| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emil Wärnberg, Arvind Kuma. Feasibility of dopamine as a vector-valued feedback signal in the basal ganglia. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 32. 2023-08-01. PMID:37527344. |
inspired by the recent observations that besides rpe, the firing rates of midbrain dopaminergic neurons correlate with motor and cognitive variables, we propose a model in which dopamine signal in the striatum carries a vector-valued error feedback signal (a loss gradient) instead of a homogeneous scalar error (a loss). |
2023-08-01 |
2023-08-14 |
Not clear |
| Olivia K Swanson, Priscilla E Yevoo, David Richard, Arianna Maffe. Altered Thalamocortical Signaling in a Mouse Model of Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-08-01. PMID:37527923. |
our results demonstrate that loss of midbrain dopaminergic neurons alters thalamocortical activation of m1 in both male and female mice, and provide novel insights into circuit mechanisms for motor cortex dysfunction in a mouse model of pd. |
2023-08-01 |
2023-08-14 |
mouse |
| Somayeh Naderi, Zahra Shiri, Masoumeh Zarei-Kheirabadi, Sepideh Mollamohammadi, Parastoo Hosseini, Golnoosh Rahimi, Azadeh Moradmand, Azam Samadian, Amir Shojaei, Meghdad Yeganeh, Seyed Ahmad Mousavi, Motahare Badri, Adeleh Taei, Seyedeh-Nafiseh Hassani, Hossein Baharvan. Cryopreserved clinical-grade human embryonic stem cell-derived dopaminergic progenitors function in Parkinson's disease models. Life sciences. 2023-07-31. PMID:37524159. |
human pluripotent stem cells have emerged as the most promising source of cells for midbrain dopaminergic (mda) neuron replacement in pd. |
2023-07-31 |
2023-08-14 |
human |
| Mitali A Tambe, Aurélie de Rus Jacquet, Katherine E Strathearn, Jennifer A Hensel, Bryce D Colón, Aswathy Chandran, Gad G Yousef, Mary H Grace, Mario G Ferruzzi, Qingli Wu, James E Simon, Mary Ann Lila, Jean-Christophe Roche. Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson's Disease. Antioxidants (Basel, Switzerland). vol 12. issue 7. 2023-07-29. PMID:37508001. |
here, we characterized botanical extracts enriched with a mixed profile of polyphenols, as well as a set of purified polyphenolic standards, in terms of their ability to mitigate dopaminergic cell death in midbrain cultures exposed to another pd-related toxicant, paraquat (pq), and we examined underlying neuroprotective mechanisms. |
2023-07-29 |
2023-08-14 |
Not clear |
| Mitali A Tambe, Aurélie de Rus Jacquet, Katherine E Strathearn, Jennifer A Hensel, Bryce D Colón, Aswathy Chandran, Gad G Yousef, Mary H Grace, Mario G Ferruzzi, Qingli Wu, James E Simon, Mary Ann Lila, Jean-Christophe Roche. Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson's Disease. Antioxidants (Basel, Switzerland). vol 12. issue 7. 2023-07-29. PMID:37508001. |
several extracts or compounds with the ability to protect against pq neurotoxicity increased the activity of the antioxidant transcription factor nrf2 in cultured astrocytes, and pq-induced dopaminergic cell death was attenuated in nrf2-expressing midbrain cultures. |
2023-07-29 |
2023-08-14 |
Not clear |
| Ryota Nakamura, Risa Nonaka, Genko Oyama, Takayuki Jo, Hikaru Kamo, Maierdanjiang Nuermaimaiti, Wado Akamatsu, Kei-Ichi Ishikawa, Nobutaka Hattor. A defined method for differentiating human iPSCs into midbrain dopaminergic progenitors that safely restore motor deficits in Parkinson's disease. Frontiers in neuroscience. vol 17. 2023-07-28. PMID:37502682. |
a defined method for differentiating human ipscs into midbrain dopaminergic progenitors that safely restore motor deficits in parkinson's disease. |
2023-07-28 |
2023-08-14 |
human |
| Ryota Nakamura, Risa Nonaka, Genko Oyama, Takayuki Jo, Hikaru Kamo, Maierdanjiang Nuermaimaiti, Wado Akamatsu, Kei-Ichi Ishikawa, Nobutaka Hattor. A defined method for differentiating human iPSCs into midbrain dopaminergic progenitors that safely restore motor deficits in Parkinson's disease. Frontiers in neuroscience. vol 17. 2023-07-28. PMID:37502682. |
parkinson's disease (pd) is a progressive neurodegenerative condition that primarily affects motor functions; it is caused by the loss of midbrain dopaminergic (mda) neurons. |
2023-07-28 |
2023-08-14 |
human |
| Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, Jie Hao, Baoyang Hu, Yukai Wan. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488911. |
one-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation numerous studies have shown that cell replacement therapy can replenish lost cells and rebuild neural circuitry in animal models of parkinson's disease. |
2023-07-25 |
2023-08-14 |
human |
| Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, Jie Hao, Baoyang Hu, Yukai Wan. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488911. |
transplantation of midbrain dopaminergic progenitor cells is a promising treatment for parkinson's disease. |
2023-07-25 |
2023-08-14 |
human |
| Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, Jie Hao, Baoyang Hu, Yukai Wan. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488911. |
here, we developed a one-step biomanufacturing platform that uses small-aperture gelatin microcarriers to produce beads carrying midbrain dopaminergic progenitor cells. |
2023-07-25 |
2023-08-14 |
human |
| Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, Jie Hao, Baoyang Hu, Yukai Wan. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488911. |
these beads allow midbrain dopaminergic progenitor cell differentiation and cryopreservation without digestion, effectively maintaining axonal integrity in vitro. |
2023-07-25 |
2023-08-14 |
human |
| Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, Jie Hao, Baoyang Hu, Yukai Wan. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488911. |
importantly, midbrain dopaminergic progenitor cell bead grafts showed increased survival and only mild immunoreactivity in vivo compared with suspended midbrain dopaminergic progenitor cell grafts. |
2023-07-25 |
2023-08-14 |
human |
| Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, Jie Hao, Baoyang Hu, Yukai Wan. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488911. |
overall, our findings show that these midbrain dopaminergic progenitor cell beads enhance the effectiveness of neuronal cell transplantation. |
2023-07-25 |
2023-08-14 |
human |
| Cameron D Hassall, Yan Yan, Laurence T Hun. The neural correlates of continuous feedback processing. Psychophysiology. 2023-07-24. PMID:37485986. |
such studies have led to the hypothesis that rapid phasic midbrain dopaminergic activity tracks reward prediction errors (rpes), the effects of which are measurable at the scalp via electroencephalography (eeg). |
2023-07-24 |
2023-08-14 |
human |
| Cameron D Hassall, Yan Yan, Laurence T Hun. The neural correlates of continuous feedback processing. Psychophysiology. 2023-07-24. PMID:37485986. |
although studies using continuous feedback are sparse, recent animal work suggests that moment-to-moment changes in reward are tracked by slowly ramping midbrain dopaminergic activity. |
2023-07-24 |
2023-08-14 |
human |
| Amélie Weiss, Peter Sommer, Johannes H Wilbert. Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons. Journal of visualized experiments : JoVE. issue 197. 2023-07-24. PMID:37486112. |
phenotypic profiling of human stem cell-derived midbrain dopaminergic neurons. |
2023-07-24 |
2023-08-14 |
human |
| Amélie Weiss, Peter Sommer, Johannes H Wilbert. Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons. Journal of visualized experiments : JoVE. issue 197. 2023-07-24. PMID:37486112. |
parkinson's disease (pd) is linked to a range of cell biological processes that cause midbrain dopaminergic (mda) neuron loss. |
2023-07-24 |
2023-08-14 |
human |
| Marcello Serra, Anna Di Maio, Valentina Bassareo, Tommaso Nuzzo, Francesco Errico, Federica Servillo, Mario Capasso, Pathik Parekh, Qin Li, Marie-Laure Thiolat, Erwan Bezard, Paolo Calabresi, David Sulzer, Manolo Carta, Micaela Morelli, Alessandro Usiell. Perturbation of serine enantiomers homeostasis in the striatum of MPTP-lesioned monkeys and mice reflects the extent of dopaminergic midbrain degeneration. Neurobiology of disease. 2023-07-14. PMID:37451474. |
perturbation of serine enantiomers homeostasis in the striatum of mptp-lesioned monkeys and mice reflects the extent of dopaminergic midbrain degeneration. |
2023-07-14 |
2023-08-14 |
mouse |
| Marcello Serra, Anna Di Maio, Valentina Bassareo, Tommaso Nuzzo, Francesco Errico, Federica Servillo, Mario Capasso, Pathik Parekh, Qin Li, Marie-Laure Thiolat, Erwan Bezard, Paolo Calabresi, David Sulzer, Manolo Carta, Micaela Morelli, Alessandro Usiell. Perturbation of serine enantiomers homeostasis in the striatum of MPTP-lesioned monkeys and mice reflects the extent of dopaminergic midbrain degeneration. Neurobiology of disease. 2023-07-14. PMID:37451474. |
loss of dopaminergic midbrain neurons perturbs l-serine and d-serine homeostasis in the post-mortem caudate putamen (cpu) of parkinson's disease (pd) patients. |
2023-07-14 |
2023-08-14 |
mouse |
| Marcello Serra, Anna Di Maio, Valentina Bassareo, Tommaso Nuzzo, Francesco Errico, Federica Servillo, Mario Capasso, Pathik Parekh, Qin Li, Marie-Laure Thiolat, Erwan Bezard, Paolo Calabresi, David Sulzer, Manolo Carta, Micaela Morelli, Alessandro Usiell. Perturbation of serine enantiomers homeostasis in the striatum of MPTP-lesioned monkeys and mice reflects the extent of dopaminergic midbrain degeneration. Neurobiology of disease. 2023-07-14. PMID:37451474. |
here, through high-performance liquid chromatography (hplc), we measured the levels of these amino acids in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated monkeys and mptp-plus-probenecid (mptpp)-treated mice to determine whether and how dopaminergic midbrain degeneration affects the levels of serine enantiomers in various basal ganglia subregions. |
2023-07-14 |
2023-08-14 |
mouse |