| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aymen H Sadaka, Justin Canuel, Marcelo Febo, Clare T Johnson, Heather B Bradshaw, Richard Ortiz, Federica Ciumo, Praveen Kulkarni, Michael A Gitcho, Craig F Ferri. Effects of inhaled cannabis high in Δ9-THC or CBD on the aging brain: A translational MRI and behavioral study. Frontiers in aging neuroscience. vol 15. 2023-02-23. PMID:36819730. |
the dopaminergic midbrain system was sensitive to chronic Δ9-thc but not cbd showing robust plasticity in volume and water diffusivity prior to and following drug cessation an effect possibly related to the abuse liability of Δ9-thc. |
2023-02-23 |
2023-08-14 |
mouse |
| Aditi Verma, Reddy Peera Kommaddi, Barathan Gnanabharathi, Etienne C Hirsch, Vijayalakshmi Ravindranat. Genes critical for development and differentiation of dopaminergic neurons are downregulated in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2023-02-23. PMID:36820885. |
genes essential for midbrain development and determination of dopaminergic phenotype such as, lmx1b, foxa1, rspo2, klhl1, ebf3, pitx3, rgs4, aldh1a1, ret, foxa2, en1, dlk1, gfra1, lmx1a, nr4a2, gap43, snca, pbx1, and grb10 were downregulated in human pd and overexpression of gfp tagged lmx1b rescued mpp |
2023-02-23 |
2023-08-14 |
mouse |
| Wei Wang, Xueyi Xie, Xiaowen Zhuang, Yufei Huang, Tao Tan, Himanshu Gangal, Zhenbo Huang, William Purvines, Xuehua Wang, Alexander Stefanov, Ruifeng Chen, Lucas Rodriggs, Anita Chaiprasert, Emily Yu, Valerie Vierkant, Michelle Hook, Yun Huang, Emmanuel Darcq, Jun Wan. Striatal μ-opioid receptor activation triggers direct-pathway GABAergic plasticity and induces negative affect. Cell reports. 2023-02-16. PMID:36796365. |
furthermore, intravenous fentanyl self-administration enhanced gabaergic striatonigral transmission and reduced midbrain dopaminergic activity. |
2023-02-16 |
2023-08-14 |
Not clear |
| Surjeet Mastwal, Xinjian Li, Rianne Stowell, Matthew Manion, Wenyu Zhang, Nam-Shik Kim, Ki-Jun Yoon, Hongjun Song, Guo-Li Ming, Kuan Hong Wan. Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function. bioRxiv : the preprint server for biology. 2023-02-13. PMID:36778456. |
the frontal cortex and its dopaminergic input from the midbrain are implicated in cognitive functions and undergo maturational changes during adolescence. |
2023-02-13 |
2023-08-14 |
mouse |
| Jayaraj John Marshal, Beena Briget Kuriakose, Amani Hamed Alhazmi, Karthikeyan Muthusam. Mechanistic insights into the role of vitamin D and computational identification of potential lead compounds for Parkinson's disease. Journal of cellular biochemistry. 2023-02-13. PMID:36780350. |
parkinson's disease (pd) is the second most common neurodegenerative disorder that affects dopaminergic neurons in the midbrain. |
2023-02-13 |
2023-08-14 |
Not clear |
| Tatiana Gerasimova, Ekaterina Stepanenko, Lyudmila Novosadova, Elena Arsenyeva, Darya Shimchenko, Vyacheslav Tarantul, Igor Grivennikov, Valentina Nenasheva, Ekaterina Novosadov. Glial Cultures Differentiated from iPSCs of Patients with International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768317. |
glial cultures differentiated from ipscs of patients with parkinson's disease (pd) is the second most common neurodegenerative diseases characterized by progressive loss of midbrain dopaminergic neurons in the substantia nigra. |
2023-02-11 |
2023-08-14 |
Not clear |
| Yee Jie Yeap, Tng J W Teddy, Mok Jung Lee, Micaela Goh, Kah Leong Li. From 2D to 3D: Development of Monolayer Dopaminergic Neuronal and Midbrain Organoid Cultures for Parkinson's Disease Modeling and Regenerative Therapy. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768843. |
from 2d to 3d: development of monolayer dopaminergic neuronal and midbrain organoid cultures for parkinson's disease modeling and regenerative therapy. |
2023-02-11 |
2023-08-14 |
human |
| Yee Jie Yeap, Tng J W Teddy, Mok Jung Lee, Micaela Goh, Kah Leong Li. From 2D to 3D: Development of Monolayer Dopaminergic Neuronal and Midbrain Organoid Cultures for Parkinson's Disease Modeling and Regenerative Therapy. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768843. |
parkinson's disease (pd) is a prevalent neurodegenerative disorder that is characterized pathologically by the loss of a9-specific dopaminergic (da) neurons in the substantia nigra pars compacta (snpc) of the midbrain. |
2023-02-11 |
2023-08-14 |
human |
| Rachel J Boyd, Sarah A McClymont, Nelson B Barrientos, Paul W Hook, William D Law, Rebecca J Rose, Eric L Waite, Dimitrios Avramopoulos, Andrew S McCallio. Evaluating the mouse neural precursor line, SN4741, as a suitable proxy for midbrain dopaminergic neurons. bioRxiv : the preprint server for biology. 2023-02-07. PMID:36747739. |
evaluating the mouse neural precursor line, sn4741, as a suitable proxy for midbrain dopaminergic neurons. |
2023-02-07 |
2023-08-14 |
mouse |
| Yuka Nago-Iwashita, Yuki Moriya, Satoshi Hara, Ryohei Ogawa, Rina Aida, Katsuya Miyajima, Takenobu Shimura, Shin-Ichi Muramatsu, Soichiro Ide, Kazutaka Ikeda, Hiroshi Ichinos. Overexpression of tyrosine hydroxylase in dopaminergic neurons increased sensitivity to methamphetamine. Neurochemistry international. 2023-01-28. PMID:36709046. |
wild-type th (wt-th) or the s40e mutant of th (s40e-th), which is an active form of th mimicking phosphorylated th at the 40th serine, was expressed in midbrain dopaminergic neurons using an adeno-associated virus (aav) vector. |
2023-01-28 |
2023-08-14 |
mouse |
| Jessica K Smith, George D Mellick, Alex M Syke. The role of the endolysosomal pathway in α-synuclein pathogenesis in Parkinson's disease. Frontiers in cellular neuroscience. vol 16. 2023-01-27. PMID:36704248. |
parkinson's disease (pd) is a chronic neurodegenerative disease that is characterized by a loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain (snpc). |
2023-01-27 |
2023-08-14 |
Not clear |
| Ditte Demontis, G Bragi Walters, Georgios Athanasiadis, Raymond Walters, Karen Therrien, Trine Tollerup Nielsen, Leila Farajzadeh, Georgios Voloudakis, Jaroslav Bendl, Biau Zeng, Wen Zhang, Jakob Grove, Thomas D Als, Jinjie Duan, F Kyle Satterstrom, Jonas Bybjerg-Grauholm, Marie Bækved-Hansen, Olafur O Gudmundsson, Sigurdur H Magnusson, Gisli Baldursson, Katrin Davidsdottir, Gyda S Haraldsdottir, Esben Agerbo, Gabriel E Hoffman, Søren Dalsgaard, Joanna Martin, Marta Ribasés, Dorret I Boomsma, Maria Soler Artigas, Nina Roth Mota, Daniel Howrigan, Sarah E Medland, Tetyana Zayats, Veera M Rajagopal, Merete Nordentoft, Ole Mors, David M Hougaard, Preben Bo Mortensen, Mark J Daly, Stephen V Faraone, Hreinn Stefansson, Panos Roussos, Barbara Franke, Thomas Werge, Benjamin M Neale, Kari Stefansson, Anders D Børglu. Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains. Nature genetics. 2023-01-26. PMID:36702997. |
overall, adhd genetic risk was associated with several brain-specific neuronal subtypes and midbrain dopaminergic neurons. |
2023-01-26 |
2023-08-14 |
Not clear |
| Yue Wu, Zhongting Zhao, Naidi Yang, Chenqi Xin, Zheng Li, Jiajia Xu, Bo Ma, Kah-Leong Lim, Lin Li, Qiong Wu, Changmin Yu, Chengwu Zhan. Vitamin B12 Ameliorates the Pathological Phenotypes of Multiple Parkinson's Disease Models by Alleviating Oxidative Stress. Antioxidants (Basel, Switzerland). vol 12. issue 1. 2023-01-21. PMID:36671015. |
parkinson's disease (pd) is the second most common neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra of the midbrain. |
2023-01-21 |
2023-08-14 |
Not clear |
| Chaofan Wang, Tong Su, Lifei Xiao, Yangyang Wang, Xianhao Huo, Wenchao Li, Jiangwei Ding, Tao Su. Right vagus nerve stimulation improves motor behavior by exerting neuroprotective effects in Parkinson's disease rats. Annals of translational medicine. vol 10. issue 24. 2023-01-20. PMID:36660708. |
compared with the left vagus nerve, the right vagus nerve is more closely connected with the midbrain dopaminergic neurons, which are the lesion locations of pd. |
2023-01-20 |
2023-08-14 |
rat |
| Jin Yi Han, Eun-Hye Lee, Sang-Mi Kim, Chang-Hwan Par. Efficient Generation of Dopaminergic Neurons from Mouse Ventral Midbrain Astrocytes. Biomolecules & therapeutics. 2023-01-15. PMID:36642416. |
efficient generation of dopaminergic neurons from mouse ventral midbrain astrocytes. |
2023-01-15 |
2023-08-14 |
mouse |
| Jin Yi Han, Eun-Hye Lee, Sang-Mi Kim, Chang-Hwan Par. Efficient Generation of Dopaminergic Neurons from Mouse Ventral Midbrain Astrocytes. Biomolecules & therapeutics. 2023-01-15. PMID:36642416. |
pd is caused by loss of dopaminergic (da) neurons in the midbrain substantia nigra (sn) and therefore, replenishment of da neurons via stem cell-based therapy is a potential treatment option. |
2023-01-15 |
2023-08-14 |
mouse |
| F Gubinelli, L Sarauskyte, C Venuti, I Kulacz, G Cazzolla, M Negrini, D Anwer, I Vecchio, F Jakobs, F P Manfredsson, M Davidsson, A Heue. Characterisation of functional deficits induced by AAV overexpression of alpha-synuclein in rats. Current research in neurobiology. vol 4. 2023-01-12. PMID:36632447. |
in the last decades different preclinical animal models of parkinson's disease (pd) have been generated, aiming to mimic the progressive neuronal loss of midbrain dopaminergic (da) cells as well as motor and non-motor impairment. |
2023-01-12 |
2023-08-14 |
human |
| Sophie Skidmore, Roger A Barke. Challenges in the clinical advancement of cell therapies for Parkinson's disease. Nature biomedical engineering. 2023-01-12. PMID:36635420. |
cell therapies as potential treatments for parkinson's disease first gained traction in the 1980s, owing to the clinical success of trials that used transplants of foetal midbrain dopaminergic tissue. |
2023-01-12 |
2023-08-14 |
Not clear |
| Nilima Prakas. Developmental pathways linked to the vulnerability of adult midbrain dopaminergic neurons to neurodegeneration. Frontiers in molecular neuroscience. vol 15. 2023-01-09. PMID:36618829. |
developmental pathways linked to the vulnerability of adult midbrain dopaminergic neurons to neurodegeneration. |
2023-01-09 |
2023-08-14 |
Not clear |
| Nilima Prakas. Developmental pathways linked to the vulnerability of adult midbrain dopaminergic neurons to neurodegeneration. Frontiers in molecular neuroscience. vol 15. 2023-01-09. PMID:36618829. |
several signaling and transcriptional pathways required for the proper embryonic development of the midbrain dopaminergic neurons, which are the most affected in pd, either continue to be active in the adult mammalian midbrain or are reactivated at the transition to adulthood and under neurotoxic conditions. |
2023-01-09 |
2023-08-14 |
Not clear |