| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Panos Zanos, Scott M Thompson, Ronald S Duman, Carlos A Zarate, Todd D Goul. Convergent Mechanisms Underlying Rapid Antidepressant Action. CNS drugs. vol 32. issue 3. 2019-03-11. PMID:29516301. |
proposed mechanisms of the antidepressant action of ketamine include n-methyl-d-aspartate receptor (nmdar) modulation, gamma aminobutyric acid (gaba)-ergic interneuron disinhibition, and direct actions of its hydroxynorketamine (hnk) metabolites. |
2019-03-11 |
2023-08-13 |
Not clear |
| Katelynn M Corder, Mariana A Cortes, Aundrea F Bartley, Samantha A Lear, Farah D Lubin, Lynn E Dobrun. Prefrontal cortex-dependent innate behaviors are altered by selective knockdown of Gad1 in neuropeptide Y interneurons. PloS one. vol 13. issue 7. 2019-01-22. PMID:30024942. |
our results show the behavioral impact of cell-specific interneuron dysfunction and suggest that gaba release by npy+ cells is important for regulating innate prefrontal cortex-dependent behavior in adolescents. |
2019-01-22 |
2023-08-13 |
mouse |
| Meng-Yi Xu, Albert H C Won. GABAergic inhibitory neurons as therapeutic targets for cognitive impairment in schizophrenia. Acta pharmacologica Sinica. vol 39. issue 5. 2018-10-10. PMID:29565038. |
dysfunctional gaba interneuron activity can disrupt the excitatory/inhibitory (e/i) balance in the cortex, which could represent a core pathophysiological mechanism underlying cognitive dysfunction in schizophrenia. |
2018-10-10 |
2023-08-13 |
Not clear |
| Tatsuya Katahira, Naoko Miyazaki, Jun Motoyam. Immediate effects of maternal separation on the development of interneurons derived from medial ganglionic eminence in the neonatal mouse hippocampus. Development, growth & differentiation. vol 60. issue 5. 2018-10-09. PMID:29878325. |
given that impairment of gaba inhibitory system is known as one of the common features of the abnormal hippocampal development induced by ms, we examined whether the ms on 4-day-old (p4) mice for 24 hr abolishes the interneuron development. |
2018-10-09 |
2023-08-13 |
mouse |
| Letizia Mariotti, Gabriele Losi, Annamaria Lia, Marcello Melone, Angela Chiavegato, Marta Gómez-Gonzalo, Michele Sessolo, Serena Bovetti, Angelo Forli, Micaela Zonta, Linda Maria Requie, Iacopo Marcon, Arianna Pugliese, Cécile Viollet, Bernhard Bettler, Tommaso Fellin, Fiorenzo Conti, Giorgio Carmignot. Interneuron-specific signaling evokes distinctive somatostatin-mediated responses in adult cortical astrocytes. Nature communications. vol 9. issue 1. 2018-09-19. PMID:29311610. |
using optogenetics and two-photon functional imaging in the adult mouse neocortex, we here reveal that parvalbumin- and somatostatin-expressing interneurons, two key interneuron classes in the brain, differentially signal to astrocytes inducing weak and robust gaba |
2018-09-19 |
2023-08-13 |
mouse |
| Corey Fee, Mounira Banasr, Etienne Sibill. Somatostatin-Positive Gamma-Aminobutyric Acid Interneuron Deficits in Depression: Cortical Microcircuit and Therapeutic Perspectives. Biological psychiatry. vol 82. issue 8. 2018-05-21. PMID:28697889. |
somatostatin-positive gamma-aminobutyric acid interneuron deficits in depression: cortical microcircuit and therapeutic perspectives. |
2018-05-21 |
2023-08-13 |
human |
| Jin Qi, Minjung Kim, Russell Sanchez, Saba M Ziaee, Jhumku D Kohtz, Sookyong Ko. Enhanced susceptibility to stress and seizures in GAD65 deficient mice. PloS one. vol 13. issue 1. 2018-03-09. PMID:29377906. |
immunohistochemical characterization of interneuron subtypes in gad65-/- mice showed a selective decrease in gaba and neuropeptide y (npy) levels and no change in calbindin (clb) or calretinin (clr) immunoreactivity in the hippocampus. |
2018-03-09 |
2023-08-13 |
mouse |
| Travis A Wearne, Lindsay M Parker, Jane L Franklin, Ann K Goodchild, Jennifer L Cornis. Behavioral sensitization to methamphetamine induces specific interneuronal mRNA pathology across the prelimbic and orbitofrontal cortices. Progress in neuro-psychopharmacology & biological psychiatry. vol 77. 2018-03-05. PMID:28351548. |
schizophrenia is associated with significant pathophysiological changes to interneurons within the prefrontal cortex (pfc), with mrna and protein changes associated with the gaba network localized to specific interneuron subtypes. |
2018-03-05 |
2023-08-13 |
Not clear |
| Wei Zhang, J Amiel Rosenkran. Effects of Repeated Stress on Age-Dependent GABAergic Regulation of the Lateral Nucleus of the Amygdala. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 9. 2018-01-09. PMID:26924679. |
furthermore, repeated stress decreased measures of presynaptic gaba function and interneuron activity in adolescent rats. |
2018-01-09 |
2023-08-13 |
human |
| Patricia Boksa, Ying Zhang, Dominique Nouel, Alice Wong, Tak Pan Won. Early Development of Parvalbumin-, Somatostatin-, and Cholecystokinin-Expressing Neurons in Rat Brain following Prenatal Immune Activation and Maternal Iron Deficiency. Developmental neuroscience. vol 38. issue 5. 2018-01-03. PMID:28214898. |
substantial evidence suggests that abnormalities in inhibitory γ-aminobutyric acid (gaba) interneuron function, especially in the parvalbumin subtype of gaba interneuron, both developmentally and in adulthood, may contribute mechanistically to cognitive deficits and psychotic symptoms in schizophrenia. |
2018-01-03 |
2023-08-13 |
rat |
| Lindsay F Morra, Gregory P Straus. Severity of hypertension predicts the generalized neurocognitive deficit in schizophrenia. Schizophrenia research. vol 176. issue 2-3. 2018-01-02. PMID:27397721. |
central nervous system accounts of the generalized deficit have been proposed (e.g., nmda and gaba interneuron receptor dysfunction); however, there may also be more diffuse "general systems" abnormalities that affect brain function. |
2018-01-02 |
2023-08-13 |
human |
| Márton Rózsa, Judith Baka, Sándor Bordé, Balázs Rózsa, Gergely Katona, Gábor Tamá. Unitary GABAergic volume transmission from individual interneurons to astrocytes in the cerebral cortex. Brain structure & function. vol 222. issue 1. 2017-10-16. PMID:26683686. |
testing several cortical interneuron types in slices of the rat cerebral cortex, we show selective unitary transmission from ngfcs to astrocytes with an early, gaba |
2017-10-16 |
2023-08-13 |
rat |
| Trung N Le, Qing-Ping Zhou, Inma Cobos, Shunzhen Zhang, Jamie Zagozewski, Sara Japoni, Jerry Vriend, Tracie Parkinson, Guoyan Du, John L Rubenstein, David D Eisensta. GABAergic Interneuron Differentiation in the Basal Forebrain Is Mediated through Direct Regulation of Glutamic Acid Decarboxylase Isoforms by The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 36. 2017-09-25. PMID:28821666. |
gabaergic interneuron differentiation in the basal forebrain is mediated through direct regulation of glutamic acid decarboxylase isoforms by gaba is the key inhibitory neurotransmitter in the cortex but regulation of its synthesis during forebrain development is poorly understood. |
2017-09-25 |
2023-08-13 |
Not clear |
| Mesbah Alam, Regina Rumpel, Xingxing Jin, Christof von Wrangel, Sarah K Tschirner, Joachim K Krauss, Claudia Grothe, Andreas Ratzka, Kerstin Schwab. Altered somatosensory cortex neuronal activity in a rat model of Parkinson's disease and levodopa-induced dyskinesias. Experimental neurology. vol 294. 2017-08-17. PMID:28445715. |
while gaba level was similar, gene expression levels of interneuron and gabaergic markers in s1fl-ctx and mctx of hp-lid rats differed to some extent. |
2017-08-17 |
2023-08-13 |
rat |
| Federica Filice, Karl Jakob Vörckel, Ayse Özge Sungur, Markus Wöhr, Beat Schwalle. Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism. Molecular brain. vol 9. 2016-10-10. PMID:26819149. |
reduction in parvalbumin expression not loss of the parvalbumin-expressing gaba interneuron subpopulation in genetic parvalbumin and shank mouse models of autism. |
2016-10-10 |
2023-08-13 |
mouse |
| Federica Filice, Karl Jakob Vörckel, Ayse Özge Sungur, Markus Wöhr, Beat Schwalle. Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism. Molecular brain. vol 9. 2016-10-10. PMID:26819149. |
here, we addressed the question whether the observed reduction in pv immunoreactivity was the result of a decrease in pv expression levels and/or loss of the pv-expressing gaba interneuron subpopulation hereafter called "pvalb neurons". |
2016-10-10 |
2023-08-13 |
mouse |
| Richard Nicholas, Roberta Magliozzi, Graham Campbell, Don Mahad, Richard Reynold. Temporal lobe cortical pathology and inhibitory GABA interneuron cell loss are associated with seizures in multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England). vol 22. issue 1. 2016-09-27. PMID:25921040. |
temporal lobe cortical pathology and inhibitory gaba interneuron cell loss are associated with seizures in multiple sclerosis. |
2016-09-27 |
2023-08-13 |
Not clear |
| Alan L Pehrson, Theepica Jeyarajah, Connie Sanche. Regional distribution of serotonergic receptors: a systems neuroscience perspective on the downstream effects of the multimodal-acting antidepressant vortioxetine on excitatory and inhibitory neurotransmission. CNS spectrums. vol 21. issue 2. 2016-07-19. PMID:26250622. |
this analysis suggests that 5-ht and ssris will have markedly different effects within the pfc, where they will induce mixed effects on gaba and glutamate neurotransmission, compared to the striatum, where they will enhance gabaergic interneuron activity and drive down the activity of medium spiny neurons. |
2016-07-19 |
2023-08-13 |
Not clear |
| Leslie M Tong, Seo Yeon Yoon, Yaisa Andrews-Zwilling, Alyssa Yang, Victoria Lin, Hanci Lei, Yadong Huan. Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 7. 2016-06-29. PMID:26888940. |
enhancing gaba signaling during middle adulthood prevents age-dependent gabaergic interneuron decline and learning and memory deficits in apoe4 mice. |
2016-06-29 |
2023-08-13 |
mouse |
| Natasja M W J de Bruin, Chris G Krus. 5-HT6 Receptor Antagonists: Potential Efficacy for the Treatment of Cognitive Impairment in Schizophrenia. Current pharmaceutical design. vol 21. issue 26. 2016-06-03. PMID:26044973. |
5-ht6r antagonists decrease gaba release and gabaergic interneuron excitability, which subsequently disinhibits glutamate and/or acetylcholine release and results in enhancement of synaptic plasticity. |
2016-06-03 |
2023-08-13 |
Not clear |