| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weifeng Xu, Meiting Wang, Xiaodan Li, Rongyan He, Ren-Bo Ding, Jiaolin Bao, Dongting Zhangsun, Sulan Lu. α-Conotoxin TxIB Reversed Nicotine-Induced Locomotor Sensitization and Nicotine-Enhanced Dopaminergic Activity in Mice. Marine drugs. vol 23. issue 3. 2025-03-26. PMID:40137295. |
a significant contributor to nicotine addiction is its interaction with α6β2* nachrs located on midbrain dopaminergic neurons, which leads to an increase in dopamine (da) release. |
2025-03-26 |
2025-03-28 |
mouse |
| Sazan Ismael, Sarah Baitamouni, Daewoo Le. Neuroprotective Role of Cyclic AMP Signaling in Dopaminergic Degeneration Induced by a Parkinson's Disease Toxin, Rotenone. NeuroSci. vol 6. issue 1. 2025-03-26. PMID:40137868. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by the selective loss of dopaminergic (da) neurons in the midbrain. |
2025-03-26 |
2025-03-30 |
Not clear |
| Zhao Li, Jinhai Duan, AnQi Cao, Zhuo Gong, Hao Liu, Danyang Shen, Tonglin Ye, Shunyan Zhu, Qikai Cen, Shuaiyin He, Yongqian He, Canbing Zheng, Xian Li. Activating Wnt1/β-Catenin signaling pathway to restore Otx2 expression in the dopaminergic neurons of ventral midbrain. Experimental neurology. 2025-03-15. PMID:40089003. |
activating wnt1/β-catenin signaling pathway to restore otx2 expression in the dopaminergic neurons of ventral midbrain. |
2025-03-15 |
2025-03-18 |
mouse |
| Zhao Li, Jinhai Duan, AnQi Cao, Zhuo Gong, Hao Liu, Danyang Shen, Tonglin Ye, Shunyan Zhu, Qikai Cen, Shuaiyin He, Yongqian He, Canbing Zheng, Xian Li. Activating Wnt1/β-Catenin signaling pathway to restore Otx2 expression in the dopaminergic neurons of ventral midbrain. Experimental neurology. 2025-03-15. PMID:40089003. |
otx2 plays a critical role in the differentiation of midbrain dopaminergic neurons (mdans) during midbrain development. |
2025-03-15 |
2025-03-18 |
mouse |
| Nathany da Silva Nogueira, Taynan Motta Portal, Thuany da Silva Nogueira, Aurenita Emile Sá Miranda, Eldo Campos, Cintia Monteiro de Barro. Neuronal degeneration, mitochondrial dysfunction, and disturbance of movements induced by rotenone in the ascidian Styela plicata. Neurotoxicology. 2025-03-12. PMID:40074177. |
parkinson's disease (pd), a movement disorder caused by dopaminergic degeneration in the midbrain, has been induced in various organisms after injection of different neurotoxins, such as rotenone (rot), which affect mitochondrial complex i. |
2025-03-12 |
2025-03-15 |
Not clear |
| Amalie Holm Nygaard, Alrik L Schörling, Zehra Abay-Nørgaard, Erno Hänninen, Yuan Li, Adrian Santonja, Gaurav Singh Rathore, Alison Salvador, Charlotte Rusimbi, Katrine Bech Lauritzen, Yu Zhang, Agnete Kirkeb. Patterning effects of FGF17 and cAMP on generation of dopaminergic progenitors for cell replacement therapy in Parkinson's disease. Stem cells (Dayton, Ohio). 2025-03-12. PMID:40071608. |
cell replacement therapies using human pluripotent stem cell-derived ventral midbrain (vm) dopaminergic (da) progenitors are currently in clinical trials for treatment of parkinson's disease (pd). |
2025-03-12 |
2025-03-14 |
human |
| Francesca Montarolo, Sarah Thielens, Maria Bove, Antonio Bertolotto, Filippo Tempia, Eriola Hoxh. NURR1 Deficiency Is Associated to Altered Microglial Phenotype in Male Mice. Molecular neurobiology. 2025-03-07. PMID:40055293. |
the transcription factor nuclear receptor related 1 (nurr1) regulates the development and maintenance of midbrain dopaminergic (mda) neurons, which control voluntary movement, motivation, and reward. |
2025-03-07 |
2025-03-12 |
mouse |
| Tsering Yangzom, Anbin Chen, Kristina Xiao Lian. Generation of 3D Midbrain Organoids from Human-Induced Pluripotent Stem Cells. Journal of visualized experiments : JoVE. issue 216. 2025-03-03. PMID:40029817. |
a notable outcome of this methodology is the effective differentiation of ipscs into dopaminergic neurons, which are characteristic of the midbrain. |
2025-03-03 |
2025-03-14 |
human |
| Leah C Beauchamp, Laura J Ellett, Sydney M A Juan, Xiang M Liu, Cameron P J Hunt, Clare L Parish, Laura H Jacobson, Claire E Shepherd, Glenda M Halliday, Ashley I Bush, Laura J Vella, David I Finkelstein, Kevin J Barnha. Evidence of COMT dysfunction in the olfactory bulb in Parkinson's disease. Acta neuropathologica. vol 149. issue 1. 2025-03-02. PMID:40024917. |
in contrast to the loss of dopaminergic neurons in the midbrain, we observed an increase in tyrosine hydroxylase-positive neurons in the parkinson's disease olfactory bulb, suggesting a potential role for dopamine in the hyposmia associated with the condition. |
2025-03-02 |
2025-03-05 |
human |
| Nicole C Miranda, Yasmin C Aquino, Tainá O Macedo, Luiz M Oliveira, Kairo A Albernaz-Mariano, Carolina D Munhoz, Jan-Marino Ramirez, Thiago S Moreira, Ana C Takakur. Role of substantia Nigra dopaminergic neurons in respiratory modulation and limitations of levodopa in Parkinson's disease. Experimental neurology. vol 387. 2025-03-01. PMID:40021074. |
the substantia nigra pars compacta (snpc), a midbrain region enriched with dopaminergic neurons projecting to the dorsal striatum, is essential for motor control and has been implicated in respiratory modulation. |
2025-03-01 |
2025-03-04 |
mouse |
| Fariba Akbari Gavabari, Mohsen Rastegari-Pouyani, Saeid Afshar, Mehrdokht Mazdeh, Armin Bahramian, Siamak Shahidi, Elahe Talebi-Ghane, Mahsa Chalabi, Mohammad Mahdi Eftekharia. Expression levels of protein inhibitor of activated STAT (PIAS) family genes in Parkinson's disease patients: results from a case-control study. Acta neurologica Belgica. 2025-02-27. PMID:40016540. |
parkinson's disease (pd) is one of the most common progressive neurological disorders characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain. |
2025-02-27 |
2025-03-02 |
Not clear |
| Manal M Khowdiary, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Ali K Albuhadily, Ahmed A Elhenawy, Ahmad O Babalghith, Mustafa M Shokr, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batih. Dysregulation of serotonergic neurotransmission in Parkinson disease: A key duet. European journal of pharmacology. 2025-02-23. PMID:39988096. |
however, motor symptoms in pd are developed due to degeneration of the dopaminergic neurons in the substantia nigra pars compacta (snpc) of midbrain. |
2025-02-23 |
2025-02-26 |
Not clear |
| Manal M Khowdiary, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Ali K Albuhadily, Ahmed A Elhenawy, Ahmad O Babalghith, Mustafa M Shokr, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batih. Dysregulation of serotonergic neurotransmission in Parkinson disease: A key duet. European journal of pharmacology. 2025-02-23. PMID:39988096. |
the pd neuropathology is related to the progressive loss of the dopaminergic neurons in the snpc of midbrain. |
2025-02-23 |
2025-02-26 |
Not clear |
| Xinyue Wang, Gaoying Sun, Mingming Tang, Da Li, Jianhuan Qi, Chuanyue Wang, Yukai Wang, Baoyang H. Human Midbrain Organoids Enriched With Dopaminergic Neurons for Long-Term Functional Evaluation. Cell proliferation. 2025-02-20. PMID:39973567. |
human midbrain organoids enriched with dopaminergic neurons for long-term functional evaluation. |
2025-02-20 |
2025-02-23 |
human |
| Xinyue Wang, Gaoying Sun, Mingming Tang, Da Li, Jianhuan Qi, Chuanyue Wang, Yukai Wang, Baoyang H. Human Midbrain Organoids Enriched With Dopaminergic Neurons for Long-Term Functional Evaluation. Cell proliferation. 2025-02-20. PMID:39973567. |
human midbrain organoids with functional dopaminergic (da) neurons are invaluable for the therapeutic development of parkinson's disease (pd). |
2025-02-20 |
2025-02-23 |
human |
| Jun Takahash. iPSC-based cell replacement therapy: from basic research to clinical application. Cytotherapy. 2025-02-19. PMID:39969437. |
using parkinson's disease as a key example, it discusses the induction of midbrain dopaminergic neurons from ipscs and the importance of precise signaling for safety and efficacy. |
2025-02-19 |
2025-02-23 |
Not clear |
| Ludi Zhang, Menghan Ji, Yufei Sun, Qingwu Wang, Mingyang Jin, Shuling Wang, Hui Sun, Hailin Zhang, Dongyang Huan. VTA dopaminergic neurons involved in chronic spared nerve injury pain-induced depressive-like behavior. Brain research bulletin. vol 222. 2025-02-18. PMID:39956400. |
the dopaminergic system, located in the midbrain, is considered one of the regions where algesia and emotional processing overlap. |
2025-02-18 |
2025-02-23 |
mouse |
| Jeha Jeon, Young Cha, Yean Ju Hong, In-Hee Lee, Heejin Jang, Sanghyeok Ko, Serhiy Naumenko, Minseon Kim, Hannah L Ryu, Zenith Shrestha, Nayeon Lee, Tae-Yoon Park, HoeWon Park, Seo-Hyun Kim, Ki-Jun Yoon, Bin Song, Jeffrey Schweitzer, Todd M Herrington, Sek Won Kong, Bob Carter, Pierre Leblanc, Kwang-Soo Ki. Pre-clinical safety and efficacy of human induced pluripotent stem cell-derived products for autologous cell therapy in Parkinson's disease. Cell stem cell. 2025-02-16. PMID:39952239. |
human induced pluripotent stem cell (hipsc)-derived midbrain dopaminergic cells (mdacs) represent a promising source for autologous cell therapy in parkinson's disease (pd), but standardized regulatory criteria are essential for clinical translation. |
2025-02-16 |
2025-02-18 |
mouse |
| Hirokazu Tanaka, Masaki Isoda, Atsushi Noritak. Subspace Analysis Identifies Low-Dimensional Interactions between Cortical and Subcortical Brain Regions in Social Reward Computation. Neuroscience research. 2025-02-13. PMID:39947349. |
we previously showed that single-unit activities in cortical (the medial prefrontal cortex, mpfc) and subcortical (the dopaminergic midbrain nuclei, da, and the lateral hypothalamus, lh) regions reflect social reward computation. |
2025-02-13 |
2025-02-16 |
Not clear |
| Qiaochu Jiang, Konstantin I Bakhurin, Ryan N Hughes, Bryan Lu, Shaolin Ruan, Henry H Yi. GABAergic neurons in the ventral tegmental area represent and regulate force vectors. Cell reports. vol 44. issue 2. 2025-02-12. PMID:39937645. |
the ventral tegmental area (vta), a midbrain region associated with motivated behaviors, contains mostly dopaminergic (da) neurons and gabaergic (gaba) neurons. |
2025-02-12 |
2025-02-15 |
mouse |