbelyova, Kristina Kostrubanicova, Michaela Kramarova, Daniela Ostatnikova, Jan Bako. Reduced Neurite Arborization in Primary Dopaminergic Neurons in Autism-Like Shank3B-Deficient Mice. Molecular neurobiology. 2024-12-09. PMID:39654001. |
significantly reduced neurite outgrowth was observed in primary dopaminergic neurons from the midbrain and striatum of shank3-deficient compared to wt mice. |
2024-12-09 |
2024-12-12 |
mouse |
| Yuma Sato, Masayuki Matsumoto, Tadachika Koganezaw. The dopaminergic system mediates the lateral habenula-induced autonomic cardiovascular responses. Frontiers in physiology. vol 15. 2024-12-06. PMID:39640253. |
in this study, we examined the participation of the midbrain dopaminergic system in the cardiovascular response elicited by activation of the lhb. |
2024-12-06 |
2024-12-08 |
rat |
| Sara Nolbrant, Jenelle L Wallace, Jingwen Ding, Tianjia Zhu, Jess L Sevetson, Janko Kajtez, Isabella A Baldacci, Emily K Corrigan, Kaylynn Hoglin, Reed McMullen, Matthew T Schmitz, Arnar Breevoort, Dani Swope, Fengxia Wu, Bryan J Pavlovic, Sofie R Salama, Agnete Kirkeby, Hao Huang, Nathan K Schaefer, Alex A Polle. Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability. bioRxiv : the preprint server for biology. 2024-11-28. PMID:39605599. |
the disproportionate expansion of telencephalic structures during human evolution involved tradeoffs that imposed greater connectivity and metabolic demands on midbrain dopaminergic neurons. |
2024-11-28 |
2024-11-30 |
human |
| You-Yen Lin, De-Maw Chuang, Cheng-Yu Chi, Shih-Ya Hun. Intranasal administration of mesenchymal stem cells overexpressing FGF21 demonstrates therapeutic potential in experimental Parkinson's disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024-11-28. PMID:39609161. |
parkinson's disease (pd) is a prevalent movement disorder characterized by mitochondrial dysfunction and dopaminergic neuronal loss in the substantia nigra of the midbrain. |
2024-11-28 |
2024-12-01 |
mouse |
| Jintae Kim, Mi-Yoon Chan. Gene Therapy for Parkinson's Disease Using Midbrain Developmental Genes to Regulate Dopaminergic Neuronal Maintenance. International journal of molecular sciences. vol 25. issue 22. 2024-11-27. PMID:39596436. |
gene therapy for parkinson's disease using midbrain developmental genes to regulate dopaminergic neuronal maintenance. |
2024-11-27 |
2024-11-29 |
Not clear |
| Riko Nakanishi, Yuki Kurauchi, Shunsuke Kotani, Natsuko Hitora-Imamura, Takahiro Seki, Hiroshi Katsuk. Structurally Distinct Nurr1 Ligands Exhibit Different Pharmacological Characteristics in Regulating Inflammatory Responses of Microglial BV-2 Cells. Biological & pharmaceutical bulletin. vol 47. issue 11. 2024-11-27. PMID:39603614. |
nurr1 (nr4a2) is a member of nuclear receptor superfamily that regulates gene transcription in midbrain dopaminergic neurons and also inhibits nuclear factor-κb-mediated inflammatory responses in brain microglial cells. |
2024-11-27 |
2024-11-30 |
Not clear |
| Alan D Kaye, Kassady A Perkinson, Noah J Spillers, Alexis J Vega, Caylin J Roberts, Evan M Downs, Melissa M Sheth, David W McGregor, Shahab Ahmadzadeh, Jibin Mathew, Sahar Shekooh. Parkinson's Disease: A Narrative of the Evolving Understanding of the Role of α-Synuclein in Screening. Current issues in molecular biology. vol 46. issue 11. 2024-11-26. PMID:39590351. |
parkinson's disease (pd) is a debilitating neurodegenerative disorder caused by the loss of dopaminergic neurons in the midbrain, leading to symptoms such as tremors, bradykinesia, postural instability, dementia, and depression. |
2024-11-26 |
2024-11-29 |
Not clear |
| Kyriaki Barmpa, Claudia Saraiva, Diego Lopez-Pigozzi, Gemma Gomez-Giro, Elisa Gabassi, Sarah Spitz, Konstanze Brandauer, Juan E Rodriguez Gatica, Paul Antony, Graham Robertson, Rahman Sabahi-Kaviani, Alessandro Bellapianta, Florentia Papastefanaki, Regina Luttge, Ulrich Kubitscheck, Ahmad Salti, Peter Ertl, Mario Bortolozzi, Rebecca Matsas, Frank Edenhofer, Jens C Schwambor. Modeling early phenotypes of Parkinson's disease by age-induced midbrain-striatum assembloids. Communications biology. vol 7. issue 1. 2024-11-23. PMID:39580573. |
parkinson's disease, an aging-associated neurodegenerative disorder, is characterised by nigrostriatal pathway dysfunction caused by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. |
2024-11-23 |
2024-11-26 |
human |
| Özge Düdükcü, Divya D A Raj, Lieke L van de Haar, Laurens M Grossouw, Louisa E Linders, Oxana Garritsen, Youri Adolfs, Nicky C H van Kronenburg, Mark H Broekhoven, Troy H W Kapteijns, Frank J Meye, R Jeroen Pasterkam. Molecular diversity and migration of GABAergic neurons in the developing ventral midbrain. iScience. vol 27. issue 11. 2024-11-21. PMID:39569362. |
dopaminergic neurons in the ventral midbrain (mda) are surrounded by gabaergic neurons. |
2024-11-21 |
2024-11-23 |
mouse |
| Emanuele Frattini, Gaia Faustini, Gianluca Lopez, Emma V Carsana, Mattia Tosi, Ilaria Trezzi, Manuela Magni, Giulia Soldà, Letizia Straniero, Daniele Facchi, Maura Samarani, Mitchell Martá-Ariza, Chiara M G De Luca, Elena Vezzoli, Alessandra Pittaro, Astghik Stepanyan, Rosamaria Silipigni, Isabel Rosety, Jens C Schwamborn, Sergio P Sardi, Fabio Moda, Stefania Corti, Giacomo P Comi, Fabio Blandini, Nicolas X Tritsch, Mario Bortolozzi, Stefano Ferrero, Fulvia M Cribiù, Thomas Wisniewski, Rosanna Asselta, Massimo Aureli, Arianna Bellucci, Alessio Di Fonz. Lewy pathology formation in patient-derived GBA1 Parkinson's disease midbrain organoids. Brain : a journal of neurology. 2024-11-21. PMID:39570889. |
here, we describe an innovative protocol for the generation of human induced pluripotent stem cell-derived midbrain organoids containing dopaminergic neurons with nigral identity that reproduce characteristics of advanced maturation. |
2024-11-21 |
2024-11-24 |
human |
| Tomohiko Yoshizawa, Makoto Funahash. Dopamine release in striatal striosome compartments in response to rewards and aversive outcomes during classical conditioning in mice. Neuroscience research. 2024-11-09. PMID:39515479. |
the striatum consists of two anatomically and neurochemically distinct compartments, striosomes and the matrix, which receive dopaminergic inputs from the midbrain and exhibit distinct dopamine release dynamics in acute brain slices. |
2024-11-09 |
2024-11-17 |
mouse |
| Maxime Vassili Vounatsos, Aryn H Gitti. GPe Projections to the Retrorubral Field Give Rise to Diverging GABAergic and DAergic Circuits. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-11-07. PMID:39510836. |
here, by anatomical and electrophysiological means we investigate the projections of the gpe to the retrorubral field (rrf), a dopaminergic nucleus in the caudal midbrain, in both male and female mice. |
2024-11-07 |
2024-11-16 |
mouse |
| N Safreena, Indu C Nair, Goutam Chandr. Therapeutic potential of Parkin and its regulation in Parkinson's disease. Biochemical pharmacology. 2024-11-05. PMID:39500382. |
parkinson's disease (pd) is a debilitating neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the midbrain substantia nigra, resulting in motor and non-motor symptoms. |
2024-11-05 |
2024-11-08 |
Not clear |
| Hyun Jung Kwon, Hyo Young Jung, Soo Young Choi, In Koo Hwang, Dae Won Kim, Min Jea Shi. TAT-PPA1 protects against oxidative stress-induced loss of dopaminergic neurons. Molecular and cellular neurosciences. 2024-11-02. PMID:39488259. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn) of the midbrain, resulting in severe motor impairments. |
2024-11-02 |
2024-11-05 |
Not clear |
| Mohd Yaseen Malik, Fei Guo, Aman Asif-Malik, Vasileios Eftychidis, Nikolaos Barkas, Elena Eliseeva, Kerstin N Timm, Aleksandra Wolska, David Bergin, Barbara Zonta, Veronika Ratz-Wirsching, Stephan von Hörsten, Mark E Walton, Peter J Magill, Claus Nerlov, Liliana Minichiell. Impaired striatal glutathione-ascorbate metabolism induces transient dopamine increase and motor dysfunction. Nature metabolism. 2024-10-29. PMID:39468205. |
here, we demonstrate that genetic disruption of ispns function by ntrk2/trkb deletion in mice results in increased striatal dopamine and midbrain dopaminergic neurons, preceding hyperkinetic dysfunction. |
2024-10-29 |
2024-10-31 |
mouse |