| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu-Han Xie, Lin Jiang, Yi Zhang, Yu-Hui Deng, Hao Yang, Qi He, Yu-Ning Zhou, Chun-Ni Zhou, Yan-Min Luo, Xin Liang, Jin Wang, Du-Juan Huang, Lin Zhu, Yong Tang, Feng-Lei Cha. Antagonizing LINGO-1 reduces activated microglia and alleviates dendritic spine loss in the hippocampus of APP/PS1 transgenic mice. Neuroscience letters. 2023-12-24. PMID:38142924. |
antagonizing lingo-1 reduces activated microglia and alleviates dendritic spine loss in the hippocampus of app/ps1 transgenic mice. |
2023-12-24 |
2023-12-27 |
mouse |
| Yu-Han Xie, Lin Jiang, Yi Zhang, Yu-Hui Deng, Hao Yang, Qi He, Yu-Ning Zhou, Chun-Ni Zhou, Yan-Min Luo, Xin Liang, Jin Wang, Du-Juan Huang, Lin Zhu, Yong Tang, Feng-Lei Cha. Antagonizing LINGO-1 reduces activated microglia and alleviates dendritic spine loss in the hippocampus of APP/PS1 transgenic mice. Neuroscience letters. 2023-12-24. PMID:38142924. |
lingo-1 is a negative regulator of nerve growth, and whether antagonizing lingo-1 can attenuate synaptic pruning by microglia and rescue dendritic spines in the hippocampus in ad is still unclear. |
2023-12-24 |
2023-12-27 |
mouse |
| Yu-Han Xie, Lin Jiang, Yi Zhang, Yu-Hui Deng, Hao Yang, Qi He, Yu-Ning Zhou, Chun-Ni Zhou, Yan-Min Luo, Xin Liang, Jin Wang, Du-Juan Huang, Lin Zhu, Yong Tang, Feng-Lei Cha. Antagonizing LINGO-1 reduces activated microglia and alleviates dendritic spine loss in the hippocampus of APP/PS1 transgenic mice. Neuroscience letters. 2023-12-24. PMID:38142924. |
compared to wild-type mice, app/ps1 transgenic mice had worse performance on behavioral tests, fewer dendritic spines but more microglia in the hippocampus. |
2023-12-24 |
2023-12-27 |
mouse |
| Yu-Han Xie, Lin Jiang, Yi Zhang, Yu-Hui Deng, Hao Yang, Qi He, Yu-Ning Zhou, Chun-Ni Zhou, Yan-Min Luo, Xin Liang, Jin Wang, Du-Juan Huang, Lin Zhu, Yong Tang, Feng-Lei Cha. Antagonizing LINGO-1 reduces activated microglia and alleviates dendritic spine loss in the hippocampus of APP/PS1 transgenic mice. Neuroscience letters. 2023-12-24. PMID:38142924. |
moreover, app/ps1 transgenic mice had more postsynaptic termini colocalized with microglia in the hippocampus than wild-type mice. |
2023-12-24 |
2023-12-27 |
mouse |
| Yu-Han Xie, Lin Jiang, Yi Zhang, Yu-Hui Deng, Hao Yang, Qi He, Yu-Ning Zhou, Chun-Ni Zhou, Yan-Min Luo, Xin Liang, Jin Wang, Du-Juan Huang, Lin Zhu, Yong Tang, Feng-Lei Cha. Antagonizing LINGO-1 reduces activated microglia and alleviates dendritic spine loss in the hippocampus of APP/PS1 transgenic mice. Neuroscience letters. 2023-12-24. PMID:38142924. |
the anti-lingo-1 antibody significantly reversed these changes in ad, indicating that the anti-lingo-1 antibody can improve hippocampus-dependent learning and memory abilities and effectively rescue dendritic spines in the hippocampus of ad mice and that microglia might participate in this progression in ad. |
2023-12-24 |
2023-12-27 |
mouse |
| Cheng Zhao, Ruiting Shi, Xu Lu, Rongrong Yang, Zhuo Chen, Bingran Chen, Wenfeng Hu, Jie Ren, Jie Peng, Tao Zhu, Haojie Zhu, Chao Huan. Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice. European journal of pharmacology. 2023-12-24. PMID:38142848. |
pretreatment with minocycline or plx3397 before β-glucan injection to suppress microglia abolished the preventive effect of β-glucan on impaired creb-bdnf signaling in the hippocampus and depression-like behaviors in cus mice. |
2023-12-24 |
2023-12-27 |
mouse |
| Cheng Zhao, Ruiting Shi, Xu Lu, Rongrong Yang, Zhuo Chen, Bingran Chen, Wenfeng Hu, Jie Ren, Jie Peng, Tao Zhu, Haojie Zhu, Chao Huan. Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice. European journal of pharmacology. 2023-12-24. PMID:38142848. |
these results suggest that an increase in hippocampal bdnf following creb activation triggered by β-glucan-induced microglia stimulation and subsequent trkb signaling mediates the preventive effect of β-glucan on depression. |
2023-12-24 |
2023-12-27 |
mouse |
| Erliang Kong, Xuqiang Geng, Feixiang Wu, Wei Yue, Yuming Sun, Xudong Fen. Microglial exosome miR-124-3p in hippocampus alleviates cognitive impairment induced by postoperative pain in elderly mice. Journal of cellular and molecular medicine. 2023-12-23. PMID:38140846. |
the levels of pro-inflammatory factors (tnf-α, il-1β, il-6), the levels of anti-inflammatory factors (ym, arg-1, il-10) and microglia proliferation marker cyclin d1 in hippocampus were measured to evaluate microglia polarization. |
2023-12-23 |
2023-12-25 |
mouse |
| Erliang Kong, Xuqiang Geng, Feixiang Wu, Wei Yue, Yuming Sun, Xudong Fen. Microglial exosome miR-124-3p in hippocampus alleviates cognitive impairment induced by postoperative pain in elderly mice. Journal of cellular and molecular medicine. 2023-12-23. PMID:38140846. |
microglial exosome mir-124-3p in hippocampus alleviates cognitive impairment induced by postoperative pain through microglia polarization in elderly mice. |
2023-12-23 |
2023-12-25 |
mouse |
| Xueru Xu, Ri Chen, Youfen Yu, Jing Yang, Chun Lin, Rongguo Li. Pulsed radiofrequency on DRG inhibits hippocampal neuroinflammation by regulating spinal GRK2/p38 expression and enhances spinal autophagy to reduce pain and depression in male rats with spared nerve injury. International immunopharmacology. vol 127. 2023-12-23. PMID:38141406. |
the sni-induced reduction in grk2 expression, elevation of p-p38 mapk levels in the scdh, and increase in il-1β and tnf-α levels in the hippocampus were reversed by prf, which was accompanied by an increase in autophagic flux in spinal microglia. |
2023-12-23 |
2023-12-25 |
rat |
| Xueru Xu, Ri Chen, Youfen Yu, Jing Yang, Chun Lin, Rongguo Li. Pulsed radiofrequency on DRG inhibits hippocampal neuroinflammation by regulating spinal GRK2/p38 expression and enhances spinal autophagy to reduce pain and depression in male rats with spared nerve injury. International immunopharmacology. vol 127. 2023-12-23. PMID:38141406. |
in addition, the improvements elicited by 85 v-prf were reversed by intrathecal injection of grk2 antisense oligonucleotide, and these changes were accompanied by grk2 downregulation and p-p38 upregulation in the scdh, increased pro-inflammatory factor levels in the hippocampus, and excessive autophagy in spinal microglia. |
2023-12-23 |
2023-12-25 |
rat |
| You-Chang Oh, Yun Hee Jeong, Hye Jin Yang, Wei Li, Jin Yeul M. Lumbricus Extract Prevents LPS-Induced Inflammatory Activation of BV2 Microglia and Glutamate-Induced Hippocampal HT22 Cell Death by Suppressing MAPK/NF-κB/NLRP3 Signaling and Oxidative Stress. Current issues in molecular biology. vol 45. issue 12. 2023-12-22. PMID:38132466. |
lumbricus extract prevents lps-induced inflammatory activation of bv2 microglia and glutamate-induced hippocampal ht22 cell death by suppressing mapk/nf-κb/nlrp3 signaling and oxidative stress. |
2023-12-22 |
2023-12-24 |
Not clear |
| Lorena Morton, Philipp Arndt, Alejandra P Garza, Solveig Henneicke, Hendrik Mattern, Marilyn Gonzalez, Alexander Dityatev, Deniz Yilmazer-Hanke, Stefanie Schreiber, Ildiko R Duna. Spatio-temporal dynamics of microglia phenotype in human and murine cSVD: impact of acute and chronic hypertensive states. Acta neuropathologica communications. vol 11. issue 1. 2023-12-20. PMID:38115109. |
an unbiased multidimensional flow cytometric analysis revealed phenotypic heterogeneity among microglia cells within the hippocampus and cortex. |
2023-12-20 |
2023-12-23 |
human |
| Lorena Morton, Philipp Arndt, Alejandra P Garza, Solveig Henneicke, Hendrik Mattern, Marilyn Gonzalez, Alexander Dityatev, Deniz Yilmazer-Hanke, Stefanie Schreiber, Ildiko R Duna. Spatio-temporal dynamics of microglia phenotype in human and murine cSVD: impact of acute and chronic hypertensive states. Acta neuropathologica communications. vol 11. issue 1. 2023-12-20. PMID:38115109. |
at early-stage hypertension, hippocampal microglia exhibited upregulated cd11b/c, p2y12r, cd200r, and cd86 surface expression. |
2023-12-20 |
2023-12-23 |
human |
| Meng Jia, Xi Guo, Ru Liu, Lei Sun, Qun Wang, Jianping W. Overexpress miR-132 in the Brain Parenchyma by a Non-invasive Way Improves Tissue Repairment and Releases Memory Impairment After Traumatic Brain Injury. Cellular and molecular neurobiology. vol 44. issue 1. 2023-12-19. PMID:38104297. |
controlled cortical impact onto the cortex would induce serious cortical injury and microglia accumulation in both cortex and hippocampus. |
2023-12-19 |
2023-12-21 |
Not clear |
| Meng Jia, Xi Guo, Ru Liu, Lei Sun, Qun Wang, Jianping W. Overexpress miR-132 in the Brain Parenchyma by a Non-invasive Way Improves Tissue Repairment and Releases Memory Impairment After Traumatic Brain Injury. Cellular and molecular neurobiology. vol 44. issue 1. 2023-12-19. PMID:38104297. |
mir-132 overexpression could accelerate neuroblast migration toward the injury core and decreased microglia accumulation in the ipsilateral cortex and hippocampus. |
2023-12-19 |
2023-12-21 |
Not clear |
| Ping Li, Yang Liu, Man-Shu Zou, Ting-Ting Wang, Hai-Peng Guo, Ting-Ting Ren, Ying He, Hua Wang, Yu-Hong Wan. [Neuroprotective effect and mechanism of Zuogui Jiangtang Jieyu Formula on diabetes mellitus complicated with depression model rats based on CX3CL1-CX3CR1 axis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114178. |
these results suggest that zgjtjy may exert its neuroprotective effect by inhibiting the cx3cl1-cx3cr1 axis and activation of hippocampal microglia, thereby improving neuroinflammation and abnormal activation of n-methyl-d-aspartate receptor(nmdar) subunits, and ultimately enhancing the expression of synaptic-related proteins psd95, syn1, and bdnf in the hippocampus. |
2023-12-19 |
2023-12-23 |
rat |
| Kaori Masai, Yuta Nakayama, Kotaro Shin, Chiaki Sugahara, Ikuko Miyazaki, Takao Yasuhara, Isao Date, Masato Asanum. Neurogenesis impairment with glial activation in the hippocampus-connected regions of intracerebroventricular streptozotocin-injected mice. Neuroscience letters. 2023-12-18. PMID:38110145. |
the present study revealed that icv-stz induces reduction of neural progenitor cells and a dramatic increase in reactive astrocytes and microglia especially in the hippocampus and various hippocampus-connected brain areas. |
2023-12-18 |
2023-12-21 |
mouse |
| Rui Yao, Yuanyuan Man, Yao Lu, Yang Su, Meiyan Zhou, Shuang Wang, Xiaoping Gu, Rongguo Wang, Yuqing Wu, Liwei Wan. Infliximab alleviates memory impairment in rats with chronic pain by suppressing neuroinflammation and restoring hippocampal neurogenesis. Neuropharmacology. 2023-12-18. PMID:38110173. |
furthermore, infliximab inhibited the activation of hippocampal astrocytes and microglia and decreased the release of proinflammatory cytokines in cci rats. |
2023-12-18 |
2023-12-21 |
rat |
| Xingyu Yang, Ziwei Yu, Li An, Xinyue Jing, Mengqian Yuan, Tiancheng Xu, Zhi Yu, Bin Xu, Mengjiang L. Electroacupuncture stimulation ameliorates cognitive impairment induced by long-term high-fat diet by regulating microglial BDNF. Brain research. vol 1825. 2023-12-17. PMID:38103878. |
studies have shown that hfd activates hippocampal microglia and induces hippocampal inflammation, which is an important factor for cognitive impairment. |
2023-12-17 |
2023-12-21 |
mouse |