| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Diego Iacono, Susan M Resnick, Richard O'Brien, Alan B Zonderman, Yang An, Olga Pletnikova, Gay Rudow, Barbara Crain, Juan C Troncos. Mild cognitive impairment and asymptomatic Alzheimer disease subjects: equivalent β-amyloid and tau loads with divergent cognitive outcomes. Journal of neuropathology and experimental neurology. vol 73. issue 4. 2014-05-12. PMID:24607960. |
we previously reported hypertrophy of neuronal cell bodies, nuclei, and nucleoli in the ca1 of the hippocampus (ca1), anterior cingulate gyrus, posterior cingulate gyrus, and primary visual cortex of asymad versus age-matched control and mild cognitive impairment (mci) subjects. |
2014-05-12 |
2023-08-12 |
human |
| José J Rodríguez, Chia-Yu Yeh, Slavica Terzieva, Markel Olabarria, Magdalena Kulijewicz-Nawrot, Alexei Verkhratsk. Complex and region-specific changes in astroglial markers in the aging brain. Neurobiology of aging. vol 35. issue 1. 2014-04-23. PMID:23969179. |
gfap-positive profiles in the dg and the ca1 of the hippocampus showed progressive age-dependent hypertrophy, as indicated by an increase in surface, volume, and somata volume at 24 months of age compared with 3-month-old mice. |
2014-04-23 |
2023-08-12 |
mouse |
| Masako Yajima, Megumi Matsumoto, Michiko Harada, Hiroshi Hara, Takaji Yajim. Effects of constant light during perinatal periods on the behavioral and neuronal development of mice with or without dietary lutein. Biomedical research (Tokyo, Japan). vol 34. issue 4. 2014-03-26. PMID:23995056. |
ll caused hypertrophy of the spleen and induced a higher expression of serotonin transporter (5htt) in the corpus striatum and hippocampus in 15-day-old pups. |
2014-03-26 |
2023-08-12 |
mouse |
| Yan Dong Zhao, Shan Ou, Sai Yu Cheng, Zhi Xiao, Wen Juan He, Jin Hai Zhang, Huai Zhen Rua. Dendritic development of hippocampal CA1 pyramidal cells in a neonatal hypoxia-ischemia injury model. Journal of neuroscience research. vol 91. issue 9. 2014-02-24. PMID:23686818. |
the functional implementation of injured hippocampus might depend mainly on the hypertrophy of contralateral hippocampus after hi brain injury. |
2014-02-24 |
2023-08-12 |
Not clear |
| Alok Kumar, Bogdan A Stoica, Boris Sabirzhanov, Mark P Burns, Alan I Faden, David J Loan. Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states. Neurobiology of aging. vol 34. issue 5. 2013-08-13. PMID:23273602. |
in this study we used gene expression, immunohistochemical, and stereological analyses to show that tbi in aged versus young mice caused larger lesions associated with an m1/m2 balance switch and increased numbers of reactive (bushy and hypertrophic) mg/mɸ in the cortex, hippocampus, and thalamus. |
2013-08-13 |
2023-08-12 |
mouse |
| Ana C Ferreira, Vítor Pinto, Sandro Dá Mesquita, Ashley Novais, João C Sousa, Margarida Correia-Neves, Nuno Sousa, Joana A Palha, Fernanda Marque. Lipocalin-2 is involved in emotional behaviors and cognitive function. Frontiers in cellular neuroscience. vol 7. 2013-08-05. PMID:23908604. |
more specifically, we found that the granular and pyramidal neurons of the ventral hippocampus, a region described to be associated with emotion, were hypertrophic, while neurons from the dorsal hippocampus, a region implicated in memory and cognition, were atrophic. |
2013-08-05 |
2023-08-12 |
mouse |
| Long-Ze Sha, Xiao-Liang Xing, Dan Zhang, Yuan Yao, Wan-Chen Dou, Li-Ri Jin, Li-Wen Wu, Qi X. Mapping the spatio-temporal pattern of the mammalian target of rapamycin (mTOR) activation in temporal lobe epilepsy. PloS one. vol 7. issue 6. 2013-03-26. PMID:22761730. |
moreover, two sclerotic hippocampus exhibited mtor activation in some of the granule cells, which was accompanied by cell body hypertrophy. |
2013-03-26 |
2023-08-12 |
mouse |
| Jerrah K Holth, Valerie C Bomben, J Graham Reed, Taeko Inoue, Linda Younkin, Steven G Younkin, Robia G Pautler, Juan Botas, Jeffrey L Noebel. Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 4. 2013-03-20. PMID:23345237. |
additionally, tau reduction increased kcna1(-/-) survival and prevented megencephaly and hippocampal hypertrophy, as determined by mri. |
2013-03-20 |
2023-08-12 |
mouse |
| A Das, G C Wallace, C Holmes, M L McDowell, J A Smith, J D Marshall, L Bonilha, J C Edwards, S S Glazier, S K Ray, N L Bani. Hippocampal tissue of patients with refractory temporal lobe epilepsy is associated with astrocyte activation, inflammation, and altered expression of channels and receptors. Neuroscience. vol 220. 2012-12-14. PMID:22698689. |
this study identifies alterations in number of commonly studied molecular targets associated with astrogliosis, cellular hypertrophy, water homeostasis, inflammation, and modulation of excitatory neurotransmission in hippocampal tissues from tle patients. |
2012-12-14 |
2023-08-12 |
human |
| Felipe S Estrada, Vito S Hernández, Estela López-Hernández, Aleph A Corona-Morales, Hugo Solís, Alfonso Escobar, Limei Zhan. Glial activation in a pilocarpine rat model for epileptogenesis: a morphometric and quantitative analysis. Neuroscience letters. vol 514. issue 1. 2012-08-20. PMID:22395088. |
gfap expression evaluated at 2 weeks revealed dose-dependent cytoskeletal hypertrophy and loss of gfap+ cell densities in hippocampus. |
2012-08-20 |
2023-08-12 |
rat |
| Herman Moreno, Nesha S Burghardt, Daniel Vela-Duarte, James Masciotti, Fan Hua, André A Fenton, Beat Schwaller, Scott A Smal. The absence of the calcium-buffering protein calbindin is associated with faster age-related decline in hippocampal metabolism. Hippocampus. vol 22. issue 5. 2012-08-14. PMID:21630373. |
we also found age-independent structural changes in cbko mice, which included an enlarged hippocampus and neocortex as well as global brain hypertrophy. |
2012-08-14 |
2023-08-12 |
mouse |
| Masae Ryufuku, Yasuko Toyoshima, Hiroki Kitaura, Yingjun Zheng, Yong-Juan Fu, Hiroaki Miyahara, Hiroatsu Murakami, Hiroshi Masuda, Shigeki Kameyama, Hitoshi Takahashi, Akiyoshi Kakit. Hypertrophy of hippocampal end folium neurons in patients with mesial temporal lobe epilepsy. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 31. issue 5. 2012-07-23. PMID:21276083. |
hypertrophy of hippocampal end folium neurons in patients with mesial temporal lobe epilepsy. |
2012-07-23 |
2023-08-12 |
Not clear |
| Masae Ryufuku, Yasuko Toyoshima, Hiroki Kitaura, Yingjun Zheng, Yong-Juan Fu, Hiroaki Miyahara, Hiroatsu Murakami, Hiroshi Masuda, Shigeki Kameyama, Hitoshi Takahashi, Akiyoshi Kakit. Hypertrophy of hippocampal end folium neurons in patients with mesial temporal lobe epilepsy. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 31. issue 5. 2012-07-23. PMID:21276083. |
hypertrophic and dysmorphic neurons have been identified in the hippocampal end folium of patients with mesial temporal lobe epilepsy (mtle). |
2012-07-23 |
2023-08-12 |
Not clear |
| Masae Ryufuku, Yasuko Toyoshima, Hiroki Kitaura, Yingjun Zheng, Yong-Juan Fu, Hiroaki Miyahara, Hiroatsu Murakami, Hiroshi Masuda, Shigeki Kameyama, Hitoshi Takahashi, Akiyoshi Kakit. Hypertrophy of hippocampal end folium neurons in patients with mesial temporal lobe epilepsy. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 31. issue 5. 2012-07-23. PMID:21276083. |
neuronal hypertrophy is evident in patients with epilepsy, and appears to advance gradually as the hippocampal sclerosis becomes more severe. |
2012-07-23 |
2023-08-12 |
Not clear |
| Lisa Eiland, Johnny Ramroop, Matthew N Hill, Jasmine Manley, Bruce S McEwe. Chronic juvenile stress produces corticolimbic dendritic architectural remodeling and modulates emotional behavior in male and female rats. Psychoneuroendocrinology. vol 37. issue 1. 2012-04-17. PMID:21658845. |
coincident with these behavioral changes, we report simplification of dendrites in the hippocampus and prefrontal cortex and concurrent hypertrophy of dendrites in the amygdala. |
2012-04-17 |
2023-08-12 |
rat |
| Annik Prat, Maik Behrendt, Edwige Marcinkiewicz, Sebastien Boridy, Ram M Sairam, Nabil G Seidah, Dusica Maysinge. A novel mouse model of Alzheimer's disease with chronic estrogen deficiency leads to glial cell activation and hypertrophy. Journal of aging research. vol 2011. 2011-11-10. PMID:21969914. |
the most prominent changes in the cerebral cortex and hippocampus of these hypoestrogenic mice were marked hypertrophy of both cortical neurons and astrocytes and an increased number of activated microglia. |
2011-11-10 |
2023-08-12 |
mouse |
| Aurélie Blugeot, Cyril Rivat, Elodie Bouvier, Jenny Molet, Amandine Mouchard, Brigitte Zeau, Christophe Bernard, Jean-Jacques Benoliel, Chrystel Becke. Vulnerability to depression: from brain neuroplasticity to identification of biomarkers. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 36. 2011-10-31. PMID:21900567. |
in contrast, 42% of animals displayed persistent decreased serum and hippocampus bdnf concentrations, reduced hippocampal volume and neurogenesis, ca3 dendritic retraction and decrease in spine density, as well as amygdala neuron hypertrophy, constituting latent vulnerability traits to depression. |
2011-10-31 |
2023-08-12 |
Not clear |
| b' Philip P Foster, Kevin P Rosenblatt, Rodrigo O Kulji\\xc5\\xa. Exercise-induced cognitive plasticity, implications for mild cognitive impairment and Alzheimer\'s disease. Frontiers in neurology. vol 2. 2011-07-14. PMID:21602910.' |
the exercise-induced hypertrophy of the hippocampus at the core of these continua is evaluated in terms of potential for prevention to stave off neuronal degeneration. |
2011-07-14 |
2023-08-12 |
Not clear |
| Yoko Mochizuki, Toshio Mizutan. [Neuropathological findings of non-herpetic limbic encephalitis]. Brain and nerve = Shinkei kenkyu no shinpo. vol 62. issue 8. 2010-10-21. PMID:20714034. |
the rostral portion of the hippocampus showed small foci characterized by neuronal loss with neuronophagia coexisting with proliferation of microglias, macrophages, hypertrophic astrocytes, and a few lymphocytes. |
2010-10-21 |
2023-08-12 |
Not clear |
| Akiko Kojo, Kentaro Yamada, Kin-ya Kubo, Anzu Yamashita, Toshiharu Yamamot. Occlusal disharmony in mice transiently activates microglia in hippocampal CA1 region but not in dentate gyrus. The Tohoku journal of experimental medicine. vol 221. issue 3. 2010-09-20. PMID:20581431. |
occlusal disharmony sometimes causes indefinite complaint syndromes, which may be associated with astrocytic hypertrophy and the reduction of numbers of neuronal somata and their dendritic spines in the hippocampus. |
2010-09-20 |
2023-08-12 |
mouse |