| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiromi Sano, Atsushi Namb. Behavioral effects of zonisamide on L-DOPA-induced dyskinesia in Parkinson's disease model mice. Frontiers in aging neuroscience. vol 15. 2023-07-13. PMID:37441679. |
however, it has also shown its beneficial effects on parkinson's disease (pd), a progressive neurodegenerative disorder caused by the loss of dopaminergic neurons in the midbrain. |
2023-07-13 |
2023-08-14 |
mouse |
| Virginie J Oberto, Jumpei Matsumoto, Marco N Pompili, Ralitsa Todorova, Francesco Papaleo, Hisao Nishijo, Laurent Venance, Marie Vandecasteele, Sidney I Wiene. Rhythmic oscillations in the midbrain dopaminergic nuclei in mice. Frontiers in cellular neuroscience. vol 17. 2023-07-10. PMID:37426551. |
rhythmic oscillations in the midbrain dopaminergic nuclei in mice. |
2023-07-10 |
2023-08-14 |
mouse |
| Jie Sun, Xiao-Min Lin, Dan-Hua Lu, Meng Wang, Kun Li, Sheng-Rong Li, Zheng-Qiu Li, Cheng-Jun Zhu, Zhi-Min Zhang, Chang-Yu Yan, Ming-Hai Pan, Hai-Biao Gong, Jing-Cheng Feng, Yun-Feng Cao, Feng Huang, Wan-Yang Sun, Hiroshi Kurihara, Yi-Fang Li, Wen-Jun Duan, Gen-Long Jiao, Li Zhang, Rong-Rong H. Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. The Journal of clinical investigation. vol 133. issue 13. 2023-07-03. PMID:37395283. |
midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. |
2023-07-03 |
2023-08-14 |
Not clear |
| Jeong Pyo Seo, Heun Jae Ry. Neural Injury of the Dopaminergic Pathways in Patients with Middle Cerebral Artery Territory Infarct: A Diffusion Tensor Imaging Study. Brain sciences. vol 13. issue 6. 2023-06-28. PMID:37371405. |
the mesocortical tract (mct) and mesolimbic tract (mlt), dopaminergic pathways originating from the ventral tegmental area in the midbrain to the ventral striatum (nucleus accumbens) and prefrontal cortex, play a crucial role in regulating incentive salience. |
2023-06-28 |
2023-08-14 |
Not clear |
| Erika D L R M Cabrera Ranaldi, Karen Nuytemans, Anisley Martinez, Corneliu C Luca, Robert W Keane, Juan Pablo de Rivero Vaccar. Proof-of-Principle Study of Inflammasome Signaling Proteins as Diagnostic Biomarkers of the Inflammatory Response in Parkinson's Disease. Pharmaceuticals (Basel, Switzerland). vol 16. issue 6. 2023-06-28. PMID:37375830. |
parkinson's disease (pd) is a neurodegenerative disorder marked by the death of dopaminergic neurons in the midbrain, the accumulation of α-synuclein aggregates, and motor deficits. |
2023-06-28 |
2023-08-14 |
human |
| Takeshi Kato, Kaneyasu Nishimura, Masahiro Hirao, Shun Shimohama, Kazuyuki Takat. Expression and role of nicotinic acetylcholine receptors during midbrain dopaminergic neuron differentiation from human induced pluripotent stem cells. Neuropsychopharmacology reports. 2023-06-27. PMID:37366076. |
nicotinic acetylcholine receptors (nachrs) expressed in midbrain dopaminergic (mda) neurons modulate mda neuronal activity. |
2023-06-27 |
2023-08-14 |
human |
| Axel Chemla, Giuseppe Arena, Gizem Onal, Jonas Walter, Clara Berenguer-Escuder, Dajana Grossmann, Anne Grünewald, Jens C Schwamborn, Rejko Krüge. Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.815G > A (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 gene encoding Miro1. Stem cell research. vol 71. 2023-06-26. PMID:37364399. |
these two isogenic pairs will be used to study miro1-related molecular mechanisms underlying neurodegeneration in relevant ipsc-derived neuronal models (e.g., midbrain dopaminergic neurons and astrocytes). |
2023-06-26 |
2023-08-14 |
Not clear |
| Min Seong Kim, Eun A Ra, Sin Ho Kweon, Bo Am Seo, Han Seok Ko, Yohan Oh, Gabsang Le. Advanced human iPSC-based preclinical model for Parkinson's disease with optogenetic alpha-synuclein aggregation. Cell stem cell. 2023-06-20. PMID:37339636. |
to overcome this barrier, we developed an optogenetics-assisted α-synuclein (α-syn) aggregation induction system (oasis) that rapidly induces α-syn aggregates and toxicity in pd hipsc-midbrain dopaminergic neurons and midbrain organoids. |
2023-06-20 |
2023-08-14 |
human |
| Min Seong Kim, Eun A Ra, Sin Ho Kweon, Bo Am Seo, Han Seok Ko, Yohan Oh, Gabsang Le. Advanced human iPSC-based preclinical model for Parkinson's disease with optogenetic alpha-synuclein aggregation. Cell stem cell. 2023-06-20. PMID:37339636. |
our oasis-based primary compound screening with sh-sy5y cells identified 5 candidates that were secondarily validated with oasis pd hipsc-midbrain dopaminergic neurons and midbrain organoids, leading us to finally select bag956. |
2023-06-20 |
2023-08-14 |
human |
| Tapan Behl, Piyush Madaan, Aayush Sehgal, Hafiz A Makeen, Mohammed Albratty, Hassan A Alhazmi, Abdulkarim M Meraya, Khalid Anwer, Raman Verm. Understanding the Molecular Aspects of Vitamins in Parkinson's Disease: Present-day Concepts and Perspectives. Current pharmaceutical design. 2023-06-15. PMID:37317922. |
parkinson's disease (pd) is designated as a convoluted nerve cell devastating disorder that encompasses the profound declination of dopaminergic (dargic) nerve cells of the mesencephalon region. |
2023-06-15 |
2023-08-14 |
Not clear |
| Natalia Jiménez-Moreno, Jon D Lan. ATG8 proteins are co-factors for human dopaminergic neuronal transcriptional control: implications for neuronal resilience in Parkinson disease. Autophagy. 2023-06-14. PMID:37312406. |
parkinson disease (pd) is caused by the loss of ventral midbrain dopaminergic neurons (mdans) in the substantia nigra pars compacta (snpc). |
2023-06-14 |
2023-08-14 |
human |
| Kaneyasu Nishimura, Emilía Sif Ásgrímsdóttir, Shanzheng Yang, Ernest Arena. A protocol for the differentiation of human embryonic stem cells into midbrain dopaminergic neurons. STAR protocols. vol 4. issue 3. 2023-06-13. PMID:37310863. |
a protocol for the differentiation of human embryonic stem cells into midbrain dopaminergic neurons. |
2023-06-13 |
2023-08-14 |
human |
| Kaneyasu Nishimura, Emilía Sif Ásgrímsdóttir, Shanzheng Yang, Ernest Arena. A protocol for the differentiation of human embryonic stem cells into midbrain dopaminergic neurons. STAR protocols. vol 4. issue 3. 2023-06-13. PMID:37310863. |
here, we present a protocol for the generation of functional midbrain dopaminergic (mda) neurons from human embryonic stem cells (hescs), which mimics the development of the human ventral midbrain. |
2023-06-13 |
2023-08-14 |
human |
| Yi Han Ng, Justyna A Jana. Transcription Factor-Directed Dopaminergic Neuron Differentiation from Human Pluripotent Stem Cells. Methods in molecular biology (Clifton, N.J.). vol 2683. 2023-06-11. PMID:37300765. |
here, we describe in detail a method for co-expression of seven transcription factors required for efficient induction of dopaminergic neurons with midbrain characteristics from human embryonic and induced pluripotent stem cells. |
2023-06-11 |
2023-08-14 |
human |
| Weidong Le, Panpan Wang, Murad Al-Nusaif, Jun Zhang, Huijia Yang, Yuting Yang, Kunhyok Kim, Song Li, Cong Liu, Huaibin Ca. Pathological characteristics of axons and proteome patterns in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency. Research square. 2023-06-09. PMID:37292937. |
pathological characteristics of axons and proteome patterns in midbrain dopaminergic neurodegeneration induced by wdr45-deficiency. |
2023-06-09 |
2023-08-14 |
Not clear |
| Rachel J Boyd, Sarah A McClymont, Nelson B Barrientos, Paul W Hook, William D Law, Rebecca J Rose, Eric L Waite, Jay Rathinavelu, Dimitrios Avramopoulos, Andrew S McCallio. Evaluating the mouse neural precursor line, SN4741, as a suitable proxy for midbrain dopaminergic neurons. BMC genomics. vol 24. issue 1. 2023-06-07. PMID:37286935. |
evaluating the mouse neural precursor line, sn4741, as a suitable proxy for midbrain dopaminergic neurons. |
2023-06-07 |
2023-08-14 |
mouse |
| Rachel J Boyd, Sarah A McClymont, Nelson B Barrientos, Paul W Hook, William D Law, Rebecca J Rose, Eric L Waite, Jay Rathinavelu, Dimitrios Avramopoulos, Andrew S McCallio. Evaluating the mouse neural precursor line, SN4741, as a suitable proxy for midbrain dopaminergic neurons. BMC genomics. vol 24. issue 1. 2023-06-07. PMID:37286935. |
here, we are using a combination of classic and contemporary genomic techniques - karyotyping, rt-qpcr, single cell rna-seq, bulk rna-seq, and atac-seq - to characterize the transcriptional landscape, chromatin landscape, and genomic architecture of this cell line, and evaluate its suitability as a proxy for midbrain dopaminergic neurons in the study of parkinson disease. |
2023-06-07 |
2023-08-14 |
mouse |
| Charlotte Helf, Maria Kober, Franz Markert, Jennifer Lanto, Leonie Overhoff, Kathrin Badstübner-Meeske, Alexander Storch, Mareike Fause. Subthalamic nucleus deep brain stimulation induces nigrostriatal dopaminergic plasticity in a stable rat model of Parkinson's disease. Neuroreport. vol 34. issue 10. 2023-06-04. PMID:37270842. |
in the context of identifying disease-modifying effects of stn-dbs by prompting cellular plasticity in midbrain dopaminergic systems, we analyzed neuronal tyrosine hydroxylase and c-fos expression in the substantia nigra pars compacta (snpc) and ventral tegmental area (vta). |
2023-06-04 |
2023-08-14 |
rat |
| Nikolaos Patikas, Rizwan Ansari, Emmanouil Metzakopia. Single-cell transcriptomics identifies perturbed molecular pathways in midbrain organoids using α-Synuclein triplication Parkinson's Disease patient-derived iPSCs. Neuroscience research. 2023-06-04. PMID:37271312. |
here, we generate midbrain dopaminergic(mda) organoids from induced pluripotent stem cells(ipsc) from healthy and parkinson's disease(pd) donors and assess them as a human pd model using single-cell rnaseq. |
2023-06-04 |
2023-08-14 |
human |
| Subham Preetam, Swathi Jonnalagadda, Lamha Kumar, Rajeswari Rath, Soham Chattopadhyay, Badrah S Alghamdi, Adel Mohammad Abuzenadahg, Niraj Jha, Akash Gautam, Sumira Malik, Ghulam Md Ashra. Therapeutic potential of Lipid Nanosystems for the treatment of Parkinson's disease: an updated review. Ageing research reviews. 2023-06-02. PMID:37268112. |
parkinson's disease (pd) is primarily the second most common neurological disorder, caused by the degeneration of dopaminergic neurons in the midbrain, which is primarily responsible for the onset of the disease. |
2023-06-02 |
2023-08-14 |
Not clear |