| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard E Frye, Manuel F Casanova, S Hossein Fatemi, Timothy D Folsom, Teri J Reutiman, Gregory L Brown, Stephen M Edelson, John C Slattery, James B Adam. Neuropathological Mechanisms of Seizures in Autism Spectrum Disorder. Frontiers in neuroscience. vol 10. 2016-05-31. PMID:27242398. |
defects in energy metabolism can reduce gaba interneuron function. |
2016-05-31 |
2023-08-13 |
Not clear |
| Tatiana Golovko, Rogier Min, Natalia Lozovaya, Caroline Falconer, Natalia Yatsenko, Timur Tsintsadze, Vera Tsintsadze, Catherine Ledent, Robert J Harvey, Delia Belelli, Jeremy J Lambert, Andrei Rozov, Nail Burnashe. Control of Inhibition by the Direct Action of Cannabinoids on GABAA Receptors. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 9. 2016-05-05. PMID:24646614. |
here we report that currents mediated by recombinant gabaars activated by high (synaptic) concentrations of gaba as well as gabaergic inhibitory postsynaptic currents (ipscs) at neocortical fast spiking (fs) interneuron to pyramidal neuron synapses are suppressed by exogenous and endogenous cannabinoids in a cb1r-independent manner. |
2016-05-05 |
2023-08-12 |
Not clear |
| Hugo Geerts, Patrick Roberts, Athan Spiros, Steven Potki. Understanding responder neurobiology in schizophrenia using a quantitative systems pharmacology model: application to iloperidone. Journal of psychopharmacology (Oxford, England). vol 29. issue 4. 2016-03-11. PMID:25691503. |
the serotonin 5-ht3 receptor-mediated effect on interneuron gamma-aminobutyric acid conductance was identified as the process that moderately drove the differentiation of iloperidone versus ziprasidone. |
2016-03-11 |
2023-08-13 |
human |
| Zhe Pei, Qiang Chen, David Koren, Benno Giammarinaro, Hector Acaron Ledesma, Wei We. Conditional Knock-Out of Vesicular GABA Transporter Gene from Starburst Amacrine Cells Reveals the Contributions of Multiple Synaptic Mechanisms Underlying Direction Selectivity in the Retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 38. 2015-12-29. PMID:26400950. |
here, we selectively eliminated the directional tuning of inhibitory inputs onto dsgcs by disrupting gaba release from the presynaptic interneuron starburst amacrine cell in the mouse retina. |
2015-12-29 |
2023-08-13 |
mouse |
| Robert Lübkemann, Judith Eberhardt, Friedrich-Wilhelm Röhl, Kathrin Janitzky, Sven Nullmeier, Oliver Stork, Herbert Schwegler, Rüdiger Link. Identification and Characterization of GABAergic Projection Neurons from Ventral Hippocampus to Amygdala. Brain sciences. vol 5. issue 3. 2015-08-12. PMID:26264032. |
we could detect the expression of different markers of interneuron subpopulations, including parvalbumin and calbindin, somatostatin, neuropeptide y, and cholecystokinin in such retrogradely labeled gaba neurons. |
2015-08-12 |
2023-08-13 |
Not clear |
| Elizabeth J Hong, Rachel I Wilso. Simultaneous encoding of odors by channels with diverse sensitivity to inhibition. Neuron. vol 85. issue 3. 2015-06-15. PMID:25619655. |
although interneurons are recruited nonspecifically, glomeruli differ dramatically in their sensitivity to interneuron activity, and this is explained by their varying sensitivity to gaba. |
2015-06-15 |
2023-08-13 |
drosophila_melanogaster |
| C Aligny, C Roux, N Dourmap, Y Ramdani, J-C Do-Rego, S Jégou, P Leroux, I Leroux-Nicollet, S Marret, B J Gonzale. Ketamine alters cortical integration of GABAergic interneurons and induces long-term sex-dependent impairments in transgenic Gad67-GFP mice. Cell death & disease. vol 5. 2015-06-04. PMID:24991763. |
in the present study, we show using gad67-gfp mice that prenatal exposure to ketamine during a time-window in which gabaergic precursors are migrating results in (i) strong apoptotic death in the ganglionic eminences and along the migratory routes of gabaergic interneurons; (ii) long-term deficits in interneuron density, dendrite numbers and spine morphology; (iii) a sex-dependent deregulation of γ-aminobutyric acid (gaba) levels and gaba transporter expression; (iv) sex-dependent changes in the response to glutamate-induced calcium mobilization; and (v) the long-term sex-dependent behavioral impairment of locomotor activity. |
2015-06-04 |
2023-08-13 |
mouse |
| Manoj K Jaiswal, Sotirios Keros, Mingrui Zhao, Melis Inan, Theodore H Schwartz, Stewart A Anderson, Gregg E Homanics, Peter A Goldstei. Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit. Frontiers in cellular neuroscience. vol 9. 2015-04-27. PMID:25914623. |
indeed, transplanted medial ganglionic eminence interneuron progenitors (mge-ips) mature into gabaergic interneurons that increase gaba release onto cortical pyramidal neurons, and this inhibition is associated with reduced seizure activity. |
2015-04-27 |
2023-08-13 |
Not clear |
| Megu Itahashi, Hajime Abe, Takeshi Tanaka, Sayaka Mizukami, Masayuki Kimura, Toshinori Yoshida, Makoto Shibutan. Maternal exposure to hexachlorophene targets intermediate-stage progenitor cells of the hippocampal neurogenesis in rat offspring via dysfunction of cholinergic inputs by myelin vacuolation. Toxicology. vol 328. 2015-03-25. PMID:25497112. |
hcp-exposure did not alter the numbers of sgz proliferating cells and reelin- or calcium-binding protein-expressing γ-aminobutyric acid (gaba)-ergic interneuron subpopulations in the dentate hilus on pnd 21 and pnd 77. |
2015-03-25 |
2023-08-13 |
rat |
| Dania Vecchia, Angelita Tottene, Arn M J M van den Maagdenberg, Daniela Pietrobo. Mechanism underlying unaltered cortical inhibitory synaptic transmission in contrast with enhanced excitatory transmission in CaV2.1 knockin migraine mice. Neurobiology of disease. vol 69. 2015-03-12. PMID:24907493. |
the mechanism underlying the unaltered gaba release at cortical fs interneuron synapses remains unknown. |
2015-03-12 |
2023-08-13 |
mouse |
| YeeWen Candace Wu, Xin Du, Maarten van den Buuse, Rachel A Hil. Sex differences in the adolescent developmental trajectory of parvalbumin interneurons in the hippocampus: a role for estradiol. Psychoneuroendocrinology. vol 45. 2015-01-12. PMID:24845187. |
reduced hippocampal expression of the gabaergic interneuron marker, parvalbumin (pv), and gaba synthesizing enzyme, gad67, are consistently reported in schizophrenia. |
2015-01-12 |
2023-08-13 |
mouse |
| Simon Molgaard, Maj Ulrichsen, Simon Boggild, Marie-Louise Holm, Christian Vaegter, Jens Nyengaard, Simon Gleru. Immunohistochemical visualization of mouse interneuron subtypes. F1000Research. vol 3. 2014-12-03. PMID:25469233. |
ideally, all can be marked using an antibody directed against the inhibitory neurotransmitter gaba, but parvalbumin, calbindin, somatostatin, and calretinin are also commonly used as markers to narrow down the specific interneuron subtype. |
2014-12-03 |
2023-08-13 |
mouse |
| Peter Somogyi, Linda Katona, Thomas Klausberger, Bálint Lasztóczi, Tim J Vine. Temporal redistribution of inhibition over neuronal subcellular domains underlies state-dependent rhythmic change of excitability in the hippocampus. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 369. issue 1635. 2014-09-08. PMID:24366131. |
all parts of pyramidal cells, except the axon initial segment, receive gaba from multiple interneuron types, each with distinct firing dynamics. |
2014-09-08 |
2023-08-12 |
Not clear |
| Marie Soukupová, Anna Binaschi, Chiara Falcicchia, Silvia Zucchini, Paolo Roncon, Eleonora Palma, Eros Magri, Enrico Grandi, Michele Simonat. Impairment of GABA release in the hippocampus at the time of the first spontaneous seizure in the pilocarpine model of temporal lobe epilepsy. Experimental neurology. vol 257. 2014-08-13. PMID:24768627. |
in this work, we analyzed gaba extracellular concentrations (using in vivo microdialysis under basal and high k(+)-evoked conditions) and loss of two gaba interneuron populations (parvalbumin and somatostatin neurons) in the ventral hippocampus at different time-points after pilocarpine-induced status epilepticus in the rat, i.e. |
2014-08-13 |
2023-08-13 |
rat |
| Ahmed I Gilani, Muhammad O Chohan, Melis Inan, Scott A Schobel, Nashid H Chaudhury, Samuel Paskewitz, Nao Chuhma, Sara Glickstein, Robert J Merker, Qing Xu, Scott A Small, Stewart A Anderson, Margaret Elizabeth Ross, Holly Moor. Interneuron precursor transplants in adult hippocampus reverse psychosis-relevant features in a mouse model of hippocampal disinhibition. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 20. 2014-07-15. PMID:24794528. |
these findings establish functional links between hippocampal gaba interneuron deficits and psychosis-relevant dopaminergic and cognitive phenotypes, and support a rationale for targeting limbic cortical interneuron function in the prevention and treatment of schizophrenia. |
2014-07-15 |
2023-08-13 |
mouse |
| Lydia Ouellet, Etienne de Villers-Sidan. Trajectory of the main GABAergic interneuron populations from early development to old age in the rat primary auditory cortex. Frontiers in neuroanatomy. vol 8. 2014-06-11. PMID:24917792. |
using the rat primary auditory cortex (a1) as a model, we probed the known markers of gabaergic interneurons with immunohistological methods, using antibodies against gamma aminobutyric acid (gaba), parvalbumin (pv), somatostatin (som), calretinin (cr), vasoactive intestinal peptide (vip), choline acetyltransferase (chat), neuropeptide y (npy), and cholecystokinin (cck) to document the changes observed in interneuron populations across the rat's lifespan. |
2014-06-11 |
2023-08-13 |
rat |
| Yan Liu, Huisheng Liu, Conall Sauvey, Lin Yao, Ewa D Zarnowska, Su-Chun Zhan. Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells. Nature protocols. vol 8. issue 9. 2014-03-26. PMID:23928500. |
availability of enriched functional human forebrain gaba interneurons, especially those from people affected by gaba interneuron deficit disease, will be instrumental to the investigation of disease pathogenesis and development of therapeutics. |
2014-03-26 |
2023-08-12 |
human |
| Kiyoshi Egawa, Junko Yamada, Tomonori Furukawa, Yuchio Yanagawa, Atsuo Fukud. Cl⁻ homeodynamics in gap junction-coupled astrocytic networks on activation of GABAergic synapses. The Journal of physiology. vol 591. issue 16. 2014-03-03. PMID:23732644. |
although gaba application evoked bidirectional cl⁻ flux via gabaa receptors and mouse gaba transporter 4 (mgat4) in ca1 astrocytes, a train of interneuron firing induced only gabaa receptor-mediated inward currents in an adjacent astrocyte. |
2014-03-03 |
2023-08-12 |
mouse |
| Kiyoshi Egawa, Junko Yamada, Tomonori Furukawa, Yuchio Yanagawa, Atsuo Fukud. Cl⁻ homeodynamics in gap junction-coupled astrocytic networks on activation of GABAergic synapses. The Journal of physiology. vol 591. issue 16. 2014-03-03. PMID:23732644. |
a gat1 inhibitor increased the interneuron firing-induced currents and induced bicuculline-insensitive, mgat4 inhibitor-sensitive currents, suggesting that synaptic spillover of gaba predominantly induced the astrocytic cl⁻ efflux because gabaa receptors are localized near the synaptic clefts. |
2014-03-03 |
2023-08-12 |
mouse |
| Andrew M Dacks, Klaudiusz R Weis. Release of a single neurotransmitter from an identified interneuron coherently affects motor output on multiple time scales. Journal of neurophysiology. vol 109. issue 9. 2014-01-09. PMID:23407357. |
to explore the consequences of this diversity, we used the buccal ganglion of aplysia to examine the effects of gaba release by a single interneuron, b40, on the intrinsic properties and motor output of the radula closure neuron b8. |
2014-01-09 |
2023-08-12 |
aplysia |