| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao Wu, Zhen-Hua Zhang, Ping Zhou, Xin Sui, Xi Liu, Yi Sun, Xin Zhao, Xiao-Ping P. A Single-Cell Atlas of the Substantia Nigra Reveals Therapeutic Effects of Icaritin in a Rat Model of Parkinson's Disease. Antioxidants (Basel, Switzerland). vol 13. issue 10. 2024-10-26. PMID:39456437. |
degeneration and death of dopaminergic neurons in the substantia nigra of the midbrain are the main pathological changes in parkinson's disease (pd); however, the mechanism underlying the selective vulnerability of specific neuronal populations in pd remains unclear. |
2024-10-26 |
2024-10-29 |
rat |
| Heather Lynne Kosakowski, Mark Eldaief, Randy L Buckne. Ventral Striatum is Preferentially Correlated with the Salience Network Including Regions in Dorsolateral Prefrontal Cortex. bioRxiv : the preprint server for biology. 2024-10-17. PMID:39416211. |
the ventral striatum (vs) receives input from the cerebral cortex and is modulated by midbrain dopaminergic projections in support of processing reward and motivation. |
2024-10-17 |
2024-10-19 |
human |
| Min Jung Kim, Daniel J Gibson, Dan Hu, Tomoko Yoshida, Emily Hueske, Ayano Matsushima, Ara Mahar, Cynthia J Schofield, Patlapa Sompolpong, Kathy T Tran, Lin Tian, Ann M Graybie. Dopamine release plateau and outcome signals in dorsal striatum contrast with classic reinforcement learning formulations. Nature communications. vol 15. issue 1. 2024-10-14. PMID:39402067. |
at most sites, we found no evidence for a transition from outcome signaling to cue signaling, a hallmark of temporal difference reinforcement learning as applied to midbrain dopaminergic neuronal activity. |
2024-10-14 |
2024-10-17 |
mouse |
| Astrid M Alsema, Sophie Puvogel, Laura Kracht, Marree J Webster, Cynthia Shannon Weickert, Bart J L Eggen, Iris E C Somme. Schizophrenia-associated changes in neuronal subpopulations in the human midbrain. Brain : a journal of neurology. 2024-10-14. PMID:39397771. |
dysfunctional gabaergic and dopaminergic neurons are thought to exist in the ventral midbrain of patients with schizophrenia, yet transcriptional changes underpinning these abnormalities have not yet been localized to specific neuronal subsets. |
2024-10-14 |
2024-10-16 |
human |
| Astrid M Alsema, Sophie Puvogel, Laura Kracht, Marree J Webster, Cynthia Shannon Weickert, Bart J L Eggen, Iris E C Somme. Schizophrenia-associated changes in neuronal subpopulations in the human midbrain. Brain : a journal of neurology. 2024-10-14. PMID:39397771. |
in the ventral midbrain, control over dopaminergic activity is maintained by both excitatory (glutamate) and inhibitory (gaba) input neurons. |
2024-10-14 |
2024-10-16 |
human |
| Xóchitl Flores-Ponce, Iván Velasc. Dopaminergic neuron metabolism: relevance for understanding Parkinson's disease. Metabolomics : Official journal of the Metabolomic Society. vol 20. issue 6. 2024-10-13. PMID:39397188. |
dopaminergic neurons from the substantia nigra pars compacta (snc) have a higher susceptibility to aging-related degeneration, compared to midbrain dopaminergic cells present in the ventral tegmental area (vta); the death of dopamine neurons in the snc results in parkinson´s disease (pd). |
2024-10-13 |
2024-10-16 |
Not clear |
| Emilía Sif Ásgrímsdóttir, Ernest Arena. Generation of a fluorescent hESC reporter line (Kle033-A-1) for the isolation of distinct midbrain progenitor cell types. Stem cell research. vol 81. 2024-10-09. PMID:39383604. |
midbrain dopaminergic (mda) neurons derived from human pluripotent stem cells (hpscs) offer a promising cell source for cell replacement therapy in parkinson's disease (pd). |
2024-10-09 |
2024-10-12 |
human |
| Azize Yasemin Göks. A review article on the development of dopaminergic neurons and establishment of dopaminergic neuron-based in vitro models by using immortal cell lines or stem cells to study and treat Parkinson's disease. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2024-10-08. PMID:39379284. |
the primary pathological hallmark of parkinson's disease (pd) is the degeneration of dopaminergic (da) neurons in the substantia nigra pars compacta, a critical midbrain region. |
2024-10-08 |
2024-10-11 |
Not clear |
| Can Tao, Guang-Wei Zhang, Wen-Jian Sun, Junxiang J Huang, Li I Zhang, Huizhong Whit Ta. Excitation-inhibition imbalance in medial preoptic area circuits underlies chronic stress-induced depression-like states. Nature communications. vol 15. issue 1. 2024-10-03. PMID:39362860. |
their projections to ventral tegmental area and periaqueductal gray/dorsal raphe suppress midbrain dopaminergic and serotonergic activity, respectively, and mediate expression of divergent depressive-like symptoms. |
2024-10-03 |
2024-10-07 |
mouse |
| Valentina Basso, Máté D Döbrössy, Lachlan H Thompson, Deniz Kirik, Heidi R Fuller, Monte A Gate. State of the Art in Sub-Phenotyping Midbrain Dopamine Neurons. Biology. vol 13. issue 9. 2024-09-28. PMID:39336117. |
while both groups of dopaminergic neurons are in close proximity in the midbrain and partially overlap, development, function, and impairments in these two classes of neurons are highly diverse. |
2024-09-28 |
2024-10-01 |
human |
| Roger A Barker, Philip C Butter. Disease-specific interventions: The use of cell and gene therapies for Parkinson disease. Handbook of clinical neurology. vol 205. 2024-09-28. PMID:39341654. |
in the case of cell therapies, the ability to make large numbers of authentic midbrain dopaminergic neuroblasts from human pluripotent stem cell sources has turned what was an interesting avenue of research into a major area of investment and trialing, by academics in conjunction with pharma. |
2024-09-28 |
2024-10-01 |
human |
| Alessandro Galgani, Marco Scotto, Filippo S Giorg. The Neuroanatomy of Induced Pluripotent Stem Cells: In Vitro Models of Subcortical Nuclei in Neurodegenerative Disorders. Current issues in molecular biology. vol 46. issue 9. 2024-09-27. PMID:39329959. |
we found that most of the current literature in the field of ipscs and nsss in ndds has focused on midbrain dopaminergic neurons in parkinson's disease, providing interesting results on cellular pathophysiology and even leading to the first human autologous transplantation. |
2024-09-27 |
2024-09-29 |
human |
| Hong-Yuan Chu, Liqiang Chen, Hiba Douja Chehad. Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation. Research square. 2024-09-16. PMID:39281856. |
moreover, it is also unknown whether cortical lewy pathology and midbrain dopaminergic degeneration interact to disrupt cortical function in late-stage. |
2024-09-16 |
2024-09-19 |
mouse |
| Hong-Yuan Chu, Liqiang Chen, Hiba Douja Chehad. Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation. Research square. 2024-09-16. PMID:39281856. |
to begin to address these questions, we injected α-synuclein (αsyn) preformed fibrils (pffs) into the dorsolateral striatum of mice to seed αsyn pathology in the cortical cortex and induce degeneration of midbrain dopaminergic neurons. |
2024-09-16 |
2024-09-19 |
mouse |
| M Tatullo, T Cocco, A Ferretta, R Caroppo, B Marrelli, G Spagnuolo, F Paduan. Unveiling the Neurodegenerative Alterations through Oral Stem Cells. Journal of dental research. 2024-09-14. PMID:39275988. |
parkinson's disease (pd) is a neurodegenerative condition characterized by the progressive and selective loss of dopaminergic (daergic) neurons in the midbrain. |
2024-09-14 |
2024-09-17 |
human |
| Shijia Ma, Qianyi Ma, Songhui Hu, Xinlei Mo, Chenze Zhu, Xingxian Zhang, Zetao Jia, Lingjie Tang, Lei Jiang, Yihui Cui, Zhong Chen, Weiwei Hu, Xiangnan Zhan. Deletion of histamine H2 receptor in VTA dopaminergic neurons of mice induces behavior reminiscent of mania. Cell reports. vol 43. issue 9. 2024-09-12. PMID:39264811. |
histaminergic neurons project dense efferents into the midbrain dopaminergic nuclei. |
2024-09-12 |
2024-09-15 |
mouse |
| Kaushik Narasimhan, Abrar Hakami, Giulia Comini, Tommy Patton, Ben Newland, Eilis Dow. Cryogel microcarriers loaded with glial cell line-derived neurotrophic factor enhance the engraftment of primary dopaminergic neurons in a rat model of Parkinson's disease. Journal of neural engineering. 2024-09-04. PMID:39231475. |
in this context, to develop a proof-of-concept, the aim of this-study was to determine the efficacy of gdnf-loaded cryogel microcarriers by assessing their impact on the survival of, and reinnervation by, primary dopaminergic grafts after intra-striatal delivery in parkinsonian rat brains.
approach: rat embryonic day 14 ventral midbrain cells were transplanted into the 6-hydroxydopamine-lesioned striatum either alone, or with gdnf, or with unloaded cryogel microcarriers, or with gdnf-loaded cryogel microcarriers. |
2024-09-04 |
2024-09-08 |
rat |
| Natalia López-González Del Rey, Nagore Hernández-Pinedo, Megan Carrillo, María Del Cerro, Noelia Esteban-García, Inés Trigo-Damas, Mariana H G Monje, José L Lanciego, Carmen Cavada, José A Obeso, Javier Bles. Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson's disease model. NPJ Parkinson's disease. vol 10. issue 1. 2024-09-02. PMID:39223183. |
in the primate midbrain, the molecular phenotypes of dopaminergic neurons and their differential vulnerability are poorly characterized. |
2024-09-02 |
2024-09-05 |
mouse |
| Jordan E Elum, Eric R Szelenyi, Barbara Juarez, Alexandria D Murry, Grigory Loginov, Catalina A Zamorano, Pan Gao, Ginny Wu, Scott Ng-Evans, Joshua X Yee, Xiangmin Xu, Sam A Golden, Larry S Zweife. Distinct dynamics and intrinsic properties in ventral tegmental area populations mediate reward association and motivation. Cell reports. vol 43. issue 9. 2024-08-29. PMID:39207900. |
here, we compare the contribution of two primarily dopaminergic and largely non-overlapping vta subpopulations, all vta dopamine neurons and vta gabaergic neurons of the mouse midbrain, to these processes. |
2024-08-29 |
2024-09-04 |
mouse |
| Panpan Wang, Yaping Shao, Murad Al-Nusaif, Jun Zhang, Huijia Yang, Yuting Yang, Kunhyok Kim, Song Li, Cong Liu, Huaibin Cai, Weidong L. Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency. Molecular neurodegeneration. vol 19. issue 1. 2024-08-25. PMID:39183331. |
pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by wdr45-deficiency. |
2024-08-25 |
2024-08-28 |
Not clear |